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Chemical Structure| 54968-74-0
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CAS No. :54968-74-0 MDL No. :MFCD00848452
Formula : C7H9N3O3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 215.23 Pubchem ID :-
Synonyms :

Safety of [ 54968-74-0 ]

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Application In Synthesis of [ 54968-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54968-74-0 ]

[ 54968-74-0 ] Synthesis Path-Downstream   1~36

  • 1
  • [ 54968-78-4 ]
  • [ 54968-74-0 ]
YieldReaction ConditionsOperation in experiment
With sodium ethanolate In ethanol
  • 2
  • [ 60100-09-6 ]
  • [ 54968-74-0 ]
  • [ 72632-98-5 ]
YieldReaction ConditionsOperation in experiment
In acetic anhydride
  • 3
  • [ 122-51-0 ]
  • [ 54968-74-0 ]
  • [ 54968-79-5 ]
YieldReaction ConditionsOperation in experiment
In acetic anhydride Heating;
  • 4
  • [ 54968-74-0 ]
  • [ 462067-90-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride Heating;
With hydrogenchloride In water for 12h; Reflux; N-(2-Cyclopropylpropan-2-yl)-7-methyl-5-(pyridin-3-yl)isothiazolo j4,5-bl pyridine-3- carboxamide A solution of ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (2 g, 9.30mmol) in concentrated HC1 (12 N, 20 mL) was stirred under reflux for 12 h, and concentratedin vacuo to afford crude 4-aminoisothiazole-3-carboxylic acid as a light green solid. LC-MS mlz: 145.0 [M+H]+ tR 0.60 min
  • 5
  • [ 54968-74-0 ]
  • [ 54968-80-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium nitrite In acetic acid
YieldReaction ConditionsOperation in experiment
O-Tosyl-oximinonitril (1), α-Mercaptocarbonylverbindung (2);
  • 8
  • [ 54968-74-0 ]
  • [ 72632-82-7 ]
YieldReaction ConditionsOperation in experiment
83% With water; sodium hydroxide In ethanol 3.d A solution of NaOH (8 g, 0.2 mol) in water (60 mL) was added drop by drop to a solution of ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate (21.5 g, 0.1 mol) in ethanol (100 mL). The reaction mixture was left under stirring overnight. It was then evaporated, the residue obtained was dissolved in water, and the aqueous phase was extracted with ethyl acetate. The aqueous phase was then acidified to pH 4 with concentrated HC1. The product precipitated as a white powder that was recovered by filtration and dried, to give pure 4-amino-3-carbamoylisothiazol-5-carboxylic acid (15.5 g, 83%).
83% With water; sodium hydroxide In ethanol 3.d d)
Preparation of 4-amino-3-carbamoylisothiazol-5-carboxylic acid
A solution of NaOH (8 g, 0.2 mol) in water (60 mL) was added drop by drop to a solution of ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate (21.5 g, 0.1 mol) in ethanol (100 mL). The reaction mixture was left under stirring overnight. It was then evaporated, the residue obtained was dissolved in water, and the aqueous phase was extracted with ethyl acetate. The aqueous phase was then acidified to pH 4 with concentrated HCl. The product precipitated as a white powder that was recovered by filtration and dried, to give pure 4-amino-3-carbamoylisothiazol-5-carboxylic acid (15.5 g, 83%).
80% With sodium hydroxide In ethanol; water at 25℃; for 12h; Inert atmosphere; 4.4.23. Procedure for synthesis of 4-amino-3-carbamoylisothiazole-5-carboxylic acid (X) To a solution of ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate(0.1 mol) in ethanol (100 mL) was added an aqueous solution (60 mL)of NaOH (0.2 mol) at room temperature and allowed to stir for overnight. After completion of the reaction by TLC analysis, the solvent was evaporated under reduced pressure to afford crude residue. The crude material was dissolved in water and the aqueous layer was washed with ethyl acetate (100 mL). Then, the aqueous layer acidified to pH 4 using concentrated HCl and resulting precipitated solid was filtered and dried under reduced pressure to afford 4-amino-3-carbamoylisothiazole-5-carboxylic acid (X) as white solid with 80% yield. Analytical data of compound X: mp = 251-253 °C, 1H NMR(400 MHz, DMSO-d6): δ 8.11 (s, 2H), 7.76 (s, 2H); 13C NMR (100 MHz,DMSO-d6): δ 163.69, 162.71, 149.17, 148.87, 122.63. MS (ESI) Calc. for[C5H5N3O3S + H]+ = 188.01, found 188.00.
With potassium hydroxide In ethanol at 20℃; for 3h;

  • 9
  • [ 3473-63-0 ]
  • [ 60100-09-6 ]
  • [ 54968-74-0 ]
  • [ 890091-55-1 ]
YieldReaction ConditionsOperation in experiment
79.1% at 180℃; for 3.5h; AZ.A To a well-mixed combination of ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (3.62 g, 16.82 mmol; Liebigs Ann. 1979, 1534-1546) and formamidine acetate (5.253 g, 50.46 mmol) was added formamide (13.36 mL, 336.4 mmol). The reaction mixture was heated at 180 0C. The solution slowly turned dark and water was observed condensing. After 3.5 h heating, the cooled reaction mixture was diluted with water and filtered to afford 7-oxo-6,7-dihydroisothiazolo[4,5-c/]pyrimidine-3-carboxarnide (2.61 g, 13.30 mmol, 79.10 % yield) as a brown solid. LC/MS: m/z 180.1 (100%), 197.1 [M+l] (55%).
  • 10
  • [ 122-51-0 ]
  • [ 54968-74-0 ]
  • [ 54968-79-5 ]
YieldReaction ConditionsOperation in experiment
83% With acetic anhydride at 135℃; for 16h; AV.D Ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (7.44 g, 34.6 mmol) was dissolved in a mixture of ethyl orthoformate (8.05 mL, 48.4 mmol) in acetic anhydride (34.58 niL, 0.3665 mol) and heated at 135 0C. After 16 hours the reaction mixture was cooled to room temperature and the precipitated solid collected by filtration to give ethyl 7-hydroxyisothiazolo[4,3-]pyrimidine-3-carboxylate (6.43 g, 83 %). 1H NMR (500 MHz, DMSO- d6) δ 12.57 (s, IH), 8.15 (s, IH), 4.40 (q, J= 7.1 Hz, 2H), 1.34 (t,J= 7.1 Hz, 3H). MS m/z = 226.0 [M+l].
  • 11
  • [ 20992-40-9 ]
  • [ 105458-99-9 ]
  • [ 54968-74-0 ]
YieldReaction ConditionsOperation in experiment
95% With morpholine In ethanol for 0.583333h; Cooling with ice; AV.C To a stirred suspension of (E)-2-Amino-2-oxo-ΛL(tosyloxy)acetimidoyl cyanide (11.01 g, 36.3 mmol) in ethanol (30 mL, 0.6 mol) cooled over an ice bath was added ethyl thioglycolate (4.77 mL, 43.5 mmol). Morpholine (4.75 mL, 54.5 mmol) dissolved in 6 mL ethanol was added via an addition funnel over fifteen minutes. After twenty minutes the reaction mixture was diluted with 150 mL ice water. The precipitated solid was collected by filtration and dried over vacuum to give ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (7.443 g, 95 %). 1H NMR (500 MHz, DMSO-J6) δ 8.11 (s, IH), 7.75 (s, IH), 6.83 (s, 2H), 4.34 -4.26 (m, 2H), 1.29 (t, J= 7.1 Hz, 3H).
  • 12
  • [ 54968-74-0 ]
  • [ 1269667-42-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 2,6-dimethylpyridine; trichlorophosphate / acetonitrile / 2 h / 50 °C 2.2: 20 °C 2.3: 1.02 h
  • 13
  • [ 54968-74-0 ]
  • [ 1269667-43-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.08 h 2.2: 1.02 h / 20 °C
  • 14
  • [ 54968-74-0 ]
  • [ 1269667-67-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 2,6-dimethylpyridine; trichlorophosphate / acetonitrile / 2 h / 50 °C 2.2: 20 °C 2.3: 1.02 h 3.1: trimethylaluminum / toluene; hexane / 1 h / 20 °C 3.2: 80 °C
  • 15
  • [ 54968-74-0 ]
  • [ 1269666-47-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 2,6-dimethylpyridine; trichlorophosphate / acetonitrile / 2 h / 50 °C 2.2: 20 °C 2.3: 1.02 h 3.1: trimethylaluminum / toluene; hexane / 1 h / 20 °C 3.2: 80 °C 4.1: trifluoroacetic acid / dichloromethane / 4.5 h / 20 - 50 °C
  • 16
  • [ 54968-74-0 ]
  • [ 1269667-68-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.08 h 2.2: 1.02 h / 20 °C 3.1: trimethylaluminum / toluene; hexane / 1 h / 20 °C 3.2: 80 °C
  • 17
  • [ 54968-74-0 ]
  • [ 1269666-48-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: acetic anhydride / 16 h / 135 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazol-1-yloxy)tris-(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.08 h 2.2: 1.02 h / 20 °C 3.1: trimethylaluminum / toluene; hexane / 1 h / 20 °C 3.2: 80 °C 4.1: trifluoroacetic acid / 3 h / 20 °C
  • 18
  • [ 1374647-93-4 ]
  • [ 623-51-8 ]
  • [ 54968-74-0 ]
YieldReaction ConditionsOperation in experiment
58% With piperidine In ethanol at 5 - 20℃; 3.c Piperidine (8.5 g, 0.1 mol) was dripped at 5°C into a solution of 2-cyano-2-[(Z)-tosyloxyimino]acetamide (53.4 g, 0.2 mol) and ethyl 2-mercaptoacetate (25 g, 0.21 mol) in ethanol (250 mL). The reaction mixture was maintained under stirring at room temperature for 6 h, and then left to stand overnight. The reaction mixture was cooled to -10°C. The precipitate formed was recovered by filtration, washed with cold ethanol (100 mL) and air-dried to give ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate (25 g, 58%).
58% With piperidine In ethanol at 5 - 20℃; for 6h; 3.c c)
Preparation of ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate
Piperidine (8.5 g, 0.1 mol) was dripped at 5° C. into a solution of 2-cyano-2-[(Z)-tosyloxyimino]acetamide (53.4 g, 0.2 mol) and ethyl 2-mercaptoacetate (25 g, 0.21 mol) in ethanol (250 mL). The reaction mixture was maintained under stirring at room temperature for 6 h, and then left to stand overnight. The reaction mixture was cooled to -10° C. The precipitate formed was recovered by filtration, washed with cold ethanol (100 mL) and air-dried to give ethyl 4-amino-3-carbamoylisothiazol-5-carboxylate (25 g, 58%).
  • 19
  • [ 54968-74-0 ]
  • [ 1032654-11-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / ethanol 2.1: methanol / 50 °C 2.2: 24 h / 20 °C
Multi-step reaction with 2 steps 1.1: sodium hydroxide; water / ethanol 2.1: methanol / 50 °C 2.2: 24 h / 20 °C
  • 20
  • [ 54968-77-3 ]
  • [ 623-51-8 ]
  • [ 54968-74-0 ]
YieldReaction ConditionsOperation in experiment
62% With morpholine In ethanol at 0℃; for 0.583333h; N-(2-Cyclopropylpropan-2-yl)-7-methyl-5-(pyridin-3-yl)isothiazolo j4,5-bl pyridine-3- carboxamide To a stirred suspension of 2-amino-2-oxo-N-(tosyloxy)acetimidoyl cyanide (10 g,37.4 mmol) in ethanol (50 mL) was added ethyl 2-mercaptoacetate (5.38 g, 44.9 mmol) at 0 °C, followed by the addition of morpholine (4.89 g, 56.1 mmol) over fifteen minutes. The reaction mixture was stirred for twenty minutes, and diluted with ice water (150 mL). The precipitate was collected by filtration and dried in vacuo to afford ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (5 g, 62%) as a white solid. ‘H NMR (500 MHz, DMSO-d6) 5 8.13 (s, 1H), 7.77(s, 1H), 6.84 (s, 2H), 4.30 (q, J= 7.0 Hz, 2H), 1.30 (t, J= 7.5 Hz, 3H). LC-MS m/z: 215.9[M+Naj. LCMS: Purity (214 nm): 96.9 %; tR= 1.60 mm
With piperidine In ethanol at 0 - 25℃; for 12h; Inert atmosphere; 4.4.22. Procedure for synthesis of ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (IX) A solution of 2-amino-2-oxo-N-(tosyloxy)acetimidoyl cyanide (VIII)(0.2 mol) and ethyl 2-mercaptoacetate (0.21 mol) in ethanol (250 mL)was charged Piperidine (0.1 mol) at 0-5 °C. The reaction mixture was slowly warmed to room temperature and stirred for 12 h. After completionof the reaction by TLC analysis, it was cooled to -10 °C, the resulting precipitate formed was filtered, washed with cold ethanol(100 mL) and dried under reduced pressure to afford ethyl 4-amino-3-carbamoylisothiazole-5-carboxylate (IX) with 50% yield which was used as such in next step without any further purification.
  • 21
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((4-fluorobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 22
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((2,6-dimethoxybenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 23
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-methylbenzo[d]oxazol-6-yl)-N5-(2-oxo-2-((1-phenylethyl)amino) ethyl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 24
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((2-methoxybenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 25
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((3,4-dichlorobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 26
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((4-methoxybenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 27
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((4-chlorobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 28
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((4-bromobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 29
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-methylbenzo[d]oxazol-6-yl)-N5-(2-oxo-2-((3-(trifluoromethyl)benzyl)amino)ethyl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 30
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((2,5-dichlorobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 31
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-methylbenzo[d]oxazol-6-yl)-N5-(2-((3-methylbenzyl)amino)-2-oxoethyl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 32
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((3,5-dimethylbenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 33
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((3-methyl-5-(trifluoromethoxy)benzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 34
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((3-chloro-5-(trifluoromethyl)benzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 35
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-methylbenzo[d]oxazol-6-yl)-N5-(2-((2-methylbenzyl)amino)-2-oxoethyl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
  • 36
  • [ 54968-74-0 ]
  • 4-amino-N5-(2-((3-chlorobenzyl)amino)-2-oxoethyl)-N5-(2-methylbenzo[d]oxazol-6-yl)isothiazole-3,5-dicarboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium hydroxide / water; ethanol / 12 h / 25 °C / Inert atmosphere 2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / ethyl acetate / 3 h / 25 °C / Inert atmosphere
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