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[ CAS No. 184177-81-9 ] {[proInfo.proName]}

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Chemical Structure| 184177-81-9
Chemical Structure| 184177-81-9
Structure of 184177-81-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 184177-81-9 ]

CAS No. :184177-81-9 MDL No. :MFCD03784249
Formula : C23H23N3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :IKRKMYDCUZYKHX-UHFFFAOYSA-N
M.W : 389.45 Pubchem ID :1317528
Synonyms :

Calculated chemistry of [ 184177-81-9 ]

Physicochemical Properties

Num. heavy atoms : 29
Num. arom. heavy atoms : 18
Fraction Csp3 : 0.17
Num. rotatable bonds : 6
Num. H-bond acceptors : 3.0
Num. H-bond donors : 2.0
Molar Refractivity : 120.87
TPSA : 65.04 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -5.37 cm/s

Lipophilicity

Log Po/w (iLOGP) : 3.09
Log Po/w (XLOGP3) : 4.66
Log Po/w (WLOGP) : 3.38
Log Po/w (MLOGP) : 3.0
Log Po/w (SILICOS-IT) : 2.25
Consensus Log Po/w : 3.28

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -5.25
Solubility : 0.00217 mg/ml ; 0.00000558 mol/l
Class : Moderately soluble
Log S (Ali) : -5.75
Solubility : 0.000688 mg/ml ; 0.00000177 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -6.31
Solubility : 0.000191 mg/ml ; 0.00000049 mol/l
Class : Poorly soluble

Medicinal Chemistry

PAINS : 1.0 alert
Brenk : 0.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 2.92

Safety of [ 184177-81-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 184177-81-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 184177-81-9 ]
  • Downstream synthetic route of [ 184177-81-9 ]

[ 184177-81-9 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 1885-14-9 ]
  • [ 74853-08-0 ]
  • [ 184177-81-9 ]
YieldReaction ConditionsOperation in experiment
94.6% at 0 - 25℃; Large scale Will be 4.00kg1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine (VII) and 35.57 kg of tetrahydrofuran100L glass reactor, open the stirring, cooling to 0 ~ 10 .Maintain the temperature below 25 drop 2.56kgPhenyl chloroformate (VIII),0.5 to 1 hour drop finished, temperature control 20 ~ 25 to continue the reaction of 0.5 to 1.0 hours. TLC monitoring reaction, the reaction finishedAfter the completion of the cooling to 0 ~ 10 ,Add saturated aqueous sodium bicarbonate solution (sodium bicarbonate 2.00kg dissolved in purified water 38kg), then add purified water 20kg,Stirring for 10 ~ 20min. Centrifuge the filter to the basic solvent-free effluent, and then rinse with 8kg of purified water, centrifugal rejection to the basic solvent-free effluent.The whole batch of wet goods in the vacuum -0.06MPa ~ -0.1MPa, the control temperature of 40-50 conditions,Dry under reduced pressure 12 to 16 hours. 5.47 kg of a gray solid,Phenyl (4- (4- (4-hydroxy) -1-piperazinyl) phenyl) carbamate(V);HPLC purity: 98.5percent yield: 94.6percent
215 g at 0 - 30℃; for 3 h; Example-8
Preparation of Phenyl-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl carbamate (Formula-19)
Phenyl chloroformate (139.5 g) was added to a pre-cooled solution of 4-(4-(4-aminophenyl)piperazin-1-yl)phenol compound of formula-18 (200 g) in dimethyl formamide (1400 ml) at 0-10° C.
Temperature of the reaction mixture was raised to 25-30° C. and then stirred for 3 hours at 25-30° C.
After completion of the reaction, the reaction mixture was quenched with water.
Filtered the precipitated solid and washed with water.
Reference: [1] Patent: CN106749207, 2017, A, . Location in patent: Paragraph 0028; 0029; 0030; 0031
[2] Patent: US2014/343285, 2014, A1, . Location in patent: Paragraph 0325
  • 2
  • [ 184177-81-9 ]
  • [ 184177-83-1 ]
YieldReaction ConditionsOperation in experiment
77.4%
Stage #1: With N-ethyl-N,N-diisopropylamine In 1,4-dioxaneLarge scale
Stage #2: at 80℃; Large scale
Will be 4.36kgN '- ((2S, 3S) -2-benzyloxy) pentyl-3-formylhydrazide oxalate(VI)And 45.36 kgDioxane into the 100L glass reactor,Stir, add 3.45kgN, N-diisopropylethylamine. Stirring for 1 to 1.5 hours,Add another 5.47kgPhenyl (4- (4- (4-hydroxy) -1-piperazinyl) phenyl) carbamate(V).After the addition is complete, the temperature is raised to 80 ± 5 ° C for 24 to 30 hours. TLC monitoring.After the reaction is completed, the system is cooled to 15 ~ 25 ,57.79 kg of dichloromethane and 21.81 kg of pure water were added and stirred for 10 to 20 minutes.Collect the lower organic phase and discard the aqueous phase.The organic phase was transferred to a 100 L glass reactor, and 21.81 kg of purified water was added to the autoclave,Stirring for 10 to 20 minutes, standing and stratifying, collecting the lower organic phase and discarding the aqueous phase. The organic phase was transferred to a 100 L glass reactor. Saturated aqueous sodium chloride solution (6.54 kg of sodium chloride was dissolved in purified water 21.81 kg) was added and stirred for 10 to 20 minutes. The layers were allowed to stand and the organic phase was collected and the aqueous phase was discarded.The organic phase was transferred to a 20 L rotary vial, and at a vacuum of -0.08 to -0.1 MPa,Control the temperature of 30 ~ 40 , concentrated to remove the dichloromethane, to the solvent-free distillation. A brown solid was obtained.The solid was transferred to a 100 L glass autoclave, 32.27 kg of methyl t-butyl ether was added, and the mixture was heated to 50 to 60 ° C for 0.5 to 1 hour, cooled to 20 ± 5, and stirred for 2 to 3 hours. Centrifuge the filter to the basicSolvent-free, filter cake with 12.91kg methyl tert-butyl ether leaching, centrifugal rejection to the basic solvent-free effluent. Will be all wet goodsAt a vacuum of -0.08 to -0.1 MPa,Control temperature 40 ~ 50 Drying under reduced pressure 6 to 10 hours. A gray solid5.31kg, that is2 - ((2S, 3S) -2- (benzyl) -3-pentyl) -4- (4- (4-(4-hydroxy) -1-piperazine) phenyl)-2,4-dihydro-3-dihydro-1,2,4-triazol-3-one (III), HPLC purity: 98.8percent, yield: 77.4percent
Reference: [1] Patent: CN106749207, 2017, A, . Location in patent: Paragraph 0032; 0033; 0034
  • 3
  • [ 184177-81-9 ]
  • [ 170985-85-0 ]
  • [ 184177-83-1 ]
YieldReaction ConditionsOperation in experiment
70% With triethylamine In 1,4-dioxane at 90 - 100℃; for 24 h; mixture of N′-((2S,3S)-2-(benzyloxy)pentan-3-yl)formohydrazide compound of formula-17 (45.5 g) obtained in example-13, dioxane (500 ml) added phenyl 4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenylcarbamate compound of formula-19 (50 g) was heated to 90-100° C. Triethylamine (26 g) was added to the reaction mixture at 90-100° C. over a period of 1 hour and stirred for 24 hours at 90-100° C. After completion of the reaction, the reaction mixture was cooled to 25-30° C. and dichloromethane was added to the reaction mixture. Filtered the reaction mixture through hyflow bed and washed with dichloromethane. Water was added to the filtrate. Both organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane. Both organic layers were combined and washed with 2percent sodium hydroxide solution followed by water, and then with 5percent hydrochloric acid solution followed by water and 5percent NaHCO3 solution washing. Distilled off the solvent from organic layer under reduced pressure to get the title compound. Isopropyl alcohol (75 ml) was added to the obtained compound and the reaction mixture was cooled to 25-30° C. The reaction mixture was stirred for 6 hours at 25-30° C. Filtered the solid, washed with isopropyl alcohol and then dried to get the title compound. Yield: 28 g; Purity by HPLC: 97.67percent; Impurity-A: 0.37percentb)
Purification of Compound of Formula-20
The obtained compound of formula-20 (30 g) was dissolved in methanol (960 ml) by heating at 60-65° C.
The reaction mixture was cooled to 25-30° C. and stirred for 30 minutes at the same temperature.
Filtered the precipitated solid and dried to get the pure compound of formula-20.
Yield: 70percent; Purity by HPLC: 99.15percent; Impurity-A: 0.09percent
Reference: [1] Patent: US2014/343285, 2014, A1, . Location in patent: Paragraph 0340; 0341; 0342
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