Alternatived Products of [ 188054-45-7 ]
Product Details of [ 188054-45-7 ]
CAS No. : | 188054-45-7 |
MDL No. : | |
Formula : |
C15H11NO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
237.25
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 188054-45-7 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 188054-45-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 188054-45-7 ]
- 1
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[ 188054-45-7 ]
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[ 31327-97-6 ]
Yield | Reaction Conditions | Operation in experiment |
87% |
With sodium hydroxide In methanol; water at 50℃; for 3h; |
|
87% |
With sodium hydroxide In aqueous EtOH |
9 Preparation of Acridine-4-carboxylic acid
EXAMPLE 9 Preparation of Acridine-4-carboxylic acid To methyl acridine-4-carboxylate, prepared in Example 4,(183 mg), was added a degassed solution of NaOH in aqueous EtOH (1:1,2M)(35 ml). The mixture was stirred for 3 hours at 50° C., when a clear solution was obtained, then neutralised with glacial AcOH. Extraction with EtOAc (3*15 50 ml) followed by chromatography on silica gel, eluding with EtOAc/petroleum ether (1:4), gave acridine-4-carboxylic acid (160 mg, 87%), mp (Me2 CO) 196-197° C. (lit, mp 202-204° C.). By the same procedure, other compounds of formula (III) were hydrolyzed to the corresponding acridine-4-carboxylic acids. |
Reference:
[1]Gamage, Swarna A.; Spicer, Julie A.; Rewcastle, Gordon W.; Denny, William A.
[Tetrahedron Letters, 1997, vol. 38, # 4, p. 699 - 702]
[2]Current Patent Assignee: XENOVA GMBH - US6111109, 2000, A