Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 4433-01-6 | MDL No. : | MFCD00226068 |
Formula : | C12H8N2O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | KNVZVRWMLMPTTJ-UHFFFAOYSA-N |
M.W : | 244.20 | Pubchem ID : | 681885 |
Synonyms : |
|
Num. heavy atoms : | 18 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 6.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 61.39 |
TPSA : | 100.38 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.41 cm/s |
Log Po/w (iLOGP) : | 0.66 |
Log Po/w (XLOGP3) : | 0.53 |
Log Po/w (WLOGP) : | 1.54 |
Log Po/w (MLOGP) : | -0.99 |
Log Po/w (SILICOS-IT) : | 1.22 |
Consensus Log Po/w : | 0.59 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -1.98 |
Solubility : | 2.54 mg/ml ; 0.0104 mol/l |
Class : | Very soluble |
Log S (Ali) : | -2.21 |
Solubility : | 1.51 mg/ml ; 0.00618 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.92 |
Solubility : | 0.292 mg/ml ; 0.00119 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 2.1 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
48% | With hydrogenchloride; sodium hydroxide In methanol; water | Example 4 9.50 g of 2-chloronicotinic acid and 5.30 g of sodium hydroxide are dissolved in a mixture of 40 ml of water and 40 ml of methanol. Following the addition of 4 g of palladium (5percent by weight on activated carbon) as catalyst, the mixture is stirred for 30 h at 80-85° C. at 0.1 MPa. The catalyst is then filtered off. Following acidification to pH 1 using hydrochloric acid, the product, 2,2'-bipyridyl-3,3'-dicarboxylic acid, precipitates out as a white solid. This gives 3.5 g (48percent yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82.8% | With potassium permanganate; sodium hydroxide In water for 6h; Reflux; | |
80% | With potassium permanganate; sodium hydroxide In water Reflux; | 3.2. Synthesis of [2,2'-Bipyridine]-3,3'-Dicarboxylic Acid(1) 1,10-Phenanthroline (6 g), water (400 mL), sodium hydroxide(2.4 g) were mixed in a 1000 mL flask. After thesodium hydroxide dissolved, KMnO4 (10 g) was added inbatches under vigorously stirring. Then the resulting mixturewas refluxed to colorless. The mixture was filtered when hot.The filtrate was evaporated to 50 mL and then cooled toroom temperature. The pH was adjusted to 2-3 by addingconcentrated hydrochloric acid (10 mL) dropwise. The whitesolid product was obtained with a yield of 80%. |
78% | With sodium hydroxide; potassium permanganate In water for 6h; Heating; |
72% | With potassium permanganate; water for 6h; Reflux; | |
67% | With sodium hydroxide; potassium permanganate | |
61.1% | With sodium hydroxide; potassium permanganate In water for 2h; Heating; | |
With potassium hydroxide; potassium permanganate | ||
With sodium hydroxide; potassium permanganate | ||
With potassium permanganate; sodium periodate | ||
With hydrogenchloride; potassium permanganate | ||
With sodium hydroxide; potassium permanganate | ||
With hydrogenchloride; potassium permanganate In water at 120℃; | ||
Stage #1: 1,10-Phenanthroline With potassium permanganate; potassium hydroxide Stage #2: With hydrogenchloride In water | ||
With potassium permanganate; sodium hydroxide | ||
1.50 g | With potassium permanganate; sodium hydroxide In water at 20 - 105℃; for 6.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium hydroxide In acetonitrile |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92.8% | With dihydrogen peroxide; acetic acid at 105 - 110℃; for 3h; | |
With dihydrogen peroxide; acetic acid at 105 - 110℃; | (8.2 mmol) ofraw material H2bpda) was added into the mixture of 16 mL aceticacid and 16 mL 30% hydrogen peroxide, placed in a 50 mL roundbottom flask, heated at 105-110 °C, refluxed for 8 h, cooled at roomtemperature, filtered and washed to obtain a white powderedsolid, namely H2bpdado ligand. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 81% 2: 4% 3: 12% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With thionyl chloride; chlorine for 1h; Heating; Stage #2: ethanol In toluene for 3h; Heating; | |
1: 45% 2: 12% 3: 39% | With thionyl chloride; chlorine for 5h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With thionyl chloride for 1h; Heating; | |
With thionyl chloride for 5h; Heating; | ||
With thionyl chloride |
With thionyl chloride Heating; | ||
With thionyl chloride for 5h; Reflux; | ||
With thionyl chloride at 78℃; for 5h; | 2,20-Bipyridine-3,30-dicarboxylic acid (0.525 g, 2.15 mmol) andthionyl chloride (8 mL) were refluxed (78 C) for 5 h. The excessof thionyl chloride was distilled and the residue vacuum driedfor 2 h. The resulting yellow powder was dissolved in dry toluene(10 mL) and the solution was added drop wise to a solution of 3-(perfluorohexyl)propanol (1.1 mL, 6.9 mmol) and triethylamine(1.2 mL, 8.6 mmol) in 5 mL of dry dichloromethane. The mixture was refluxed (85 C) for 20 h. After removal of the solvent, the obtained powder was dissolved in chloroform (10 mL) and the mixture was extracted with a cold blank solution of saturated sodium bicarbonate (5 5 mL). The organic layer was dried onMgSO4 and the solvent removed in vacuum to obtain a solid product,which was purified by chromatography on silica gel using diethyl ether as eluent. A spectroscopically pure white solid was obtained after trituration with pentane. | |
With thionyl chloride In dichloromethane at 0 - 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 78% 2: 3% 3: 16% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With thionyl chloride; chlorine for 1h; Heating; Stage #2: 2-methyl-propan-1-ol In toluene for 3h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 73% 2: 12% 3: 6% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With thionyl chloride; chlorine for 1h; Heating; Stage #2: isopropyl alcohol In toluene for 3h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: SOCl2 / 5 h / Heating 2: SOCl2 / 3 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
48% | With hydrogenchloride; sodium hydroxide In methanol; water | 4 Example 4 Example 4 9.50 g of 2-chloronicotinic acid and 5.30 g of sodium hydroxide are dissolved in a mixture of 40 ml of water and 40 ml of methanol. Following the addition of 4 g of palladium (5% by weight on activated carbon) as catalyst, the mixture is stirred for 30 h at 80-85° C. at 0.1 MPa. The catalyst is then filtered off. Following acidification to pH 1 using hydrochloric acid, the product, 2,2'-bipyridyl-3,3'-dicarboxylic acid, precipitates out as a white solid. This gives 3.5 g (48% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.8% | In water reflux a mixt. of ligand and platinum complex in water for 18 h, cooling; elem. anal.; | |
84% | In water N2-atmosphere, absence of light; slow warming to 50°C, stirring for 8 h; cooling, collection (filtration), washing (cold water, EtOH, Et2O; in air), drying over CaCl2; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With NaOH In water ligand soln. added dropwise to soln. of metal compd. (1:1), pH 8 (NaOH),heated at 40°C for 12 h, cooled to room temp.; crystd. on storage, filtered off, washed (MeOH), dried in air, elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid at 115℃; | ||
With hydrogenchloride Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
26% | With triethylphosphine In tetrahydrofuran; toluene at 80℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65.8% | With NaOH In water High Pressure; mixt. of SmCl3*6H2O, 2,2'-bipyridine-3,3'-dicarboxylic acid (1:3) and NaOH stirred in H2O in air for 30 min, heated in an autoclave at 165°C for 96 h; slowly cooled to room temp. over 45 h, filtered, washed (H2O, Et2O), elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With NaOH In water High Pressure; a mixt. of Pb salt, ligand, NaOH, and H2O sealed, heated at 160°Cfor 6 d; cooled to room temp.; elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With triethylamine In ethanol for 7h; Reflux; | Synthesis of the [Ni(dioxime)2Cu2(N-N)2](ClO4)2 (3-7) complexes General procedure: The mononuclear [Ni(dioxime)2] complex (0.4 g, 0.91 mmol) was added to Et3N (0.30 mmol) in absolute ethanol (70 ml) and the mixture was stirred for 2 h. A solution of Cu(ClO4)2·6H2O (0.69 g, 1.82 mmol) in absolute ethanol (20 ml) was added to the stirred ethanol mixture of [Ni(dioxime)2] (2) complex and Et3N. Then an ethanolic solution (15 mL) of the N-N ligand [2,2′-bipyridine (0.29 g, 1.82 mmol), 1,10-phenanthroline monohydrate (0.36 g, 1.82 mmol), 3,3′-dicarboxy-2,2′-bipyridine (0.44 g, 1.82 mmol), 4,5-diazafluoren-9-one (0.35 g, 1.82 mmol) or 1,10-phenanthroline-5,6-dione (0.38 g, 1.82 mmol)] was added and stirred under reflux for 5 h. After boiling under reflux for 5 h, the mixture was left to precipitate up to 2 days. The solvent was slowly evaporated at room temperature, and the products were recrystallized from EtOH/H2O (1:2). Different color crystals obtained were filtered, washed with EtOH, MeOH and Et2O, and dried in air. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | In N,N-dimethyl-formamide at 100℃; for 72h; | A mixture of Mg(NO3)2·6H2O (0.1282 g, 0.5 mmol) and H2bpda (0.1221 g,0.5 mmol) in DMF (10 mL) was sealed in a Teflon-lined stainless steel vessel and heated at 100 °C for 3 d, and then cooled to room temperature. C12H14MgN2O8 (338.56): calcd. C 42.57, H 4.17, N 8.27; found C42.60, H 4.15, N 8.29. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | With triethylamine In ethanol; water; N,N-dimethyl-formamide for 6h; Reflux; | General procedure: The complexes [{dmgCu(N-N)}2ClCo-(4,4′-bpy)-CoCl{dmgCu(N-N)}2](ClO4)4 (3-9) and as linked ligands, N-N=2,2′-bipyridine (bpy), 1,10-phenanthroline (phen), 3,3′-dicarboxy-2,2′-bipyridine (dcbpy), 4,5-diazafluoren-9-one (dafo), 1,10-phenanthroline-5,6-dione (dione), 4,4′-ditertbutyl-2,2′-bipyridine (dtbpy) and 4,5-diazafluorene-9-oxime (dafoxi) containing these multinuclear complexes were synthesized according to the reported analogous procedure with some modifications. The complex (1) (0.5 g, 0.62 mmol) was added to Et3N (5 mL) in absolute ethanol-DMF-H2O (80:5:3 mL) and the mixture was stirred for 1 h. The separated solution of Cu(ClO4)2·6H2O (0.94g, 2.48mmol) for all of multinuclear [{dmgCu(N-N)}2ClCo-(4,4′-bpy)-CoCl{dmgCu(N-N)}2](ClO4)4 in absolute ethanol (20 mL) and 2,2′-bipyridine (0.40 g, 2.48 mmol), 1,10-phenanthroline monohydrate (0.49 g, 2.48 mmol), 3,3′-dicarboxy-2,2′-bipyridine (0.60 g, 2.48 mmol), 4,5-diazafluoren-9-one (0.48 g, 2.48 mmol), 1,10-phenanthroline-5,6-dione (0.52 g, 2.48 mmol), 4,4′-ditertbutyl-2,2′-bipyridine (0.67 g, 2.48 mmol) and 4,5-diazafluorene-9-oxime (0.49 g, 2.48 mmol) in absolute ethanol (15 mL) was successively added to the resulting mixture, which was boiled under reflux for 6 h. Then, the mixtures left to 48 h for precipitating. The solvent was evaporated slowly at room temperature and the products were recrystallized from EtOH/H2O (1:2) to give different color crystals which were filtered, then washed with EtOH, MeOH and Et2O and dried in air. Color: green; Yield (%): 68, m.p: 210°C, Anal. Calc. for [C74H64N18O40Cl6Cu4Co2] (F.W: 2430.2g/mol): C, 36.57; H, 2.65; N, 10.38. Found: C, 36.52; H, 2.61; N, 10.45%. ΛM=258Ω-1cm2mol-1, μeff=1.59 [B.M]. (for per Cu(II) ion), LC-MS (Scan ES+): m/z (%) 2431.3 (18) [M+H]+, FT-IR (KBr pellets, νmax/cm-1): 3564-3114 ν(COOH), 3087 ν(Ar-CH), 2983-2871 ν(Aliph-CH), 1681 ν(C=O), 1609 ν(C=N of oxime), 1573 ν(C=N of pyridine), 1493-1417 ν(C=C), 1241 ν(N-O), 1099 and 624 ν(ClO4), 518 ν(Co-N) and 466 ν(Cu-O). UV-Vis (λmax, nm, FontWeight="Bold" FontSize="10" = shoulder peak): 239, 269 FontWeight="Bold" FontSize="10" and 320 (in C2H5OH); 248, 283, 318 FontWeight="Bold" FontSize="10" and 412 FontWeight="Bold" FontSize="10" (in DMSO). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With europium(III) oxide In water at 170℃; for 72h; Autoclave; High pressure; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | In tetrahydrofuran at 20℃; for 17h; Inert atmosphere; Schlenk technique; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | Stage #1: zinc(II) nitrate hexahydrate; 1,10-phenanthroline-5,6-dione; 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine; water; acetonitrile In methanol for 2h; Reflux; Stage #2: sodium perchlorate monohydrate In methanol | 2.5. Preparation of [Zn2(bpy-3,30-dc)(ptd)2(H2O)6](ClO4)2(H2O)6(CH3CN)(4) The way was similar to that described for the preparation of 3,except that was Zn(NO3)26H2O instead of Cd(OAc)22H2O. Slowevaporation of the reaction solution at room temperature yieldedyellow crystals suitable for X-ray diffraction determination. Yield:53%. Anal. Calc. for C38H41N7O28Zn2Cl2: C, 36.65; H, 3.32; N, 7.87.Found: C, 37.74; H, 3.42; N, 7.63%. IR (cm1): 3325(m), 3071(m),1689(s), 1571(s), 1465(m), 1439(s), 1323(m), 1235(w), 1128(w),1022(w), 938(w), 837(w), 734(w), 704(w), 635(w), 545(w). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With sodium hydroxide at 120℃; for 72h; | 2.3. Preparation of [Zn(bpy-3,30-dc)(bibp)(H2O)2.5]n (2) The synthesis was similar to that described for 1 except usingZn(NO3)26H2O (0.5 mmol) instead of CdCl22H2O (yield: 32% basedon Zn). Anal. Calc. for C32H29N6O6.5Zn: C, 57.62; H, 4.38; N, 12.60.Found: C, 57.45; H, 4.73; N, 12.35%. IR spectrum (cm1):3547(m), 3395(m), 3115(m), 1630(s), 1573(s), 1444(m), 1368(s),1234(m), 1155(m), 1109(s), 1095(s), 1058(w), 951(w), 847(m),804(w), 774(s), 704(s), 657(m), 631(w), 556(w). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
26% | Stage #1: 1,10-phenanthroline-5,6-dione; 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine; water; cadmium(II) acetate dihydrate In methanol; acetonitrile for 2h; Reflux; Stage #2: sodium perchlorate monohydrate In methanol; acetonitrile | 2.4. Preparation of [Cd2(bpy-3,30-dc)(ptd)2(H2O)6](ClO4)2(H2O)5 (3) The ligand H2bpy-3,30-dc (0.24 mmol), ptd (0.12 mmol) andCd(OAc)22H2O (0.24 mmol) were mixed in methanol/acetonitrile/H2O (15 mL/10 mL/5 mL). After refluxing for 2 h, the resultantsolution was added to a saturated solution (5 mL) of NaClO4H2O.Slow evaporation of the resulting yellow solution at room temperatureyielded yellow crystals suitable for X-ray diffraction determination.Yield: 26%. Anal. Calc. for C36H40Cl2N6O27Cd2: C, 33.66; H,3.14; N, 6.54. Found: C, 34.03; H, 3.28; N, 6.76%. IR spectrum(cm1): 3329(m), 3067(m), 3012(m), 1695(s), 1575(s), 1470(m),1426(s), 1313(m), 1258(w), 1210(w), 1128(w), 1073(w), 933(w),840(w), 737(w), 692(w), 634(w). Anal. Calc. for C37H38N6O25Cd2Cl2(30): C, 35.20; H, 3.03; N, 6.66. Found: C, 34.66; H, 3.25; N, 6.83%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With sodium hydroxide at 120℃; for 72h; | 2.2. Preparation of [Cd(bpy-3,3’-dc)(bibp)(H2O)3] A mixture of CdCl22H2O (0.5 mmol), H2bpy-3,3’-dc (0.5 mmol),bibp (0.5 mmol), NaOH (1 mmol), and H2O (6 mL) was placed in aParr Teflon-lined stainless steel vessel (25 cm3), and then the vesselwas sealed and heated at 120 C for 3 days. After the mixturewas slowly cooled to room temperature, colorless crystals of 1were obtained (yield: 45% based on Cd). Anal. Calc. for C32H30N6O7-Cd: C, 53.16; H, 4.18; N, 11.62. Found: C, 53.38; H, 4.62; N, 11.85%.IR (cm1): 3575(m), 3504(m), 3124(m), 1614(s), 1564(s), 1449(w),1393(s), 1288(w), 1236(w), 1159(w), 1109(m), 1083(m), 936(w),861(m), 796(m), 775(w), 701(w), 656(w). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
26% | In methanol; water; acetonitrile for 2h; Reflux; | 2.4. Preparation of [Cd2(bpy-3,30-dc)(ptd)2(H2O)6](ClO4)2(H2O)5 (3) The ligand H2bpy-3,30-dc (0.24 mmol), ptd (0.12 mmol) andCd(OAc)22H2O (0.24 mmol) were mixed in methanol/acetonitrile/H2O (15 mL/10 mL/5 mL). After refluxing for 2 h, the resultantsolution was added to a saturated solution (5 mL) of NaClO4H2O.Slow evaporation of the resulting yellow solution at room temperatureyielded yellow crystals suitable for X-ray diffraction determination.Yield: 26%. Anal. Calc. for C36H40Cl2N6O27Cd2: C, 33.66; H,3.14; N, 6.54. Found: C, 34.03; H, 3.28; N, 6.76%. IR spectrum(cm1): 3329(m), 3067(m), 3012(m), 1695(s), 1575(s), 1470(m),1426(s), 1313(m), 1258(w), 1210(w), 1128(w), 1073(w), 933(w),840(w), 737(w), 692(w), 634(w). Anal. Calc. for C37H38N6O25Cd2Cl2(30): C, 35.20; H, 3.03; N, 6.66. Found: C, 34.66; H, 3.25; N, 6.83%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With sodium hydroxide In water at 120℃; for 72h; Autoclave; | 2.2. Preparation of [Cd(bpy-3,3’-dc)(bibp)(H2O)3]n (1) A mixture of CdCl22H2O (0.5 mmol), H2bpy-3,3’-dc (0.5 mmol),bibp (0.5 mmol), NaOH (1 mmol), and H2O (6 mL) was placed in aParr Teflon-lined stainless steel vessel (25 cm3), and then the vesselwas sealed and heated at 120 C for 3 days. After the mixturewas slowly cooled to room temperature, colorless crystals of 1were obtained (yield: 45% based on Cd). Anal. Calc. for C32H30N6O7-Cd: C, 53.16; H, 4.18; N, 11.62. Found: C, 53.38; H, 4.62; N, 11.85%.IR (cm1): 3575(m), 3504(m), 3124(m), 1614(s), 1564(s), 1449(w),1393(s), 1288(w), 1236(w), 1159(w), 1109(m), 1083(m), 936(w),861(m), 796(m), 775(w), 701(w), 656(w). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With sodium hydroxide In water at 120℃; Autoclave; | 2.3. Preparation of [Zn(bpy-3,30-dc)(bibp)(H2O)2.5]n (2) General procedure: A mixture of CdCl22H2O (0.5 mmol), H2bpy-3,3’-dc (0.5 mmol),bibp (0.5 mmol), NaOH (1 mmol), and H2O (6 mL) was placed in aParr Teflon-lined stainless steel vessel (25 cm3), and then the vesselwas sealed and heated at 120 C for 3 days. After the mixturewas slowly cooled to room temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | In methanol; water; acetonitrile for 2h; Reflux; | 2.5. Preparation of [Zn2(bpy-3,30-dc)(ptd)2(H2O)6](ClO4)2(H2O)6(CH3CN)(4) General procedure: The ligand H2bpy-3,30-dc (0.24 mmol), ptd (0.12 mmol) andCd(OAc)22H2O (0.24 mmol) were mixed in methanol/acetonitrile/H2O (15 mL/10 mL/5 mL). After refluxing for 2 h, the resultantsolution was added to a saturated solution (5 mL) of NaClO4H2O.Slow evaporation of the resulting yellow solution at room temperatureyielded yellow crystals suitable for X-ray diffraction determination. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With thionyl chloride at 20℃; for 12h; Inert atmosphere; | 2.2. Synthesis of [2,2′-Bipyridine]-3,3′-dicarbonyl dichloride hydrochloride (D) A solution of 1.0 g (4.1 mM) of 3,3′-dicarboxybipyridine acid in 4 mL of thionyl chloride was stirred under argon at room temperature for 12 h. Thionyl chloride was removed under reduced pressure and 5 mL of diethyl ether was added to the flask. The precipitate was filteredoff and washed three times with diethyl ether to eliminate residues of SOCl2. The white solid was dried under vacuum. Yield: 94% (1.36 g). 1H NMR (DMSO-d6) 8.85 (dd, 2 H, 2J = 5.0, 3J = 1.5, H1), 8.54 (dd, 2 H, 2J = 7.9, 3J = 1.5, H3), 7.78 (dd, 2 H, 2J = 7.9, 2J = 5.0, H2). FT-IR (cm-1) 2454 (NH), 1711 (CO). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere; Stage #2: (S)-2,2'-diamino-1,1'-binaphthalene In N,N-dimethyl-formamide Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | at 170℃; for 3h; Autoclave; High pressure; | 2.2. Synthesis of [Dy4(m3-OH)4(bpdc)3(ox)(H2O)5]·13H2O 1 H2bpdc (0.15 mmol, 0.0733 g), H2ox (0.05 mmol, 0.0063 g) andDy2O3 (0.2 mmol, 0.0746 g) were added in 10 mL distilled water.The reaction mixture was sealed in a 25 mL Teflon-lined stainlesssteel vessel and heated at 170 °C for 3 days, then cooled by 10 C/hto room temperature. The product was washed with distilled waterand air dried. White block-shaped crystals were obtained with theyield of 58% based on Dy. Anal. Calcd (%) for C38H34O26N6Dy4 1′ (aformula after loss of 12 lattice water molecules): C, 27.81%; H,2.09%; N, 5.12%. Found: C, 27.31%; H, 1.89%; N, 5.03%. IR(KBr, cm-1):3440(vs), 1597(s),1456(s), 1397(s), 1160(m), 778(s), 693(m), 576(m). |
at 170℃; for 72h; | 1 Preparation of Dy4 (μ3-OH) 4 (bpdc) 3 (ox) (H2O) 5] · 13H2O Will be dysprosium oxide,I.e. Dy2O3 (0.2 mmol, 0.0746 g),2,2'-bipyridine-3,3'-dicarboxylic acid (0.15 mmol, 0.0733 g)And oxalic acid (0.05 mmol, 0.0063 g) were added to 10 ml of deionized water,Magnetic stirring for 30 minutes;And then transferred to the hydrothermal reactor in the PTFE liner,Pack a good reactor into the oven,Heated at 170 ° C for 3 days,The solution was cooled to room temperature at 1 ° C /After removal of the product, the solid was separated,Get white lumps of crystals,Which is a functional metal-organic skeleton based on rare earth clusters. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | at 170℃; for 3h; Autoclave; High pressure; | 2.3. Synthesis of [Er4(m3-OH)4(bpdc)3(ox)(H2O)5]·11H2O 2 H2bpdc (0.15 mmol, 0.0733 g), H2ox (0.05 mmol, 0.0063 g) andEr2O3 (0.2 mmol, 0.0765 g) were added in 10 mL distilled water. Thereaction mixture was sealed in a 25 mL Teflon-lined stainless steelvessel and heated at 170° C for 3 days, then cooled by 10 C/h toroom temperature. The product was washed with distilled waterand air dried. Pink block-shaped crystals were obtained with theyield of 62% based on Er. Anal. Calcd (%) for C38H36O27N6Er4 2′ (aformula after loss of 9 lattice water molecules): C, 27.20%; H, 2.16%;N, 5.01%. Found: C, 26.93%; H, 2.01%; N, 5.13%. IR (KBr, cm-1):3430(v), 1599(s), 1454(s), 1395(s), 1161(m), 778(s), 693(m), 576(m). |
In N,N-dimethyl-formamide at 170℃; for 72h; | 2 Preparation of Er4(μ3-OH)4(bpdc)3(ox)(H2O)5]·11H2O Erbium oxide,I.e. Er2O3 (0.2 mmol, 0.0778 g),2,2'-bipyridine-3,3'-dicarboxylic acid (0.15 mmol, 0.0733 g) and oxalic acid (0.05 mmol,0.0063 g) was added to 5 ml of deionized water and 5 ml of DMF,Magnetic stirring for 30 minutes;And then transferred to the hydrothermal reactor in the PTFE liner,Pack a good reactor into the oven,Heated at 170 ° C for 3 days,The temperature was lowered to room temperature at 20 ° C /After removal of the product, the solid was separated,To obtain pink lumpy crystals, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With potassium hydroxide In methanol; water at 105℃; for 60h; Autoclave; High pressure; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81.6% | With sodium hydroxide In water; isopropyl alcohol at 130℃; for 120h; Autoclave; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.3% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With potassium hydroxide In methanol for 0.5h; Reflux; Stage #2: nickel(II) chloride hexahydrate In methanol for 2h; Reflux; | Stage one: Preparation of [Ni(κ2-bpdc)( H2O)4] A solution of KOH (0.6 millimole, 0.0336 g) in methanol (5 milliliter) was placed to a solution of bpdc (0.3 millimole, 0.0732 g) in methanol (10 milliliter) and refluxed for (30 minutes). The subsequent mixture was refluxed for a further(2 h) after addition of a methanol solution (5 milliliter) of NiCl2.6H2O (0.3 millimole, 0.0713 g) and filtered. When the solution was evaporated at room temperature the dark-green solid was formed. (Chemical formula: C12H14NiN2O8; Yield: 0.13 g, 94.3%; Melting point: 230-232°C; Color: dark-green). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65.7% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With potassium hydroxide In methanol for 0.5h; Reflux; Stage #2: cobalt(II) chloride hexahydrate In methanol for 2h; Reflux; | Stage one: Preparation of [Co(κ2-bpdc)(H2O)4] 2, 2'-bipyridine-3, 3'-dicarboxylic acid (bpdc) (0.3 millimole, 0.0732 g) was dissolved in methanol (10 milliliter) and (5 milliliter) methanol solution of KOH (0.6 millimole, 0.0336 gram) was added. After refluxing for (30 min), a solution of CoCl2.6H2O(0.3 millimole, 0.0713 g) in methanol (5 milliliter) was added dropwise. The resulted solution was heated under reflux for 2 h and filtered. The light brown precipitate was produced when the filtrate was evaporated at room temperature. (Chemical formula: C12H14CoN2O8; Yield: 0.09 gram, 65.7%; decomposition point: 296°C; Color: light brown). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61.9% | Stage #1: 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine With potassium hydroxide In methanol for 0.5h; Reflux; Stage #2: copper(II) choride dihydrate In methanol for 2h; Reflux; | Stage one: Preparation of [Cu(κ2-bpdc)(H2O)4] To a methanol solution (10 mL) of bpdc (0.3 millimole, 0.0732 g), a methanol solution(5 milliliter) of KOH (0.6 millimole, 0.0336 g) was added and refluxed for (30 min) then a solution of CuCl2.2H2O (0.3 millimole, 0.0514 g) dissolved in (5 milliliter) methanol was added and the resultant solution was refluxed for a further 2 h and filtered. The green solid was achieved when the solvent was evaporated at room temperature. (Chemical formula: C12H14CuN2O8; Yield: 0.07 g, 61.9 %; Melting point: 236-238°C; Color: green). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Methyltriphenylphosphonium bromide In water at 140℃; | [H2N(CH3)2]2[UO2(bpdc)2] (1) 2,2′-bipyridine-3,3′-dicarboxylic acid (24 mg, 0.10 mmol),[UO2(NO3)2(H2O)2]·4H2O (35 mg, 0.07 mmol), andPPh3MeBr(36 mg, 0.10 mmol) were dissolved in a mixtureof water (0.8 mL) and DMF (0.2 mL). The solution wasplaced in a 10 mL tightly closed glass vessel and heated at140 °C in a sand bath, under autogenous pressure, giving afew yellow crystals of complex 1 within one month. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | In aq. acetate buffer at 79.99℃; for 72h; | Synthesis of [Co(3,3′-BDA)(H2O)2]n (1) Complex 1 was synthesized in the high-pressure reactor ofmicrocalorimetry under the simulated hydrothermal conditionat different holding temperatures of 353.15 K, 393.15 K,413.15 K, 433.15 K. A mixture of Co(NO3)2· 6H2O(0.032 g,0.05 mmol), 3,3′-BDA (0.012 g, 0.05 mmol) was added to a3 mL HAc-NaAc buffer solution (pH = 4). The mixture wasstirred for 10 min and was placed in the high-pressure reactorheated at holding temperature for 72 h. The reactor wascooled at a cooling rate of 5 K·min-1 to room temperature.The wine block-like crystals of 1 were collected by filtration,washed with ethanol and dried in air (yield 65%-82%based on Co). Elemental analyses: calcd for C12H10CoN2O6(1): C: 43.02, H:2.61, N:8.19%; Found for C: 42.75, H:2.99,N:8.31%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | Stage #1: sodium tetrachloroaurate(III) dihyrate; 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine In ethanol for 3h; Stage #2: sodium dibenzyldithiocarbamate In ethanol for 0.166667h; | 3.4. Synthesis of Complexes 1-3 General procedure: In the first step, 0.122 g (0.5 mmol) 2,20-bipyridine-3,30-dicarboxylic acid in 10 mL ofethanol was added to 0.200 g (0.5 mmol) Na[AuCl4]2H2O in 10 mL of ethanol, and themixture was stirred for 3 h, generating a yellow product. In the second step, 0.5 mmolof the respective sodium dithiocarbamate in 5 mL of ethanol was added dropwise to theabove mixture. The mixture was stirred for an additional 10 min. For complexes 1 and2, yellow precipitates were obtained, while in the case of 3, it was an orange color. Theproducts were collected by filtration, washed with distilled water (3 10 mL), and driedunder vacuum. Yield: 0.215 g, 68% for 1; 0.245 g, 74.2% for 2; 0.278 g, 71% for 3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77.6% | In ethanol at 20℃; for 3h; | 3.3. Synthesis of [Au(Bipydc))Cl2]Cl (A) It was prepared by combining 0.122 g (0.5 mmol) 2,20-bipyridine-3,30-dicarboxylic acidin 10 mL of ethanol and 0.20 g (0.5 mmol) NaAuCl42H2O in 10 mL of ethanol. The mixturewas stirred for 3 h at room temperature and then filtered. The yellow product was washedtwice with ethanol (5 mL) and three times with diethyl ether (10 mL), then dried in thedark and stored in a fridge. Yield = 0.212 g, 77.6%. Analysis (C12H8AuCl3N2O4, 547.52):Calcd. C 26.32, H 1.47, N 5.11; found C 25.98, H 1.53, N 5.54. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | Stage #1: sodium tetrachloroaurate(III) dihyrate; 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine In ethanol for 3h; Stage #2: sodium dimethyldithiocarbamate In ethanol for 0.166667h; | 3.4. Synthesis of Complexes 1-3 General procedure: In the first step, 0.122 g (0.5 mmol) 2,20-bipyridine-3,30-dicarboxylic acid in 10 mL ofethanol was added to 0.200 g (0.5 mmol) Na[AuCl4]2H2O in 10 mL of ethanol, and themixture was stirred for 3 h, generating a yellow product. In the second step, 0.5 mmolof the respective sodium dithiocarbamate in 5 mL of ethanol was added dropwise to theabove mixture. The mixture was stirred for an additional 10 min. For complexes 1 and2, yellow precipitates were obtained, while in the case of 3, it was an orange color. Theproducts were collected by filtration, washed with distilled water (3 10 mL), and driedunder vacuum. Yield: 0.215 g, 68% for 1; 0.245 g, 74.2% for 2; 0.278 g, 71% for 3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74.2% | Stage #1: sodium tetrachloroaurate(III) dihyrate; 3,3'-bis(hydroxycarbonyl)-2,2'-bipyridine In ethanol for 3h; Stage #2: sodium N,N-diethyldithiocarbamate In ethanol for 0.166667h; | 3.4. Synthesis of Complexes 1-3 General procedure: In the first step, 0.122 g (0.5 mmol) 2,20-bipyridine-3,30-dicarboxylic acid in 10 mL ofethanol was added to 0.200 g (0.5 mmol) Na[AuCl4]2H2O in 10 mL of ethanol, and themixture was stirred for 3 h, generating a yellow product. In the second step, 0.5 mmolof the respective sodium dithiocarbamate in 5 mL of ethanol was added dropwise to theabove mixture. The mixture was stirred for an additional 10 min. For complexes 1 and2, yellow precipitates were obtained, while in the case of 3, it was an orange color. Theproducts were collected by filtration, washed with distilled water (3 10 mL), and driedunder vacuum. Yield: 0.215 g, 68% for 1; 0.245 g, 74.2% for 2; 0.278 g, 71% for 3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With perchloric acid at 160℃; for 144h; Autoclave; Sealed tube; | 2.2. Synthesis of [Ln2(phen)2(bpdc)3(H2O)2]n6nH2O [Ln = Eu (1), Tb(2), Gd (3)] General procedure: A mixture of H2bpdc (0.0241 g, 0.1 mmol), phen (0.0191 g, 0.1mmol), Ln2O3 {Ln = Eu (0.0351 g, 0.1 mmol), Tb (0.0361 g, 0.1 mmol)and Gd (0.0361 g, 0.1 mmol)} and water (5 mL) was stirred for 10 min,and then the pH value of the mixed solution was adjusted to 3 by HClO4acid. The final mixture was sealed in a 25 mL Teflonlined autoclave andheated at 160 C for 6 days. After cooling to room temperature slowly,colorless-block crystals of 1-3 were isolated. The yield of 1 is 52% basedon Eu2O3. Anal. calcd. for 1, C30H25EuN5O10, C 46.95%, H 3.28%, N9.12%, found: C 47.03%, H 3.34%, N 9.06%. IR (cm 1):3593(w), 3054(w), 1631(s), 1568(vs), 1375(vs), 1155(m), 1097(w), 1058(m), 854(m),769(s), 729(vs), 684(m), 633(s), 547(s). The yield of 2 is 56% based onTb2O3. Anal. calcd. for 2, C30H25TbN5O10, C 46.52%, H 3.25%, N 9.04%,found: C 46.45%, H 3.31%, N 9.11%. IR (cm 1): 3591(w), 3066(w),1641(vs), 1571(s), 1514(w), 1377(vs), 1231(w), 1158(m), 1100(w),1055(m), 958(w), 848(s), 769(s), 729(vs), 627(m), 552(m). The yield of3 is 52% based on Gd2O3. Anal. calcd. for 3, C30H25GdN5O10, C 46.63%,H 3.26%, N 9.06%, found: C 46.57%, H 3.32%, N 9.12%. IR (cm 1):3597(w), 3057(w), 1638(vs), 1579(vs), 1380(vs), 1225(w), 1152(m),1098(w), 1057(m), 958(w), 848(s), 767(s), 731(vs), 626(s), 554(s). TheCCDC reference numbers are 2164586-2164588. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With perchloric acid at 160℃; for 144h; Autoclave; Sealed tube; | 2.2. Synthesis of [Ln2(phen)2(bpdc)3(H2O)2]n6nH2O [Ln = Eu (1), Tb(2), Gd (3)] General procedure: A mixture of H2bpdc (0.0241 g, 0.1 mmol), phen (0.0191 g, 0.1mmol), Ln2O3 {Ln = Eu (0.0351 g, 0.1 mmol), Tb (0.0361 g, 0.1 mmol)and Gd (0.0361 g, 0.1 mmol)} and water (5 mL) was stirred for 10 min,and then the pH value of the mixed solution was adjusted to 3 by HClO4acid. The final mixture was sealed in a 25 mL Teflonlined autoclave andheated at 160 C for 6 days. After cooling to room temperature slowly,colorless-block crystals of 1-3 were isolated. The yield of 1 is 52% basedon Eu2O3. Anal. calcd. for 1, C30H25EuN5O10, C 46.95%, H 3.28%, N9.12%, found: C 47.03%, H 3.34%, N 9.06%. IR (cm 1):3593(w), 3054(w), 1631(s), 1568(vs), 1375(vs), 1155(m), 1097(w), 1058(m), 854(m),769(s), 729(vs), 684(m), 633(s), 547(s). The yield of 2 is 56% based onTb2O3. Anal. calcd. for 2, C30H25TbN5O10, C 46.52%, H 3.25%, N 9.04%,found: C 46.45%, H 3.31%, N 9.11%. IR (cm 1): 3591(w), 3066(w),1641(vs), 1571(s), 1514(w), 1377(vs), 1231(w), 1158(m), 1100(w),1055(m), 958(w), 848(s), 769(s), 729(vs), 627(m), 552(m). The yield of3 is 52% based on Gd2O3. Anal. calcd. for 3, C30H25GdN5O10, C 46.63%,H 3.26%, N 9.06%, found: C 46.57%, H 3.32%, N 9.12%. IR (cm 1):3597(w), 3057(w), 1638(vs), 1579(vs), 1380(vs), 1225(w), 1152(m),1098(w), 1057(m), 958(w), 848(s), 767(s), 731(vs), 626(s), 554(s). TheCCDC reference numbers are 2164586-2164588. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With perchloric acid at 160℃; for 144h; Autoclave; Sealed tube; | 2.2. Synthesis of [Ln2(phen)2(bpdc)3(H2O)2]n6nH2O [Ln = Eu (1), Tb(2), Gd (3)] General procedure: A mixture of H2bpdc (0.0241 g, 0.1 mmol), phen (0.0191 g, 0.1mmol), Ln2O3 {Ln = Eu (0.0351 g, 0.1 mmol), Tb (0.0361 g, 0.1 mmol)and Gd (0.0361 g, 0.1 mmol)} and water (5 mL) was stirred for 10 min,and then the pH value of the mixed solution was adjusted to 3 by HClO4acid. The final mixture was sealed in a 25 mL Teflonlined autoclave andheated at 160 C for 6 days. After cooling to room temperature slowly,colorless-block crystals of 1-3 were isolated. The yield of 1 is 52% basedon Eu2O3. Anal. calcd. for 1, C30H25EuN5O10, C 46.95%, H 3.28%, N9.12%, found: C 47.03%, H 3.34%, N 9.06%. IR (cm 1):3593(w), 3054(w), 1631(s), 1568(vs), 1375(vs), 1155(m), 1097(w), 1058(m), 854(m),769(s), 729(vs), 684(m), 633(s), 547(s). The yield of 2 is 56% based onTb2O3. Anal. calcd. for 2, C30H25TbN5O10, C 46.52%, H 3.25%, N 9.04%,found: C 46.45%, H 3.31%, N 9.11%. IR (cm 1): 3591(w), 3066(w),1641(vs), 1571(s), 1514(w), 1377(vs), 1231(w), 1158(m), 1100(w),1055(m), 958(w), 848(s), 769(s), 729(vs), 627(m), 552(m). The yield of3 is 52% based on Gd2O3. Anal. calcd. for 3, C30H25GdN5O10, C 46.63%,H 3.26%, N 9.06%, found: C 46.57%, H 3.32%, N 9.12%. IR (cm 1):3597(w), 3057(w), 1638(vs), 1579(vs), 1380(vs), 1225(w), 1152(m),1098(w), 1057(m), 958(w), 848(s), 767(s), 731(vs), 626(s), 554(s). TheCCDC reference numbers are 2164586-2164588. |
Tags: 4433-01-6 synthesis path| 4433-01-6 SDS| 4433-01-6 COA| 4433-01-6 purity| 4433-01-6 application| 4433-01-6 NMR| 4433-01-6 COA| 4433-01-6 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :