Alternatived Products of [ 540750-97-8 ]
Product Details of [ 540750-97-8 ]
CAS No. : | 540750-97-8 |
MDL No. : | |
Formula : |
C8H7NO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
149.15
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 540750-97-8 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 540750-97-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 540750-97-8 ]
- 1
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2-hydroxy-3-methoxy-benzaldehyde-(<i>O</i>-acetyl oxime )
[ No CAS ]
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[ 540750-97-8 ]
-
[ 6812-16-4 ]
- 2
-
[ 2169-99-5 ]
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[ 540750-97-8 ]
Yield | Reaction Conditions | Operation in experiment |
93% |
With triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 0.0166667h; |
|
90% |
With trifluoromethylsulfonic anhydride In dichloromethane at 20℃; for 3h; Inert atmosphere; |
Typical Procedure for the Synthesis of 1,2-Benzisoxazole UsingTriflic Anhydride
General procedure: The desired 2-hydroxyaryl aldoxime or ketoxime (2.0 mmol) in 5 mL dry DCM was taken in an oven-dried round-bottom flask. To the reaction mixture was adde ddropwise triflic anhydride (2.0 mmol) in DCM under nitrogen for 15 min. The reaction mixture was stirred at rt and the progress of the reaction was monitored by TLC and GC-MS (Table 1). After completion of reaction, the contents were poured on tocrushed ice (100 mL), neutralized with 10% NaHCO3 solution (20 mL), and extracted with DCM (315 mL). The pure products were obtained by column chromatography with hexane-ethyl acetate mixture (80:20). All the 1,2-benzisoxazole derivatives were characterized by GC-MS, 1H and 13C NMR, and elemental analysis, and the results are compared with authentic samples. |
|
With triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 0.0166667h; |
|
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With triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane for 0.0166667h; |
|
Reference:
[1]Iranpoor, Nasser; Firouzabadi, Habib; Nowrouzi, Najmeh
[Tetrahedron Letters, 2006, vol. 47, # 47, p. 8247 - 8250]
[2]Kalkhambkar, Rajesh G.; Yuvaraj
[Synthetic Communications, 2014, vol. 44, # 4, p. 547 - 555]
[3]Sun, Li; Liu, Yi; Wang, Yankai; Li, Yuanyuan; Liu, Zhiwen; Lu, Tao; Li, Wenhai
[Organic and Biomolecular Chemistry, 2019, vol. 17, # 32, p. 7526 - 7530]
[4]Feng, Juan; Zhao, Ming; Lin, Xuanzi
[Journal of Organic Chemistry, 2019, vol. 84, # 15, p. 9548 - 9560]