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CAS No. : | 169624-67-3 | MDL No. : | MFCD01318734 |
Formula : | C26H24N2O5 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | WJQWIPAQNBOEBX-QHCPKHFHSA-N |
M.W : | 444.48 | Pubchem ID : | 11328236 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16.2 mg | Stage #1: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.833333 h; Stage #2: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16 h; Stage #3: With trifluoroacetic acid In dichloromethane; N,N-dimethyl-formamide for 1 h; |
General procedure: The Fmoc-amino acid-Wang resin (300 mg) was suspended in a 30percent piperidine solution in DMF and stirred 50 min at r.t (room temperature).The resin was washed with CH2Cl2 (3×2 mL), EtOAc(3×2 mL), MeOH (3×2 mL) and CH2Cl2 (2 mL), and finally dried in vacuum. The resin was suspended in 5 mL of a DMF:DCM (2:1) mixture and Fmoc-amino acid (3 equiv.), 1-hydroxybenzotriazole (3 equiv.), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (3 equiv.) and diisopropylethylamine(3 equiv.) were successively added. The solution was stirred at r.t. for 16 h. After this, the resin was washed with DMF(3×2 mL), CH2Cl2 (3×2 mL), MeOH (3×2 mL) and CH2Cl2 (2 mL), and finally dried in vacuum. Resin was treated with 5 mL of 10percent TFA in CH2Cl2 for 1 h. The mixture was filtered and the filtrate was evaporated under reduced pressure to give the crude product. |