[ CAS No. 22916-47-8 ] {[proInfo.proName]}

Name: 22916-47-8|1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole|98%
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SKU: A209924
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Quality Control of [ 22916-47-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 22916-47-8 ]

Product Details of [ 22916-47-8 ]

CAS No. :	22916-47-8	MDL No. :	MFCD00216019
Formula :	C₁₈H₁₄Cl₄N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BYBLEWFAAKGYCD-UHFFFAOYSA-N
M.W :	416.13	Pubchem ID :	4189
Synonyms :	R18134	Chemical Name :	1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

Calculated chemistry of [ 22916-47-8 ]

Physicochemical Properties

Num. heavy atoms :	25
Num. arom. heavy atoms :	17
Fraction Csp3 :	0.17
Num. rotatable bonds :	6
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	103.2
TPSA :	27.05 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	Yes
Log Kp (skin permeation) :	-4.63 cm/s

Lipophilicity

Log Po/w (iLOGP) :	3.69
Log Po/w (XLOGP3) :	5.93
Log Po/w (WLOGP) :	5.98
Log Po/w (MLOGP) :	4.31
Log Po/w (SILICOS-IT) :	5.88
Consensus Log Po/w :	5.16

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-6.26
Solubility :	0.000227 mg/ml ; 0.000000546 mol/l
Class :	Poorly soluble
Log S (Ali) :	-6.27
Solubility :	0.000222 mg/ml ; 0.000000534 mol/l
Class :	Poorly soluble
Log S (SILICOS-IT) :	-8.41
Solubility :	0.0000016 mg/ml ; 0.0000000038 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	3.13

Safety of [ 22916-47-8 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 22916-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 22916-47-8 ]
Downstream synthetic route of [ 22916-47-8 ]

[ 22916-47-8 ] Synthesis Path-Upstream 1~7

1
[ 94-99-5 ]
[ 24155-42-8 ]
[ 22916-47-8 ]

Reference： [1] Organic Preparations and Procedures International, 1992, vol. 24, # 3, p. 342 - 345

2
[ 24155-42-8 ]
[ 22916-47-8 ]

Reference： [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294

3
[ 1777-82-8 ]
[ 22916-47-8 ]

Reference： [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294

4
[ 4252-78-2 ]
[ 22916-47-8 ]

Reference： [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294

5
[ 46503-52-0 ]
[ 22916-47-8 ]

Reference： [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294

6
[ 874-42-0 ]
[ 22916-47-8 ]

Reference： [1] Organic Preparations and Procedures International, 1992, vol. 24, # 3, p. 342 - 345

7
[ 13692-15-4 ]
[ 22916-47-8 ]

Reference： [1] Organic Preparations and Procedures International, 1992, vol. 24, # 3, p. 342 - 345

[ 22916-47-8 ] Synthesis Path-Downstream 1~63

1
[ 75-03-6 ]
[ 22916-47-8 ]
3-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1-ethyl-3H-imidazol-1-ium; iodide [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 8955 - 8958

2
[ 542-69-8 ]
[ 22916-47-8 ]
1-butyl-3-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-3H-imidazol-1-ium; iodide [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 8955 - 8958

3
[ 2043-57-4 ]
[ 22916-47-8 ]
3-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-octyl)-3H-imidazol-1-ium; iodide [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 8955 - 8958

4
[ 22916-47-8 ]
[ 74-88-4 ]
1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-3-methyl-1H-imidazol-3-ium iodide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294
[2]Biochemical Pharmacology,2000,vol. 60,p. 317 - 324
[3]Tetrahedron Letters,1998,vol. 39,p. 8955 - 8958

Yield	Reaction Conditions	Operation in experiment
		(Comparative Example 8) Pulverization of miconazole was performed in the same manner as in Comparative Example 1. The average particle diameter of the resulting miconazole was 651 nm.

7
[ 94-99-5 ]
[ 24155-42-8 ]
[ 22916-47-8 ]

Reference： [1]Organic Preparations and Procedures International,1992,vol. 24,p. 342 - 345

8
[ 2550-36-9 ]
[ 22916-47-8 ]
1-cyclohexylmethyl-3-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-3H-imidazol-1-ium; bromide [ No CAS ]

Reference： [1]Biochemical Pharmacology,2000,vol. 60,p. 317 - 324

9
[ 141776-91-2 ]
[ 22916-47-8 ]
3-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1-(3,5-difluoro-benzyl)-3H-imidazol-1-ium; bromide [ No CAS ]

Reference： [1]Biochemical Pharmacology,2000,vol. 60,p. 317 - 324

10
[ 874-42-0 ]
[ 22916-47-8 ]

Reference： [1]Organic Preparations and Procedures International,1992,vol. 24,p. 342 - 345

11
[ 13692-15-4 ]
[ 22916-47-8 ]

Reference： [1]Organic Preparations and Procedures International,1992,vol. 24,p. 342 - 345

12
[ 104-81-4 ]
[ 22916-47-8 ]
[ 57265-38-0 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-Dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-(p-methylbenzyl)imidazolium bromide; mp. 152.2° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole and p-methylbenzyl bromide.

Reference： [1]Patent: US3991202,1976,A

13
2-chloroaceto-2',5'-dimethoxyanilide [ No CAS ]
[ 108-20-3 ]
[ 22916-47-8 ]
1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,5-dimethoxyphenyl)carbamoylmethyl]imidazolium chloride monohydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile;	EXAMPLE XXXIII In a similar operation and employing recovery techniques similar to Example XXXII, but employing different amounts of reactants or different purification techniques as indicated, the following compounds are prepared: 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,5-dimethoxyphenyl)carbamoylmethyl]imidazolium chloride monohydrate, m.p. 121.1° C., by (a) refluxing for 2 days, 4.2 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole, 2.5 parts of 2-chloroaceto-2',5'-dimethoxyanilide and 40 parts of acetonitrile, (b) recovering as in Example XXXII, and (c) washing the crude product with ether.

Reference： [1]Patent: US3991202,1976,A

14
[ 94-99-5 ]
[ 22916-47-8 ]
[ 57265-33-5 ]

Yield	Reaction Conditions	Operation in experiment
	In isopropyl alcohol; acetone;	EXAMPLE XVI 15 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)-phenethyl]imidazole and 60 parts of 2,4-dichlorobenzyl chloride are mixed together in 120 parts of acetone as solvent and the resulting mixture is stirred at reflux temperature for 40 hours. At the end of this period, the mixture is warmed to evaporate off most of the solvent and the residue is poured onto diisopropyl ether, whereupon the 1-(2,4-dichlorobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride product separates as an oil. The ether is decanted off and the oily residue is washed with warm xylene and thereafter triturated in 2-propanol whereupon the oily product solidified. The solid product is filtered off, washed with 2-propanol and dried to obtain a purified product, 1-(2,4-dichlorobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazolium chloride, mp. 178.9° C.

Reference： [1]Patent: US3991202,1976,A

15
[ 620-13-3 ]
[ 22916-47-8 ]
[ 57265-37-9 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-Dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-(m-methylbenzyl)imidazolium bromide; mp. 99°-101° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole and m-methylbenzyl bromide.

Reference： [1]Patent: US3991202,1976,A

16
[ 111-83-1 ]
[ 22916-47-8 ]
[ 57264-59-2 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]3-n-octylimidazolium bromide; mp. 141.5°-143° C., from 1-[2,4dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and n-octyl bromide after an overnight reflux.

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294
[2]Patent: US3991202,1976,A

17
[ 112-29-8 ]
[ 22916-47-8 ]
[ 57264-60-5 ]

Yield	Reaction Conditions	Operation in experiment
		1-decyl-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium bromide; mp. 90°-94° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and n-decyl bromide after an overnight reflux.

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294
[2]Patent: US3991202,1976,A

18
[ 1131-01-7 ]
[ 22916-47-8 ]
1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,6-xylyl)carbamoylmethyl]-imidazolium chloride hydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,6-xylyl)carbamoylmethyl]-imidazolium chloride hydrate, m.p. 143°-150° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 2-chloroaceto-2',6'-xylidide.

Reference： [1]Patent: US3991202,1976,A

19
[ 77975-44-1 ]
[ 22916-47-8 ]
1-(2,4-dichlorocinnamyl)-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-imidazolium chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In di-isopropyl ether; acetonitrile;	A. A mixture of 4.2 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole, 2.7 parts of 2,4-dichlorocinnamylchloride and 40 parts of acetonitrile is stirred and refluxed overnight. Upon the addition of diisopropyl ether, the product crystallizes. It is filtered off and dried, yielding 5.8 parts of 1-(2,4-dichlorocinnamyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazolium chloride; mp. 142.2° C.

Reference： [1]Patent: US3991202,1976,A

20
[ 31736-73-9 ]
[ 22916-47-8 ]
[ 57265-28-8 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2-(p-Bromobenzoyl)ethyl]-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride, m.p. 161.5° C., yield 11.5 parts, by the reaction of 8.3 parts of 1-[2,4-dichloro-beta(2,4-dichlorobenzyloxy)phenethyl]imidazole and 5 parts of 4'-bromo3-chloropropiophenone.

Reference： [1]Patent: US3991202,1976,A

21
[ 4209-02-3 ]
[ 108-10-1 ]
[ 22916-47-8 ]
[ 57265-17-5 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE XV In a manner similar to that described in Examples XIII and XIV, 1-(p-bromobenzoylmethyl)-3-[2,4-dichloro-beta-(2,4 -dichlorobenzyloxy)phenethyl]imidazolium chloride is prepared by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 4'-bromo-2-chloroacetophenone. The product after successive treatment steps of stirring with 4-methyl-2-pentanone, stirring a chloroform solution thereof with silica gel and triturating with 4-methyl-2-pentanone has a melting point of 198.2° C.

Reference： [1]Patent: US3991202,1976,A

22
[ 108-10-1 ]
[ 35424-56-7 ]
[ 22916-47-8 ]
[ 57265-35-7 ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane; di-isopropyl ether;	EXAMPLE X 4.2 Parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)-phenethyl]imidazole, 3.7 parts of p-chlorobenzyl iodide and 56 parts of methylene chloride are mixed together and stirred at reflux temperature for 5 hours to obtain a 1-(p-chlorobenzyl)-3-[2,4-dichlorobeta-(2,4-dichlorobenzyloxy)phenethyl imidazolium iodide product which remains in the reaction mixture. The reaction mixture is warmed to evaporate off the solvent and to recover the product as residue. The crude product is purified by washing with 2-propanol and crystallizing from a mixture of 4-methyl-2-pentanone and diisopropyl ether, to yield 1-(p-chlorobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium iodide; m.p. 145°- 148° C.

Reference： [1]Patent: US3991202,1976,A

23
[ 223512-70-7 ]
[ 22916-47-8 ]
[ 57265-34-6 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; di-isopropyl ether; acetone;	EXAMPLE XVII 4.2 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 2.7 parts of alpha-bromo-5-nitrotoluonitrile are mixed together in 24 parts of methanol as solvent and the resulting mixture is stirred at reflux temperature overnight. At the end of this period, the solvent is evaporated off to obtain a crude 1-(2-cyano-4-nitrobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium bromide product as a residue. The residue is purified by triturating in acetone, and crystallizing from a mixture of methanol and diisopropyl ether to yield pure 1-(2-cyano-4-nitrobenzyl)-3-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium bromide; mp. 171°-173° C.

Reference： [1]Patent: US3991202,1976,A

24
[ 5177-35-5 ]
[ 22916-47-8 ]
[ 57264-71-8 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,5-xylyl)carbamoylmethyl]imidazolium chloride; mp. 178° C., from 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 2-chloroaceto-2',5'-xylidide after an overnight reflux.

Reference： [1]Patent: US3991202,1976,A

25
[ 6974-56-7 ]
[ 22916-47-8 ]
1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(3,4-dichlorophenyl)carbamoyloxy]imidazolium chloride hydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(3,4-dichlorophenyl)carbamoyloxy]imidazolium chloride hydrate, m.p. 117°-200° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 2,2',4'-trichloroacetanilide, purification as above described followed by recrystallization from ethanol-water.

Reference： [1]Patent: US3991202,1976,A

26
2-bromo-N-(p-methylbenzyl)propionamide [ No CAS ]
[ 22916-47-8 ]
[ 57264-99-0 ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile;	EXAMPLE XXIII A mixture of 8 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole, 5.6 parts of 2-bromo-N-(p-methylbenzyl)propionamide and 80 parts of acetonitrile is stirred and refluxed for 20 hours. The reaction mixture is evaporated and the residue is crystallized from a mixture of 4-methyl-2-pentanone and diisopropyl ether, yielding 9 parts of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-{1-[N-(p-methylbenzyl)carbamoyl]ethyl}-imidazolium bromide; mp. 136.2° C.

Reference： [1]Patent: US3991202,1976,A

27
2-bromo-N-(p-chlorobenzyl)propionamide. imidazole [ No CAS ]
[ 22916-47-8 ]
[ 57265-02-8 ]

Yield	Reaction Conditions	Operation in experiment
		1-{1-[N-(p-Chlorobenzyl)carbamoyl]ethyl} -3-[2,4-dichlorobeta-(2,4-dichlorobenzyloxy)phenethyl]imidazolium bromide; m.p. 162.1° C., yield 3 parts, by the reaction of 8 parts of 1-[2,4-dichloro-beta(2,4-dichlorobenzyloxy)phenethyl]imidazole and 6 parts of 2-bromo-N-(p-chlorobenzyl)propionamide. imidazole

Reference： [1]Patent: US3991202,1976,A

28
[ 22303-26-0 ]
[ 22916-47-8 ]
[ 57304-29-7 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE XXVIII In operations carried out in a manner similar to those described in Examples XXVI and XXVII, the following compounds are prepared: 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-[N-(2,5-dichlorophenyl)carbamoylmethyl]imidazolium chloride; m.p. 137.8° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 2,2',5'-trichloroacetanilide.

Reference： [1]Patent: US3991202,1976,A

29
[ 142713-63-1 ]
[ 22916-47-8 ]
[ 57265-00-6 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-Dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-{1-[N-(p-methoxybenzyl)carbamoyl]ethyl]imidazolium bromide, m.p. 136° C., yield 8 parts, by the reaction of 8 parts of 1-[2,4dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 5.9 parts of 2-bromo-N-(p-methoxybenzyl)propionamide.

Reference： [1]Patent: US3991202,1976,A

30
[ 3831-29-6 ]
[ 22916-47-8 ]
[ 57265-36-8 ]
[ 101023-55-6 ]

Yield	Reaction Conditions	Operation in experiment
		1-[2,4-Dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-(p-fluorobenzyl)-imidazolium iodide; mp. 151°-153° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole and p-fluorobenzyl iodide. 1-[2,4-Dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-3-(o-nitrobenzyl(imidazolium bromide; mp. 138.5°-141° C., by the reaction of 1-[2,4-dichloro-beta-(2,4-dichlorobenzyloxy)phenethyl]-imidazole and o-nitrobenzyl bromide.

Reference： [1]Patent: US3991202,1976,A

31
[ 22916-47-8 ]
(+)-Miconazole [ No CAS ]
(-)-Miconazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With colistin sulfate-based polymer monolithic column; In methanol; water; at 20℃;Resolution of racemate; Green chemistry;	General procedure: The colistin sulfate-based polymer monolithic capillary column was prepared as describedabove and investigated for the nano-LC enantioseparation of a set of different classes of racemicpharmaceuticals, namely: beta-blockers, alpha-blockers, anti-inflammatory drugs, antifungal drugs,norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistamines,antibacterial drugs, anticancer drugs and antiarrhythmic drugs. Although reversed phaseenantio-selective LC examples are limited, macrocyclic antibiotics were previously used inenantioseparation chromatography under reversed phase chromatographic mode [34,36-38,42-45].The initial mobile phase selected for the enantioseparation separation of racemates 1-37 (Figure 3) wasa binary mixture of methanol/water screened from 95:5 to 5:95 nu/nu at 1 mL/min flow rate at fixed UVdetection 219 nm with eleven compounds separated (Rs 1) (Table 1). For examples, in MeOH/H2O80:20 nu/nu, only ibuprofen (7) was separated, while in MeOH/H2O 40:60, indoprofen (10), hexaconazole(15) and <strong>[22916-47-8]miconazole</strong> (16) were separated. In MeOH/H2O 10:90 nu/nu, aminoglutethimide (22), tyrosine(29) and O-methoxymandelic acid (34) were also separated. The addition of an additive, namelytriethylamine (TEA) 1% nu/nu in 10:90, resulted in the separation of acebutolol (4) normetanephrine(21), propafenone (26), tyrosine (29) and 4-hydroxy-3-methoxymandelic acid (35) (Figure 4), whilenon-acceptable separations were achieved by addition of the acidic additive namely trifluoroaceticacid (TFA). In an attempt to use normal phase namely n-hexane/2-propanol mixture ranging from10-90% (nu/nu) resulted in resolution less than 1. All chromatographic data are summarized in Table 1.

Reference： [1]Chirality,2010,vol. 22,p. 69 - 76
[2]Acta poloniae pharmaceutica,2017,vol. 74,p. 777 - 784
[3]Chirality,2014,vol. 26,p. 677 - 682
[4]Molecules,2019,vol. 24

32
nickel(II) chloride hexahydrate [ No CAS ]
[ 22916-47-8 ]
[Ni(II)Cl₂(miconazol)2(water)2]*3water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

33
copper(II) choride dihydrate [ No CAS ]
[ 22916-47-8 ]
[Cu(II)Cl₂(miconazol)2(water)2]*2water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

34
iron(III) chloride hexahydrate [ No CAS ]
[ 22916-47-8 ]
[Fe(III)Cl₂(miconazol)2(water)2]Cl*3water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

35
chromium chloride hexahydrate [ No CAS ]
[ 22916-47-8 ]
[Cr(III)Cl₂(miconazol)2(water)2]Cl*3water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

36
zinc(II) chloride dihydrate [ No CAS ]
[ 22916-47-8 ]
[Zn(II)Cl₂(miconazol)2(water)2]*3water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

37
cobalt(II) chloride hexahydrate [ No CAS ]
[ 22916-47-8 ]
[Co(II)Cl₂(miconazol)2(water)2]*2water [ No CAS ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

38
manganese(II) chloride dihydrate [ No CAS ]
[ 22916-47-8 ]
[ 1410795-51-5 ]

Reference： [1]Journal of Thermal Analysis and Calorimetry,2012,vol. 109,p. 883 - 892

39
[Ru(p-cymene)Cl₂]₂ [ No CAS ]
[ 22916-47-8 ]
[Ru(η⁶-p-cymene)Cl₂(miconazole)] [ No CAS ]

Reference： [1]Chemistry - A European Journal,2013,vol. 19,p. 14768 - 14772

40
[ 26042-63-7 ]
[RhCl₂(p-cymene)]2 [ No CAS ]
[ 22916-47-8 ]
[(η⁶-p-cymene)Ru(miconazole)₃](PF₆)₂ [ No CAS ]

Reference： [1]Organometallics,2014,vol. 33,p. 1594 - 1601

41
[RhCl₂(p-cymene)]2 [ No CAS ]
[ 22916-47-8 ]
[Ru(η⁶-p-cymene)Cl₂(miconazole)] [ No CAS ]

Reference： [1]Organometallics,2014,vol. 33,p. 1594 - 1601

42
[RhCl₂(p-cymene)]2 [ No CAS ]
[ 22916-47-8 ]
[ 1581279-28-8 ]

Reference： [1]Organometallics,2014,vol. 33,p. 1594 - 1601

43
[ 13496-05-4 ]
[ 22916-47-8 ]
[iron(III)(protoporphyrin IX)miconazole]⁺ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol;Gas phase; Alkaline conditions;	General procedure: The sampled ions were generated in the gas-phase by directly infusing a slightly basic solution of FeIII(PPIX)Cl and azole ligand, both compounds 1 x 10-5 M in methanol, through a fused-silica capillary to the ESI source by a syringe pump at a flow rate of 10 muL/min. Typical values of declustering potential and entrance potential were 80 and 5 V, respectively. Full scan positive-ion ESI mass spectra of a 10-5 M 1:1 methanolic solution of FeIII(PPIX)Cl complexed with the five different azole ligands and the two model ligands N-Me-Im and Tri are reported in Figs. S1 and S2 in the Supplementary data. CID experiments at variable energy were carried out using an Applied Biosystems 2000 Q-Trap instrument, a commercial hybrid triple-quadrupole linear ion trap mass spectrometer (Q1q2QLIT). The ions were desolvated in the first region (Q0) at a temperature of 373 K using argonand then mass selected by the first quadrupole (Q1). They werethen allowed to collide with argon (3.1 105 mbar) in the q2 collision cell while monitoring the product ion abundance as a function of collision energy (Elab = 0-50 eV). There is only one dissociation channel for each complex of interest, involving the loss of the neutral azole ligand. The dissociation product pattern was monitored by scanning QLIT by using the enhanced mode of operation where the ions, formed in q2, are trapped in QLIT for 35 accumulation spectra in order to increase both resolution and signal intensity.

Reference： [1]Polyhedron,2015,vol. 90,p. 245 - 251

44
ammonium hexafluorophosphate [ No CAS ]
MnBr(bpyCOOCH₃,COOCH₃)(CO)3 [ No CAS ]
[ 22916-47-8 ]
[Mn(bpy^{COOCH₃,COOCH₃})(CO)₃(miconazole)]PF₆ [ No CAS ]

Reference： [1]Organometallics,2015,vol. 34,p. 3809 - 3815

45
ammonium hexafluorophosphate [ No CAS ]
[ 38173-71-6 ]
[ 22916-47-8 ]
[Mn(bpy)(CO)₃(miconazole)]PF₆ [ No CAS ]

Reference： [1]Organometallics,2015,vol. 34,p. 3809 - 3815

46
[ 22916-47-8 ]
(−) MIC [ No CAS ]
(+) MIC [ No CAS ]

Reference： [1]Chirality,2018,vol. 30,p. 807 - 815

47
[ 150994-84-6 ]
[ 22916-47-8 ]
4-((1,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobutanoate 1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-1-ium [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In acetonitrile; at 50℃; for 6h;	To a solution of 4-((l,3-bis(dodecanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid 6A (6.0 g, 0.013 mol) in acetonitrile (150 mL) was added l-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4- dichlorophenyl)ethyl)-lH-imidazole 7 (5.62 g, 0.013 mol) at ambient temperature. The resulting reaction mixture was heated up to 50°C for next 6h followed by the evaporation of solvent under reduced pressure to get the desired product 8 as colorless viscous oil. Yield: 11.62 g, quant.

Reference： [1]Patent: WO2018/96497,2018,A1 .Location in patent: Paragraph 00106-00107

48
2,4-dichlorobenzyl methanesulfonate [ No CAS ]
[ 24155-42-8 ]
[ 22916-47-8 ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

49
[ 1777-82-8 ]
[ 22916-47-8 ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

50
[ 4252-78-2 ]
[ 22916-47-8 ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

51
[ 111-25-1 ]
[ 22916-47-8 ]
1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-3-hexyl-1H-imidazol-3-ium bromide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

52
[ 143-15-7 ]
[ 22916-47-8 ]
1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-3-dodecyl-1H-imidazol-3-ium bromide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

53
[ 112-71-0 ]
[ 22916-47-8 ]
1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-3-tetradecyl-1H-imidazol-3-ium bromide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

54
[ 112-82-3 ]
[ 22916-47-8 ]
1-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-3-hexadecyl-1H-imidazol-3-ium bromide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

55
[ 46503-52-0 ]
[ 22916-47-8 ]

Reference： [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 4288 - 4294

56
C₁₄H₂₀B₉^(1-)*C₄H₁₂N⁽¹⁺⁾ [ No CAS ]
[ 22916-47-8 ]
C₃₂H₃₃B₉Cl₄N₂O [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 11886 - 11892
Angew. Chem.,2019,vol. 131,p. 12012 - 12018,7

57
[ CAS Unavailable ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
86.96%	In methanol for 3h; Reflux;	[Cr(MCNZ)(NO3)3] (2) was prepared by adding (400 mg,1 mmol) of Cr(NO3)3*9H2O to MCNZ (416 mg, 1 mmol) dissolved inmethanol. The mixture was refluxed for 3 h. The green precipitatewas filtered off, washed with diethyl ether and dried out. Yield:86.96% (521 mg). M.p. 180 C. Elm. Anal. Calc. (C18H14Cl4CrN5O10) C, 33.05; H, 2.16; Cl, 21.68; Cr, 7.95; N, 10.71; O, 24.46; IR: (C]C)1587 cm1, (C]N) 1561 cm1, (CeC) 1290 cm1, (CeOeC)1090 cm1, (CeCl) 786 cm1, (CeH) 3154 cm1, n(NO3) 1378 cm1,d(NO3) 1041 cm1. (CreN) 420 cm1, (CreO) 471 cm1.

Reference： [1]Alshehri, Nujud S.; Aziz, Saadullah G.; Babgi, Bandar A.; Elroby, Shaaban A.; Hussien, Mostafa A.; Jedidi, Abdesslem [Journal of Molecular Structure, 2020, vol. 1215]

58
[ CAS Unavailable ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
92%	In ethanol at 20℃; for 24h;
82%	In ethanol; water at 20℃; for 24h;

Reference： [1]Chęcińska, Lilianna; Kusz, Joachim; Ochocki, Justyn; Posyniak, Andrzej; Radko, Lidia; Stryjska, Karolina [International Journal of Molecular Sciences, 2020, vol. 21, # 10]
[2]Stryjska, Karolina; Korona-Glowniak, Izabela; Chęcińska, Lilianna; Kusz, Joachim; Ochocki, Justyn [International Journal of Molecular Sciences, 2021, vol. 22, # 4, p. 1 - 18]

59
[ CAS Unavailable ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
82%	In ethanol; water at 20℃; for 24h;

Reference： [1]Stryjska, Karolina; Korona-Glowniak, Izabela; Chęcińska, Lilianna; Kusz, Joachim; Ochocki, Justyn [International Journal of Molecular Sciences, 2021, vol. 22, # 4, p. 1 - 18]

60
[ 14104-20-2 ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
82%	In ethanol; water at 20℃; for 24h;

Reference： [1]Stryjska, Karolina; Korona-Glowniak, Izabela; Chęcińska, Lilianna; Kusz, Joachim; Ochocki, Justyn [International Journal of Molecular Sciences, 2021, vol. 22, # 4, p. 1 - 18]

61
[ CAS Unavailable ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
65%	In ethanol; water at 20℃; for 24h;

Reference： [1]Stryjska, Karolina; Korona-Glowniak, Izabela; Chęcińska, Lilianna; Kusz, Joachim; Ochocki, Justyn [International Journal of Molecular Sciences, 2021, vol. 22, # 4, p. 1 - 18]

62
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
88%	With (dmpe)<SUB>2</SUB>FeCl<SUB>2</SUB>; deuterated methanol; 4,4,5,5-tetramethyl-1,3,2-dioxaborolane; sodium tertiary butoxide In tetrahydrofuran at 60℃; for 15h; Inert atmosphere; Irradiation;

Reference： [1]Britton, Luke; Docherty, Jamie H.; Sklyaruk, Jan; Cooney, Jessica; Nichol, Gary S.; Dominey, Andrew P.; Thomas, Stephen P. [Chemical Science, 2022, vol. 13, # 35, p. 10291 - 10298]

63
[ CAS Unavailable ]
[ 22916-47-8 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
78.78%	In ethanol	2.2.1. Synthesis of [Cu(CTZ)2(H2O)2Cl2] Synthesis of [Cu(CTZ)2(H2O)2Cl2] a mixture of CuCl2.2H2O (170mg, 1 mmol) and CTZ (689.70 mg, 2 mmol) dissolved in 25 mL ethanol.The mixture was refluxed and yellowish green precipitate was filteredand washed with diethyl ether then dried out. Yield: 79.12% (680 mg).M.P. 242 C. IR: ν (H2O)3344, ν (C- -C) 1587, ν (C- -N) 1489, ν (C-C)1324, ν (C-N) 1220, ν (C-Cl) 742, ν (Cu-O) 590, ν (Cu-N) 466, ν (Cu-Cl)390.
78.78%	In ethanol	2.2.1. Synthesis of [Cu(CTZ)2(H2O)2Cl2] Synthesis of [Cu(CTZ)2(H2O)2Cl2] a mixture of CuCl2.2H2O (170mg, 1 mmol) and CTZ (689.70 mg, 2 mmol) dissolved in 25 mL ethanol.The mixture was refluxed and yellowish green precipitate was filteredand washed with diethyl ether then dried out. Yield: 79.12% (680 mg).M.P. 242 C. IR: ν (H2O)3344, ν (C- -C) 1587, ν (C- -N) 1489, ν (C-C)1324, ν (C-N) 1220, ν (C-Cl) 742, ν (Cu-O) 590, ν (Cu-N) 466, ν (Cu-Cl)390.

Reference： [1]Alshehri, Nujud S.; Sharfalddin, Abeer A.; Domyati, Doaa; Basaleh, Amal S.; Hussien, Mostafa A. [Journal of the Indian Chemical Society, 2022, vol. 99, # 10]
[2]Alshehri, Nujud S.; Sharfalddin, Abeer A.; Domyati, Doaa; Basaleh, Amal S.; Hussien, Mostafa A. [Journal of the Indian Chemical Society, 2022, vol. 99, # 10]

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[ 22916-47-8 ]

A625321[ 22832-87-7 ]

1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate

Reason: Free-salt

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
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Code	Phrase
P201	Obtain special instructions before use.
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P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ 22916-47-8 ] Synthesis Path-Upstream 1~7

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