[ CAS No. 3395-91-3 ] {[proInfo.proName]}

Name: 3395-91-3|Methyl 3-bromopropanoate|98%
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Quality Control of [ 3395-91-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 3395-91-3 ]

CAS No. :	3395-91-3	MDL No. :	MFCD00000250
Formula :	C₄H₇BrO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	KQEVIFKPZOGBMZ-UHFFFAOYSA-N
M.W :	167.00	Pubchem ID :	76934
Synonyms :

Calculated chemistry of [ 3395-91-3 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.75
Num. rotatable bonds :	3
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	30.5
TPSA :	26.3 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.74 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.86
Log Po/w (XLOGP3) :	0.81
Log Po/w (WLOGP) :	0.94
Log Po/w (MLOGP) :	1.09
Log Po/w (SILICOS-IT) :	0.98
Consensus Log Po/w :	1.14

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.19
Solubility :	10.8 mg/ml ; 0.0649 mol/l
Class :	Very soluble
Log S (Ali) :	-0.94
Solubility :	19.0 mg/ml ; 0.114 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.61
Solubility :	4.09 mg/ml ; 0.0245 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.72

Safety of [ 3395-91-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H227-H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 3395-91-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 3395-91-3 ]
Downstream synthetic route of [ 3395-91-3 ]

[ 3395-91-3 ] Synthesis Path-Upstream 1~14

1
[ 120-72-9 ]
[ 3395-91-3 ]
[ 6639-06-1 ]

Yield	Reaction Conditions	Operation in experiment
900mg	Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1 h; Stage #2: at 20℃; for 24 h;	Synthesis of 3-(1H-indol-1-yI)propanoic acid (Intermediate-25): A lOOmI RB flask fittedwith magnetic stirrer was charged with 10 ml of DMF. To the stirred solvent Starting Material-1 (1 .Og, 8.53 mmol) followed by Sodium hydride (400 mg, 10.24 mmol) were added. The resulting solution was stirred at room temperature for 1 hour. To the above solution methyl-3- bromo-propionate (2.13 g, 12.79 mmol) was added and stirred at room temperature for 24 hours. After completion of the reaction (reaction monitored by TLC), reaction mass wasdiluted with 3OmL of ice cold water and washed with ether. Aqueous portion was acidified with 1 N HCI (pH =2) and was then extracted with EtOAc and concentrated to give Intermediate-24 (900mg).
900 mg	Stage #1: With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1 h; Stage #2: at 20℃; for 24 h;	Synthesis of 3-(1H-indol-1-yl)propanoic acid (Intermediate-25) A 100 ml RB flask fitted with magnetic stirrer was charged with 10 ml of DMF. To the stirred solvent Starting Material-1 (1.0 g, 8.53 mmol) followed by Sodium hydride (400 mg, 10.24 mmol) were added. The resulting solution was stirred at room temperature for 1 hour. To the above solution methyl-3-bromo-propionate (2.13 g, 12.79 mmol) was added and stirred at room temperature for 24 hours. After completion of the reaction (reaction monitored by TLC), reaction mass was diluted with 30 mL of ice cold water and washed with ether. Aqueous portion was acidified with 1N HCl (pH=2) and was then extracted with EtOAc and concentrated to give Intermediate-24 (900 mg).

Reference： [1] Patent: WO2013/128465, 2013, A1, . Location in patent: Page/Page column 94
[2] Patent: US2015/158860, 2015, A1, . Location in patent: Paragraph 0332
[3] Patent: WO2004/43899, 2004, A1, . Location in patent: Page 37; 38

2
[ 554-12-1 ]
[ 3395-91-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	With N-Bromosuccinimide; silver nitrate In acetone at 20℃; for 6 h;	Methyl propiolate [(52] ml, 0. [583] mol) is combined with recrystallized N [BROMO-SUCCINIMIDE] (120 g, 0.674 mol) in 1,700 ml acetone under nitrogen. The solution is treated with silver nitrate (9.9 g, 0.0583 mol) neat in a single lot and the reaction is stirred 6 h at RT. The acetone is removed under reduced pressure [(25°C,] bath temperature) to provide a gray slurry. The slurry is washed with 2 x 200 ml hexane, the gray solid is removed by filtration, and the filtrate is concentrated in vacuo to provide 95 g of a pale yellow oily residue. The crude material is distilled via short path under reduced pressure [(65 °C,] about 25 mm Hg) into a dry ice/acetone cooled receiver to give 83.7 g (88percent) of methyl-3-bromo-propiolate as a pale yellow oil. Anal. calc'd for [C4H3BRO2] : C, 29.48 ; H, 1.86. Found: C, 29.09 ; H, 1.97.

Reference： [1] Patent: WO2004/13137, 2004, A1, . Location in patent: Page 76
[2] Tetrahedron Letters, 2010, vol. 51, # 13, p. 1793 - 1796

3
[ 292638-85-8 ]
[ 3395-91-3 ]

Reference： [1] Journal of the Chinese Chemical Society, 2014, vol. 61, # 3, p. 364 - 368
[2] Org.Synth. Coll.Vol.III<1955>576,
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1921, vol. 172, p. 1269[4] Annales de Chimie (Cachan, France), 1921, vol. <9> 15, p. 249
[5] Journal of Organic Chemistry, 1972, vol. 37, p. 3431 - 3433

4
[ 590-92-1 ]
[ 67-56-1 ]
[ 3395-91-3 ]

Reference： [1] Russian Journal of Bioorganic Chemistry, 1995, vol. 21, # 9, p. 626 - 632[2] Bioorganicheskaya Khimiya, 1995, vol. 21, # 9, p. 724 - 730
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 2009, vol. 52, # 9, p. 341 - 349
[4] Steroids, 1991, vol. 56, # 6, p. 311 - 315
[5] Journal of the American Chemical Society, 1938, vol. 60, p. 1375
[6] Journal of the Chemical Society, 1959, p. 103,104
[7] Tetrahedron Letters, 1998, vol. 39, # 47, p. 8563 - 8566
[8] Journal of Organometallic Chemistry, 2009, vol. 694, # 3, p. 323 - 331

5
[ 67-56-1 ]
[ 57-57-8 ]
[ 3395-91-3 ]

Reference： [1] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 937 - 960

6
[ 14213-56-0 ]
[ 3395-91-3 ]

Reference： [1] Journal fuer Praktische Chemie (Leipzig), 1966, vol. 34, p. 262 - 271

7
[ 67-56-1 ]
[ 3395-91-3 ]

Reference： [1] Journal of the American Chemical Society, 2017, vol. 139, # 16, p. 5724 - 5727

8
[ 3878-55-5 ]
[ 3395-91-3 ]

Reference： [1] Journal of Organic Chemistry, 1969, vol. 34, # 4, p. 1172 - 1173

9
[ 98-81-7 ]
[ 79-10-7 ]
[ 3395-91-3 ]
[ 16827-42-2 ]

Reference： [1] Chemische Berichte, 1954, vol. 87, p. 237,244

10
[ 3395-91-3 ]
[ 122-52-1 ]
[ 3699-67-0 ]

Reference： [1] Journal of the American Chemical Society, 1956, vol. 78, p. 4450
[2] Journal of Organic Chemistry, 1959, vol. 24, p. 532,535
[3] Trudy Kazansk.chim.technol.Inst., 1957, # 23, p. 105;[4] Chem.Abstr., 1958, p. 9949

11
[ 3395-91-3 ]
[ 75-16-1 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
71.7%	at -20℃; for 1 h; Inert atmosphere	In a 250 mL round bottom flask, methyl 3-bromopropanoate (5.0 mL, 45.8 mmol, 1.0 eq.) was taken up in dry ether (55.2 mL, 0.83 M) under nitrogen and cooled to -20° C. To this, 3.0 M methylmagnesium bromide (45.8 ml, 137 mmol, 3.0 eq) was added in dropwise fashion and the resulting mixture was stirred for an hour. The reaction was quenched with aqueous ammonium chloride. The resulting white suspension was extracted with ether multiple times. The combined organics were washed with brine, dried over MgSO₄, and concentrated to yield 4-bromo-2-methylbutan-2-ol as an oil (5.49 g, 71.7percent)
65%	at 0 - 20℃; for 2 h;	To a stirred solution of 4-bromo-butyric acid methyl ester (2 g, 12.27 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (16.4 mL, 49.08 mmol) at 0° C. and the mixture is stirred at room temperature for 2 hours. The reaction mixture is quenched with 1 N HCl and extracted with diethyl ether (2*20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified with silica gel column chromatography (combiflash) eluting in 20percent EtOAc/hexanes to give the title compound (1.3 g, 65percent). ¹H NMR (400 MHz, CDCl₃): δ 3.48 (t, J=8.0 Hz, 2H), 2.16 (t, J=7.4 Hz, 2H), 1.89 (s, 6H), 1.76 (s, 3H), 1.27 (s, 6H).
60%	at 0 - 20℃; for 1 h;	To a stirred solution of 4-bromo-butyric acid methyl ester (1 g, 5.9 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (19.9 mL, 23.9 mmol) at 0 °C and the mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with aqueous ammonium chloride (40 mL) and extracted with diethyl ether (2x20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified by silica gel column chromatography (combiflash) eluting with 20percentEtOAc/hexanes to obtain title compound as pale pink liquid (0.6 g, 60percent). ^NMR (400 MHz, DMSO) δ 4.38 (s, 1H), 3.52-3.48 (m, 2H), 1.97-1.91 (m, 2H), 1.08 (s, 6H).

48.9%	at 0 - 20℃; for 16 h;	a) 4-Bromo-2-methylbutan-2-olTo a solution of methyl 3-bromopropanoate (5.0 g, 29.94 mmol, and 1.0 eq) in dry THF was added methyl magnesium bromide at 0°C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50 percent ethyl acetate in hexane). Yield 48.9 percent (2.4 g). LC-MS (ESI): Calculated mass: 167.0; Observed massl67.1 [M+H]⁺ (it: 0.8-1.0 min).
48.9%	at 0 - 20℃; for 16 h;	To a solution of methyl 3-bromopropanoate (5.0 g,29.94 mmol, and 1.0 eq) in dry THF was added methyl mag21 nesium bromide at 0° C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50percent ethyl acetate in hexane). Yield 48.9percent (2.4 g). LCMS (ESI): Calculatedmass: 167.0; Observedmass 167.1[M+ H] (it: 0.8-1.0mm).

Reference： [1] Patent: US2011/105509, 2011, A1, . Location in patent: Page/Page column 51
[2] Patent: US2016/333005, 2016, A1, . Location in patent: Paragraph 0074-0075
[3] Steroids, 1991, vol. 56, # 6, p. 311 - 315
[4] Patent: WO2015/105786, 2015, A1, . Location in patent: Page/Page column 13; 14
[5] Patent: WO2013/53983, 2013, A1, . Location in patent: Page/Page column 45; 46
[6] Patent: US2015/11548, 2015, A1, . Location in patent: Paragraph 0180

12
[ 917-64-6 ]
[ 3395-91-3 ]
[ 35979-69-2 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 1417 - 1424

13
[ 3395-91-3 ]
[ 37488-40-7 ]
[ 23574-01-8 ]
[ 793-19-1 ]

Reference： [1] RSC Advances, 2014, vol. 4, # 35, p. 18229 - 18233

14
[ 3395-91-3 ]
[ 62-53-3 ]
[ 21911-84-2 ]

Reference： [1] Journal of pharmaceutical sciences, 1972, vol. 61, # 11, p. 1739 - 1745

[ 3395-91-3 ] Synthesis Path-Downstream 1~88

1
[ 590-92-1 ]
[ 67-56-1 ]
[ 3395-91-3 ]

Reference： [1]Russian Journal of Bioorganic Chemistry,1995,vol. 21,p. 626 - 632
Bioorganicheskaya Khimiya,1995,vol. 21,p. 724 - 730
[2]Journal of labelled compounds and radiopharmaceuticals,2009,vol. 52,p. 341 - 349
[3]Steroids,1991,vol. 56,p. 311 - 315
[4]Journal of the American Chemical Society,1938,vol. 60,p. 1375
[5]Journal of the Chemical Society,1959,p. 103,104
[6]Tetrahedron Letters,1998,vol. 39,p. 8563 - 8566
[7]Journal of Organometallic Chemistry,2009,vol. 694,p. 323 - 331

2
[ 3395-91-3 ]
[ 593-51-1 ]
[ 105-71-5 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol; silver(l) oxide

Reference： [1]Tomita [Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 1053,1057][Chem.Abstr., 1952, p. 5044]

3
[ 3395-91-3 ]
[ 122-52-1 ]
[ 3699-67-0 ]

Reference： [1]Journal of the American Chemical Society,1956,vol. 78,p. 4450

4
[ 3395-91-3 ]
[ 62-53-3 ]
[ 21911-84-2 ]

Reference： [1]Journal of Pharmaceutical Sciences,1972,vol. 61,p. 1739 - 1745

5
[ 615-15-6 ]
[ 3395-91-3 ]
[ 138942-42-4 ]

Yield	Reaction Conditions	Operation in experiment
96%	With potassium carbonate; In N,N-dimethyl-formamide;	Compound 1 is prepared by the condensation of 2-hydroxy-1-naphthaldehyde (2) and 3-(2-methyl-1H-benzimidazol-1-yl)propanohydrazide (3). The intermediate 3 was prepared through the hydrazinolysis of methyl ester 5, which in turn was prepared by the reaction of 2-methyl-1H-benzimidazole (4) with <strong>[3395-91-3]methyl 3-bromopropionate</strong> in the presence of anhydrous potassium carbonate as a base.
96%	With potassium carbonate; In N,N-dimethyl-formamide;	Compound 1 is prepared by the condensation of 2-hydroxy-1-naphthaldehyde (2) and 3-(2-methyl-1H-benzimidazol-1-yl)propanohydrazide (3). The intermediate 3 was prepared through the hydrazinolysis of methyl ester 5, which in turn was prepared by the reaction of 2-methyl-1H-benzimidazole (4) with <strong>[3395-91-3]methyl 3-bromopropionate</strong> in the presence of anhydrous potassium carbonate as a base.

Reference： [1]Heterocycles,1991,vol. 32,p. 1923 - 1931
[2]Patent: US2013/18079,2013,A1 .Location in patent: Paragraph 0145; 0146
[3]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 880 - 885
[4]Patent: US9282738,2016,B2 .Location in patent: Page/Page column 19; 20

6
[ 3395-91-3 ]
[ 75-16-1 ]
[ 35979-69-2 ]

Yield	Reaction Conditions	Operation in experiment
71.7%	In diethyl ether; at -20℃; for 1h;Inert atmosphere;	In a 250 mL round bottom flask, <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (5.0 mL, 45.8 mmol, 1.0 eq.) was taken up in dry ether (55.2 mL, 0.83 M) under nitrogen and cooled to -20 C. To this, 3.0 M methylmagnesium bromide (45.8 ml, 137 mmol, 3.0 eq) was added in dropwise fashion and the resulting mixture was stirred for an hour. The reaction was quenched with aqueous ammonium chloride. The resulting white suspension was extracted with ether multiple times. The combined organics were washed with brine, dried over MgSO4, and concentrated to yield 4-bromo-2-methylbutan-2-ol as an oil (5.49 g, 71.7%)
65%	In diethyl ether; at 0 - 20℃; for 2h;	To a stirred solution of 4-bromo-butyric acid methyl ester (2 g, 12.27 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (16.4 mL, 49.08 mmol) at 0 C. and the mixture is stirred at room temperature for 2 hours. The reaction mixture is quenched with 1 N HCl and extracted with diethyl ether (2*20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified with silica gel column chromatography (combiflash) eluting in 20% EtOAc/hexanes to give the title compound (1.3 g, 65%). 1H NMR (400 MHz, CDCl3): delta 3.48 (t, J=8.0 Hz, 2H), 2.16 (t, J=7.4 Hz, 2H), 1.89 (s, 6H), 1.76 (s, 3H), 1.27 (s, 6H).
60%	In diethyl ether; at 0 - 20℃; for 1h;	To a stirred solution of 4-bromo-butyric acid methyl ester (1 g, 5.9 mmol) in diethyl ether (20 mL) is added methyl magnesium bromide (19.9 mL, 23.9 mmol) at 0 C and the mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with aqueous ammonium chloride (40 mL) and extracted with diethyl ether (2x20 mL). The combined organic extracts are washed with saturated brine solution (20 mL), dried over sodium sulphate, filtered, and concentrated. The crude material is purified by silica gel column chromatography (combiflash) eluting with 20%EtOAc/hexanes to obtain title compound as pale pink liquid (0.6 g, 60%). ^NMR (400 MHz, DMSO) delta 4.38 (s, 1H), 3.52-3.48 (m, 2H), 1.97-1.91 (m, 2H), 1.08 (s, 6H).

48.9%	In tetrahydrofuran; at 0 - 20℃; for 16h;	a) 4-Bromo-2-methylbutan-2-olTo a solution of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (5.0 g, 29.94 mmol, and 1.0 eq) in dry THF was added methyl magnesium bromide at 0C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50 % ethyl acetate in hexane). Yield 48.9 % (2.4 g). LC-MS (ESI): Calculated mass: 167.0; Observed massl67.1 [M+H]+ (it: 0.8-1.0 min).
48.9%	In tetrahydrofuran; at 0 - 20℃; for 16h;	To a solution of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (5.0 g,29.94 mmol, and 1.0 eq) in dry THF was added methyl mag21 nesium bromide at 0 C. The mixture was stirred at RT for 16 h and quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 50% ethyl acetate in hexane). Yield 48.9% (2.4 g). LCMS (ESI): Calculatedmass: 167.0; Observedmass 167.1[M+ H] (it: 0.8-1.0mm).

Reference： [1]Patent: US2011/105509,2011,A1 .Location in patent: Page/Page column 51
[2]Patent: US2016/333005,2016,A1 .Location in patent: Paragraph 0074-0075
[3]Steroids,1991,vol. 56,p. 311 - 315
[4]Patent: WO2015/105786,2015,A1 .Location in patent: Page/Page column 13; 14
[5]Patent: WO2013/53983,2013,A1 .Location in patent: Page/Page column 45; 46
[6]Patent: US2015/11548,2015,A1 .Location in patent: Paragraph 0180

7
[ 3395-91-3 ]
[ 925-90-6 ]
[ 128312-82-3 ]

Yield	Reaction Conditions	Operation in experiment
12%	With titanium(IV) isopropylate; In tetrahydrofuran; at 0 - 20℃; for 2h;Inert atmosphere;	[00204] To a solution of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (2.0 g, 12.0 mmol) and titanium tetraisopropanolate (3.4 g, 12.0 mmol) in dry THF (40 mL) was added C2H5MgBr (26 mL, 1 .0 M) dropwise at 0 C-5 C under N2 atmosphere. The mixture was stirred at rt for 2 h. The reaction mixture was quenched with saturated ammonium chloride solution and then extracted with EA. The EA phase was washed with brine, dried over Na2S04, concentrated and then purified by column chromatography on silica gel (PE:EA =5:1) to give the title compound (250 mg, yield:12%) as a brown oil. 1H NMR (300 MHz, CDCI3) delta ppm 3.62 (t, 2H), 2.12 (t, 2H), 1 .97 (s, 1 H), 0.82 (t, 2H), 0.55 (q, 2H).
		Example M46: 1-Methylcyclopropyl 4-((5-(4-(2-(l- acetoxycyclopropyl)ethylsulfonyl)piperazin- 1 -yl)pyrazin-2-yloxy)methyl)piperidine- 1 - carboxylate. <n="127"/>OTTMeO^^^Br Step A / _BrOM46a M46bExample M46[00275] Step A: A solution of M46a (1.99 g, 12 mmol) in diethyl ether (40 mL) is treated with titanium(IV)isopropoxide (369 mg, 1.2 mmol) followed by dropwise addition of ethylmagnesium bromide (8.8 mL of a 3 M solution in diethyl ether, 26 mmol). The reaction is quenched into ice cold 10% sulfuric acid and the aqueous phase is extracted with ether once more. The combined organics are dried over MgSO4, filtered, evaporated and the residue is purified on silica gel using a linear gradient of 0- 100% ethyl acetate in hexane to afford M46b; 1H-NMR (400MHz, CDCl3) delta 3.60 (dd, J = 7.3, 7.3 Hz, 2H), 2.41 (s, IH), 2.10 (dd, J = 7.3, 7.3 Hz, 2H), 0.78 (m, 2H), 0.52 (m, 2H); A satisfactory ESIMS spectrum could not be obtained.

Reference： [1]European Journal of Organic Chemistry,2003,p. 551 - 561
[2]Patent: WO2017/149463,2017,A1 .Location in patent: Paragraph 00204
[3]Journal of Organic Chemistry USSR (English Translation),1991,vol. 27,p. 1251 - 1253
Zhurnal Organicheskoi Khimii,1991,vol. 27,p. 1431 - 1433
[4]Patent: WO2009/38974,2009,A1 .Location in patent: Page/Page column 125-126

8
[ 3395-91-3 ]
[ 84468-17-7 ]
[ 129786-37-4 ]

Yield	Reaction Conditions	Operation in experiment
95%	With triethylamine In methanol for 4h; Heating;

Reference： [1]Ricouart, A.; Gesquiere, J. C.; Tartar, A.; Sergheraet, C. [Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 73 - 78] Houdin; Sergheraert [European Journal of Medicinal Chemistry, 1992, vol. 27, # 9, p. 925 - 930]

9
[ 3395-91-3 ]
[ 23605-39-2 ]

Yield	Reaction Conditions	Operation in experiment
100%	With sodium azide; In dimethyl sulfoxide; at 45℃; for 24h;	Methyl 3-bromopropanoate (1.09 mL, 10 mmol) and sodium azide (0.91 g, 14 mmol) were dissolved in DMSO (4.6 mL) in a 25mL round bottom flask. The mixture solution was heated to 45 C and stirred for 24 h. After the mixture was cooled down to room temperature, and extracted with diethyl ether. The combined organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated on a rotary evaporator to give azidopropanoate as colorless liquid (1.29 g, quan). 1H NMR (300 MHz, CDCl3) delta 3.62 (s, 3H), 3.47 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.6 Hz, 2H).
98%	With sodium azide; In water; acetone; at 60℃; for 4h;Inert atmosphere;	General procedure: To a solution of bromo compound (1 equiv.) in water/acetone (1:3)was added NaN3 (1.5 equiv.) and the mixture was heated at 60 C for4 h. Then the reaction mixture was diluted with DCM and washed withwater. The organic layer was dried over anhydrous Na2SO4 and concentratedin vacuum. The crude material was obtained in quantitativeyield. This can be used for next step without further purification.
89%	With sodium azide; In water; N,N-dimethyl-formamide; at 55℃; for 18h;Inert atmosphere;	Sodium azide (655 mg, 10.1 mmol) was dissolved in water (10 ml) and DMF (10 ml) was added. To this solution, <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1 mL, 9.16 mmol) was added dropwise and the biphasic mixture was stirred at 55 C for 18 h. After cooling to rt, the crude reaction mixture was extracted with Et2O (3x50 mL). The combined organic layers were washed with BRINE (3x50 mL), dried over anhydrous MgSO4 and carefully concentrated to afford the methyl ester 42 (1.051 g, 89%) as a yellow oil that was suitable for use without further purification.1H NMR (400 MHz, CDCl3) delta 3.73 (s, 3H), 3.58 (t, J = 6.5 Hz, 2H), 2.59 (t, J = 6.5 Hz, 2H). 13C NMR (101 MHz, CDCl3) delta 171.4, 52.2, 46.9, 33.9. HRMS calcd. for C3H6N3O2 ([M + H]+): 116.0460, found: 130.0619.

Reference： [1]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 2623 - 2634
[2]Journal of Photochemistry and Photobiology A: Chemistry,2019,vol. 378,p. 171 - 183
[3]Bulletin de la Societe Chimique de France,1985,p. 815 - 819
[4]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 4381 - 4389
[5]Journal of Medicinal Chemistry,2011,vol. 54,p. 562 - 571
[6]Organic and Biomolecular Chemistry,2016,vol. 14,p. 9598 - 9611

10
[ 3395-91-3 ]
[ 98-86-2 ]
[ 1636-34-6 ]
[ 7210-42-6 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1986,p. 475 - 476
[2]Journal of the Chemical Society. Chemical communications,1986,p. 475 - 476

11
[ 18514-84-6 ]
[ 3395-91-3 ]
[ 170646-73-8 ]

Reference： [1]Acta poloniae pharmaceutica,1995,vol. 52,p. 113 - 121

12
[ 644-98-4 ]
[ 3395-91-3 ]
4-Methyl-4-pyridin-2-yl-pentanoic acid methyl ester [ No CAS ]

Reference： [1]Tetrahedron,1998,vol. 54,p. 8771 - 8782

13
[ 3395-91-3 ]
[ 3034-38-6 ]
[ 328056-86-6 ]

Reference： [1]Synthetic Communications,2003,vol. 33,p. 1977 - 1995

14
[ 866546-07-8 ]
[ 3395-91-3 ]
[ 1236215-89-6 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; tetrabutylammomium bromide; In toluene; at 100℃;	To a solution of NaOH (5.19 g, 129.8 mmol) in water (10 mL) was added tetrabutylammonium bromide (0.35 g, 1.08 mmol), <strong>[866546-07-8]5-chloro-1H-pyrrolo[2,3-b]pyridine</strong> (1.5 g, 9.83 mmol), toluene (60 mL) and methyl 3-bromopropanoate (9.8 g, 59 mmol). The reaction mixture was heated overnight at 100 C. The reaction was quenched with water, the layers were separated and the aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and concentrated. 3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)propanoate solution in THF was treated with NaOH and stirred at RT for 5 hours. The reaction mixture was diluted with water and the pH was adjusted to 1 with 1N HCl to crash out the product. The reaction was then filtered, azeotroped with acetonitrile and dried to give 3-(5-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)propanoic acid. (1.97 g, 90% yield). 1H NMR (400 MHz, DMSO-d6) delta 8.25 (d, J=2.3 Hz, 1H), 8.09 (d, J=2.3 Hz, 1H), 7.64 (d, J=3.5 Hz, 1H), 6.46 (d, J=3.5 Hz, 1H), 4.46 (t, J=7.0 Hz, 2H), 2.82 (t, J=7.0 Hz, 3H). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=225.3; tR=1.20 min.

Reference： [1]Patent: US2008/27067,2008,A1 .Location in patent: Page/Page column 295

15
[ 3395-91-3 ]
[ 76806-96-7 ]
[ 1012058-42-2 ]

Yield	Reaction Conditions	Operation in experiment
83%	With potassium carbonate; In N,N-dimethyl-formamide; at 40℃; for 5h;	Step 2a. Methyl 3-(ethyl(2-(4-nitrobenzamido)ethyl)amino)propanoate (compound <n="49"/>403-31); To a solution of N-(2-(ethylamino)ethyl)-4-nitrobenzamide ( 402) (1.19g, 5 mmol) in DMF (10ml) was added K2CO3 (1.38g, lOmmol), and then methyl 3- bromopropanoate (994mg, 6mmol) was added to the mixture. The mixture was stirred for 5 h at 40C and then the solid was removed by filtration. The solvent was removed under reduced pressure. The residue was purified on column chromatography to give 1380 mg of pure product 403-31 (83 % yield). 1H NMR (CDCl3) delta 8.292 t, IH), 8.262 (t,lH), 8.081 (t, IH), 8.051 (t, lH),3.635(s, 3H), 3.56(m, 2H), 2.786 (t, 2H), 2.666 (t, 2H), 2.539 (m, 4H), 0.978(t, 3H); LC-MS: 323 (M+l).
83%	With potassium carbonate; In N,N-dimethyl-formamide; at 40℃; for 5h;	To a solution oN-(2-(ethylamino)ethyl)-4-nitrobenzam,ide ( 402) (1.19g, 5 mmol) in DMF (10ml) was added K2CO3 (1.38g, lOmmol), and then methyl 3- bromopropanoate (994mg, 6mmol) was added to the mixture. The mixture was stirred for 5 h at 40C and then the solid was removed by filtration. The solvent was removed under reduced pressure. The residue was purified on column chromatography to give 1380 mg of pure product 403-31 (83 % yield). 1H NMR (CDCl3) delta 8.292 t, IH), 8.262 (t,lH), 8.081 (t, IH), 8.051 (t, lH),3.635(s, 3H), 3.56(m, 2H), 2.786 (t, 2H), 2.666 (t, 2H), 2.539 (m, 4H), 0.978(t, 3H); LC-MS: 323 (M+l).

Reference： [1]Patent: WO2008/33744,2008,A2 .Location in patent: Page/Page column 47-48
[2]Patent: WO2008/33747,2008,A2 .Location in patent: Page/Page column 226-227

16
[ 120-72-9 ]
[ 3395-91-3 ]
[ 6639-06-1 ]

Yield	Reaction Conditions	Operation in experiment
900mg		Synthesis of 3-(1H-indol-1-yI)propanoic acid (Intermediate-25): A lOOmI RB flask fittedwith magnetic stirrer was charged with 10 ml of DMF. To the stirred solvent Starting Material-1 (1 .Og, 8.53 mmol) followed by Sodium hydride (400 mg, 10.24 mmol) were added. The resulting solution was stirred at room temperature for 1 hour. To the above solution methyl-3- bromo-propionate (2.13 g, 12.79 mmol) was added and stirred at room temperature for 24 hours. After completion of the reaction (reaction monitored by TLC), reaction mass wasdiluted with 3OmL of ice cold water and washed with ether. Aqueous portion was acidified with 1 N HCI (pH =2) and was then extracted with EtOAc and concentrated to give Intermediate-24 (900mg).
900 mg		Synthesis of 3-(1H-indol-1-yl)propanoic acid (Intermediate-25) A 100 ml RB flask fitted with magnetic stirrer was charged with 10 ml of DMF. To the stirred solvent Starting Material-1 (1.0 g, 8.53 mmol) followed by Sodium hydride (400 mg, 10.24 mmol) were added. The resulting solution was stirred at room temperature for 1 hour. To the above solution methyl-3-bromo-propionate (2.13 g, 12.79 mmol) was added and stirred at room temperature for 24 hours. After completion of the reaction (reaction monitored by TLC), reaction mass was diluted with 30 mL of ice cold water and washed with ether. Aqueous portion was acidified with 1N HCl (pH=2) and was then extracted with EtOAc and concentrated to give Intermediate-24 (900 mg).
		Zu einer Loesung von Indol (5,0 g, 40,0 MMOL) und 3-Brompropionsaeuremethylester (4,37 ML, 40 MMOL) in DMSO (35 ML) wurde KOH (11,5 g, 0,2 mol) gegeben und 24 h bei RT geruehrt. Zur Aufarbeitung wurde der Ansatz mit Wasser (50 ml) versetzt, mit Ether (5 x 20 ml) gewaschen, die waessrige Phase mit 1 M HCI auf pH 4 eingestellt und mit Ether (5 x 20 ml) extrahiert. Die vereinigten Extrakte wurden getrocknet, filtriert und eingeengt. Nach Chromatographie mit Methanol wurde 3-INDOL-1-YL- propionsaeure in einer Ausbeute von 3,8 g erhalten (weisser Feststoff, Smp. 54-56 C). Zu einer Loesung von 3-INDOL-1-YL-PROPIONSaeURE (383 mg, 2,0 MMOL) in abs. Methanol (35 ML) wurde ein Gemisch der Diastereoisomeren von (4-Aminomethyl-1-phenyl- cyclohexyl) dimethylamin (465 mg, 2,0 mmol) und 4- (4, 6-Dimethoxy-1, 3, 5-triazin-2- yl)-4-methylmorpholiniumchlorid (830 mg, 3 MMOL) gegeben und 2 d bei RT geruehrt. Zur Aufarbeitung wurde eingeengt, der Rueckstand mit Wasser (15 ml) versetzt, mit 5M NAOH auf pH 11 eingestellt und mit EE (4 x 15 ml) extrahiert. Die vereinigten Extrakte wurden getrocknet, filtriert und eingeengt. Als Rueckstand wurde ein Gemisch der DIASTEREoeISOMEREN Basen des Zielprodukts erhalten, das durch Flash- chromatographie an Kieselgel (70 G) aufgetrennt und gereinigt wurde (Eluent : 1300 ml METHANOL/EE 1 : 1) eingesetzt. Es wurden 254 mg des UNPOLAREREN Diastereo- isomers von N- (4-DIMETHYLAMINO-4-PHENYLCYCLOHEXYLMETHYL)-3-INDOL-1-YLPROPIONAMID als viskoses Oel erhalten. 226 mg (0,56 MMOL) hiervon wurden in abs. Ethanol (3 ML) geloest und unter Ruehren bei RT in heissem Ethanol (1 ml) geloeste Zitronensaeure (108 mg, 0,56 MMOL) tropfenweise zugegeben. Nach 1 h Ruehren bei RT wurde der gebildete weisse Niederschlag abgesaugt, mit kaltem Ethanol (1 ml) und mit Diethylether (3 x 1 ml) gewaschen und im Vakuum getrocknet. Es wurden 262 mg des korrespondierenden Citrats erhalten (hellbeiger Feststoff, Smp. 192-194 C).

Reference： [1]Patent: WO2013/128465,2013,A1 .Location in patent: Page/Page column 94
[2]Patent: US2015/158860,2015,A1 .Location in patent: Paragraph 0332
[3]Patent: WO2004/43899,2004,A1 .Location in patent: Page 37; 38

17
[ 554-12-1 ]
[ 3395-91-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	With N-Bromosuccinimide; silver nitrate; In acetone; at 20℃; for 6h;	Methyl propiolate [(52] ml, 0. [583] mol) is combined with recrystallized N [BROMO-SUCCINIMIDE] (120 g, 0.674 mol) in 1,700 ml acetone under nitrogen. The solution is treated with silver nitrate (9.9 g, 0.0583 mol) neat in a single lot and the reaction is stirred 6 h at RT. The acetone is removed under reduced pressure [(25C,] bath temperature) to provide a gray slurry. The slurry is washed with 2 x 200 ml hexane, the gray solid is removed by filtration, and the filtrate is concentrated in vacuo to provide 95 g of a pale yellow oily residue. The crude material is distilled via short path under reduced pressure [(65 C,] about 25 mm Hg) into a dry ice/acetone cooled receiver to give 83.7 g (88%) of methyl-3-bromo-propiolate as a pale yellow oil. Anal. calc'd for [C4H3BRO2] : C, 29.48 ; H, 1.86. Found: C, 29.09 ; H, 1.97.

Reference： [1]Patent: WO2004/13137,2004,A1 .Location in patent: Page 76
[2]Tetrahedron Letters,2010,vol. 51,p. 1793 - 1796

18
[ 3395-91-3 ]
[ 171723-80-1 ]
[ 743460-35-7 ]

Yield	Reaction Conditions	Operation in experiment
70%	With 3-methyl-N-(3-methylbutyl)-1-butanamine; In acetonitrile; at 50℃;	Preparation 19 3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionic Acid Methyl Ester <strong>[3395-91-3]methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product of Preparation 8 (1.00 g, 3.38 mmol) and DIPEA (1.76 ML, 10.1 mmol) in acetonitrile (34 ML) at 50 C. and the reaction mixture was heated at 50 C. overnight.The solvent was then removed under reduced pressure and the residue was dissolved in dichloromethane (30 ML).The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 ML), dried (magnesium sulfate) and the solvent was removed under reduced pressure.The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give the title compound (905 mg, 70%).

Reference： [1]Patent: US2004/167167,2004,A1 .Location in patent: Page/Page column 37

19
[ 3395-91-3 ]
[ 171722-92-2 ]
[ 743460-35-7 ]

Yield	Reaction Conditions	Operation in experiment
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	<strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product from Example 1, Step 1 (1.00 g, 3.38 mmol) and diisopropylethylamine (1.76 mL, 10.1 mmol) in acetonitrile (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in dichloromethane (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude residue was purified by column chromatography to give the title compound (905 mg, 70% yield).
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	Preparation 2 3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionic Acid Methyl Ester <strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product of Preparation 1 (1.00 g, 3.38 mmol) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried (magnesium sulfate), filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	<strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product of Preparation 1 (1.00 g, 3.38 mmol) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried (magnesium sulfate), filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).

70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	<strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product of Preparation 1 (1.00 g, 3.38 mmol) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried (magnesium sulfate), filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	Preparation 9 3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionic Acid Methyl Ester <strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of the product of Preparation 1 (1.00 g, 3.38 mmol) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried (magnesium sulfate), filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	Preparation 2; 3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionic Acid Methyl Ester <strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of biphenyl-2-ylcarbamic acid piperidin-4-yl ester (1.00 g, 3.38 mmol; prepared as described in Preparation 1) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried (magnesium sulfate), filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).
70%	With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50℃;	<strong>[3395-91-3]Methyl 3-bromopropionate</strong> (553 muL, 5.07 mmol) was added to a stirred solution of biphenyl-2-ylcarbamic acid piperidin-4-yl ester (1.00 g, 3.38 mmol; prepared as described in Preparation 1) and DIPEA (1.76 mL, 10.1 mmol) in ACN (34 mL) at 50 C. and the reaction mixture was heated at 50 C. overnight. The solvent was then removed under reduced pressure, and the residue was dissolved in DCM (30 mL). The resulting solution was washed with saturated aqueous sodium bicarbonate solution (10 mL), dried over MgSO4, filtered and the solvent was removed under reduced pressure. The crude residue was purified by column chromatography (5-10% MeOH/DCM) to give 905 mg of the title intermediate (70% yield).

Reference： [1]Patent: US2005/113417,2005,A1 .Location in patent: Page/Page column 38
[2]Patent: US2005/203134,2005,A1 .Location in patent: Page/Page column 18
[3]Patent: US2005/203132,2005,A1 .Location in patent: Page/Page column 17
[4]Patent: US2005/203083,2005,A1 .Location in patent: Page/Page column 22
[5]Patent: US2006/205775,2006,A1 .Location in patent: Page/Page column 28
[6]Patent: US2006/205779,2006,A1 .Location in patent: Page/Page column 20
[7]Patent: US2006/281740,2006,A1 .Location in patent: Page/Page column 30

20
[ 3395-91-3 ]
[ 778646-68-7 ]

Yield	Reaction Conditions	Operation in experiment
80%		2-METHYLSULFANYL-4-(LH-PYRROL-3-YL)-PYRIMIDINE (260 mg, 1.36 mmol) was added to a suspension of fat free sodium hydride (39 mg, 1.63 mmol) in 5 ml of THF. The mixture was heated to 50 C for 20 minutes. Then, 3-bromo-propionic acid methyl ester (0.156 ml, 1. 36 mmol) was added and the temperature was increased to 80 C. After 14 hours, the mixture was cooled, quenched with water and extracted with ether. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated. The crude product was used without further purification. Yield: 302 mg (80%).

Reference： [1]Patent: WO2004/89913,2004,A1 .Location in patent: Page 34

21
[ 3395-91-3 ]
[ 40064-34-4 ]
3-(4-oxo-piperidine-1-yl)-propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; triethylamine; In acetone;	23a. Methyl 3-(4-oxopiperidyl)propanoate To a suspension of 4-oxopiperidine hydrochloride monohydrate (10.0 g, 65.1 mmol) and methyl 3-bromopropanoate (7.8 ml, 71.6 mmol) in acetone (100 ml) was added K2CO3 (9.9 g, 71.6 mmol) and Et3N (9.1 ml, 65.3 mmol). The mixture was refluxed for 24 hours. The solid was removed by filtration and the solvent was evaporated. The residue was partitioned between EtOAc and H2O. The organic extracts were combined and dried over Na2SO4. The solvent was evaporated to give the title compound (15.0 g, 27.0 mmol, 42%) as an oil. 1H NMR (300 MHz, CDCI) delta 3.70 (s, 3H), 2.75-2.85 (mult, 6H), 2.52-2.57 (mult, 2H), 2.42-2.46 (mult, 4H).

Reference： [1]Patent: US6297260,2001,B1

22
[ 3395-91-3 ]
[ 22717-55-1 ]
[ 131210-59-8 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In N-methyl-acetamide;	Step A: 4-Chloro-2-(2-methoxy-1-methyl-2-oxoethoxy)-benzoic acid, methyl ester A solution of <strong>[22717-55-1]methyl 4-chlorosalicylate</strong> (5.0 g) in dimethylformamide (10 ml) was treated sequentially with methyl 3-bromopropionate (4.0 g) and potassium carbonate (6.0 g). The mixture was stirred at room temperature for 18 hrs and diluted with water. The mixture was extracted with ether and the organics were washed with water. The organic layer was dried and evaporated to give the desired material (6.7 g) as a low melting solid. NMR: 7.8 (d, 1H), 7.2 (m 1H), 6.9 (m, 1H), 4.8 (q, 1H), 3.9 (s, 3H), 3.8 (s, 3H), 1.7 (d, 3H).

Reference： [1]Patent: US5182303,1993,A

23
[ 29786-93-4 ]
[ 3395-91-3 ]
[ 90101-20-5 ]
[ 190190-16-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; acetic acid In tetrahydrofuran; ethanol	[3(R)-[2-(Pyridin-4-yl)ethyl]-2-piperidone-1-yl]-acetyl-2(S)-ethylsulfonylamino-β-alanine (9-8) STR90 4-(2-N-Boc-Amino-4-pyridyl)butanoic acid (10-1) The protected picoline 5-2 (90 g, 0.43 mol) was dissolved in 3 L THF under N2, cooled to -78° C., and n-Buli (1.6M, 675 mL, 1.08 mol) was added during 30 min. The mixture was allowed to warm to RT for 1 h, then the resulting orange suspension was cooled to -78° C. Methyl 3-bromopropionate (79 g, 0.47 mol) was added during 2 min. After 15 min the cooling bath was removed and the mixture was allowed to warm to -20° C. at which point it was quenched with 60 mL HOAc in 250 mL THF. The solution was diluted with 2 L EtOAc, washed with water, sat. NaHCO3, and brine, dried (MgSO4). The aqueous layers were re-extracted with EtOAc (2), and these organic layers were combined, washed with brine, and dried (MgSO4). The combined organic layers were filtered, concentrated, and dissolved in 1.5 L EtOH and 1.5 L 1N NaOH (1.5 mol). After 1 h the reaction was concentrated by 1/3, diluted with 4 L EtOAc, the aqueous layer was removed. The pH of the aqueous layer was adjusted to 4-5 with 10% KHSO4, then extracted with EtOAc (23 L). The EtOAc layers were washed with brine, dried (MgSO4), filtered and concentrated, providing the acid 10-1 as a yellow oil. TLC Rf 0.65 (silica, 20:1:1 CH2 Cl2 /MeOH/HOAc). 1 H NMR (400 MHz, CD30D) δ8.08 (d, J=5 Hz, 1H), 7.70 (s, 1H), 6.89 (d, J=5 Hz, 1H), 2.66 (t, J=8 Hz, 2H), 2.32 (t, J=7 Hz, 2H), 1.92 (quin, J=8 Hz, 2H), 1.52 (s, 9H).

Reference： [1]Current Patent Assignee: MERCK & CO INC - US5852045, 1998, A

24
[ 62473-92-1 ]
[ 3395-91-3 ]
methyl 3-(3-bromosaccharinyl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride; In N,N-dimethyl-formamide; at 20 - 130℃; for 6h;	To a 100-mL round-bottomed flask containing 3-bromosaccharin (1.0 g, 3.8 mmol,Synthelee) in DMF (5 mL), was slowly added NaH (0.15 g, 3.8 mmol, 60percent in mineral oil, Aldrich) at room temp. Methyl 3-bromo-propanoate (2.1 mL, 19 mmol, Aldrich) was added and the reaction mixture was refluxed at 130 °C for 6 h. The reaction was quenched with water (15 mL) and the compound was extracted with EtOAc (2x20 mL). The organic phase was washed with 5percent brine (2x 10 mL), dried over Na2SO4, filtered, and concentrated. Purification EPO <DP n="124"/>with column chromatography over silica gel with hexane:EtOAc:MeOH (5:5:1) gave the title compound.

Reference： [1]Patent: WO2006/36664,2006,A1 .Location in patent: Page/Page column 122-123

25
[ 3395-91-3 ]
[ 885685-67-6 ]

Yield	Reaction Conditions	Operation in experiment
60%		A solution of ethyl isocyanoacetate (0.92 g, 7.7 mmol) in THF (8 mL) was added dropwise to a suspension of potassium tert-butoxide (1.0 g, 8.5 mmol) in THF (6 mL) at -40C. The mixture was cooled to -600C, and a solution of carbon disulfide (0.59 g, 7.7 mmol) in THF (8 mL) was EPO <DP n="54"/>added dropwise while keeping the temperature below -500C. The mixture was warmed to 1O0C and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1.33 g, 7.70 mmol) was added. The mixture was allowed to stir for 2 h and was concentrated in vacuo. The product was recrystalized from dichloromethane/hexanes to give 1.28 g (60%) of the desired product as a white solid.
60%		A solution of ethyl isocyanoacetate (0.92 g, 7.7 mmol) in THF (8 mL) was added dropwise to a suspension of potassium tert-butoxide (1.0 g, 8.5 mmol) in THF (6 mL) at -40C. The mixture was cooled to -600C, and a solution of carbon disulfide (0.59 g, 7.7 mmol) in THF (8 mL) was EPO <DP n="54"/>added dropwise while keeping the temperature below -500C. The mixture was warmed to 1O0C and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1.33 g, 7.70 mmol) was added. The mixture was allowed to stir for 2 h and was concentrated in vacuo. The product was recrystalized from dichloromethane/hexanes to give 1.28 g (60%) of the desired product as a white solid.

Reference： [1]Patent: WO2006/91506,2006,A2 .Location in patent: Page/Page column 49
[2]Patent: WO2006/121588,2006,A2 .Location in patent: Page/Page column 52

26
[ 929915-54-8 ]
[ 3395-91-3 ]
methyl 3-[(2R)-2-[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With triethylamine; In dichloromethane; at 30℃;	EXAMPLE 19; Step 1; 3-{(R)-2-[4-(4-Chloro-phenoxy)-phenoxymethyl]-pyrrolidin-1-yl}-propionic acid methyl ester; To a solution of Example 18 (step 4) (0.8 g, 2.63 mmol) in dichloromethane (7.6 mL) was added triethylamine (0.78 mL, 5.60 mmol) and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.32 mL, 2.93 mmol). The resulting solution was stirred at 30 C. overnight. The reaction mixture was poured into water/dichloromethane (50 mL/50 mL). The crude residue was extracted into dichloromethane. The organic portion was washed with water (50 mL), washed with brine (50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by silica gel flash chromatography using hexane/EtOAc (gradient system) to give the title compound (0.79 g, 77%).

Reference： [1]Patent: US2007/66820,2007,A1 .Location in patent: Page/Page column 28

27
[ 3395-91-3 ]
[ 6269-89-2 ]
[ 108890-83-1 ]

Yield	Reaction Conditions	Operation in experiment
63.6%		Step 1 3-[4-(4-Nitro-phenyl)-piperazin-1-yl]-propionic acid methyl ester: To a solution of 1-(4-nitro-phenyl)-piperazine (2 g, 9.66 mmol) in DMF (10 mL) was added 3-bromopropionic acid methyl ester (1.6 g, 9.66 mmol) and the mixture was stirred at ambient temperature for 16 h. Water was added to the reaction, followed by adjusting pH to 7 with sat. aqueous NaHCO3. The resulting precipitate was collected by filtration and washed with water to furnish the title compound as a yellow solid (1.8 g, 63.6%): MS (ESI) m/z 294 (M+H); 1H NMR (400 MHz, CDCl3) delta 2.55 (t, J=7.2 Hz, 2H), 2.62 (t, J=4.8 Hz, 4H), 2.77 (t, J=6.8 Hz, 2H), 3.42 (t, J=5.2 Hz, 4H), 3.71 (s, 3H), 6.81-6.83 (m, 2H), 8.11-8.14 (m, 2H).

Reference： [1]Patent: US2007/149544,2007,A1 .Location in patent: Page/Page column 7; 8

28
4-(4-Phenoxy-phenoxy)-piperidine [ No CAS ]
[ 3395-91-3 ]
3-[4-(4-Phenoxy-phenoxy)-piperidin-1-yl]-propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With triethylamine; In dichloromethane; at 20℃; for 48h;	Step 1 3-[4-(4-Phenoxy-phenoxy)-piperidin-1-yl]-propionic acid methyl ester: To a solution of 4-(4-Phenoxy-phenoxy)-piperidine (152 mg, 0.5 mmol) in anhydrous CH2Cl2 (0.5 mL) was added methyl-3-bromopropionate (91 mg, 0.55 mmol) in CH2Cl2 (0.5 mL) and triethylamine (101 mg, 1.0 mmol). The resulting mixture was purged with nitrogen and stirred at if for 48 h. CH2Cl2 was removed in vacuo and crude mixture was partioned between EtOAc and water. EtOAc layer was removed, washed with saturated NaHCO3, dried over anhydrous MgSO4 and concentrated. The crude mixture was purified by silica gel flash chromatography (50% EtOAc/Hexane) to obtain the product (146 mg, 82%): MS; m/z 356.5 (M+H); 1H NMR (400 MHz, DMSO-d6); delta 1.56-1.60 (m, 2H), 1.89-1.92 (m, 2H), 2.19-2.49 (m, 2H), 2.46-2.49 (m, 2H), 2.58 (t, 2H, J=6.8Hz), 2.60-2.69 (m, 2H), 3.59 (s, 3H), 4.28-4.30 (m, 1H), 6.91-6.96 (m, 6H), 7.04-7.08 (m, 1H), 7.32-7.36 (m, 2H); HPLC (UV); 94.7%.

Reference： [1]Patent: US2007/142432,2007,A1 .Location in patent: Page/Page column 9

29
[ 876929-42-9 ]
[ 3395-91-3 ]
[ 876929-41-8 ]

Yield	Reaction Conditions	Operation in experiment
73%	With potassium carbonate; In N,N-dimethyl-formamide; at 50℃; for 20h;	To a solution of 3-benzyl-5-[N-(4-hydroxyphenyl)-methylamino]- methylene}-2-thioxothiazolidin-4-one (71 mg, 0.20 mmol) in DMF (1.0 mL, anhyd) was added anhyd K2CO3 (29 mg, 0.21 mmol) and 2-bromoethyl methyl ether (20 muL, 0.21 mmol). The reaction mixture was heated at 5O0C. After 2Oh the reaction mixture was cooled, diluted with CHCI3 (50 mL), washed with H2O (3x 25 mL) and brine, dried over anhyd Na2SO4, concentrated and then chromatographed (silica gel, 0:100 to 20:80 EtOAc-DCM) to give the title product (60 mg, 73%) as a yellow solid. 1H-NMR (CDCI3): delta 7.73 (1H, s), 7.44 (2H, d), 7.21-7.30 (3H, m), 7.11 (2H, d), 6.97 (2H, d), 5.23 (2H, s), 4.15 (2H, m), 3.79 (2H, m), 3.48 (3H, s), 3.47 (3H, s)

Reference： [1]Patent: WO2006/20680,2006,A2 .Location in patent: Page/Page column 80

30
[ 28903-71-1 ]
[ 3395-91-3 ]
Co(C₂₀N₄H₈(C₆H₄OCH₃)4)(CH₂CH₂COOCH₃) [ No CAS ]

Reference： [1]Organometallics,1993,vol. 12,p. 4871 - 4880

31
[ 3395-91-3 ]
[ 1072790-37-4 ]
[ 1072790-95-4 ]

Yield	Reaction Conditions	Operation in experiment
42%	With N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; at 80℃; for 2h;	Example 129 rac-3-{{2-[3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-oxo-oxazolidin-5-yl]-ethyl}-[2-(6-methoxy-[1,5]naphthyridin-4-yl)-ethyl]-amino}-propionic acid methyl ester A solution of the compound of Example 72 (0.2 g, 0.44 mmol) in THF (3 mL) was treated with DIPEA (0.147 mL, 2 eq.), <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.074 g, 1 eq.) and NaI (0.067 g, 1 eq.). The mixture was heated at 80 C. for 2 h, partitioned between EA and water. The org. phase was dried over MgSO4 and concentrated. The residue was purified by FC (EA) to give the title compound as a yellowish oil (0.1 g, 42% yield). 1H NMR (DMSO d6) delta: 8.64 (d, J=4.4 Hz, 1H), 8.22 (d, J=9.1 Hz, 1H), 7.57 (d, J=4.4 Hz, 1H), 7.23 (d, J=9.1 Hz, 1H), 7.07 (d, J=2.3 Hz, 1H), 6.93 (m, 1H), 6.83 (m, 1H), 4.56 (d, J=0.6 Hz, 1H), 4.21 (m, 4H), 4.01 (m, 4H), 3.95 (m, 1H), 3.63 (m, 1H), 3.54 (s, 3H), 3.29 (m, 2H), 2.82 (m, 4H), 2.63 (m, 2H), 2.47 (m, 2H), 1.80 (m, 2H).
42%	With N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; at 80℃; for 2h;	Example 129: r°c-3-{{2-[3-(2,3-dihydro-benzo[l,4]dioxin-6-yl)-2-oxo-oxazolidin- 5-yl] -ethyl}- [2-(6-methoxy- [1,5] naphthyridin-4-yl)-ethyl] -amino}-propionic acid methyl ester:; A solution of the compound of Example 72 (0.2 g, 0.44 mmol) in THF (3 mL) was treated with DIPEA (0.147 mL, 2 eq.), <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.074 g, 1 eq.) and NaI (0.067 g, 1 eq.). The mixture was heated at 800C for 2 h, partitioned between EA and water. The org. phase was dried over MgSO4 and concentrated. The residue was purified by FC (EA) to give the title compound as a yellowish oil (0.1 g, 42% yield). 1H NMR (DMSO d6) delta: 8.64 (d, J = 4.4 Hz, IH), 8.22 (d, J = 9.1 Hz, IH), 7.57 (d, J = 4.4 Hz, IH), 7.23 (d, J = 9.1 Hz, IH), 7.07 (d, J = 2.3 Hz, IH), 6.93 (m, IH), 6.83 (m, IH), 4.56 (d, J = 0.6 Hz, IH), 4.21 (m, 4H), 4.01 (m, 4H), 3.95 (m, IH), 3.63 (m, IH), 3.54 (s, 3H), 3.29 (m, 2H), 2.82 (m, 4H), 2.63 (m, 2H), 2.47 (m, 2H), 1.80 (m, 2H).

Reference： [1]Patent: US2010/137290,2010,A1 .Location in patent: Page/Page column 102
[2]Patent: WO2008/126024,2008,A2 .Location in patent: Page/Page column 230

32
[ 3395-91-3 ]
[ 371-40-4 ]
[ 135154-75-5 ]

Yield	Reaction Conditions	Operation in experiment
91%		Example 2901; Part A:; To a solution of compound 2901 A (8.8 mL, 91.6 mmols) in THF (50 mL) at -78 C was added 2.0M Trimethylaluminum in Hexane (46 mL). The reaction was warmed up to RT and stirred for 20 min. Above solution was added to a flask containing <strong>[3395-91-3]methyl 3-bromopropionate</strong> (5 mL, 45.8 mmol) in THF (50 mL). After 2 h, reaction was cool to 0 C and added 1 N HCI, poured into a separatory funnel and extracted with EtOAc. The organic layer was dried with MgSO4, concentrated to give compound 2901 B as a light brown solid (10.2 g, 91%).
		Example 152A 3-Bromo-N-(4-fluorophenyl)propanamide 5.75 ml of 4-fluoroaniline (6.65 g, 59.88 mmol, 1 equivalent) were initially charged in 65 ml of THF, 33 ml of 2 M trimethylaluminium solution in hexane (65.87 mmol, 1.1 equivalents) were added at -78 C. and the mixture was stirred for 20 min, slowly warming to RT. At -20 C., this solution was added dropwise to a solution of 6.54 ml (10 g, 59.8 mmol, 1 equivalent) of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> in 65 ml of THF and then stirred at RT for 3 h. At 0 C., the reaction solution was acidified carefully with 1 N aqueous hydrochloric acid solution and extracted twice with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and concentrated. This gave 12.6 g (67% of theory; purity 78%) of the title compound which was reacted further without purification. LC-MS (Method 7): Rt=0.83 min MS (ESpos): m/z=248.0 (M+H)+

Reference： [1]Patent: WO2009/52288,2009,A1 .Location in patent: Page/Page column 404
[2]Patent: US2014/128372,2014,A1 .Location in patent: Paragraph 0808; 0809; 0810; 0811

33
[ 895152-66-6 ]
[ 3395-91-3 ]
[ 1199943-46-8 ]

Reference： [1]Journal of Medicinal Chemistry,2010,vol. 53,p. 295 - 315

34
[ 25419-06-1 ]
[ 3395-91-3 ]
Methyl 3-[N-(1-hexyl)-N-methylamino]propionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In toluene; at 20 - 70℃;	<strong>[25419-06-1]N-methyl-N-pentylamine</strong> (59.06 gms), which was taken in toluene (590 ml), to which potassium carbonate (80.592 g, 0.584 moles) was added. To this white suspension methyl-3-bromopropionate (99.478 g, 0.595 moles) was added dropwise. The temperature of reaction mass was gradually increased to 70C and the reaction mass was stirred at this temperature for three hours. The reaction mass was filtered and the filtrate which contains 3-[N-(methylpentyl) amino] propionate was directly taken for hydrolysis.

Reference： [1]Patent: EP2038291,2010,B1 .Location in patent: Page/Page column 7

35
[ 889129-61-7 ]
[ 3395-91-3 ]
3-[6-methoxy-3-(4-methoxy-benzenesulfonyl)-indol-1-yl]-propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%		Step 3: Preparation of 3-[6-Methoxy-3-(4-methoxy-benzenesulfonyl)-indol-l -yl] - propionic acid methyl ester (10)[0251] To a solution of 6-Methoxy-3-(4-methoxy-benzenesulfonyl)-l H-indole 9 (10 mg, 0.03 mmol) dissolved in dichloromethane (3 ml), potassium hydroxide solution (50%, 1 ml) and tetrabutylammonium hydrogen sulfate (1 mg, 0.0003 mmol) were added. After stirring at ambient temperature for 5 minutes, <strong>[3395-91-3]methyl 3-bromopropionate</strong> (9 mg, 0.054 EPO <DP n="70"/>mmol) was added and the reaction proceeded at room temperature for 16 hours. The reaction mixture was diluted with water (20 ml), and extracted with ethyl acetate (3X, 30 ml). The combined organic layers were washed with water (3X, 30 ml), saturated sodium bicarbonate solution (IX, 30 ml), and brine (IX, 30 ml). After drying over sodium sulfate, solvent was evaporated under reduced pressure to yield 3-[6-Methoxy-3-(4-methoxy- benzenesulfonyl)-indol-l-yl] -propionic acid methyl ester (10) as the major product (12 mg, 90%).

Reference： [1]Patent: WO2006/60535,2006,A2 .Location in patent: Page/Page column 68-69

36
[ 3395-91-3 ]
[ 86-74-8 ]
[ 88107-73-7 ]

Yield	Reaction Conditions	Operation in experiment
49%		[0225] S-Carbazol-^-yl-propionic acid methyl ester (22): Carbazole (1.0 g, 5.98 mmol) and sodium hydride (60 wt. % in mineral oil, 0.36 g, 8.97 mmol) were placed under argon, dissolved in DMF (10 mL) and stirred for 20 min at 60 C. This was followed by addition of 6-bromo-propanoic acid methyl ester (0.65 mL, 5.98 mmol). The reaction was stirred at 60 C for 4 h. The reaction was then diluted with ethyl acetate (30 mL) and water (30 mL). The organic layer was isolated and the aqueous layer extracted with ethyl acetate (2 x 20 mL). The combined organic layers were washed with brine (3 x 30 mL), dried (Na2SO4) and concentrated in vacuo. Purification by MPCC (0-20% gradient of ethyl acetate in hexane) afforded the title compound (735 mg, 49%). 1H NMR (400MHz, CDCl3): delta 8.12 (d, 2H, J= 7.8 Hz), 7.49 (m, 4H), 7.27 (t, 2H, J= 6.5 Hz), 4.68 (t, 2H, J= 7.3 Hz), 3.67 (s, 3H), 2.89 (t, 2H, J= 7.2 Hz). 13C NMR (100 MHz, CDCl3): <5 171.8, 140.0, 125.8, 123.1, 120.4, 119.2, 108.6, 51.9, 38.7, 33.3. ESI-HRMS (m/z): [M+H]+ calcd. for C16H15NO2, 253.1103; found, 254.1154.

Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 10842 - 10846
[2]Patent: WO2011/11186,2011,A2 .Location in patent: Page/Page column 56-57

37
[ 75-15-0 ]
[ 3395-91-3 ]
[ 2999-46-4 ]
[ 885685-67-6 ]

Yield	Reaction Conditions	Operation in experiment
60%		A solution of ethyl isocyanoacetate (0.92 g, 7.7 mmol) in THF (8 niL) was added dropwise to a suspension of potassium tert-butoxide (1.0 g, 8.5 mmol) in THF (6 ml_) at -400C. The mixture was cooled to -600C, and a solution of carbon disulfide (0.59 g, 7.7 mmol) in THF (8 mL) was added dropwise while keeping the temperature below -5O0C. The mixture was warmed to 100C and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1.33 g, 7.70 mmol) was added. The mixture was allowed to stir for 2 h and was concentrated in vacuo. The product was recrystalized from dichloromethane/hexanes to give 1.28 g (60%) of the desired product as a white solid. LC-MS m/z 276 (M+H+); RT 1.65 min.
60%		A solution of ethyl isocyanoacetate (0.92 g, 7.7 mmol) in THF (8 mL) was added dropwise to a suspension of potassium tert-butoxide (1.0 g, 8.5 mmol) in THF (6 mL) at -40C. The mixture was cooled to -600C, and a solution of carbon disulfide (0.59 g, 7.7 mmol) in THF (8 mL) was EPO <DP n="54"/>added dropwise while keeping the temperature below -500C. The mixture was warmed to 1O0C and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1.33 g, 7.70 mmol) was added. The mixture was allowed to stir for 2 h and was concentrated in vacuo. The product was recrystalized from dichloromethane/hexanes to give 1.28 g (60%) of the desired product as a white solid.

Reference： [1]Patent: WO2006/49681,2006,A2 .Location in patent: Page/Page column 47
[2]Patent: WO2006/121860,2006,A2 .Location in patent: Page/Page column 52

38
[ 3395-91-3 ]
[ 17422-32-1 ]
[ 18108-89-9 ]

Yield	Reaction Conditions	Operation in experiment
68%		Under an N2 atmosphere, crushed KOH was added to a solution of 5-chloro-1H-indole (2.0 g, 13.2 mmol) in DMSO (19 mL, 0.7 M), and the mixture was stirred for 2 h at RT. Methyl 3-bromopropanoate (1.9 mL, 17.2 mmol) was added dropwise, and the reaction was continued to stir at RT overnight. After diluting with H2O, the reaction was cleared with a 4.5 N aqueous KOH solution and washed 3 times with CH2Cl2. The aqueous layer was acidified with a 2N HCl solution to pH 3 and extracted 3 times with CH2Cl2. The organic fractions were combined, dried over MgSO4, filtered, and concentrated. Purification via silica gel chromatography using 0-8% MeOH in CH2Cl2 gave 3-(5-chloro-1H-indol-1-yl)propanoic acid (2 g, 68%). 1H NMR (400 MHz, DMSO-d6) delta 7.58 (d, J=2.0 Hz, 1H), 7.54 (d, J=8.7 Hz, 1H), 7.44 (d, J=3.1 Hz, 1H), 7.13 (dd, J=8.7, 2.1 Hz, 1H), 6.42 (dd, J=3.2, 0.7 Hz, 1H), 4.40 (t, J=6.8 Hz, 2H), 2.75 (t, J=6.8 Hz, 2H). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=224.5; tR=2.74 min.

Reference： [1]Patent: US2008/27067,2008,A1 .Location in patent: Page/Page column 265

39
[ 301675-24-1 ]
[ 3395-91-3 ]
[ 1253736-83-2 ]

Yield	Reaction Conditions	Operation in experiment
61%	With potassium carbonate; In water; N,N-dimethyl-formamide; acetone; at 20 - 55℃; for 40h;Inert atmosphere;	To a sealed flask containing a stir bar was dissolved N- lEta-benzimidazol-2-yl-3- nitrobenzamide (0.500 g, 1.77 mmol) in acetone (10 mL), DMF (2 mL) and water (0.2 mL). Next , added sequentially, were K2CO3 (490 mg, 3.54 mmol) and <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (0.296 g, 1.77 mmol). The reaction mixture was stirred at room temperature for 16 h, followed by heating at 55 0C for 24 h. After cooling to room temperature, the reaction mixture was concentrated to near dryness and then suspended in water (5 mL). The contents were extracted with 10% THF in EtOAc (3x). The combined organic extracts were washed with brine (10 mL), dried over Na2SOzI, filtered, and the solvent removed under vacuo. The residue was triturated with EtOAc and filtered to afford the product as a yellow solid (0.40 g, 61%). LC-MS (ES) m/z =368.9 (M+H)+ 1H NMR (400 MHz, DMSO-d6) delta ppm 12.87 (s, IH), 8.94 (s, IH), 8.63 (d, J = 7.6 Hz, IH), 8.35 (d, J = 7.6 Hz, IH), 7.79-7.82 (m, IH), 7.55-7.58 (m, 2H), 7.23-7.29 (m, 2H), 4.50 (t, J = 6.9 Hz, 2H), 3.51 (s, 3H), 2.93-2.96 (m, 2H).

Reference： [1]Patent: WO2010/126922,2010,A1 .Location in patent: Page/Page column 18

40
[ 3395-91-3 ]
[ 103-67-3 ]
[ 17946-01-9 ]

Yield	Reaction Conditions	Operation in experiment
95%	With sodium carbonate; In acetonitrile; at 70℃; for 70h;	Methyl 3 -bromopropanoate (5.00 g, 29.9 mmol) and N-methyl-1- benzylamine (3.63 g, 29.9 mmol) were dissolved in acetonitrile (200 mli) . After 2 min. stirring at room temperature, Na2CO3 (31 g, 299 mmol) was added and the temperature increased to 70 0C for 70 h. After cooling, the reaction solution was filtered, and to the filtrate were added 100 mL of 2M NaOH. The product was extracted with 3 x 100 mL of CH2Cl2 and the extracts dried over Na2SO4. After filtration, the solvents were evaporated under vacuum to yield the product as a colourless oil (5.89 g, 95 %) . 1H-NMR (CDCl3, 400.3 MHz, 298 K) <;5H (ppm) 7.34 (m, 5H, C6H5 -CH2 -N) , 3.70 (s, 3H, -COOCH3) , 3.54 (s, 2H, C6H5-CH2-N) , 2.77 (t, J = 7.6 Hz, 2H, -N-CH2-CH2-) , 2.55 (t, J = 7.6 Hz, 2H, -CH2-COOCH3) , 2.23 (s, 3H, -N-CH3) ; 13C-NMR (CDCl3, 100.7 MHz, 298 K) deltac (ppm) 173.03 (-COOCH3) , 138.88, 128.91, 128.20 and 127.03 (C6H5-CH2-) , 62.11 (C6H5-CH2-) , 52.74 (-N-CH2-CH2-) , 51.56 (-COOCH3) , 41.91 (-N-CH3) , 32.75 (-N-CH2-CH2-) . Found: C, 69.57; H, 8.18; N, 6.63. Ci2H17NO2 requires: C, 69.54; H, 8.27; N, 6.76. MS (ESI) 208.1339 (M+H+, found), 208.1338 (M+H+, calculated)
92%	With sodium carbonate; In acetonitrile; at 70℃; for 24h;	Methyl-3-bromopropanoate (3.00 g, 18.0 mmol) and N-methyl-1 - phenylmethanamine (2.18 g, 18.0 mmol) were dissolved in acetonitrile (120 mL). After 2 min stirring at rt, Na2C03 (19.0 g, 180 mmol) was added and the temperature were increased to 70 C for 24 h. After cooling, the reaction solution was filtered, and 120 mL DCM was added to the filtrate. The organic phase was washed with 0.5 M NaOH (3 chi 50 mL) and dried over Na2S0 . After filtration, the product was concentrated at reduced pressure to yield 13 as colourless oil (3.44 g, 16.5 mmol 92%). H NMR (400 MHz, CDCI3): delta 7.30 - 7.18 (m, 5H, C6H5-CH2-N), 3.63 (s, 3H, -COOCH3), 3.48 (s, 2H, C6H5-CH2-N), 2.71 (t, J = 7.2 Hz, 2H, -N-CH2-CH2-), 2.49 (t, J = 7.2 Hz, 2H, -Ctf2-COOCH3), 2.17 (s, 3H, -N-CH3). 13C NMR (101 MHz, CDCI3): 5 173.00 (-COOCH3), 138.85 (q), 128.95, 128.24 and 127.04 (C6H5-CH2), 62.12 (C6H5-CH2), 52.75 (-N-CH2-CH2-), 51 .56 (-COOCH3), 41 .91 (-N-CH3), 32.75 (CH2-COOCH3). HRMS (ESI+): calc. for C12H18N02+ [M+H]+: 208,13321 ; found: 208.13313. IR (cm 1): v = 2950 (w), 2841 (w), 2790 (w), 1737 (s), 1495 (w), 1452 (m), 1236 (m), 1357 (w), 1325 (w), 1202 (m), 1 168 (s), 1 125 (m), 1975 (w), 1038 (m), 1025 (m).

Reference： [1]Patent: WO2010/116132,2010,A2 .Location in patent: Page/Page column 41; 42
[2]Angewandte Chemie - International Edition,2011,vol. 50,p. 5509 - 5513
[3]Angewandte Chemie - International Edition,2018,vol. 57,p. 2958 - 2962
Angew. Chem.,2018,vol. 130,p. 3008 - 3013,6
[4]Patent: WO2019/48450,2019,A1 .Location in patent: Page/Page column 23; 24; 25

41
[ 2075-46-9 ]
[ 3395-91-3 ]
3-(4-nitro-pyrazol-1-yl)-propionic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%		Example 213: 3 -(4-(( 1 -(3 -Morpholinobenzyl)- 1 H-pyrazo lo [3 ,4-d]pyrimidin-6-yl)amino)- 1 H- pyrazo 1- 1 -yl)- 1 -(piperidin- 1 -yl)propan- 1 -oneStep (i)4-Nitro-1H-pyrazole (0.50g, 4.4mmol) was dissolved in DMF (5mL). After addition of methyl-3-bromopropionate (0.72mL, 1.5eq) and potassium carbonate (0.92g, 1.5eq), the reaction mixture was stirred at 50C for 3h, then partitioned between water and DCM. The aqueous phase was extracted with DCM, the combined organic phases dried over sodium sulfate and evaporated. The residue was hydro lyzed at rt over 30min with lithium hydroxide (3M, aqueous) (4.4mL, 3eq) in methanol (5mL) and the reaction mixture evaporated to dryness to afford 3-(4-nitro-1H-pyrazol-1-yl)propanoic acid in a quantitative yield.

Reference： [1]Patent: WO2011/48082,2011,A1 .Location in patent: Page/Page column 184; 185

42
[ 3395-91-3 ]
[ 943344-85-2 ]
[ 943346-10-9 ]

Yield	Reaction Conditions	Operation in experiment
67.1%	With triethylamine; In tetrahydrofuran; at 20 - 40℃;	Add 82 mul (0.749 mmol) of 3-bromopropanoic acid methyl ester and 104 mul (0.749 mmol) of triethylamine to a solution of 150 mg (0.375 mmol) of (+/-)-5-(4-methoxyphenyl)-6-phenyl-N-piperidin-3-ylfuro[2,3-d]pyrimidin-4-amine (Example 39A) in 0.75 ml of THF, and stir at 20-40 C. overnight. Dilute the mixture with dichloromethane and wash with saturated sodium hydrogencarbonate solution. After concentration under reduced pressure, stir the residue with methanol, filter off the precipitated product with suction and dry under high vacuum. Isolate a second product batch from the filtrate after concentration by preparative RP-HPLC (eluent: acetonitrile/water gradient). A total of 124 mg (67.1% of theory) of the target product are obtained. LC-MS (Method 5): Rt=1.83 min; m/z=487 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): delta=8.31 (s, 1H), 7.49-7.44 (m, 4H), 7.39-7.30 (m, 3H), 7.14 (d, 2H), 5.59 (d, 1H), 4.24 (m, 1H), 3.83 (s, 3H), 3.59 (s, 3H), 2.42-2.35 (m, 2H), 2.28-2.18 (m, 2H), 2.05-1.97 (m, 1H), 1.62-1.55 (m, 1H), 1.40 (br. s, 2H).

Reference： [1]Patent: US2011/124665,2011,A1 .Location in patent: Page/Page column 63

43
[ 63837-11-6 ]
[ 3395-91-3 ]
[ 1335148-09-8 ]

Yield	Reaction Conditions	Operation in experiment
		5-Bromo-2-methylbenzothiazole (1000 mg) was dissolved in tetrahydrofuran (25 mL) and the mixture was cooled to -78 C. using an isopropanol/dry ice bath. Lithium diisopropylamide (1.5M in cyclohexane, 4.40 mL) was added, and the solution stirred for 30 minutes at -78 C. Methyl 3-bromopropionate (1.20 mL, 1836 mg) was added and the solution stirred at -78 C. for two hours. The reaction was quenched with 1M aqueous hydrochloric acid, extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, filtered, concentrated, and purified by flash column chromatography on silica gel using 10% ethyl acetate hexanes

Reference： [1]Patent: US2011/237553,2011,A1 .Location in patent: Page/Page column 42

44
[ 861417-45-0 ]
[ 3395-91-3 ]
[ 929562-48-1 ]

Yield	Reaction Conditions	Operation in experiment
72%		b) Preparation of Intermediate 34; A mixture of intermediate 33 (0.04393 mol) and EtOH, sodium salt (0.08786 mol) in EtOH (100 ml) was heated for 3 hours at 80 C. The reaction mixture was cooled. 3-Bromopropanoic acid methyl ester (0.04393 mol) was added drop wise to the reaction mixture and stirred overnight at 50 C. The residue was purified by column chromatography. The product fractions were collected and the solvent was evaporated, yielding 9.6 g (72%) of intermediate 34.

Reference： [1]Patent: US2011/269748,2011,A1 .Location in patent: Page/Page column 29

45
[ 3395-91-3 ]
[ 29547-04-4 ]
[ 100-46-9 ]
[ 1353160-88-9 ]

Reference： [1]European Journal of Organic Chemistry,2011,p. 6619 - 6623

46
[ 3395-91-3 ]
[ 131341-86-1 ]
[ 1335094-51-3 ]

Yield	Reaction Conditions	Operation in experiment
		PREPARATION EXAMPLE; 0.584 g (2.352 mmol) of fludioxonil are initially charged in 20 ml of tetrahydrofuran. At from -5 C. to 0 C., 1.035 ml (2.587 mmol) of butyllithium are added dropwise, and the mixture is stirred at this temperature for a further 3 hours. The mixture is then heated under reflux, and methyl bromopropionate (0.786 g, 4.704 mmol) is added dropwise under reflux. The mixture is stirred for another 16 hours and then allowed to cool to room temperature, 1.5 ml of water are added dropwise and the solvent is removed. The residue is taken up in dichloromethane, washed, dried, concentrated and chromatographed on silica gel (hexane/acetone 9:1). The crude product (0.16 g) is purified further, giving 0.03 g of methyl 3-[3-cyano-4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrol-1-yl]propanoate of a purity of 100%.Melting point: 90-92 C.1H-NMR (d6-DMSO): delta=3.42 (t, 2H), 4.23 (s, 3H), 4.85 (t, 2H), 7.71 (d, 1H), 7.80 (t, 1H), 7.87 (d, 1H), 8.07 (d, 1'-1), 8.17 (d, 1H) ppm.

Reference： [1]Patent: US2011/313015,2011,A1 .Location in patent: Page/Page column 12

47
[ 3395-91-3 ]
[ 57260-71-6 ]
[ 656803-51-9 ]

Yield	Reaction Conditions	Operation in experiment
90%	With triethylamine; In tetrahydrofuran; at 20℃;	Step 1 : ieri-butyl 4-(3-methoxy-3-oxopropyl)piperazine-1 -carboxylate (1 01 a) Methyl 3-bromopropanoate (0.607 mL, 5.56 mmoles, 1 .05 eq.) was added to a solution of N-Boc-piperazine (1 g, 5.3 mmoles, 1 eq.) and TEA (0.870 mL, 6.36 mmoles, 1 .2 eq.) in anhydrous THF (8 mL), and the reaction was stirred overnight at room temperature. The mixture was diluted with EtOAc, the organic phase was washed with sodium bicarbonate solution and brine, dried over sodium sulphate and evaporated under reduced pressure. The residue was chromatographed on silica gel (SNAP 25) eluting with a gradient of 20-1 00% of EtOAc in ciclohexane to give 1 .3 g of ieri-butyl 4-(3-methoxy- 3-oxopropyl)piperazine-1 -carboxylate 101 a (Y=90%). LC-MS (M-H+) = 273.2.
74%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃;	To a solution of tert-butyl piperazine-1-carboxylate (1 g, 5.37 mmol) in DMF (20 mL) was added Cs2CO3 (589 mg, 1.81 mmol) and <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (744 mg, 4.46 mmol). The resulting mixture was stirred at room temperature overnight. Water (50 m) and EtOAc (50 mL) was added. Phases were separated. The aqueous phase was extracted with EtOAc (50 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by flash chromatography on silica gel eluting with 3.5% MeOH in DCM. Collection of appropriate fractions and evaporation of solvent afforded tert-butyl 4-(3-methoxy-3-oxopropyl)piperazine-1-carboxylate (895 mg, 74%) as yellow oil. TLC: Rf=0.3; ethyl acetate/petroleum ether=1/2.
	With triethylamine; In tetrahydrofuran; at 20℃; for 18h;	General procedure: The commercial bromomethyl ester (1.2 eq) was added at room temperature to a solution of Boc-piperazine (1 eq) and triethylamine (1.2 eq) in anhydrous THF (1 mL/mmol). The flask was sealed and the reaction stirred at room temperature for 18h. The resulting mixture was filtered and the solid washed with THF (3x). The filtrate and washings were concentrated in vacuo to give the crude product, which was purified by column chromatography (2-3% MeOH/CHCl3) to give the methyl ester (60-84%) as a colourless oil.The methyl ester (1 eq) was dissolved in THF (1 mL/mmol), magnesium chloride (2.2 eq) was added and the mixture stirred at room temperature for 5min, at which point 2N dimethylamine in THF (4 eq) was added, the flask tightly sealed and stirred at room temperature for 18h [ ]. The dimethylamine and THF were removed in vacuo and the residue partitioned between EtOAc and 5%NaHCO3. The layers were separated and the organic phase washed with 5%NaHCO3. The combined aq. washes were back-extracted with EtOAc, then the combined organic extracts were washed with H2O and satd. NaCl, dried (Na2SO4), filtered and the filtrate concentrated in vacuo. The crude product was purified by column chromatography (10% MeOH-CHCl3) to give the desired dimethylamide (41%) and recovered starting material (30%). Excess 4N HCl/dioxane was added at room temperature to a solution of the Boc protected compound in DCM-MeOH (1:1). Stirring was continued at room temperature until TLC showed complete consumption of the starting material (ca. 4h). The solvents and HCl were removed in vacuo, the residue evaporated from MeOH (2x) and then triturated with ether. The mixture was filtered, the solid washed with ether (3x) and dried under a stream of nitrogen to give the piperazino dimethylamide as the bis hydrochloride salt (NMR) in near quantitative yield. This was used without further purification.A 1N solution of LiAlH4 in THF (2 eq) was added to a chilled suspension of the dimethylamide in THF. After the addition was completed the solution was heated at reflux for 5h, then the reaction was chilled, diluted with THF and cautiously quenched by adding sequentially water (1 mL/20 mL 1N LiAlH4/THF), 15%NaOH (1 mL/20 mL 1N LiAlH4/THF) and water (3 mL/20 mL 1N LiAlH4/THF). The resulting mixture was stirred at room temperature for 30 min, then filtered to remove the inorganic salts and the filtrate concentrated in vacuo to give the crude product, which was analysed by MS and then used without further purification.

Reference： [1]Patent: WO2016/96631,2016,A1 .Location in patent: Page/Page column 59-60
[2]Journal of Organic Chemistry,2019,vol. 84,p. 3762 - 3779
[3]Patent: US2015/336962,2015,A1 .Location in patent: Paragraph 0784
[4]Bioorganic and Medicinal Chemistry,2012,vol. 20,p. 2091 - 2100

48
[ 3395-91-3 ]
[ 18085-37-5 ]
[ 1353160-88-9 ]

Yield	Reaction Conditions	Operation in experiment
41%		A solution of LDA (2.68 mmol, 1.1 equiv) [prepared from diisopropylamine (0.38 mL, 2.68 mmol) in THF (6.5 mL) and n-BuLi (1.52 M in hexane, 1.8 mL, 2.68 mmol) stirred at -78 C for 30 min] was added to a solution of <strong>[18085-37-5]methyl N-benzylazetidine-2-carboxylate</strong> 4 (500 mg, 2.44 mmol, 1 equiv) in THF (3.2 mL), cooled to -78 C. The reaction mixture was allowed to warm to -65 C (l h), cooled again to -78 C and a mixture of methyl 3-bromopropionate (0.8 mL, 7.31 mmol, 3 equiv) and HMPA (2.7 mL, 15.35 mmol, 6.3 equiv) in THF (2.5 mL) was added. The solution was allowed to warm to rt and then stirred for 16 h. Then the reaction was quenched with saturated aqueous NH4Cl and was extracted with Et2O (3×5 mL). The combined organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography (AcOEt/petroleum ether, 1:7 to 1:1) to afford the diester 1 (291 mg, 41%) as a yellow oil. TLC Rf 0.63 (silica gel, AcOEt/petroleum ether, 1:2); IR (film) 1726 cm-1; 1H NMR (300 MHz, CDCl3) delta 7.32-7.16 (m, 5H, Ph), 3.77 (s, 3H, CO2Me), 3.69 (d, 1H, J=13.2 Hz, CH2Ph), 3.65 (s, 3H, CO2Me), 3.58 (d, 1H, J=13.0 Hz, CH2Ph), 3.17 (m, 2H, H-4), 2.52-1.96 (m, 6H, H-3, H-1', H-2'); 13C NMR (75 MHz, CDCl3) delta 173.8 (CO), 173.5 (CO), 138.3 (Cq-Ar), 128.6 (2CH-Ar), 128.3 (2CH-Ar), 127.0 (1CH-Ar), 71.5 (C-2), 56.0 (CH2Ph), 51.7 (OCH3), 51.6 (OCH3), 49.7 (C-4), 29.6 (C-1' or C-2'), 29.0 (C-1' or C-2'), 25.6 (C-3); HRMS (ESI) [M+Na]+ calcd for C16H21NO4Na: 314.136, found 314.135.

Reference： [1]Tetrahedron,2012,vol. 68,p. 4117 - 4128

49
[ 3395-91-3 ]
[ 60261-46-3 ]
[ 1401094-72-1 ]

Yield	Reaction Conditions	Operation in experiment
47%	With triethylamine; In dichloromethane; at 30℃;	Synthesis Example 5a - methyl 3-{(2S)-2[(diphenylphosphino)methyl]pyrrolidin-1- yl}propanoate (13)(2S)-2-[(diphenylphosphino)methyl]pyrrolidine (shown below) was prepared following the procedure of Tomiaka Tetrahedron .Lett. 1996. 37. 7805 A solution of methyl-3-bromopropionate (1.55 g, 9.28 mmol, 1.01 ml) indichloromethane (8.0 ml) was added dropwise to a solution of the thethylamine (1.88 g, 18.57 mmol, 2.61ml) and (2S)-2-[(diphenylphosphino)methyl]pyrrolidine(2.50 g, 9.28 mmol) in dichloromethane (27 ml). The resulting solution was stirred at 30 C overnight. The reaction mixture was poured into water/dichloromethane (100 ml/100 ml). The crude residue was extracted with dichloromethane (100 ml), the organic phase was washed with water (100 ml), followed by brine (100 ml) and then dried over sodium sulfate and concentrated under reduced pressure.Purification by column chromatography ([5:95], methanol : dichloromethane) afforded the title compound as a yellow viscous oil (1.57 g) 47% yield.1H NMR (500 MHz, cdcl3) delta = 7.50 - 7.39 (m, 4H, CH-Ar), 7.37 - 7.28 (m, 6H, CH- Ar), 3.66 (s, 3H, CH3-9), 3. 9 - 3.03 (m, 2H, CH2-5,6), 2.54 (dt, J=3.3, 13.3, 1H, CH2-4), 2.49 - 2.29 (m, 4H, CH-2, CH2-6,7), 2.15 - 2.06 (m, 1H, CH2-5), 2.06 ~ 1.91 (m, 2H, CH2-1 ,3), 1.83 - 1.53 (m, 3H, CH2-3,4).13C NMR (126 MHz, cdcl3) delta = 172.85 (s, C-8), 139.28 (d, J=12.1 , Ar), 138.47 (d,J=13.3, Ar), 132.95 (d, J=19.3, Ar), 132.57 (d, J=18.7, Ar), 128.68 (s, Ar), 128.45 (s, Ar), 128.40 (s, Ar), 128.35 (s, Ar), 128.33 (s, Ar), 128.28 (s, Ar), 62.08 (d, J=19.3,C-2), 53.44 (d, J=0.8, C-5), 51.50 (s, C-9), 49.09 (s.C-6), 33.62 (d, J= 3.3, C- ),33.48 (s, C-7), 31.67 (d, J=7.8, C-3), 22.21 (d, J=0.6, C-4).IR (diamond, vWAx, cm'1) 2961 , 2802 (CH30 st), 1735 (C=0 st), 1433 (H-C-H st as), 1175 (C-0 st as).Acc. Mass (FAB): C2iH27 02PCalculated: 356.1774Found: 356.1778 error [ppm]: -1.28
47%	With triethylamine; In dichloromethane; at 30℃;	A solution of methyl-3-bromopropionate (1.55 g, 9.28 mmol, 1.01 ml) in dichloromethane (8.0 ml) was added dropwise to a solution of the triethylamine (1.88 g, 18.57 mmol, 2.61 ml) and (2S)-2-[(diphenylphosphino)methyl]pyrrolidine (2.50 g, 9.28 mmol) in dichloromethane (27 ml). The resulting solution was stirred at 30 C. overnight. The reaction mixture was poured into water/dichloromethane (100 ml/100 ml). The crude residue was extracted with dichloromethane (100 ml), the organic phase was washed with water (100 ml), followed by brine (100 ml) and then dried over sodium sulfate and concentrated under reduced pressure. Purification by column chromatography ([5:95], methanol:dichloromethane) afforded the title compound as a yellow viscous oil (1.57 g) 47% yield. [0466] 1H NMR (500 MHz, cdcl3) delta=7.50-7.39 (m, 4H, CH-Ar), 7.37-7.28 (m, 611, CH-Ar), 3.66 (s, 3H, CH3-9), 3.19-3.03 (m, 2H, CH2-5,6), 2.54 (dt, J=3.3, 13.3, 1H, CH2-4), 2.49-2.29 (m, 4H, CH-2, CH2-6,7), 2.15-2.06 (m, 1H, CH2-5), 2.06-1.91 (m, 21-1, CH2-1,3), 1.83-1.53 (m, 3H, CH2-3,4). [0467] 13C NMR (126 MHz, cdcl3) delta=172.85 (s, C-8), 139.28 (d, J=12.1, Ar), 138.47 (d, J=13.3, Ar), 132.95 (d, J=19.3, Ar), 132.57 (d, J=18.7, Ar), 128.68 (s, Ar), 128.45 (s, Ar), 128.40 (s, Ar), 128.35 (s, Ar), 128.33 (s, Ar), 128.28 (s, Ar), 62.08 (d, J=19.3, C-2), 53.44 (d, J=0.8, C-5), 51.50 (s, C-9), 49.09 (s, C-6), 33.62 (d, J=13.3, C-1), 33.48 (s, C-7), 31.67 (d, J=7.8, C-3), 22.21 (d, J=0.6, C-4). [0468] IR (diamond, VMAX, cm-1) 2961, 2802 (CH3O st), 1735 (C?O st), 1433 (H-C-H st as), 1175 (C-O st as). [0469] Acc. Mass (FAB): C21H27NO2P [0470] Calculated: 356.1774 [0471] Found: 356.1778 error [ppm]: -1.28

Reference： [1]Patent: WO2012/131313,2012,A1 .Location in patent: Page/Page column 62
[2]Organic and Biomolecular Chemistry,2013,vol. 11,p. 3255 - 3260
[3]Dalton Transactions,2013,vol. 42,p. 6592 - 6602
[4]Patent: US2014/39200,2014,A1 .Location in patent: Paragraph 0465-0471

50
[ 312-73-2 ]
[ 3395-91-3 ]
[ 1449030-55-0 ]

Reference： [1]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 880 - 885

51
[ 6478-79-1 ]
[ 3395-91-3 ]
[ 1449030-60-7 ]

Reference： [1]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 880 - 885

52
[ 3395-91-3 ]
3-((tert-butyldimethylsilyloxy)methyl)-2-(1H-pyrazol-5-yl)pyridine [ No CAS ]
methyl 3-(3-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
61%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 6h;	[0346] To a mixture of 3-((tert-butyldimethylsilyloxy)methyl)-2-(lH-pyrazol-5-yl)pyridine (140 mg, 0.48 mmol, 1 eq.) and Cs2C03(312 mg, 0.96 mmol, 2 eq.) in DMF (3 mL) was added <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (122 mg, 0.73 mmol, 1.5 eq.). The mixture was stirred at rt for 6 h, filtered, concentrated, and purified on silica gel using a mixture of EtOAc and hexanes as eluent to give methyl 3-(3-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)-lH-pyrazol-l- yl)propanoate (1 10 mg, 61%). LRMS (M+H+) m/z 376.1.
61%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 6h;	Step 2 ;To a mixture of 3-((tert-butyldimethylsilyloxy)methyl)-2-(1H-pyrazol-5-yl)pyridine (140 mg, 0.48 mmol, 1 eq.) and Cs2CO3 (312 mg, 0.96 mmol, 2 eq.) in DMF (3 mL) was added <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (122 mg, 0.73 mmol, 1.5 eq.). The mixture was stirred at rt for 6 h, filtered, concentrated, and purified on silica gel using a mixture of EtOAc and hexanes as eluent to give methyl 3-(3-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)-1H-pyrazol-1-yl)propanoate (110 mg, 61%). LRMS (M+H+) m/z 376.1.

Reference： [1]Patent: WO2013/102145,2013,A1 .Location in patent: Paragraph 0346
[2]Patent: US2015/344483,2015,A1 .Location in patent: Paragraph 0639; 0640

53
[ 3395-91-3 ]
[ 1555930-60-3 ]
[ 1555932-07-4 ]

Yield	Reaction Conditions	Operation in experiment
70.4%		5.29 Example 29: Synthesis of Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Com ounds U056, U057, U058, and U059 To a solution of Cycl ic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound R15a(i) (0.468mmol, 227mg) in DMA (2.3mL) at a temperature of about 25C was added NaH ( 1 .874mmol, 74.9mg); the resulting mixture was stirred at that temperature for 30min. Then, <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (Compound X52, 1 .405mmol, 0.1 53mL, Sigma-Aldrich) was added and the resulting reaction mixture was stirred at a temperature of about 25C for 1 hour. Thereafter, the mixture was diluted with water and extracted with EtOAc. The organic portion was washed with water, washed with brine, dried (over Na2S04), and evaporated to dryness to provide an amorphous solid which was chromatographed on a silica-gel column (Yamazen Corp. W003) eluted with a gradient of from 0: 100 MeOH (28% MH40H):CHC13 to 1 5:85 MeOH (28% NH40H):CHC13 to provide 188.2mg of Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound U056, methyl 3-(3-(4-((lR,rR,3r,3'R,5S,5'S)-[3,9,-bi(9'-azabicyclo[3J. l]nonan)]-3'-yl)-3-oxo-3,4-dihydroquinoxa^ 2-yl)-2-oxopyridin- l(2H)-yl)propanoate, as an orange amorphous solid (yield 70.4%). The identity of Cyclic Urea- or Lactam-Substituted Quinoxal ine-Type Piperidine Compound U056 was confirmed using -NMR. Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound U056: -NMR: deltaEta (ppm, 400MHz, CDC13 with one drop each of DC1 and /4-MeOH): 0.83- 1 .14 (m, 2H), 1 .27-2.06 (m, 14H), 2.14-2.38 (m, l H), 2.40-2.63 (m, 2H), 2.67-2.88 (m, 2H), 3.27-3.70 (m, 9H), 4.00-4.27 (m, 2H), 4.83-5.30 (m, 1 H), 6.24-6.42 (m, 1 H), 7.30-7.45 (m, 1 H), 7.48-7.72 (m, 3H), 7.72-7.92 (m, 2H), 8.24-8.37 (m, 1 H).

Reference： [1]Patent: WO2014/20405,2014,A1 .Location in patent: Page/Page column 313-314

54
[ 3395-91-3 ]
3-(4-((trans-4-(tert-butyl)cyclohexyl)oxy)phenyl)pyrrolidine trifluoroacetic acid [ No CAS ]
methyl 3-(3-(4-((trans-4-(tert-butyl)cyclohexyl)oxy)phenyl)pyrrolidin-1-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%		[00234] [0001]To a suspension of 3-(4-((trans-4-(tert- butyl)cyclohexyl)oxy)phenyl)pyrrolidine TFA salt (18 mg, 0.042 mmol) in acetonitrile (0.5 mL) was added N,N-diisopropylethyl amine (22 pL, 0.13 mmol) and stirred at rt for 2 minutes. 3-Bromopropanoic acid methyl ester (7.0 uL, 0.063 mmol) was then added. The suspension turned to a clear solution after heating with an oil bath (60C). The reaction solution was heated at 60C for lh. It was partitioned between EtOAc and saturated NaHCO3solution. The aqueous layer was extracted with EtOAc. The combined organic phases were dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel column to get the desired methyl ester as a colorless oil (11 mg, yield 67%). LCMS mlz 388.2 [M+H].

Reference： [1]Patent: WO2014/81752,2014,A1 .Location in patent: Paragraph 00234

55
[ 3395-91-3 ]
[ 540-63-6 ]
[ 201991-10-8 ]

Yield	Reaction Conditions	Operation in experiment
79%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 45℃; for 8h;Inert atmosphere;	Methyl 3-bromopropanoate 51 (10.010 g, 60.24 mmol) in DMA (80 ml) was added ethane- 1,2-dithiol (40.0 g, 425.4 mmol) and DIPEA (150 ml). The mixture was stirred at 45 C under Ar for 8 h, evaporated and purified on S1O2 chromatography eluted with 1 : 10:0.01% EtOAc/DCM/HOAc, pooled the fractions, and evaporated to afford the title compound 71 (8.56 g, 79% yield). ESI MS m/z+ 203.10 (M+Na)

Reference： [1]Patent: WO2014/80251,2014,A1 .Location in patent: Page/Page column 59

56
[ 109-80-8 ]
[ 3395-91-3 ]
[ 140183-90-0 ]

Yield	Reaction Conditions	Operation in experiment
82%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 45℃; for 8h;Inert atmosphere;	Compound 63 (10.010 g, 60.25 mmol) in DMA (40 ml) was added propane-1,3- dithiol (40.0 g, 370.3 mmol) and DIPEA (100 ml). The mixture was stirred at 45 C under Ar for 8 h, evaporated and purified on Si02 chromatography eluted with 1: 10:0.01% EtOAc/DCM/HOAc, pooled the fractions, and evaporated to afford the title compound (9.58 g, 82% yield). ESI MS m/z+ 217.2 (M+Na)

Reference： [1]Patent: WO2014/80251,2014,A1 .Location in patent: Page/Page column 57

57
[ 3395-91-3 ]
[ 491-30-5 ]
3-(1-oxo-1H-isoquinolin-2-yl)propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
64%		General procedure: A suspension of commercially available 1,6-naphthyridin-5(6H)-one 4a (188mg, 1.29mmol) and NaH (37mg, 1.55mmol) in dry DMF (10mL) was left under stirring at 0C for 1h. Then, a solution of <strong>[3395-91-3]methyl 3-bromopropionate</strong> (197muL, 1.81mmol) in dry DMF (3mL) was added dropwise and the reaction mixture was stirred at 50C for 18h. After quenching NaH with saturated NH4Cl solution (5mL), the reaction mixture was extracted with CHCl3 (3× 15mL) and the organic phase was washed first with saturated NaHCO3 solution (2× 20mL) and then with distilled water (2×20mL). The organic layer was dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The crude was purified by column chromatography (CHCl3/MeOH=95:5) to give the title compound 5a as a white solid (183mg, 61%); Rf=0.48 (CHCl3/MeOH 95:5). 1H NMR (300MHz, CDCl3): delta 2.90 (t, 2H, J=6.6Hz), 3.68 (s, 3H), 4.28 (t, 2H, J=6.6Hz), 6.8 (d, 1H, J=7.0Hz), 7.4 (dd, 1H, J=7.6Hz), 7.5 (d, 1H, J=7.0Hz), 8.7 (d, 1H, J=7.6Hz), 8.90 (s, 1H)

Reference： [1]European Journal of Medicinal Chemistry,2014,vol. 83,p. 1 - 14

58
[ 3395-91-3 ]
[ 223671-15-6 ]
[ 1621259-45-7 ]

Yield	Reaction Conditions	Operation in experiment
30%		General procedure: A suspension of commercially available 1,6-naphthyridin-5(6H)-one 4a (188mg, 1.29mmol) and NaH (37mg, 1.55mmol) in dry DMF (10mL) was left under stirring at 0C for 1h. Then, a solution of methyl 3-bromopropionate (197muL, 1.81mmol) in dry DMF (3mL) was added dropwise and the reaction mixture was stirred at 50C for 18h. After quenching NaH with saturated NH4Cl solution (5mL), the reaction mixture was extracted with CHCl3 (3× 15mL) and the organic phase was washed first with saturated NaHCO3 solution (2× 20mL) and then with distilled water (2×20mL). The organic layer was dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The crude was purified by column chromatography (CHCl3/MeOH=95:5) to give the title compound 5a as a white solid (183mg, 61%)

Reference： [1]European Journal of Medicinal Chemistry,2014,vol. 83,p. 1 - 14

59
[ 23616-31-1 ]
[ 3395-91-3 ]
[ 1621259-40-2 ]

Yield	Reaction Conditions	Operation in experiment
61%		A suspension of commercially available <strong>[23616-31-1]<strong>[23616-31-1]1,6-naphthyridin</strong>-5(6H)-one</strong> 4a (188mg, 1.29mmol) and NaH (37mg, 1.55mmol) in dry DMF (10mL) was left under stirring at 0°C for 1h. Then, a solution of methyl 3-bromopropionate (197muL, 1.81mmol) in dry DMF (3mL) was added dropwise and the reaction mixture was stirred at 50°C for 18h. After quenching NaH with saturated NH4Cl solution (5mL), the reaction mixture was extracted with CHCl3 (3× 15mL) and the organic phase was washed first with saturated NaHCO3 solution (2× 20mL) and then with distilled water (2×20mL). The organic layer was dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The crude was purified by column chromatography (CHCl3/MeOH=95:5) to give the title compound 5a as a white solid (183mg, 61percent); Rf=0.48 (CHCl3/MeOH 95:5). 1H NMR (300MHz, CDCl3): delta 2.90 (t, 2H, J=6.6Hz), 3.68 (s, 3H), 4.28 (t, 2H, J=6.6Hz), 6.8 (d, 1H, J=7.0Hz), 7.4 (dd, 1H, J=7.6Hz), 7.5 (d, 1H, J=7.0Hz), 8.7 (d, 1H, J=7.6Hz), 8.90 (s, 1H)

Reference： [1]European Journal of Medicinal Chemistry,2014,vol. 83,p. 1 - 14

60
[ 155057-97-9 ]
[ 3395-91-3 ]
[ 1621259-41-3 ]

Yield	Reaction Conditions	Operation in experiment
57%		General procedure: A suspension of commercially available 1,6-naphthyridin-5(6H)-one 4a (188mg, 1.29mmol) and NaH (37mg, 1.55mmol) in dry DMF (10mL) was left under stirring at 0C for 1h. Then, a solution of <strong>[3395-91-3]methyl 3-bromopropionate</strong> (197muL, 1.81mmol) in dry DMF (3mL) was added dropwise and the reaction mixture was stirred at 50C for 18h. After quenching NaH with saturated NH4Cl solution (5mL), the reaction mixture was extracted with CHCl3 (3× 15mL) and the organic phase was washed first with saturated NaHCO3 solution (2× 20mL) and then with distilled water (2×20mL). The organic layer was dried over Na2SO4 and filtered, and the solvent was removed in vacuo. The crude was purified by column chromatography (CHCl3/MeOH=95:5) to give the title compound 5a as a white solid (183mg, 61%)

Reference： [1]European Journal of Medicinal Chemistry,2014,vol. 83,p. 1 - 14

61
[ 3395-91-3 ]
[ 78443-72-8 ]
[ 1448336-51-3 ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 - 100℃; for 76h;	A.2.4.1. Synthesis of 2-(3,5-dichloro-2-formylphenoxy)ethyl acetate To a soln. of <strong>[78443-72-8]4,6-dichlorosalicylaldehyde</strong> (3.72 mmol) in 5 mL DMF was added Cs2C03 (3.72 mmol) followed by Kl (3.72 mmol) and 2-bromoethylacetate (8.68 mmol). The reaction mixture was heated to 100C for 4 h and then stirred at RT for 3 days. The mixture was diluted with EtOAc and washed 3 times with water and then with brine. The comb. org. layers were dried over MgS04 and cone, in vacuo. Purification with CC (20- 100% EtOAc/Hept) gives the desired compound as beige solid. LC-MS (5): tR = 0.86 min; [M+H]+: 227.12.

Reference： [1]Patent: WO2014/115072,2014,A1 .Location in patent: Page/Page column 56

62
[ 3395-91-3 ]
[ 5579-85-1 ]
methyl 3-(6-bromo-5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With potassium carbonate; In acetonitrile; at 70℃; for 16h;	Methyl 3-(6-bromo-5-chloro-2-oxobenzo[d]oxazol-3(2H)- A mixture of 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one (Intermediate 8, 7.7 g, 31 mmol), <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (6.2 g, 37 mmol), potassium carbonate (8.5 g, 62 mmol) in acetonitrile (200 mL), was stirred at 70 C for 16 h, the solvent was evaporated under vacuum, the residue purified by column chromatography (silica:200 - 400 mesh, 50 g) eluting with petroleum ether/ ethyl acetate 4:1 to give methyl 3-(6-bromo-5-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)propanoate as an orange solid (6.2 g, 62%). LCMS (A): Rt 1.66 min, MH+ =334/336.

Reference： [1]Patent: WO2015/91647,2015,A1 .Location in patent: Page/Page column 42; 43
[2]Journal of Medicinal Chemistry,2017,vol. 60,p. 3383 - 3404

63
[ 3395-91-3 ]
3-[3-(cyclopentyloxy)-4-methoxyphenyl]-1H-pyrazole [ No CAS ]
methyl 3-{3-[3-(cyclopentyloxy)-4-methoxyphenyl]-1H-pyrazol-1-yl}propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	With triethylamine; In acetonitrile; at 0℃; for 48h;Reflux;	To a solution of 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-lH-pyrazole (0.6 g, 2.25 mmol) in an. acetonitrile (15 mL) methyl-3-bromopropionate (1.91 g, 11.45 mmol) and triethylamine (1 mL, 0.73 g, 7.19 mmoli) were added dropwise at 0 C; then, the mixture was heated at reflux for 48 h. After cooling to room temperature, the solvent was removed under reduced pressure and the crude was solved in diethyl ether (30 mL), the organic phase was washed with water (3 x 20 mL), 4N NaOH solution (2 x 20 mL), brine (2 x 20 mL), dried (MgS04), and concentrated under reduced pressure. The obtained oil was purified by silicagel (100-200 mesh) column chromatography, using diethyl ether as the eiuent to afford the pure product as a light yellow oil. (0317) Yield: 67%. FontWeight="Bold" FontSize="10" H-NMR (CDC13): delta 1.50-2.18 (m, 8H, 4C cyclopent), 3.00 (tf J - 6.0 Hz, 2H, CCO), 3.73 (s, 3H, OCH3), 3.90 (s, 3H, OCH3-Ar), 4.49 (t, J = 6.0 Hz, 2H, CH2N), 4.77-5.08 (m, 1H, OCH cyclopent.), 6.45 (d, J - 3.0 Hz, 1H, H-4 pyraz.), 6.95 (d, J - 6.8 Hz, 1H, H-5 Ar), 7.20-7.50 (m, 3H, H-6 + H-2 Ar + H-5 pyraz.). IR (CH<) cm"1: 1735 (CO). Anal. (<HMN204) C, H, N. (% calculated/found) C: 66.26/ 66.24; H: 7.02/ 7.33; N: 8.13/ 7.90.
67%	With triethylamine; In acetonitrile; at 0℃; for 48h;Reflux;	Methyl-3-bromopropionate (1.91g, 11.45mmol) and TEA (1mL, 0.73g, 7.19mmol) were added dropwise at 0C to a solution of 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-1H-pyrazole 22 (0.6g, 2.25mmol) in an. acetonitrile (15mL); then, the mixture was heated at reflux for 48h. After cooling to room temperature, the solvent was removed under reduced pressure and the crude was solved in diethyl ether (30 mL). The organic phase was washed with water (3×20mL), 4N NaOH solution (2×20mL), brine (2×20 mL), dried (MgSO4), and concentrated under reduced pressure. The obtained oil was purified by silica gel (100-200 mesh) column chromatography, using diethyl ether as the eluent to afford the pure product as a light yellow oil. Yield: 67%, 1H NMR (CDCl3): delta 1.50-2.18 (m, 8H, 4CH2 cyclopent.), 3.00 (t, J=6.0Hz, 2H, CH2CO), 3.73 (s, 3H, OCH3), 3.90 (s, 3H, OCH3-Ar), 4.49 (t, J=6.0Hz, 2H, CH2N), 4.77-5.08 (m, 1H, OCH cyclopent.), 6.45 (d, J=3.0Hz, 1H, H-4 pyraz.), 6.95 (d, J=6.8Hz, 1H, H-5 Ar), 7.20-7.50 (m, 3H, H-6+H-2 Ar+H-5 pyraz.); IR (CHCl3) cm-1: 1735 (CO); Anal. (C19H24N2O4) calcd for C, H, N.

Reference： [1]Patent: WO2015/121212,2015,A1 .Location in patent: Page/Page column 45
[2]European Journal of Medicinal Chemistry,2016,vol. 124,p. 82 - 102

64
[ 3395-91-3 ]
ethyl 6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidine-7-carboxylate [ No CAS ]
[ 103-72-0 ]
ethyl 6-((((3-methoxy-3-oxopropyl)thio)(phenylamino)methylene)amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidine-7-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%		General procedure: To a solution of compound 2 (2.83 g, 0.01mol) in mixture of DMF/ EtOH (1:2) (20 mL) and phenyl isothiocyanate (1.5 mL, 0.01 mol) in the presence of KOH (0.56 g, 0.01 mol), was stirred overnight at room temperature to give non-isolable salt 3, followed by addition alpha-halo compounds such as chloroacetone (0.75 g, 0.01 mol) or phenacyl bromide (2.0 g, 0.01mol) or chloroacetonitrile (0.70 g, 0.01 mol) or ethyl bromoacetate (1.15 mL, 0.01 mol) or chloroacetylchloride (0.8 mL, 0.01 mol) or methyl bromopropionate (1.67 g, 0.01 mol), and stirred at room temperature for 12 h, and then poured into ice-cold water. The solid product was filtered off and recrystallized from EtOH-DMF to give compounds 7a, 7b, 9, 11, 13 and 14, respectively.

Reference： [1]Heterocycles,2015,vol. 91,p. 2271 - 2284

65
[ 3395-91-3 ]
8-[(2,6-difluorobenzyl)oxy]-2,6-dimethyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine [ No CAS ]
methyl 3-(4-{8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}-1H-pyrazol-1-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 70℃; for 2.5h;	Example 102 Methyl 3-(4-{8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}-1H-pyrazol-1-yl)propanoate 520 mg (1.60 mmol) of caesium carbonate, 10.2 mg (0.06 mmol) of potassium iodide and 133 mg (0.80 mmol) of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> were added to 218 mg (0.61 mmol) of 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine from Example 88 in 3.3 ml of DMF, and the mixture was stirred at 70 C. for 2.5 h. After cooling, the solid was filtered off and washed with THF/methanol, the filtrate was concentrated and the residue was purified by preparative HPLC (RP18 column, mobile phase: acetonitrile/water gradient with addition of 0.1% TFA). The concentrated product fractions were partitioned between dichloromethane and saturated aqueous sodium bicarbonate solution. The aqueous phase was extracted twice with dichloromethane, the combined organic phases were dried over sodium sulphate and filtered and the filtrate was concentrated. The crude product was purified by silica gel chromatography (solvent: dichloromethane/methanol=80/1). This gave 179 mg of the target compound (65% of theory). LC-MS (Method 1): Rt=0.78 min MS (ESpos): m/z=441 (M+H)+ 1H NMR (400 MHz, DMSO-d6) delta=2.25-2.32 (m, 6H), 2.98 (t, 2H), 3.62 (s, 3H), 4.44 (t, 2H), 5.28 (s, 2H), 6.74 (s, 1H), 7.23 (t, 2H), 7.55-7.65 (m, 1H), 7.72 (s, 1H), 7.78 (s, 1H), 8.14 (s, 1H).

Reference： [1]Patent: US2016/122341,2016,A1 .Location in patent: Paragraph 1080; 1081; 1082; 1083; 1084

66
[ 3395-91-3 ]
[ 22478-90-6 ]
C₂₀H₁₉N₃O₄S [ No CAS ]
C₁₉H₁₉N₃O₂S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In acetone; at 20 - 60℃; for 11h;	Following the general alkylation procedure, the reactionof 0.01 mol of <strong>[22478-90-6]5-benzyl-4-phenyl-4H-1,2,4-triazole-3-thiol</strong> with 0.01 mol of methyl 3-bromopropanoatein the presence of 0.006 mol of anhydrouspotassium carbonate gave 2.9 g of a crystalline product.After repeated fractional recrystallization, theproduct contained two compounds 3a and 3b (TLC)with fairly similar Rf values.

Reference： [1]Russian Journal of Organic Chemistry,2017,vol. 53,p. 935 - 940
Zh. Org. Khim.,2017,vol. 53,p. 919 - 924,6

67
[ 675109-26-9 ]
[ 3395-91-3 ]
methyl 3-(6-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 18-crown-6 ether; caesium carbonate; In N,N-dimethyl-formamide; at 70℃; for 18h;Inert atmosphere;	Preparation 124: Methyl 3-(6-bromo-1 -oxo-2,3-dihydro-1 H-isoindol-2-yl)propanoate (1728) To a stirred solution of 6-bromo-2,3-dihydro-1 H-isoindol-1-one (550 mg, 2.59 mmol), 18-crown-6 (69 mg, 0.26 mmol) and methyl 3-bromopropionate (350 pL, 3.1 1 mmol) in DMF (9 ml.) was added CS2CO3 (2.113 g, 6.48 mmol) under nitrogen. The reaction was heated to 70 C (1729) (thermally) slowly and maintained at this temperature for 18 hours. After cooling and the reaction was quenched with NH4CI (sat., aq.). The mixture was extracted with EtOAc (x3) and the combined organic layers were washed with brine, dried over MgSO, filtered and (1730) concentrated under vacuum to yield methyl 3-(6-bromo-1-oxo-2,3-dihydro-1 H-isoindol-2- yl)propanoate as a yellow oil. LC-MS was consistent with a complex mixture which was taken on as is. To the residue was added bis(pinacolato)diboron (0.746 g, 2.91 mmol), AcOK (0.491 mg, 5.00 mmol) and anhydrous 1 ,4-dioxane (8 ml_). The reaction was degassed with nitrogen for 5 minutes. 1 ,1 '-Bis(diphenylphosphino)ferrocene-palladium(ll)dichloride dichloromethane complex (61 mg, 0.08 mmol) was then added and the reaction heated at 90C under nitrogen for 16 hours. The reaction was allowed to cool to room temperature and was then diluted with water. The mixture was extracted with EtOAc (x3) and the combined organic layers were washed with brine, dried over MgSO, filtered and concentrated under vacuum to yield the title compound (1.5 g, 168 %) which was used without further purification. MS: [M+H]+ = 346.

Reference： [1]Patent: WO2017/68412,2017,A1 .Location in patent: Page/Page column 232; 233

68
[ 3395-91-3 ]
[ 22990-19-8 ]
methyl 3-(1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propanoate [ No CAS ]

Reference： [1]ACS Medicinal Chemistry Letters,2017,vol. 8,p. 824 - 829

69
[ 147497-32-3 ]
[ 3395-91-3 ]
3-(6-bromo-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%		6-bromo-3,4-dihydro-2H-isoquinolin-1-one (0.3 g, 1.32 mmol) obtained in Step A of Preparation Example 7was dissolved in 10 mL of THF and cooled to 0C. NaH (60%)(0.11 g, 2.65 mmol) was added thereto, and the mixturewas stirred at room temperature for 0.5 hour. 3-bromo-propionic acid methyl ester (0.33 g, 2.00 mmol) was added tothe reaction solution, and the mixure was stirred for 2 hours under reflux. The reaction solution was extracted with EtOAc,dried with MgSO4 and purified by column chromatography to obtain the title compound (0.38 g, 92 %).1H-NMR (CDCl3) delta 7.90 (1H, d), 7.47 (1H, d), 7.34 (1H, s), 3.80 (2H, t), 3.69 (3H, s), 3.63 (2H, t), 2.94 (2H, t), 2.73 (2H, t)

Reference： [1]Patent: EP3239143,2017,A2 .Location in patent: Paragraph 0091

70
[ 500789-41-3 ]
[ 3395-91-3 ]
4-(tert-butyl) 2-methyl 2-(3-methoxy-3-oxopropyl)morpholine-2,4-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		4-(t-Butyl) 2-methyl morpholine-2,4-dicarboxylate (1 equiv.) is dissolved in dry THF and cooled to-78 C. A solution of LiHMDS (1.0 M in THF) (1.1 equiv.) is then added dropwise and the solution is stirred for 1 hour. Methyl 3-bromopropanoate (1 equiv.) was then added dropwise. The is allowed to stir for 30 minutes and is then warmed gradually to room temperature. When the reaction is judged to be complete based on TLC or LCMS analysis, it is quenched with saturated aqueous ammonium chloride solution and diluted with ethyl acetate. The organic layer is separated and the aqueous layer is extracted with ethyl acetate (3x). The combined organic layers are washed with brine and dried over sodium sulfate before concentrating under reduced pressure. The crude product is then purified on silica providing 4-(tert-butyl) 2-methyl 2-(3-methoxy-3- oxopropyl)morpholine-2,4-dicarboxylate.

Reference： [1]Patent: WO2017/197036,2017,A1 .Location in patent: Page/Page column 235

71
[ 610791-05-4 ]
[ 3395-91-3 ]
1-(tert-butyl) 3-methyl 3-(3-methoxy-3-oxopropyl)azetidine-1,3-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		1-(Tert-butyl) 3-methyl azetidine-1,3-dicarboxylate (1 equiv.) is dissolved in dry tetrahydrofuran and cooled to-78 C. A solution of lithium hexamethyldisilazide (1.0 M in tetrahydrofuran) (1.1 equiv.) is then added dropwise and the solution is stirred for 1 hour. Methyl 3-bromopropanoate (1 equiv.) was then added dropwise. The is allowed to stir for 30 minutes and is then warmed gradually to room temperature. When the reaction is judged to be complete based on TLC or LCMS analysis, it is quenched with saturated aqueous ammonium chloride solution and diluted with ethyl acetate. The organic layer is separated and the aqueous layer is extracted with ethyl acetate (3x). The combined organic layers are washed with brine and dried over sodium sulfate before concentrating under reduced pressure. The crude product is then purified on silica providing 1-(tert-butyl) 3-methyl 3-(3-methoxy-3-oxopropyl)azetidine-1,3-dicarboxylate (Synlett, 2015, 26, 1815-1818.).

Reference： [1]Patent: WO2017/197036,2017,A1 .Location in patent: Page/Page column 192

72
5-chloropyridazin-3(2H)-one [ No CAS ]
[ 3395-91-3 ]
methyl 3-(4-chloro-6-oxopyridazin-1(6H)-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 22h;Inert atmosphere; Sealed tube;	Example 5A: methyl 3-(4-chloro-6-oxopyridazin-l(6H)-yl)propanoate A 50 mL round bottom flask, equipped with a magnetic stir bar, was charged with 5- chloropyridazin-3(2H)-one (Maybridge, CASNo. 660425-07-0, 350 mg, 2.68 mmol) and cesium carbonate (1310 mg, 4.02 mmol). The vial was sealed with a septum and placed under a dry nitrogen atmosphere, and then NV-dimethyl formamide (7 mL) was introduced via syringe. The reaction mixture was vigorously stirred at ambient temperature while methyl 3- bromopropanoate (0.351 mL, 3.22 mmol) was added via syringe. The reaction mixture was stirred at ambient temperature for 22 hours. The reaction mixture was diluted with water, neutralized with aqueous citric acid, and extracted with ethyl acetate (twice). The combined organic layers were washed with brine, then dried (MgS04), and filtered. The filtrate was concentrated under reduced pressure to give a yellow oil that was purified by column chromatography on an Analogix IntelliFlash-310 (Isco RediSep 40 g silica gel cartridge, 70:30 to 65:35 heptane/ethyl acetate) to give the title intermediate as a clear, colorless oil (479 mg, 82% yield). l NMR (CDC13) 5Dppm 7.72 (d, J = 2.4 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 4.42 (t, J = 7.1Hz, 2H), 3.70 (s, 3H), 2.83 (t, J = 7.1Hz, 2H). MS (DCI-NH3) m/z 217 (M+H)+, m/z 234 (M+NH4)+.
82%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 22h;Sealed tube; Inert atmosphere;	A 50 mL round bottom flask, equipped with a magnetic stir bar, was charged with 5- chloropyridazin-3(2H)-one (Maybridge, CAS 660425-07-0, 350 mg, 2.68 mmol) and cesium carbonate (1310 mg, 4.02 mmol). The vial was sealed with a septum and placed under a dry nitrogen atmosphere, and then N,N-dimethylformamide (7 mL) was introduced via syringe. The reaction mixture was vigorously stirred at ambient temperature while <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (0.351 mL, 3.22 mmol) was added via syringe. The reaction mixture was stirred at ambient temperature for 22 hours. The reaction mixture was diluted with water, neutralized with aqueous citric acid, and extracted with ethyl acetate (twice). The combined organic layers were washed with brine, then dried (MgSO/t), and filtered. The filtrate was concentrated under reduced pressure to give a yellow oil that was purified by column chromatography on an Analogix IntelliFlash-310 (Isco RediSep 40 g silica gel cartridge, 70:30 to 65:35 heptane/ethyl acetate) to give the title intermediate as a clear, colorless oil (479 mg, 82% yield).JH NMR (CDC13) delta ppm 7.72 (d, J = 2.4 Hz, 1H), 6.96 (d, J = 2.4 Hz, 1H), 4.42 (t, J = 7.1 Hz, 2H), 3.70 (s, 3H), 2.83 (t, J = 7.1 Hz, 2H). MS (DCI-NH3) m/z 217 (M+H)+, m/z 234 (M+NH4)+.

Reference： [1]Patent: WO2017/193034,2017,A1 .Location in patent: Page/Page column 226
[2]Patent: WO2019/90069,2019,A1 .Location in patent: Page/Page column 254; 255

73
[ 3395-91-3 ]
[ 66-22-8 ]
[ 90007-75-3 ]

Yield	Reaction Conditions	Operation in experiment
79%	With potassium carbonate; In dimethyl sulfoxide; at 20℃; for 12h;Inert atmosphere;	Naturaluracil (1000 mg, 8.93 mmol) was taken in a dry RB then dry DMSO was added to it,then <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (1.22 ml, 11.16 mmol) is added into it followed byK2CO3 (1540.4 mg, 11.16 mmol) and the mixture was allowed to stirr at roomtemperature for 12 hours. After completion of the reaction (Monitered by TLC), thereaction mixture was diluted with EtOAc and washed with water. Combined organiclayer was dried over anhydrous Na2SO4, concentrated in vacuo and purified by coloumnchromatography (Si-gel, PE:EA = 1:3) in pure form 1400mg as white solid . Yield 79%.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 5387 - 5392

74
[ 3395-91-3 ]
5-(5-methylpiperidin-3-yl)quinoline-8-carbonitrile dihydrochloride [ No CAS ]
3-[3-(8-cyanoquinolin-5-yl)-5-methylpiperidin-1-yl]propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80℃; for 1h;Inert atmosphere;	A mixture of 5-(5-Methyl-piperidin-3-yl)-quinoline-8-carbonitrile dihydrochloride (300 mg; 0.93 mmol), 3-Bromo-propionic acid methyl ester (0.15 ml; 1.39 mmol) and DIEA (0.83 ml; 4.63 mmol) in DMF (1.5 ml) was stirred at 80C for 1 h. The completed reaction was concentrated and the crude was purified by prep HPLC (basic, eluting with ACN/water 20-70%) to yield the title compound (185mg, yield 59%). Compound 48: LC-MS (M+1) =338. ?H NMR (400 MHz, Methanol-d4) 9.10 -9.01 (m, 1H), 8.63 (dd, J = 8.6, 1.7 Hz, 1H), 8.28 - 8.20 (m, 1H), 7.81 - 7.64 (m, 2H), 3.78 (d, J= 12.4 Hz, 1H), 3.70 (d, J = 3.5 Hz, 3H), 3.18 - 2.99 (m, 1H), 2.96 - 2.85 (m, 1H), 2.85 - 2.75(m, 1H), 2.67 -2.53 (m, 1H), 2.29 (dd, J = 11.4, 8.3 Hz, 1H), 2.20 (t, J = 11.2 Hz, 1H), 2.10-1.92 (m, 2H), 1.85 (t, J = 11.0 Hz, 1H), 1.41 (q, J = 12.4 Hz, 1H), 1.14 (dd, J = 22.0, 6.9 Hz,2H), 1.03 (d, J= 6.4 Hz, 3H).

Reference： [1]Patent: WO2018/31434,2018,A1 .Location in patent: Paragraph 00198; 00296; 00297

75
[ 3395-91-3 ]
[ 15883-20-2 ]
2-[[(2, 6-dimethylphenyl)amino]carbonyl]-1-piperdinepropanoic acid methyl ester hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78.6%		General procedure: General procedure for preparation of 4a-4q2-fluoroethylbromide (2.2 ml, 0.024 mol) was added to asuspension of N-(2, 6-dimethylphenyl)-2- piperidinecarboxamide(3) (5.0 g, 0.022 mol) and K2CO3 (3.6 g,0.26 mol) in DMF (50 ml). The mixture was stirred andheated at 80 C for 90 min and then allowed to cool to roomtemperature. The solid were filtered off and the DMFsolution was added to cold water (200 ml). 1-(2-fluoroethyl)-N-(2, 6-dimethyl phenyl)-2-piperidinecarboxamideprecipitated as a pale cream solid. It was dissolved inanhydrous ether and dried gas of hydrogen chloride wasadded at room temperature for 5 min, 1-(2-fluoroethyl)-<strong>[15883-20-2]N-(2, 6-dimethylphenyl)-2-piperidinecarboxamide</strong> was transformedinto 1-(2-fluoroethyl)-N-(2, 6-dimethylphenyl)-2-piperidine carboxamide hydrochloride (4a). Compounds4b-4q was prepared by following the same procedure.

Reference： [1]Medicinal Chemistry Research,2018,vol. 27,p. 954 - 965

76
[ 3395-91-3 ]
2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)oxazole-5-carboxamide [ No CAS ]
methyl 3-(6-(2-(2,4-dimethyloxazole-5-carboxamido)thiazol-4-yl)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%		To a solution of 2,4-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)oxazole-5-carboxamide (0.050 g, 0.136 mmol) in anhydrous dimethylformamide (3 mL) in a flamed dried flask under argon atmosphere at 0 C. was added sodium hydride (60% in mineral oil, 0.014 g, 0.339 mmol) was added in one portion. The reaction was stirred for 10 min at 0 C. then 3-bromopropionate (0.025 g, 0.149 mmol) was added via syringe. The mixture was stirred for 90 minutes, then 20 hours at room temperature. After consumption of starting material, the reaction mixture was quenched with sat. ammonium chloride (1 mL) and extracted with ethyl acetate (2*25 mL). The combined organics were washed once with saturated sodium bicarbonate (20 mL), brine (20 mL), and dried over anhydrous sodium sulfate. The concentrated residue was purified by flash chromatography over silica gel using 95:5 dichloromethane/methanol to give methyl 3-(6-(2-(2,4-dimethyloxazole-5-carboxamido)thiazol-4-yl)-2-oxo-3,4-dihydroquinoiolin-1 (2H)-yl)propanoate (0.048 g, 78%) a white solid. 1H NMR (400 MHz, DMSO-d): delta 12.53 (bs, 1H), 7.80 (m, 2H), 7.61 (s, 1H), 7.21 (d, 1H, J=8.8 Hz), 4.16 (m, 2H), 3.58 (s, 3H), 2.90 (m, 2H), 2.59 (m, 4H), 2.49 (s, 3H), 2.41 (s, 3H). MS (ESI): Calcd. for C22H22N4O5S: 454, found 455 (M+1)+.

Reference： [1]Patent: US2018/201610,2018,A1 .Location in patent: Paragraph 0297; 0298

77
[ 3395-91-3 ]
[ 1533519-84-4 ]
C₁₉H₁₉N₃O₂S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	In N,N-dimethyl-formamide; at 60℃; for 96h;Autoclave;	A pressure vessel containing the compound of Formula (5) (10 g, 37.40 mmol) and methyl 3-bromopropionate (7.73 g, 44.88 mmol) in N,N-dimethylformamide (70 mL) was sealed and heated to an external temperature of 60 C. for 3 days. The reaction was then cooled to room temperature to allow for a sample of the reaction mixture to be taken for 1H-NMR analysis (91% conversion). Methyl 3-bromopropionate (97%, 1.25 g, 7.48 mmol) was charged to the vessel and the reaction was re-sealed and heated to an external temperature of 60 C. for 24 hours. Following completion of the reaction, the reaction solution was concentrated in vacuo at 35-40 C. to remove the N,N-dimethylformamide. The resulting oil residue was then dissolved in dichloromethane (100 mL) and washed with a saturated aqueous sodium bicarbonate solution (50 mL), with the organic phase being dried over anhydrous sodium sulfate and concentrated in vacuo at 30-35 C. to afford a green oil (17.07 g). The oil was purified by silica gel column chromatography (column 27 cm*6 cm), using a gradient system of ethyl acetate and heptanes (2 L, 40:60 ethyl acetate:heptanes; 1 L, 50:50 ethyl acetate:heptanes; 2 L, ethyl acetate) to afford the compound of Formula (11) (9.75 g; 67% yield from the compound of Formula (5)) as a dark oil. 1H-NMR (CDCl3, 300 MHz) delta: 0.78-0.93 (2H, m), 1.12-1.21 (2H, m), 2.42 (1H, tt, J=5.44 Hz, 8.46 Hz), 2.91 (2H, t, J=6.77 Hz), 3.47 (2H, t, J=6.86 Hz), 3.64 (3H, s), 7.30 (1H, d, J=8.25 Hz), 7.35 (2H, s), 7.57 (1H, apparent dt, J=1.02 Hz, 8.22 Hz), 7.66 (1H, apparent dt, J=1.02 Hz, 8.04 Hz), 8.30 (1H, s), 8.54 (1H, d, J=8.44 Hz).

Reference： [1]Patent: US2018/258057,2018,A1 .Location in patent: Paragraph 0221-0223

78
[ 3395-91-3 ]
tert-butyl N-(1H-pyrazol-4-yl)carbamate [ No CAS ]
methyl 3-(4-((tert-butoxycarbonyl)amino)-1H-pyrazol-1-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With caesium carbonate; In acetonitrile; at 40 - 50℃;	1.0 g of tert-butyl 4-(1H-pyrazole)carbamate 3 was dissolved in acetonitrile, and 1.07 g of <strong>[3395-91-3]methyl 3-bromopropionate</strong> 4a was added dropwise to the above solution. After the dropwise addition was completed, 3.0 g of cesium carbonate was further added, and the temperature was raised to 40 to 50 C to react overnight. After the TLC detection reaction was completed, the insoluble solid was filtered off, and the solvent was evaporated to dryness. The crude product was dissolved in ethyl acetate, and washed three times with water, citric acid aqueous solution, and saturated sodium chloride solution; The organic phase was dried over anhydrous sodium sulfate (MgSO4). The resulting crude product is eluted with petroleum ether: Purification by column chromatography of ethyl acetate = 5:1 by volume gave 1.2 g of Compound 5a as a white solid. The yield was 82%.

Reference： [1]Patent: CN108864057,2018,A .Location in patent: Paragraph 0105; 0206; 0211-0212
[2]Journal of Medicinal Chemistry,2019,vol. 62,p. 3898 - 3923

79
[ 3395-91-3 ]
[ 91188-13-5 ]
methyl 3-(3-((tert-butoxycarbonyl)amino)azetidin-1-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
350 mg	With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20℃;Inert atmosphere;	To a solution of tert-butyl azeti din-3 -ylcarbamate (416 mg, 2.0 mmol) and K2C03(560 mg, 4.0 mmol) in DMF (10 mL) was added methyl 3-bromopropanoate (330 mg, 2.0 mmol) dropwise at 0C. The mixture was stirred for 30 min at 0C. Then the reaction was stirred at room temperature overnight under a N2atmosphere. After the reaction was complete water was added and the water later was extracted with DCM. The dichloromethane layer was dried over anhydrous Na2S04, filtered and concentrated to give crude product. The crude product was purified by chromatography (silica gel, 1 to -10 % MeOH in DCM) to give methyl 3-(3-((tert-butoxycarbonyl)amino)azetidin-l-yl)propanoate (350 mg) as a white solid. LC-MS (ESI) found: 259 [M+H]+.

Reference： [1]Patent: WO2019/118612,2019,A1 .Location in patent: Paragraph 0232

80
[ 3395-91-3 ]
C₄H₅BrN₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With C8H8N4O4S; triethylamine; In 1,2-dichloro-ethane; at 0 - 20℃; for 1h;	100 mmol of the compound of formula (II), methyl beta-bromopropionate, 15 mL of triethylamine and 100 mL of dry dichloroethane were added to the reaction flask.Stir well and mix well.The mixture was cooled at 0 C.110 mmol of the compound of formula (III) is dissolved in 100 mL of dichloroethane.And dripping into the above cooled reaction bottle,After the half hour, the reaction was carried out at 0 C for 0.5 h.The reaction was then stirred at room temperature for 0.5 h.Add 200 mL of water to the reaction system.After standing, the organic layer is separated.The aqueous layer is washed with dichloroethane.Combine the organic layers,Dry over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure.a compound of formula (IV),The yield was 92%.

Reference： [1]Patent: CN109942584,2019,A .Location in patent: Paragraph 0020-0021

81
[ 52415-29-9 ]
[ 3395-91-3 ]
methyl 3-(6-bromo-1H-indol-2-yl)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With norborn-2-ene; bis(benzonitrile)palladium(II) dichloride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 70℃; for 12h;Inert atmosphere;	General procedure: To a vial were added 6-bromo-1H-indole (1.0 eq), methyl bromoacetateor <strong>[3395-91-3]methyl 3-bromopropionate</strong> or <strong>[3395-91-3]methyl 3-bromopropionate</strong> (1.2 eq), Pd(PhCN)2Cl2 (10mol%, 0.1 eq), norbornene (2.0 eq), NaHCO3 (4.0 eq), water (1.0 eq) and DMF (3 mL). Thereaction mixture was stirred underN2 atmosphere at 70 Cfor 12 h. After completion of the reaction, the resulting mixture was dilutedwith ethyl acetate (EA) and washed with water. The separated aqueous phase waswashed with EA. The combined organic layers were dried over MgSO4,filtered, and concentrated in vacuo. The crude mixture was purified by columnchromatography on silica gel (petroleum: ethyl acetate = 10:1~5:1) to affordthe desired products 8a - 10a.

Reference： [1]European Journal of Medicinal Chemistry,2019,vol. 182

82
[ 5054-59-1 ]
[ 3395-91-3 ]
methyl 3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxy]propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60.89%	With potassium carbonate; In N,N-dimethyl-formamide; at 25℃; for 2h;	To a stirred solution of 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1 ,3-dione (500.00 mg, 1 .823 mmol, 1 .00 equiv) and <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (395.84 mg, 2.370 mmol, 1 .30 equiv) in DMF was added K2CO3 (755.96 mg, 5.470 mmol, 3.00 equiv). The resulting solution was stirred for 2 hours at 25 C. The solids were filtered out. The filtrate was concentrated. The residue was applied onto a silica gel column with dichloromethane/methanol (10:1 ). This resulted in 400 mg (60.89%) of methyl 3-[[2-(2,6- dioxopiperidin-3-yl)-1 ,3-dioxoisoindol-4-yl]oxy]propanoate as a green solid. LCMS (ESI) m/z: [M-H]+ = 361 .

Reference： [1]Patent: WO2019/152440,2019,A1 .Location in patent: Page/Page column 156

83
[ 269410-08-4 ]
[ 3395-91-3 ]
[ 1093307-33-5 ]

Yield	Reaction Conditions	Operation in experiment
63%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 24h;	4-pyrazole boronic acid pinacol ester (3.9 g, 20.0 mmol) was dissolved in 30.0 ml of DMF at room temperature.Potassium carbonate (5.5 g, 40.0 mmol) and <strong>[3395-91-3]methyl 3-bromopropionate</strong> (4.0 g, 24.0 mmol) were added.After stirring at room temperature for 24 hours, TLC was monitored (the ratio of petroleum ether to ethyl acetate was 2:1) still left the reaction starting material. 30 ml of water was added to the reaction mixture, and the mixture was stirred until a clear solution.Then extracted with ethyl acetate (50 ml × 2).The extract was washed with saturated brine (50 ml×2) and dried over anhydrous sodium sulfate.Filtered, and the filtrate was concentrated under reduced pressure.The residue was isolated (5:1 by volume ratio of petroleum ether to ethyl acetate) to obtain intermediate (a) 3.5 g, yield 63%;

Reference： [1]Patent: CN110016013,2019,A .Location in patent: Paragraph 0041; 0046-0048

84
[ 3395-91-3 ]
[ 145149-48-0 ]
methyl 3-(2-[[(tert-butoxy)carbonyl]amino]-3-phenylpropoxy)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
36%	With sodium hydride; In tetrahydrofuran; at 20 - 30℃; for 3h;	A solution of <strong>[145149-48-0]tert-butyl N-(1-hydroxy-3-phenylpropan-2-yl)carbamate</strong> (2.51 g, 9.99 mmol, 1.00 equiv), NaH (600 mg, 25.0 mmol, 1.10 equiv), and methyl 3-bromopropanoate (1.8 g, 10.8 mmol, 1.10 equiv) in THF (30 mL) was stirred for 3 h at RT. The solvent was concentrated under vacuum and the residue was applied onto a silica gel column eluting with EtOAc/petroleum ether (1:5) to afford 1.2 g (36%) of title compound as a white solid. LCMS: [M+H]+ 338.20

Reference： [1]Patent: US2019/330194,2019,A1 .Location in patent: Paragraph 1508

85
[ 3395-91-3 ]
[ 57165-75-0 ]
3-((2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)amino)propionic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59.7%	With potassium carbonate; In tetrahydrofuran; water; at 70℃; for 12h;	Intermediate 4a (1g, 4.1mmol) was dissolved in 12ml of tetrahydrofuran, then <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.7g, 4.1mmol), K2CO3 (1.7g, 12.3mmol) and 4ml of water were added. A The reaction was refluxed at 70C and completed by TLC about 12h. The reaction mixture was cooled to room temperature, and then 100ml of dichloromethane was added. The mixture was washed with saturated brine (50ml*3). The organic layer was dried over anhydrous MgSO4 for 30min. The solution was filtered and evaporated under vacuum to afford crude intermediate 18, purified by silica gel column chromatography (0.8g, 59.7%). 1H NMR (600MHz, DMSO-d6) delta 8.08 (dd, J=8.5, 1.4Hz, 1H), 7.71 (dd, J=8.5, 1.3Hz, 1H), 7.52 (ddd, J=8.2, 6.7, 1.3Hz, 1H), 7.34 (ddd, J=8.2, 6.7, 1.4Hz, 1H), 5.50-5.25 (m, 1H), 3.59 (s, 3H), 3.45 (t, J=6.1Hz, 2H), 2.90 (t, J=6.1Hz, 2H), 2.77 (t, J=6.7Hz, 2H), 2.71 (t, J=6.1Hz, 4H), 2.44 (t, J=6.6Hz, 2H), 1.82 (dd, J=7.9, 4.7Hz, 4H).
	With potassium carbonate; In tetrahydrofuran; water; at 70℃; for 12h;	Dissolve intermediate 10 (1 g, 4.1 mmol) in 12 ml of tetrahydrofuran, add <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.7 g, 4.1 mmol), K2CO3 (1.7 g, 12.3 mmol), and then add 4 ml of water and heat at 70 C. After refluxing for 12 h, the reaction was detected by TLC. After the reaction solution was cooled to room temperature, 100 ml of dichloromethane was added, and the mixture was washed with saturated brine (50 ml * 3). The organic layer was collected, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure.The product 20a (0.8 g) was obtained as a yellow oil with a yield of 59.7%.

Reference： [1]Bioorganic Chemistry,2020,vol. 98
[2]Patent: CN110551067,2019,A .Location in patent: Paragraph 0236-0239

86
[ 3395-91-3 ]
[ 3038-47-9 ]
(+/-)-methyl 4-cyano-4-[2-(trifluoromethyl)phenyl]butanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%		[0632] To a solution of [2-(trifluoromethyl)phenyl]acetonitrile (5.00 g, 27.0 mmol) in THF (15 ml) under argon was added gradually while stirring, at -78C., a 2 M solution of LDA in THF (16 ml, 32 mmol). The mixture was allowed to come to 0C. and, after 15 min, cooled back down again to -78C. Subsequently, a solution of <strong>[3395-91-3]methyl 3-bromopropanoate</strong> (5.41 g, 32.4 mmol) in THF (10 ml) was slowly added dropwise thereto at -78C. while stirring. Stirring of the mixture was continued overnight, in the course of which the cooling bath (dry ice/acetone) was allowed to come gradually to RT. Subsequently, water and ethyl acetate (100 ml of each) were gradually added at about 0C. to the mixture, which was agitated. After phase separation, the aqueous phase was extracted once with ethyl acetate (100 ml). The combined organic phases were washed once with saturated aqueous sodium chloride solution (150 ml), dried over sodium sulfate, filtered and concentrated, and the residue was taken up in dichloromethane and purified by flash column chromatography (50 g silica gel Biotage Snap-Cartridge Ultra, cyclohexane/ethyl acetate gradient 93:7?7:3, Isolera One). The combined target fractions were concentrated and the residue was dried under reduced pressure. This gave 4.97 g (98% purity, 66% of theory) of the title compound. [0633] LC-MS (Method 1): Rt=1.82 min [0634] 1H-NMR (400 MHz, DMSO-d6) delta [ppm]: 7.92-7.75 (m, 3H), 7.67-7.56 (m, 1H), 4.39 (dd, 1H), 3.59 (s, 3H), 2.57-2.43 (m, 2H, partially obscured), 2.37-2.23 (m, 1H), 2.22-2.09 (m, H).

Reference： [1]Patent: US2020/31775,2020,A1 .Location in patent: Paragraph 0631-0634

87
[ 3395-91-3 ]
[ 73183-34-3 ]
[ 1150561-77-5 ]

Reference： [1]Organic Letters,2020,vol. 22,p. 1431 - 1436

88
[ 3395-91-3 ]
[ 1392319-30-0 ]
methyl 3-((2-((6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)amino)propanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	With potassium carbonate; In tetrahydrofuran; water; at 70℃; for 12h;	General procedure: Intermediate 4a (1g, 4.1mmol) was dissolved in 12ml of tetrahydrofuran, then <strong>[3395-91-3]methyl 3-bromopropionate</strong> (0.7g, 4.1mmol), K2CO3 (1.7g, 12.3mmol) and 4ml of water were added. A The reaction was refluxed at 70C and completed by TLC about 12h. The reaction mixture was cooled to room temperature, and then 100ml of dichloromethane was added. The mixture was washed with saturated brine (50ml*3). The organic layer was dried over anhydrous MgSO4 for 30min. The solution was filtered and evaporated under vacuum to afford crude intermediate 18, purified by silica gel column chromatography (0.8g, 59.7%).

Reference： [1]Bioorganic Chemistry,2020,vol. 98

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P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 3395-91-3 ] {[proInfo.proName]}

Quality Control of [ 3395-91-3 ]

Related Doc. of [ 3395-91-3 ]

Product Details of [ 3395-91-3 ]

Calculated chemistry of [ 3395-91-3 ]

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 3395-91-3 ]

Application In Synthesis of [ 3395-91-3 ]

[ 3395-91-3 ] Synthesis Path-Upstream 1~14

[ 3395-91-3 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 3395-91-3 ]

Aliphatic Chain Hydrocarbons

Bromides

Esters

Precautionary Statements-General

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Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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[ 3395-91-3 ]