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[ CAS No. 170570-77-1 ] {[proInfo.proName]}

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Chemical Structure| 170570-77-1
Chemical Structure| 170570-77-1
Structure of 170570-77-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 170570-77-1 ]

CAS No. :170570-77-1 MDL No. :MFCD11188542
Formula : C11H9F3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 246.18 Pubchem ID :-
Synonyms :

Safety of [ 170570-77-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 170570-77-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 170570-77-1 ]
  • Downstream synthetic route of [ 170570-77-1 ]

[ 170570-77-1 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 170570-77-1 ]
  • [ 169590-41-4 ]
Reference: [1] Patent: US6376528, 2002, B1,
[2] Patent: US6407140, 2002, B1,
[3] Patent: US5990148, 1999, A,
[4] Patent: US6136839, 2000, A,
[5] Patent: US5700816, 1997, A,
[6] Patent: US6172096, 2001, B2,
  • 2
  • [ 17852-52-7 ]
  • [ 170570-77-1 ]
  • [ 169590-41-4 ]
YieldReaction ConditionsOperation in experiment
93.1% for 16 h; Reflux Dissolve 7.0 g (28.4 mmol) of 4,4-difluoro-1-(3-fluoro-4-methoxyphenyl)-1,3-butanedione in 150 ml of ethanol and add 7.4 g (33 mmol) of 4 The sulfonamide phenylhydrazine hydrochloride was stirred under reflux for 16 hours. The reaction solution was allowed to cool, and water was added until the crystal slowly precipitated. The product was dried by suction and dried to give a pale yellow product. Yield 87percent.
87% for 16 h; Heating / reflux 4,4-Difluoro-1-(3-fluoro-4-methoxyphenyl)-butane-1,3-dione from Step 2 (7.0 g, 28.4 mmol) was dissolved in ethanol (150 mL). To the stirred mixture was added 4-sulphonamidophenyl hydrazine hydrochloride (7.4 g, 33 mmol) and stirred at reflux overnight (16 hours). The mixture was cooled and water was added until crystals slowly appeared. The product was isolated by filtration and air dried to provide the desired product as a light tan solid (9.8 g, 87percent): mp 159-161 °C. Anal. Calc'd. for C17H14N3SO3F3: C, 51.38; H, 3.55; N, 10.57. Found: C, 51.46; H, 3.52; N, 10.63.
Reference: [1] Patent: CN107686465, 2018, A, . Location in patent: Paragraph 0043; 0065; 0066
[2] Patent: US6342510, 2002, B1, . Location in patent: Page column 28 - 29
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 9, p. 1347 - 1365
  • 3
  • [ 170570-77-1 ]
  • [ 169590-41-4 ]
Reference: [1] Patent: US5756529, 1998, A,
[2] Patent: US5760068, 1998, A,
  • 4
  • [ 288-13-1 ]
  • [ 170570-77-1 ]
  • [ 169590-41-4 ]
Reference: [1] Patent: US5521207, 1996, A,
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