Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 4242-18-6 | MDL No. : | MFCD01464030 |
Formula : | C11H12O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GCFQXKYHWFWGSB-UHFFFAOYSA-N |
M.W : | 176.21 | Pubchem ID : | 239604 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.36 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 50.83 |
TPSA : | 37.3 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.37 cm/s |
Log Po/w (iLOGP) : | 1.72 |
Log Po/w (XLOGP3) : | 2.83 |
Log Po/w (WLOGP) : | 2.26 |
Log Po/w (MLOGP) : | 2.45 |
Log Po/w (SILICOS-IT) : | 2.7 |
Consensus Log Po/w : | 2.39 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -2.99 |
Solubility : | 0.18 mg/ml ; 0.00102 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.27 |
Solubility : | 0.0944 mg/ml ; 0.000536 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.88 |
Solubility : | 0.234 mg/ml ; 0.00133 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.82 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With borane-THF In tetrahydrofuran at 0 - 20℃; for 16 h; | 5,6,7,8-tetrahydronaphthalene 1-carboxylic acid (2.0 g, 11mmol) was dissolved in the tetrahydrofuran (following, THF) (30 mL), borane.THF (23 mL, a 0.98M THF solution, 23mmol) were added at 0 degree C, and it agitated at the room temperature for 16 hours. Water was added to the reaction solution at 0 degree C, and ethyl acetate extracted. The saturated sodium chloride solution washed the organic layer, and it condensed after drying with anhydrous sodium sulfate, and obtained the rough product. silica gel column chromatography (n-hexane -> n-hexane/ethyl acetate =3/1) refined the obtained rough product, and it obtained the title compound (1.9 g and colourless oil, quantitive) |
99% | With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 24.5 h; | To a solution of 1-tetrahydronaphthoic acid (5.70 g, 32.3 mmol) in THF (100 mL, dist. Na) at 0 °C was added lithium aluminium hydride (2.46 g, 64.7 mmol) in small portions. The reaction mixture was stirred at 0 °C for 30 min and then stirred for further 24 h at r.t. The reaction mixture was washed with water (100 mL) and extracted with EtOAc (3 x 50 mL). The organic phase was dried with Na2S04 and concentrated under reduced pressure to obtain 44 as colourless oil (5.23 g, 99percent). 1H NMR (CDC13) δ 7.18 (d, J = 7.4 Hz, 1H), 7.11 (d, J = 7.5 Hz, 1H), 7.05 (d, J = 7.6 Hz, 1H), 4.67 (s, 2H), 2.80 (t, J = 6.2 Hz, 2H), 2.76 (t, J = 6.4 Hz, 2H), 1.88- 1.77 (m, 4H). Found: [M+H-18]=145.5 |
98% | With potassium hydrogensulfate; LiAlH4 In tetrahydrofuran; diethyl ether | b 5,6,7,8-Tetrahydro-1-hydroxymethylnaphthalene A solution of 20 mL (0.019 mol) of 1.0M LiAlH4 in Et2 O was cooled to -78° C. and treated dropwise with a solution of 3.42 g (0.019 mol) of 5,6,7,8-tetrahydro-1-naphthoic acid in 20 mL THF. The solution was allowed to warm to room temperature and stirred overnight. The solution was cooled to 0° C. and decomposed with 40 mL of a 0.43M solution of KHSO4. The mixture was filtered through Celite and washed with EtOAc. The organic phase was washed with 1N HCl and saturated NaCl. Drying over MgSO4 and removal of the solvent under reduced pressure left 3.02 g (98percent yield) of the product. The structure was confirmed by NMR spectroscopy. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74.3% | With hydrogen; acetic acid;palladium 10% on activated carbon; at 80 - 85℃; under 2942.29 - 3677.86 Torr; | EXAMPLE 1 : Preparation of palonosetron hydrochloride.Step (i): Preparation of 5,6, 7,8-tetrahydro-1 -naphthalene carboxylic acid (formula II).1 -Naphthoic acid (50 g) and acetic acid (300 ml_) are charged into a hydrogenation flask, and 10percent Pd/C (50percent wet; 10 g) is added. The reaction vessel is flushed twice with hydrogen gas. Hydrogen pressure of 4-5 Kg/cm2 is applied, and the mass is heated to 80-850C. The mass is maintained at this temperature and pressure until completion of the reaction. After completion of the reaction, stirring is stopped, the catalyst is allowed to settle, and the hydrogen pressure is released. The mass is filtered at 80-850C and washed with acetic acid (100 ml_). The filtrate is charged into a round bottom flask and water (400 ml_) is added slowly at 35°C over about 30-60 minutes. The mass is stirred at 25-35°C for 30-60 minutes, filtered, the solid washed with water (2chi100 ml_) and the product obtained is dried at 70-750C. Yield: 38 g (74.3percent). Purity by HPLC: 99.54percent. |
67% | PtO2; In acetic acid; | a 5,6,7,8-Tetrahydro-1-naphthoic acid A solution of 10.0 9 (0.058 mol) of 1-naphthoic acid in 100 mL HOAc was treated with 0.5 g PtO2 and reduced at 29° C., 50 psi. When the required amount of H2 had been taken up, the mixture was filtered and the solvent removed under reduced pressure. The residue was recrystallized from EtOAc/hexane to give 6.84 g (67percent yield) of the product. The structure was confirmed by NMR spectroscopy. |
palladium; In dichloromethane; water; acetic acid; | PREPARATION 33 1,2,3,4-Tetrahydro-5-naphthoic acid 10percent w/w Palladium-on-carbon (10 g) was added to a solution of 1-naphthoic acid (33.4 g) in glacial acetic acid (150 ml) and the mixture hydrogenated at 345 kPa (50 psi) and 85° C. for 4 days. The warm mixture was filtered through a short column of Arbacel (trade mark) filter aid and the pad washed with glacial acetic acid (150 ml). Water (1.5L) was added to the filtrate and the resulting precipitate filtered off and washed with water. The precipitate was dissolved in dichloromethane, the solution dried over anhydrous sodium sulphate and the solvent removed under reduced pressure to give an oil which was crystallized from ethyl acetate to give 1,2,3,4-tetrahydro-5-naphthoic acid (2.94 g) as a white solid (m.p. 148-150° C.). 1H-NMR (CDCl3): delta=7.85 (1H, d), 7.28 (1H, d), 7.16 (1H, m), 3.15 (2H, br. s), 2.84 (2H, br. s), 1.72-1.90 (4H, m) ppm. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In thionyl chloride; toluene; | The requisite 5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was prepared as follows. A solution of <strong>[4242-18-6]5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid</strong> (J. W, Burnham, W. P. Duncan, E. J. Eisenbaum, G. W. Keen, M. C. Hamming, Org. Prep. Proc. Int. 285-290 (1973))(0.205 g, 1.16 mmol) in thionyl chloride (3.26 g, 27.42 minol) was heated at 80 C. for 3 h under a stream of nitrogen. Excess thionyl chloride was removed in vacuo, and the residue concentrated a second time from toluene to afford 5,6,7,8 tetrahydo-1-naphthalenecarbonyl chloride as a brown oil. The residue was dissolved in dry CH2Cl2 and used without further purification. | |
With oxalyl dichloride;N,N-dimethyl-formamide; In dichloromethane; for 1h;Product distribution / selectivity; | Preparation of Cp 9588 (where X is Cl): In 2 L reactor connected to acid gas scrubber, 665 g of dichloromethane, 2.37 g of DMF and 51.5 g of 5,6,7,8-tetrahydro-1-naphthalene carboxylic acid were charged, followed by a drop-wise addition of 37.5 g of oxalyl chloride.After 1 hour the mixture was concentrated at 40 under vacuum to give an oil residue, which was dissolved in 665 g of dichloromethane. | |
With thionyl chloride;N,N-dimethyl-formamide; In toluene; at 51℃; for 2h;Product distribution / selectivity; | Example 2; Preparation of Cp 9563 (as Free Base) using Thionyl ChloridePreparation of Cp 9588 (Where X is Cl):In a 250 mL glass reactor, under nitrogen atmosphere, 0.24 g of DMF, 310 mL of toluene and 44.8 g of tetrahydronaphthoic acid were charged at room temperature. The suspension was heated to 51+/-2 C. and 32 g of thionyl chloride were added drop-wise in about 60 minutes. The addition involves the evolution gas.The solution was stirred at 51+/-2 C. for 60 minutes. The solvent was then distilled off at reduced pressure with internal temperature 46+/-2 C. until 210 mL of residual volume (5.1 volumes vs tetrahydronaphtoic acid). The yellowish solution of acyl chloride thus obtained was used with no further purification nor isolation in the following step. |
With thionyl chloride;N,N-dimethyl-formamide; In toluene; at 25 - 45℃; | Part B: Preparation of 5,6, 7,8-tetrahydro-1 -naphthalene carboxylic acid chloride (formula IMb).5,6,7,8-Tetrahydronapthoic acid (100 g) and toluene (500 ml_) are charged into a round bottom flask at 28C and stirred. Dimethylformamide (0.6 ml_) is added and then thionyl chloride (50 ml_) is added drop-wise at 25-35C over 15- 30 minutes. The temperature is raised to 40-450C and the mass is stirred for 1-2 hours. The mass is concentrated at temperatures below 60C under vacuum, until no more solvent is distilled, then toluene (200 ml_) is added. The mass is concentrated below 600C under vacuum, until no more solvent distills. The obtained mass is dissolved in toluene (500 ml_). | |
With thionyl chloride;N,N-dimethyl-formamide; In dichloromethane; at 0 - 45℃; | 5,6,7, delta-tetrahydro-l-naphthalenecarboxylic acid (5 g) was dissolved in methylene chloride (25 ml) at about 25C. Dimethylformamide (0.1 ml) was added to the solution at about 25C followed by a slow addition of thionyl chloride (3.9 g) at 00C. The reaction mixture was refluxed for 2 hours at 40 to 45C. The solvent was removed from the reaction mixture by concentration under vacuum at 40 to 45C to get a residue. The residue was re-dissolved in methylene chloride (25 ml) | |
With oxalyl dichloride; at 20℃; for 2h; | EXAMPLE 37; oxalyl chloride DCM DIPEA l-r^^S-Tetrahydro-naphthalene-l-carbonylVaminol-indan-l-carboxylic acid ethyl ester (37):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (500mg, 2.84mmol) in DCM (1OmL) is added oxalyl chloride (0.5OmL, 5.68mmol) dropwise. The resulting solution is stirred at RT for 2h. After the removal of DCM and excess oxalyl chloride, the residue, 2- amino-indan-2-carboxylic acid ethyl ester (583mg, 2.84mmol) and DIPEA (1.88mL, 11.3mmol) are dissolved in DCM (2OmL). The resulting solution is stirred overnight. The reaction solution is diluted with DCM (3OmL) and washed with water (I x 5mL) and brine (2 x 5mL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (12Og silica gel, gradient elution: 0%- 20% EtOAc in heptane) to give the pure product (37) as white solid (610mg, 59%).66 <n="68"/>1H NMR (CDCl3, 300MHz): delta 1.29(t, 3H), 1.74(m, 4H), 2.76(m, 2H), 2.84(m, 2H), 3.34(d, 2H), 3.75d, 2H), 4.72(q, 2H), 6.20(s, IH), 7.02-7.12(m, 3H), 7.18-7.25(m, 4H) LC/MS (ES+) m/z = 364.18 | |
With thionyl chloride; In toluene; at 90℃; for 2.5h; | General procedure: To a suspension of 5,6,7,8-tetrahydro-2-naphthalenecarboxylic acid 9b (100 mg, 0.57 mmol) in toluene (1 mL) was added SOCl2 (0.21 mL, 2.9 mmol) at ambient temperature. After the reaction mixture was stirred for 2.5 hours at 90oC, the reaction mixture was concentrated under reduced pressure to yield 5,6,7,8-tetrahydro-2-naphthalenecarbonyl chloride as the crude product. To the crude product was added CH2Cl2, 2-aminobenzonitrile (101 mg, 0.86 mmol in CH2Cl2) and Et3N (0.16 mL, 1.14 mmol) at 0oC (total amount of CH2Cl2 was 1 mL). After the resulting mixture was stirred at ambient temperature for 19 hours, it was quenched with 1 mol/L HCl-aq. The reaction mixture was extracted with CH2Cl2 (×2). Combined organic extracts were dried over MgSO4 and the filtrate was evaporated under reduced pressure. The residue was purified by Gilson HPLC separation system using (0.1percent TFA in water) / CH3CN as an eluent to give N-(2-cyanophenyl)-5,6,7,8-tetrahydro-2-naphthalenecarboxamide 10b as a beige powder (60 mg, 38percent yield). To a solution of 10b (20 mg, 0.072 mmol) in DMF (0.3 mL) was added NH4Cl (5.9 mg, 0.11 mmol) and NaN3 (7.0 mg, 0.11 mmol) at ambient temperature. After the reaction mixture was stirred for 5 hours at 130oC, it was poured into water (0.2 mL) at 0 oC. NaNO2 (10 mg) in water (0.3 mL) and 1 mol/L HCl-aq (2 mL) were added to the mixture, which was extracted with EtOAc (×2). After combined organic extracts were washed with brine and dried over MgSO4, the filtrate was evaporated under reduced pressure. The residue was triturated with Et2O to give N-[2-(1H-tetrazol-5-yl)phenyl]-5,6,7,8-tetrahydro-2-naphthalenecarboxamide 8b (19 mg, 83percent yield) as an orange powder. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 25℃; for 24h; | (S)-3-Amino-l-azabicyclo[2.2.2.]octane dihydrochloride (22.74 g) was converted into its free base as per the method provided in Synthesis, (1996) 816-818, and stirred with methylene chloride (200 ml). 5,6,7,8-Tetrahydro-l-naphthalenecarboxylic acid (20 g) was added to the reaction mixture followed by the addition of dicyclohexylcarbodiimide (23.44 g) and 4-dimethylaminopyridine (1 g). The reaction mixture was stirred at about 25°C for 24 hours. The reaction mixture was filtered and washed with methylene chloride (40 ml). The methylene chloride solution was washed with deionised water (20 ml), dried over sodium sulfate (2 g) and the solvent was recovered under vacuum. Ethyl acetate (100 ml) was added to the residue obtained and heated to reflux temperature. The hot solution was filtered through Celite bed and washed with hot ethyl acetate (40 ml). The filtrate was concentrated to about 40 ml and stirred at about 25°C for 2 hours. The reaction mixture was cooled to 10° to 15°C and stirred for 2 hours. The solid was filtered, washed with cold ethyl acetate (10 ml) and dried under vacuum at 40° to 45°C for 8 hours to obtain the title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With nitric acid; In benzene; | Step A Preparation of 3-nitro-<strong>[4242-18-6]5,6,7,8-tetrahydronaphthalene-1-carboxylic acid</strong> Fuming red nitric acid (150 ml.) was cooled to 2° C. and 27.3 g. of <strong>[4242-18-6]5,6,7,8-tetrahydronaphthalene-1-carboxylic acid</strong> was added portionwise over 0.5 hour with stirring maintaining the temperature at 2°-6° C. After another 45 minutes at about 5° C. the mixture was poured into 1500 ml. of crushed ice. The precipitate was collected and washed well with 5 * 500 ml. portions of water. The dried precipitate was heated with about 200 ml. of benzene. The insoluble material was collected and recrystallized from ethyl acetate to give 3-nitro-<strong>[4242-18-6]5,6,7,8-tetrahydronaphthalene-1-carboxylic acid</strong>, m.p. 209°-212° C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
[-BUTYL] lithium (9.6 ml of 2. [5M] solution in hexane) was added [DROPWIS OVER] 30 minutes to a stirred solution of [5-BROM-1,] 2,3, 4-tetrahydronaphthalene in mixture with its regioisomer [6-BROM-1,] 2,3, 4-tetrahydronaphthalene (5 g) in dry THF (125 ml) and hexane (35 ml) [AT-70 C,] stirring was continued at-78 C for 30 minutes, carbon dioxide gas was bubbled through the mixture at-70 C until no further exotherm was evident, carbon dioxide gas addition was continued for a further 10 minutes as the reaction was allowed to warm to ambient temperature, the mixture was poured into 2M aqueous hydrochloric acid (100 ml) and the resulting mixture was extracted with diethyl ether (3 x 50 ml). The combined organic extracts were washed with water (100 ml) and were then extracted with 10percent aqueous sodium carbonate solution (3 x 50 ml). The combined aqueous carbonate extracts were acidified carefully by addition of 2M hydrochloric acid to adjust the pH to pH 1. The resulting mixture was extracted with diethyl ether (3 x 50 ml), the combined organic extracts were washed with water (50 ml) and dried [(MGS04)] before solvent was removed by evaporation [IN VACUO TO] give the crude product in 64percent yield comprising a mixture [OF REGIOISOMERS] of 5,6, 7,8-tetrahydronaphthalene carboxylic acid. This mixture was purified by repeated recrystallisation from ethyl acetate to give 5,6, 7,8- tetrahydronaphthalene-2-carboxylic acid as crystallised solid in 93percent purity along with 5,6, 7, [8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC] acid as the major component present in the crystallisation mother liquors. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N-methyl-acetamide; dichloromethane; water; | p and q are 0; and R3 is 1-azabicyclo[2.2.2]oct-3-yl. A solution of <strong>[4242-18-6]5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid</strong> (Ofosu-Asante, K. and Stock, L. M., J. Org. Chem. 1986; 51: 5452) (2.06 g, 11.7 mmol), oxalyl chloride (1 mL, 11.7 mmol), and dimethylformamide (0.1 mL) in dichloromethane (20 mL) was stirred at room temperature for one hour. The mixture was then concentrated under reduced pressure, and the residue was dissolved in dichloromethane (20 mL). The resulting solution was added dropwise at 0° C. to a solution of (S)-3-amino-1-azabicyclo[2.2.2]octane (1.48 g, 11.7 mmol) in dichloromethane (20 mL). The solution was stirred at room temperature for 30 minutes, and the solvent was evaporated under vacuum. The residue was dissolved in water and washed with ethyl acetate. The aqueous layer was basified with NH4 OH and extracted with dichloromethane. The dichloromethane was dried with anhydrous potassium carbonate, filtered and then evaporated to afford 2.75 g of white crystals. A sample recrystallized from ethyl acetate/hexane gave (S)-N-(1-azabicyclo[2.2.2]oct-3 -yl)-5,6,7,8-tetrahydro-1-napthalenecarboxamide, m.p. 159°-160° C.; [alpha]D25 -42.1° (c=0.65, CHCl3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With PPA; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; cyclohexane; | EXAMPLE 1 2-(5,6,7,8-Tetrahydronaphth-1-yl)oxazolo[4,5-b]pyridin A mixture of 15.5 g. (0.141 mole) of 2-amino-3-hydroxypyridine, 25.0 g. (0.141 mole) of <strong>[4242-18-6]5,6,7,8-tetrahydronaphthalen-1-carboxylic acid</strong> and 75 g. of polyphosphoric acid was placed in oil bath at about 100° C. and heated to 180° C. over a period of 70 minutes. The mixture was poured into 1 l. of ice-water and adjusted to pH 6 with solid sodium bicarbonate and finally to pH 10 with concentrated ammonium hydroxide. Methylene chloride (500 ml.) was added and stirring was continued for 2 hours. The aqueous phase was separated and extracted with 2 * 250 ml. of methylene chloride. The combined extracts were dried over magnesium sulfate, filtered, and concentrated to dryness to give 30.0 g. of product, m.p. 87°-90° C. Recrystallization from 300 ml. of cyclohexane gave 24.2 g. of 2-(5,6,7,8-tetrahydronaphth-1-yl)oxazolo[4,5-b]pyridin, m.p. 88°-91° C. Employing the procedure substantially as described in Example 1, but substituting for the 5,6,7,8-tetrahydronaphthalene-1-carboxylic used therein a molar equivalent of a carboxylic acid of formula: STR6 and a pyridine of formula: STR7 described in Table I, there are produced the 2-substituted oxazolo[4,5-b]pyridines also described in Table I in accordance with Equation I. STR8 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 86; 5-Fluoro-2-[f5.l6.l7.l8-tetrahvdro-naphthalene-l-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (86):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (400mg, 2.27mmol), 2- amino-5-fluoro-indan-2-carboxylic acid ethyl ester (610mg, 2.72mmol), HATU (1.3Og, 3.41mmol) in anhydrous DMF (15mL) is added DIPEA (563muL, 3.41mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (7OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 5percent-40percent EtOAc in heptane) to give a pure product (86) as white solid (345mg, 40percent).95 <n="97"/>1H NMR (CDCl3, 300MHz): delta 1.28(t, 3H), 1.75(m, 4H), 2.76(br s, 2H), 2.83(br s, 2H), 3.33(dd, 2H), 3.69(dd, 2H), 4.25(q, 2H), 6.29(s, IH), 6.85-6.93(m, 2H), 7.02-7.16(m, 4H) LC/MS (ES+) m/z = 382.16 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 74; 13-Dimethyl-5-r(^,6J,8-tetrahydro-naphthalene-l-carbonyl)-aminol-5,6-dihydro-4H- cyclopenta[clthiophene-5-carboxylic acid ethyl ester (74):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (500mg, 2.84mmol), 5- amino-l,3-dimethyl-5,6-dihydro-4H-cyclopenta[c]thiophene-5-carboxylic acid ethyl ester (816mg, 3.41mmol), HATU (1.62g, 4.26mmol) in anhydrous DMF (15mL) is added DIPEA (704muL, 4.26mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (5OmL) and washed with water (1 x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 5-50percent EtOAc in heptane) to give a pure product (74) as white solid (l.lOg, 97percent).1H NMR (CDCl3, 300MHz): delta 1.29(t, 3H), 1.76(m, 4H), 2.25(s, 6H), 2.80(m, 4H), 2.97(d, 2H), 3.3 l(d, 2H), 4.26(q, 2H), 6.22(s, IH), 7.15-7.15(m, 3H) LC/MS (ES+) m/z = 398.16 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 76; (cis)- 1 ,3-Dimethyl-2- \\( 5,6,7,8-tetr ahydro-naphthalene- l-carbonyl)-aminol -indan-2- carboxylic acid ethyl ester (76):To a solution of 5,6,7, 8-tetrahydro-naphthalene-l-carboxylic acid (400mg, 2.27mmol), (cis)- 2-Amino-l,3-dimethyl-indan-2-carboxylic acid ethyl ester (636mg, 2.72mmol), HATU (1.3g, 3.41mmol) in anhydrous DMF (15mL) is added DIPEA (563muL, 3.41mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (5OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 50-50percent EtOAc in heptane) to give a pure product (76) as white solid (79mg, 9percent).1H NMR (CDCl3, 300MHz): delta 1.32(t, 3H), 1.50(d, 6H), 1.75(m, 4H), 2.75(br s, 2H), 2.88(br s, 2H), 3.80(q, 2H), 4.3 l(q, 2H), 5.73(s, IH), 7.00-7.25(m, 7H) LC/MS (ES+) m/z = 392.22 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 78; 5-,6-Dimethyl-2-[f5.,6.l7.l8-tetrahvdro-naphthalene-l-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (78):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (400mg, 2.27mmol), 2- amino-5,6-dimethyl-indan-2-carboxylic acid ethyl ester (636mg, 2.72mmol), HATU (1.3Og, 3.41mmol) in anhydrous DMF (15mL) is added DIPEA (563muL, 3.41mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (10OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is90 <n="92"/>purifed by flash column chromatography (115g silica gel, gradient elution: 5-50percent EtOAc in heptane) to give a pure product (78) as white solid (817mg, 92percent).1H NMR (CDCl3, 300MHz): delta 1.29(t, 3H), 1.74(m, 4H), 2.23(s, 6H), 2.75(br s, 2H), 2.84(br s, 2H), 3.25(d, 2H), 3.69(d, 2H), 4.26(q, 2H), 6.20(s, IH), 6.99-7.1 l(m, 5H) LC/MS (ES+) m/z = 392.20 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 80; 91 <n="93"/>5-Methoxy-2-[f5.l6.l7.l8-tetrahvdro-naphthalene-l-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (80):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (400mg, 2.27mmol), 2- amino-5-methoxy-indan-2-carboxylic acid ethyl ester (639mg, 2.72mmol), HATU (1.3g, 3.41mmol) in anhydrous DMF (15mL) is added DIPEA (563muL, 3.41mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (5OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115g silica gel, gradient elution: 5percent-40percent EtOAc in heptane) to give a pure product (52) as white solid (622mg, 70percent).1H NMR (CDCl3, 300MHz): delta 1.28(t, 3H), 1.74(m, 4H), 2.75(br s, 2H), 2.84(br s, 2H), 3.27(dd, 2H), 3.69(dd, 2H), 3.78(s, 3H), 4.25(q, 2H), 6.26(s, IH), 6.72-6.76(m, 2H), 7.01- 7.1 l(m, 4H), LC/MS (ES+) m/z = 394.21 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 82; 92 <n="94"/>3-Methyl-6-r(^,6J,8-tetrahydro-naphthalene-l-carbonyl)-aminol-6J-dihydro-5H- [21 pyrin dine-6-carboxylic acid ethyl ester (82):To a solution of l,2,3,4-tetrahydro-quinoline-8-carboxylic acid (240mg, 1.36mmol), 6-amino- 3-methyl-6,7-dihydro-5H-[2]pyrindine-6-carboxylic acid ethyl ester (not pure, 300mg,1.36mmol), HATU (608mg, l.betaOmmol) in anhydrous DMF (1OmL) is added DIPEA (264muL, l.betaOmmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (4OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by HPLC to give a product (82) as a colorless oil (lOOmg, 19percent).1H NMR (CDCl3, 300MHz): delta 1.26(t, 3H), 1.75(br s, 4H), 2.76(br s, 2H), 3.68(s, 2H), 3.86(q, 2H), 4.26(q, 2H), 7.02-7.12(m, 3H), 7.32(s, IH), 7.52(s, IH), 8.5 l(s, IH) LC/MS (ES+) m/z = 379.22 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 84; 2-r(^,6J,8-Tetrahvdro-naphthalene-l-carbonyl)-aminol-5-trifluoromethyl-indan-2^ carboxylic acid ethyl ester (84): To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (306mg, 1.74mmol), 2- amino-5-trifluoro-indan-2-carboxylic acid ethyl ester (583mg, 2.13mmol), HATU (992mg, 2.61mmol) in anhydrous DMF (15mL) is added DIPEA (431muL, 2.61mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (8OmL) and washed with water (1 x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (12Og silica gel, gradient elution: 5percent-70percent EtOAc in heptane) to give a pure product (84) as white solid (589mg, 78percent).1H NMR (CDCl3, 300MHz): delta 1.27(t, 3H), 1.75(m, 4H), 2.76(br s, 2H), 2.83(br s, 2H), 3.44(dd, 2H), 3.74(dd, 2H), 4.26(q, 2H), 6.35(s, IH), 7.02-7.12(m, 3H), 7.32(d, IH), 7.46(br s, 2H) LC/MS (ES+) m/z = 432.17 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; | EXAMPLE 106; 109 <n="111"/>107 108 1095-Cvano-2-r(5,6,7,8-tetrahvdro-naphthalene-l-carbonyl)-aminol-indan-2-carboxylic acid ethyl ester (106):To a solution of 5,6,7,8-tetrahydro-naphthalene-l-carboxylic acid (306mg, 1.74mmol), 2- amino-5-cyano-indan-2-carboxylic acid ethyl ester (601mg, 2.61mmol), HATU (992mg, 2.61mmol) in anhydrous DMF (15mL) is added DIPEA (431muL, 2.61mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (7OmL) and washed with water (I x 1OmL) and brine (2 x 1OmL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (12Og silica gel, gradient elution: 5percent-80percent EtOAc in heptane) to give a pure product (106) as white solid (473mg, 70percent).1H NMR (CDCl3, 300MHz): delta 1.26(t, 3H), 1.74(m, 4H), 2.76(br s, 2H), 2.82(br s, 2H),3.47(dd, 2H), 3.72(t, 2H), 4.25(q, 2H), 6.47(s, IH), 7.03-7.12(m, 3H), 7.3 l(d, IH), 7.49(d,2H)LC/MS (ES+) m/z = 389.18 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | General procedure: To a solution of DCC (271 mg, 1.20 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2, acetic acid (66mg, 1.10 mmol) was added and the reaction mixture was stirred for 30 min, and then compound 2 (226 mg, 1.00 mmol) was added to this slurry. The mixture was stirred at room temperature overnight, then the white precipitate was filtered off and CH2Cl2 was removed in vacuo, the residue was purified on a silicagel chromatography column to get compound 3a (239 mg, 89percent) as a red solid. |
Tags: 4242-18-6 synthesis path| 4242-18-6 SDS| 4242-18-6 COA| 4242-18-6 purity| 4242-18-6 application| 4242-18-6 NMR| 4242-18-6 COA| 4242-18-6 structure
[ 776-79-4 ]
2-(2-Carboxyethyl)benzoic acid
Similarity: 0.97
[ 38628-51-2 ]
4-(2-Carboxyethyl)benzoic acid
Similarity: 0.97
[ 7148-03-0 ]
4'-Methyl-[1,1'-biphenyl]-2-carboxylic acid
Similarity: 0.95
[ 776-79-4 ]
2-(2-Carboxyethyl)benzoic acid
Similarity: 0.97
[ 38628-51-2 ]
4-(2-Carboxyethyl)benzoic acid
Similarity: 0.97
[ 7148-03-0 ]
4'-Methyl-[1,1'-biphenyl]-2-carboxylic acid
Similarity: 0.95
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :