Home Cart 0 Sign in  

[ CAS No. 39124-19-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 39124-19-1
Chemical Structure| 39124-19-1
Structure of 39124-19-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 39124-19-1 ]

Related Doc. of [ 39124-19-1 ]

Alternatived Products of [ 39124-19-1 ]

Product Details of [ 39124-19-1 ]

CAS No. :39124-19-1 MDL No. :MFCD01710740
Formula : C7H10N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 170.17 Pubchem ID :-
Synonyms :

Safety of [ 39124-19-1 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 39124-19-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 39124-19-1 ]
  • Downstream synthetic route of [ 39124-19-1 ]

[ 39124-19-1 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 39124-19-1 ]
  • [ 24424-99-5 ]
  • [ 172843-97-9 ]
YieldReaction ConditionsOperation in experiment
82%
Stage #1: for 48 h; Reflux
Stage #2: With sodium hydroxide In 1,4-dioxane; methanol; water at 20℃; for 15 h;
[Step 2]
Synthesis of 4-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylic acid:
Calcium hydroxide (3.0 g, 41 mmol) was added to an aqueous solution (30 mL) of Reference Example Compound 31 (2.2 g, 13 mmol) at room temperature.
The resulting reaction solution was heated to reflux for 48 hours with stirring, and then filtered through Celite, followed by washing of the filtered product with hot water.
The filtrate was concentrated under reduced pressure, and the obtained crude product was dissolved in a mixture of water, 1,4-dioxane and methanol (water: 1,4-dioxane:methanol = 10:10:3, 23 mL). Di-tert-butyldicarbonate (3.4 g, 16 mmol) and sodium hydroxide (0.50 g, 13 mmol) were added to the reaction solution at room temperature.
The reaction solution was stirred at room temperature for 15 hours, and then concentrated under reduced pressure.
Dilute hydrochloric acid (15 mL) was added to the obtained crude product, and extraction was performed with a mixture of chloroform and methanol (chloroform:methanol = 10:1).
The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure, to obtain 2.6 g (82percent) of 4-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylic acid (hereinafter referred to as Reference Example Compound 32).
Reference: [1] Patent: EP2832724, 2015, A1, . Location in patent: Paragraph 0181
  • 2
  • [ 39124-19-1 ]
  • [ 172843-97-9 ]
Reference: [1] Journal of the American Chemical Society, 1997, vol. 119, # 49, p. 11807 - 11816
[2] Patent: WO2015/32945, 2015, A1,
Same Skeleton Products
Historical Records