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[ CAS No. 5350-41-4 ] {[proInfo.proName]}

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Chemical Structure| 5350-41-4
Chemical Structure| 5350-41-4
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Product Details of [ 5350-41-4 ]

CAS No. :5350-41-4 MDL No. :MFCD00011780
Formula : C10H16BrN Boiling Point : -
Linear Structure Formula :- InChI Key :UUZYBYIOAZTMGC-UHFFFAOYSA-M
M.W : 230.15 Pubchem ID :21449
Synonyms :

Safety of [ 5350-41-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5350-41-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 5350-41-4 ]
  • Downstream synthetic route of [ 5350-41-4 ]

[ 5350-41-4 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 119-64-2 ]
  • [ 5350-41-4 ]
  • [ 6134-56-1 ]
YieldReaction ConditionsOperation in experiment
48.1% With acetic acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water EXAMPLE II-18
(Synthesis of Ex. Comp. No. (II-15))
In a 5 liter-three necked flask, 169.5 g (1.28 M) of 1,2,3,4-tetrahydronaphthalene and 3 liters of acetic acid were placed and stirred at room temperature.
Under stirring, to the mixture, 650 g (1.67 M) of benzyltrimethylammonium bromide and 244.8 g (1.80 M) of zinc chloride were successively added, followed by stirring for 5.5 hours at 70° C.
After the reaction, the reaction mixture was cooled to room temperature and poured into 3 liters of ice water, followed by extraction with methyl t-butyl ether.
The organic layer was successively washed with 5percent-NaHSO3 aqueous solution, 5percent-NaOH aqueous solution and distilled water, followed by distilling-off of the solvent under reduced pressure to obtain 243.2 g of a dark brown liquid.
The liquid was subjected to vacuum distillation (distillation under reduced pressure) (boiling point=108-110° C. at 667 Pa) to obtain 130.2 g of 6-bromo-1,2,3,4-tetrahydronaphthalene (Yield: 48.1percent).
Reference: [1] Patent: US2002/64681, 2002, A1,
  • 2
  • [ 100-39-0 ]
  • [ 75-50-3 ]
  • [ 5350-41-4 ]
YieldReaction ConditionsOperation in experiment
98% at 25℃; for 24 h; Inert atmosphere General procedure: In analogy to literature4, to a solution of benzyl halide 9 (1 equiv.) in THF (50 ml/g benzyl halide) were added 1.5 equiv. of trimethylamine 10 (33 wtpercent in EtOH).The resulting solution was stirred at RT for 24 hours, during which the product precipitated asa white solid. The resulting suspension was cooled to 0 °C, filtrated, washed with ice-cold Et2O and dried in vacuo to yield benzyl ammonium salts 6 in the reported yields.
Reference: [1] Synlett, 2016, vol. 27, # 13, p. 1963 - 1968
[2] Journal of the American Chemical Society, 2015, vol. 137, # 27, p. 8730 - 8737
[3] Patent: KR2018/8481, 2018, A, . Location in patent: Paragraph 0290-0292
[4] B.Ph.P., 1907, vol. 9, p. 477
  • 3
  • [ 3459-92-5 ]
  • [ 2840-24-6 ]
  • [ 5350-41-4 ]
Reference: [1] Advanced Synthesis and Catalysis, 2007, vol. 349, # 7, p. 1095 - 1101
  • 4
  • [ 103-83-3 ]
  • [ 74-83-9 ]
  • [ 5350-41-4 ]
Reference: [1] Journal of Solution Chemistry, 2001, vol. 30, # 12, p. 1101 - 1109
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