* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With sodium hydride; In N,N-dimethyl-formamide; at 30℃; for 2h;
4-Bromothienylmethanol (1.32 g, 6.9 mmol) was weighed into a 100 mL round bottom flask,18 mL of N, N-dimethylformamide was added,To the reaction solution was added sodium hydride (0.110 g, 4.6 mmol) and 2-aminopurine-6-trimethylammonium chloride (0.525 g, 2.3 mmol)30 , stirring reaction 2h.After the reaction,Adding ethyl acetate and water in accordance with the volume of 1: 1 composition of the mixture for extraction,After the organic phase was washed with saturated ammonium chloride solution,Dried over anhydrous sodium sulphate,30 vacuum distillation,The resulting crude product was dissolved in methanol,Filter to remove impurities,Recrystallization gave (6- (4-bromothiophenoxy) -9-hydrogen-purin-2) amine (0.517 g, 1.59 mmol) in 69% yield.