[ CAS No. 526-18-1 ] {[proInfo.proName]}

Name: 526-18-1|2-Hydroxy-N-(4-hydroxyphenyl)benzamide|98%
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Quality Control of [ 526-18-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 526-18-1 ]

Product Details of [ 526-18-1 ]

CAS No. :	526-18-1	MDL No. :	MFCD00020026
Formula :	C₁₃H₁₁NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LGCMKPRGGJRYGM-UHFFFAOYSA-N
M.W :	229.23	Pubchem ID :	4602
Synonyms :	4'-Hydroxysalicylanilide;Oxaphenamide;Saryuurin;PHPS;Salmidochol;NSC 93960;Oksafenamid;Auxobil;Osalmid	Chemical Name :	2-Hydroxy-N-(4-hydroxyphenyl)benzamide

Calculated chemistry of [ 526-18-1 ]

Physicochemical Properties

Num. heavy atoms :	17
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.0
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	3.0
Molar Refractivity :	64.7
TPSA :	69.56 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.24 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.53
Log Po/w (XLOGP3) :	3.46
Log Po/w (WLOGP) :	2.16
Log Po/w (MLOGP) :	1.82
Log Po/w (SILICOS-IT) :	1.62
Consensus Log Po/w :	2.12

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.77
Solubility :	0.0393 mg/ml ; 0.000172 mol/l
Class :	Soluble
Log S (Ali) :	-4.6
Solubility :	0.00573 mg/ml ; 0.000025 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-3.77
Solubility :	0.0388 mg/ml ; 0.000169 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.28

Safety of [ 526-18-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 526-18-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 526-18-1 ]
Downstream synthetic route of [ 526-18-1 ]

[ 526-18-1 ] Synthesis Path-Upstream 1~4

1
[ 123-30-8 ]
[ 65-45-2 ]
[ 526-18-1 ]

Yield	Reaction Conditions	Operation in experiment
84%	With thionyl chloride In ethyl acetate at 170℃; for 6 h;	General procedure: To the reaction vessel were added 0.07 mol of p-aminophenol, 0.076 mol of 2-hydroxy-benzamide and 80 ml of ethyl acetate, and the stirring rate was controlled at150rpm, slowly adding stannous chloride 0.031mol, the solution becomes darker color, add finished slowly heated to 170 , the reaction 6h, 2.1kPa vacuum distillationDistill part of ethyl acetate, lower the temperature of the solution to 38 , pour the reactant into 500ml mass fraction of 23percent sodium bisulfite solution,Adding water 33percent oxalic acid solution, adjusting the pH value to 4, precipitating the solid, separating the substance from the solution,Was recrystallized from 87percent ethylenediamine solution to obtain 13.47 g of white solid N-p-hydroxyphenyl salicylamide in 84percent yield.

Reference： [1] Patent: CN105503633, 2016, A, . Location in patent: Paragraph 0006; 0014; 0015

2
[ 123-30-8 ]
[ 69-72-7 ]
[ 526-18-1 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 12, p. 4113 - 4124

3
[ 123-30-8 ]
[ 118-55-8 ]
[ 526-18-1 ]

Reference： [1] Journal fuer Praktische Chemie (Leipzig), 1900, vol. <2> 61, p. 552[2] Chem. Zentralbl., 1900, vol. 71, # II, p. 612
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 2913
[4] Org.Synth.Coll.Vol.III <1955> 765,
[5] J.Textile Inst., 1930, vol. 21, p. 245T,255T
[6] Journal fuer Praktische Chemie (Leipzig), 1900, vol. <2> 61, p. 552[7] Chem. Zentralbl., 1900, vol. 71, # II, p. 612
[8] Journal of the American Chemical Society, 1947, vol. 69, p. 2913
[9] Org.Synth.Coll.Vol.III <1955> 765,

4
[ 19065-81-7 ]
[ 526-18-1 ]

Reference： [1] Journal of Organic Chemistry, 1948, vol. 13, p. 796,799

[ 526-18-1 ] Synthesis Path-Downstream 1~20

1
[ 19065-81-7 ]
[ 526-18-1 ]

Reference： [1]Journal of Organic Chemistry,1948,vol. 13,p. 796,799

2
[ 123-30-8 ]
[ 118-55-8 ]
[ 526-18-1 ]

Reference： [1]Journal fur praktische Chemie (Leipzig 1954),1900,vol. <2> 61,p. 552
Chemisches Zentralblatt,1900,vol. 71,p. 612
[2]Journal of the American Chemical Society,1947,vol. 69,p. 2913
[3],1930,vol. 21,p. 245T,255T
[4]Journal fur praktische Chemie (Leipzig 1954),1900,vol. <2> 61,p. 552
Chemisches Zentralblatt,1900,vol. 71,p. 612
[5]Journal of the American Chemical Society,1947,vol. 69,p. 2913

3
[ 526-18-1 ]
[ 75-36-5 ]
1-acetoxy-4-salicyloylamino-benzene [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1948,vol. 13,p. 796,799

4
[ 526-18-1 ]
[ 75-36-5 ]
[ 36957-34-3 ]

Reference： [1]Journal of Organic Chemistry,1948,vol. 13,p. 796,799

5
[ 526-18-1 ]
[ 541-41-3 ]
[ 52942-41-3 ]

Reference： [1]European Journal of Medicinal Chemistry,1974,vol. 9,p. 44 - 50

6
[ 526-18-1 ]
[ 74-86-2 ]
[ 69319-30-8 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1983,vol. 19,p. 379 - 382
Khimiya Geterotsiklicheskikh Soedinenii,1983,p. 469 - 472

7
[ 526-18-1 ]
[ 74-86-2 ]
[ 86269-47-8 ]
[ 86269-44-5 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1983,vol. 19,p. 379 - 382
Khimiya Geterotsiklicheskikh Soedinenii,1983,p. 469 - 472

9
[ 123-30-8 ]
[ 69-72-7 ]
[ 526-18-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2007,vol. 15,p. 4113 - 4124

10
[ 526-18-1 ]
[ 20978-99-8 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1983,vol. 19,p. 379 - 382
Khimiya Geterotsiklicheskikh Soedinenii,1983,p. 469 - 472

11
[ 526-18-1 ]
2-[N-(4-sulfamoyloxyphenyl)carbamoyl]phenyl sulfamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Example 68 The procedure of Example 2 was repeated, except that 23 mg of <strong>[526-18-1]2-hydroxy-N-(4-hydroxyphenyl)benzamide</strong> was used in place of 2'-nitrobiphenyl-4-ol, and 1.5 ml of N,N-dimethylformamide was used in place of methylene chloride. Thus, there was obtained 21 mg of 2-[N-(4-sulfamoyloxyphenyl)carbamoyl]phenyl sulfamate. 1H-NMR(DMSO-d6, delta): 6.7-8.4(12H, m), 10.49(1H, br s). MS(m/z): 308(M+-SO2NH), 229.

Reference： [1]Patent: EP1193250,2002,A1

12
[ 123-30-8 ]
[ 65-45-2 ]
[ 526-18-1 ]

Yield	Reaction Conditions	Operation in experiment
84%	With thionyl chloride; In ethyl acetate; at 170℃; for 6h;	General procedure: To the reaction vessel were added 0.07 mol of p-aminophenol, 0.076 mol of 2-hydroxy-benzamide and 80 ml of ethyl acetate, and the stirring rate was controlled at150rpm, slowly adding stannous chloride 0.031mol, the solution becomes darker color, add finished slowly heated to 170 , the reaction 6h, 2.1kPa vacuum distillationDistill part of ethyl acetate, lower the temperature of the solution to 38 , pour the reactant into 500ml mass fraction of 23% sodium bisulfite solution,Adding water 33% oxalic acid solution, adjusting the pH value to 4, precipitating the solid, separating the substance from the solution,Was recrystallized from 87% ethylenediamine solution to obtain 13.47 g of white solid N-p-hydroxyphenyl salicylamide in 84% yield.

Reference： [1]Patent: CN105503633,2016,A .Location in patent: Paragraph 0006; 0014; 0015

13
[ 18259-15-9 ]
[ 526-18-1 ]
[ 13515-97-4 ]
C₃₃H₃₃N₂O₉P [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%		Phosphorus oxychloride (0.50 mL, 5.5 mmol) was dissolved in dichloromethane (60 ml), protected with nitrogen and cooled in ice bath.Compound 1 was added dropwise (1.28 g, 5.0 mmol)And triethylamine (0.85 mL, 6.0 mmol)a solution in dichloromethane (15 mL),The reaction was stirred for 2 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath.Then add alanine methyl ester hydrochloride 3c (0.70 g,After stirring, a solution of triethylamine (1.70 mL, 12.0 mmol) in dichloromethane (10 mL) was added.The reaction was stirred for 5 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath, and Compound 2 (1.145 g, 5.0 mmol), N,N-dimethylA solution of the aminopyridine (122 mg, 1.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (10 mL) was stirred for 10 hr. Dilute with water, dilute the reaction solution with dichloromethane.The organic phase is separated, washed with water and washed with saturated sodium chloride.Dry over anhydrous sodium sulfate and evaporated to dryness under reduced pressure.The residue was separated on a silica gel column (PE / EA = 1:1; dichloromethane / methanol = 20:1), the white solid product DCZ0805 (2.5 g,Yield 80%).

Reference： [1]Patent: CN109942630,2019,A .Location in patent: Paragraph 0046-0048

14
[ 18259-15-9 ]
[ 526-18-1 ]
[ CAS Unavailable ]
[ CAS Unavailable ]

Reference： [1]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; TONGJI UNIVERSITY; Shanghai Institute of Materia Medica (in: CAS) - CN109942630, 2019, A Location in patent: Paragraph 0018; 0032

15
[ 18259-15-9 ]
[ 526-18-1 ]
[ 93246-53-8 ]
C₃₉H₃₇FN₃O₈P [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%		Phosphorus oxychloride (0.50 mL, 5.5 mmol) was dissolved in dichloromethane (60 mL).A solution of compound 1 (1.28 g, 5.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (15 mL)The reaction was stirred for 2 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath, then a solution of 3-fluoro-4-morpholinanilide 3b (0.98 g, 5.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (10 mL).The reaction was stirred for 5 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath, and Compound 2 (1.145 g, 5.0 mmol) was added dropwise.a solution of N,N-dimethylaminopyridine (122 mg, 1.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (10 mL)The reaction was stirred for 10 hours and the reaction was monitored by sampling.Dilute with water, dilute the reaction solution with dichloromethane.The organic phase is separated, washed with water and washed with saturated sodium chloride.Dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure, the residue was subjected to silica gel column (PE / EA = 1: 1; CH2Cl2 / MeOH = 20: 1), to give the product as a white solid DCZ0817 (2.2g, 60% yield).

Reference： [1]Patent: CN109942630,2019,A .Location in patent: Paragraph 0038-0040

16
[ 18259-15-9 ]
[ 2577-48-2 ]
[ 526-18-1 ]
DCZ₀₈₁₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%		Phosphorus oxychloride (0.50 mL, 5.5 mmol) was dissolved in dichloromethane (60 mL).A solution of compound 1 (1.28 g, 5.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (15 mL)The reaction was stirred for 2 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath, then a solution of L-valine methyl ester hydrochloride 3 (825 mg, 5.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (10 mL).The reaction was stirred for 5 hours and the reaction was monitored by sampling.The reaction solution was cooled again in an ice bath, and Compound 2 (1.145 g, 5.0 mmol) was added dropwise.a solution of N,N-dimethylaminopyridine (122 mg, 1.0 mmol) and triethylamine (0.85 mL, 6.0 mmol) in dichloromethane (10 mL)The reaction was stirred for 10 hours and the reaction was monitored by sampling.Dilute with water, dilute the reaction solution with dichloromethane.The organic phase is separated, washed with water and washed with saturated sodium chloride.Dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure, the residue was subjected to silica gel column (PE / EA = 1: 1; CH2Cl2 / MeOH = 20: 1), to give the product as a white solid DCZ0814 (2.6g, 80% yield).

Reference： [1]Patent: CN109942630,2019,A .Location in patent: Paragraph 0042-0044

17
[ 18259-15-9 ]
[ 526-18-1 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
40%	Stage #1: 3,5-dimethoxy-4'-hydroxystilbene With triethylamine; trichlorophosphate In dichloromethane for 2h; Inert atmosphere; Cooling with ice; Stage #2: 2-hydroxy-N-(4-hydroxyphenyl)benzamide With triethylamine In acetone for 10h; Cooling with ice;	1 Preparation Example 1 Phosphorus oxychloride (0.50mL, 5.5mmol) dissolved in dichloromethane (60mL), protected by nitrogen,To cool down in an ice bath, add compound 1 (1.28g, 5.0mmol) and triethylamine (0.85mL, 6.0mmol) dropwiseIn dichloromethane (15 mL), the reaction was stirred for 2 hours, and samples were taken to monitor the completion of the reaction.The reaction solution was cooled in an ice bath again, and then compound 2-1 (1.145 g, 5.0 mmol) was addedAnd triethylamine (1.70 mL, 12.0 mmol) in acetone (10 mL), stirred for 10 hours, and sampled to monitor the completion of the reaction.Dilute with water, extract the reaction solution with dichloromethane, separate the organic phase, wash with water, and wash with saturated sodium chloride.Dry with anhydrous sodium sulfate, evaporate to dryness under reduced pressure, and separate the residue on a silica gel column (PE/EA(v:v)=1:1; CH2Cl2/MeOH(v:v)=20:1),A white solid product DCZ0801 (1.1 g, yield 40%) was obtained.

Reference： [1]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; TONGJI UNIVERSITY; Shanghai Institute of Materia Medica (in: CAS) - CN111569084, 2020, A Location in patent: Paragraph 0044-0047

18
[ 22979-35-7 ]
[ 526-18-1 ]
[ 2919720-95-7 ]

Yield	Reaction Conditions	Operation in experiment
75%	Stage #1: 2-hydroxy-N-(4-hydroxyphenyl)benzamide With sodium hexaflorophosphate; C₂₈H₃₅B₉NiP₂*CH₂Cl₂ In acetonitrile at 20℃; for 0.25h; Schlenk technique; Inert atmosphere; Stage #2: Methyl phenyldiazoacetate In acetonitrile at 35℃; Schlenk technique; Inert atmosphere; regioselective reaction;

Reference： [1]Wang, Linghua; Perveen, Saima; Ouyang, Yizhao; Zhang, Shuai; Jiao, Jiao; He, Gang; Nie, Yong; Li, Pengfei [Chemistry - A European Journal, 2021, vol. 27, # 18, p. 5754 - 5760]

19
[ 123-30-8 ]
[ 1441-87-8 ]
[ 526-18-1 ]

Yield	Reaction Conditions	Operation in experiment
85 %	With triethylamine In dichloromethane at 0 - 20℃;	4.1.2. Polyhydroxy resveratrol amide derivative (1a-c, 6a-11b, 13a-c) General procedure: A solution of benzoic acid compound (10 mmol) in SOCl2 (20 mL)was refluxed in a water bath at 75 C for 2-6 h. The mixture was cooledto ambient temperature and then the excess SOCl2 was removed underreduced pressure. Aniline (20 mmol) and TEA (30 mmol) were dissolvedin dichloromethane (DCM) (30 mL) which was put into an ice-waterbath and a solution of the acyl chloride above in DCM (15 mL) wasadded to the reaction. After the mixture was stirred at room temperaturefor 2 h, the reaction was quenched with deionized water (30 mL), andextracted with EA (3 × 20 mL). The combined organic layers werewashed with 5% HCl (3 × 30 mL), water (1 × 20 mL), saturated NaHCO3(3 × 30 mL), and water (1 × 20 mL), and dried over Na2SO4 andconcentrated under reduced pressure. Then evaporated under reducedpressure to obtain a crude product, the residue was purified by columnchromatography (PE/EA = 4:1, v/v) to give 1a-c, 6a-11b, and 13a-c.
85 %	With triethylamine In dichloromethane at 0 - 20℃;	4.1.2. Polyhydroxy resveratrol amide derivative (1a-c, 6a-11b, 13a-c) General procedure: A solution of benzoic acid compound (10 mmol) in SOCl2 (20 mL)was refluxed in a water bath at 75 C for 2-6 h. The mixture was cooledto ambient temperature and then the excess SOCl2 was removed underreduced pressure. Aniline (20 mmol) and TEA (30 mmol) were dissolvedin dichloromethane (DCM) (30 mL) which was put into an ice-waterbath and a solution of the acyl chloride above in DCM (15 mL) wasadded to the reaction. After the mixture was stirred at room temperaturefor 2 h, the reaction was quenched with deionized water (30 mL), andextracted with EA (3 × 20 mL). The combined organic layers werewashed with 5% HCl (3 × 30 mL), water (1 × 20 mL), saturated NaHCO3(3 × 30 mL), and water (1 × 20 mL), and dried over Na2SO4 andconcentrated under reduced pressure. Then evaporated under reducedpressure to obtain a crude product, the residue was purified by columnchromatography (PE/EA = 4:1, v/v) to give 1a-c, 6a-11b, and 13a-c.

Reference： [1]Xin, Min; Wu, Haoyu; Du, Yuan; Liu, Sheng; Zhao, Feng; Mou, Xiaofeng [Chemico-Biological Interactions, 2023, vol. 380]
[2]Xin, Min; Wu, Haoyu; Du, Yuan; Liu, Sheng; Zhao, Feng; Mou, Xiaofeng [Chemico-Biological Interactions, 2023, vol. 380]

20
[ 69-72-7 ]
[ 526-18-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: thionyl chloride / 75 °C 2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

Reference： [1]Xin, Min; Wu, Haoyu; Du, Yuan; Liu, Sheng; Zhao, Feng; Mou, Xiaofeng [Chemico-Biological Interactions, 2023, vol. 380]

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P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 526-18-1 ] {[proInfo.proName]}

Quality Control of [ 526-18-1 ]

Related Doc. of [ 526-18-1 ]

Product Details of [ 526-18-1 ]

Calculated chemistry of [ 526-18-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 526-18-1 ]

Application In Synthesis of [ 526-18-1 ]

[ 526-18-1 ] Synthesis Path-Upstream 1~4

[ 526-18-1 ] Synthesis Path-Downstream 1~20

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry