Alternatived Products of [ 473416-22-7 ]
Product Details of [ 473416-22-7 ]
CAS No. : | 473416-22-7 |
MDL No. : | MFCD11617131 |
Formula : |
C12H12BrN3O4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
342.15
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 473416-22-7 ]
Application In Synthesis of [ 473416-22-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 473416-22-7 ]
- 1
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[ 67400-25-3 ]
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[ 24424-99-5 ]
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[ 473416-22-7 ]
Yield | Reaction Conditions | Operation in experiment |
79.2% |
With dmap; triethylamine; In acetonitrile; at 20℃; for 12h; |
Take (1.0g, 4.13mmol) of <strong>[67400-25-3]3-bromo-5nitroindazole</strong> in 20mL of acetonitrile, and then add (947mg, 4.34mmol) BORYC-2O, (202mg, 1.65mmol) DMAP, (859muL, 6.20mmol)Triethylamine,Reaction at room temperature for 12h. TLC monitors the reaction,After the reaction is complete, spin-dry the reaction solution.The concentrate was dissolved in ethyl acetate,It was extracted once with saturated sodium bicarbonate and brine, and the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated.After column chromatography of petroleum ether-ethyl acetate 9: 1, 1.1 g of solid was obtained with a yield of 79.2%. |
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In tetrahydrofuran; at 20℃; for 0.5h; |
To a solution of 24.0 g of <strong>[67400-25-3]3-bromo-5-nitro-1H-indazole</strong> and 12.2 g of 4-(dimethylamino)pyridine in 50 ml tetrahydrofuran was added dropwise 23 ml of di-tert-butyl carbonate at room temperature. After stirring at room temperature for 30 minutes, the mixture was added with water, acidified by adding diluted hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and the solvent was evaporated. The residue was purified and separated by silica gel column chromatography (ethyl acetate:hexane = 1:10), to give 20.5 g of the title compound as colorless needles.1H-NMR (400 MHz, CDCl3) d 1.73 (9H, s), 8.32 (1H, d, J = 9.0 Hz), 8.46 (1H, dd, J = 2.3, 9.0 Hz), 8.59 (1H, d, J = 2.3 Hz). |