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[ CAS No. 5845-66-9 ] {[proInfo.proName]}

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Chemical Structure| 5845-66-9
Chemical Structure| 5845-66-9
Structure of 5845-66-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 5845-66-9 ]

CAS No. :5845-66-9 MDL No. :MFCD00155466
Formula : C11H12N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 220.22 Pubchem ID :-
Synonyms :

Safety of [ 5845-66-9 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P270-P301+P312-P330-P501 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 5845-66-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5845-66-9 ]

[ 5845-66-9 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 870-63-3 ]
  • [ 5845-66-9 ]
  • [ 112900-76-2 ]
YieldReaction ConditionsOperation in experiment
73% With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; 223 Example 223; 3-(S)-(4-(3-Methyl-but-2-enyloxy)-benzyl)-piperazine-2,5-dione; To a suspension of 3- (S)- (4-hydroxy-benzyl)-piperazine-2, 5-dione (15 g, 68.2 mmol), cesium carbonate (111 g, 340 mmol), and tetrabutylammonium iodide (1.25 g, 3.4 mmol) in anhydrous DMF (500 mL), add at once, at ambient temperature, l-bromo-3- methyl-but-2-ene (51 g, 340 mmol). Stir 12 hours then add water (300 mL). Concentrate to dryness then add water (500 mL) and extract with a dichloromethane/isopropyl alcohol (3/1) mixture. Wash the organic phases with 10% aqueous potassium carbonate and water then dry over magnesium sulfate. Evaporate the solvent, then triturate the resulting solid with chloroform. Filter and dry to yield (14.3 g, 73%) of the title compound as a white solid: mp 217-220 °C :'H NMR (DMSO-d6): 8 1.69 (s, 3H), 1.74 (s, 3H), 2.84-2. 76 (m, 2H), 3.02 (dd, 1H), 3.36 (dd, 1H), 4.01 (m, 1H), 4.48 (d, 2H), 5.41 (m, 1H), 6.84 (d, 2H), 7.05 (d, 2H), 7.86 (s, 1H), 8.12 (d, 1H).
46% With potassium carbonate In N,N-dimethyl-formamide at 20℃; 2.2.7. Compound 3 (c[Tyr(O-Dal)-Gly]) DKP 2 (0.108 g, 0.5 mmol) was alkylated in DMF (5 mL),K2CO3 (0.339 mg) and 3,3-dimethylallyl-bromide (0.3 mL) byfollowing the general O-alkylation procedure described above.After the work-up the crude residue was treated with Et2O togive the pure product 3 in 46% of yield. Rf=0.2 (CHCl3/MeOH95:5). 1H NMR (DMSO-d6) δ: 1.66 and 1.71 (6H, 2d, 2 × CH3Dal); 2.65-3.02 (4H, m, βCH2 Tyr and CH2 Gly); 4.00 (2H, d, α-CH Tyr); 4.45 (2H, d, O-CH2 Dal); 5.39 (1H, t,_CHCH2O);6.81 and 7.15 (4H, 2d, aromatics); 7.87 and 8.11 (2H, br, NHTyrand NH Gly).
23 mg With sodium hydride In dimethyl sulfoxide 0 deg C, then room t., 20 h;
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