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CAS No. : | 368421-58-3 | MDL No. : | MFCD28404611 |
Formula : | C13H14F2N4OS | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UWVOPVUWKIHGRF-ISVAXAHUSA-N |
M.W : | 312.34 | Pubchem ID : | 20692784 |
Synonyms : |
|
Num. heavy atoms : | 21 |
Num. arom. heavy atoms : | 11 |
Fraction Csp3 : | 0.31 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 5.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 76.46 |
TPSA : | 109.05 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.62 cm/s |
Log Po/w (iLOGP) : | 1.9 |
Log Po/w (XLOGP3) : | 0.82 |
Log Po/w (WLOGP) : | 2.1 |
Log Po/w (MLOGP) : | 1.58 |
Log Po/w (SILICOS-IT) : | 2.59 |
Consensus Log Po/w : | 1.8 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.35 |
Solubility : | 1.39 mg/ml ; 0.00446 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.69 |
Solubility : | 0.635 mg/ml ; 0.00203 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.2 |
Solubility : | 0.195 mg/ml ; 0.000625 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 3.37 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With sodium hydrogencarbonate; In ethanol; | h) Preparation of 4-{2-[(1R,2R)-2-(2,5-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl}-benzonitrile A mixture of (2R,3R)-3-(2,5-Difluoro-phenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-ylthiobutyramide (26.7 g, 85.4 mmol) and a-bromo-4'-cyano-acetophenone (24.0 g, 0.107 mol) in EtOH (500 ml) was refluxed for 1 hr. The reaction mixture was cooled down to r.t. And the solvent was removed under reduced pressure down to 150 ml. The residue was poured into in to cold (0° C.) saturated NaHCO3 aq. (400 ml). The resulting mixture was extracted with EtOAc (300 ml+150 ml*2). The combined organic layer was washed with brine (200 ml), dried over Na2SO4 and concentrated in vacuo. The residue was chromatographed on silica gel (Wako-gel C-300, Hexane:EtOAc=1:2) to give 4-{2-[(1R,2R)-2-(2,5-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl }-benzonitrile (32.0 g, 86percent). Physical form: colorless heavy syrup; ESI-MS: m/z 437 (M)+; 1H-NMR(CDCl3): 1.25(3H,d,J=7.3 Hz),4.12(1 H,q,J=7.3 Hz),4.26,4.96 (2H,Abq,J=14.5 Hz), 5.75(1H,s),6.89~7.07(2H,m),7.23~7.29(1 H,m),7.65 (1H,s),7.71(1H,s),7.75, 8.02(4H,Abq,J=8.6 Hz),7.85(1H,s). |
77.4% | In ethanol; at 78℃; for 3h; | The white solid obtained above (3.85 g, 12.75 mmol) was dissolved in absolute ethanol (60 ml), then add alpha-bromo-4-cyanoacetophenone (3.14g, 14.02mmol) to 78°C,The reaction was refluxed for 3 h. After cooling to room temperature, the reaction solution was concentrated and extracted with ethyl acetate.The ethyl acetate phase is washed with saturated sodium bicarbonate solution, the organic phase is dried and concentrated.Ice methyl tert-butyl ether washing, drying white solidIsoconazole4.31g(yield: 77.4percent, e.e. >99percent, d.e. >99percent). |
In ethanol; at 70℃; | In a round bottomed flask charged ethanol (250 ml), thioamide compound (25.0 gm) and 4-cyano phenacyl bromide (18.4 gm) under stirring. The reaction mixture were heated to 70 °C. After completion of reaction the solvent was removed under vacnum distillation and water (250 ml) and Ethyl acetate (350 ml) were added to reaction mass. The reaction mixture was stirred and its pH was adjusted between 7 to 7.5 by 10 percent solution of sodium bicarbonate. The layer aqneous layer was discarded and organic layer was washed with saturated sodium chloride solution (100 ml) and concentrated under vacuum to get residue. The residue was suspended in methyl tert-butyl ether (250 ml) and the reaction mixtnre was heated to at 40°C to make crystals uniform and finally reaction mass is cooled to room temperature filtered and washed with the methyl tert-butyl ether. The product was isolated dried to get pale yellowish solid product.Yield: 26.5 gmHPLC purity: 92.7percent |
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