Alternatived Products of [ 306935-40-0 ]
Product Details of [ 306935-40-0 ]
CAS No. : | 306935-40-0 |
MDL No. : | MFCD01570586 |
Formula : |
C7H4F3NO2S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
223.17
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 306935-40-0 ]
Application In Synthesis of [ 306935-40-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 306935-40-0 ]
- 1
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[ 306935-40-0 ]
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[ CAS Unavailable ]
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[ CAS Unavailable ]
Yield | Reaction Conditions | Operation in experiment |
98% |
With trifluorormethanesulfonic acid In chloroform at 25℃; for 2h; stereoselective reaction; |
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- 2
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[ 7357-70-2 ]
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[ 306935-40-0 ]
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[ 1581726-03-5 ]
Yield | Reaction Conditions | Operation in experiment |
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With 1,4-diaza-bicyclo[2.2.2]octane In ethanol at 20℃; Reflux; |
Step c
General procedure: Cyanothioacetamide (for X=S) (1.5 equiv) or cyanoacetamide (for X=O) (1.5 equiv) was added to a solution of the 1, 3-diones (for R4= -CF3 and -CH3) (1.0 equiv) or enaminones (for R4=H) (1.0 equiv) in ethanol in the presence of DABCO (1.0 equiv) at room temperature. The reaction mixture was stirred under reux for 3-6 h until complete conversion of the starting materials, as monitored by TLC. After cooled to room temperature, the solvent was evaporated under reduced pressure and the residue was neutralized with diluted hydrochloric acid (1 N) to precipitate the crude products. After filtrated and dried in vacuo, the product can be straight used for step d. Yield: 70-90%. |
Reference:
[1]Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
[Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1581 - 1588]
- 3
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[ 306935-40-0 ]
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[ 107-91-5 ]
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[ CAS Unavailable ]
Yield | Reaction Conditions | Operation in experiment |
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With 1,4-diaza-bicyclo[2.2.2]octane In ethanol at 20℃; Reflux; |
Step c
General procedure: Cyanothioacetamide (for X=S) (1.5 equiv) or cyanoacetamide (for X=O) (1.5 equiv) was added to a solution of the 1, 3-diones (for R4= -CF3 and -CH3) (1.0 equiv) or enaminones (for R4=H) (1.0 equiv) in ethanol in the presence of DABCO (1.0 equiv) at room temperature. The reaction mixture was stirred under reux for 3-6 h until complete conversion of the starting materials, as monitored by TLC. After cooled to room temperature, the solvent was evaporated under reduced pressure and the residue was neutralized with diluted hydrochloric acid (1 N) to precipitate the crude products. After filtrated and dried in vacuo, the product can be straight used for step d. Yield: 70-90%. |
Reference:
[1]Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
[Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1581 - 1588]
- 4
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[ 24295-03-2 ]
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[ 383-63-1 ]
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[ 306935-40-0 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium methylate In tetrahydrofuran; methanol at 0 - 20℃; |
Step a
General procedure: To a freshly prepared sodium methylate solution in methanol and THF ethyl trifluoroacetate (1.2 equiv) was added under stirring at 0° followed by addition of ketone 2 (1.0 equiv). The reaction mixture was allowed to stir for additional 3-24 h until the starting materials were consumed, as determined by thin-layer chromatography (TLC). Then the solvent was removed under reduced pressure and the residue was acidified with hydrochloric acid (1 N), followed by extracted with acetic ether. The combined organic layers were dried (MgSO4), Fitered and the filtrate was concentrated under reduced pressure. The crude product was puried by column chromatography. Yield: 40-90%. For some cases, the crude products can be straight used for step c without the column chromatography procedure. |
Reference:
[1]Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
[Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1581 - 1588]
- 5
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[ 306935-40-0 ]
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[ 1581726-17-1 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / Reflux
2: potassium hydroxide / N,N-dimethyl-formamide; water / 20 °C |
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Reference:
[1]Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
[Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1581 - 1588]