Name: 154-42-7|2-Amino-3,7-dihydro-6H-purine-6-thione|98%
Brand: Ambeed
SKU: A393548
Price: 5.0 USD
Availability: InStock
Rating: 92 (28 reviews)

1
[ 74-96-4 ]
[ 154-42-7 ]
[ 63071-69-2 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 1898,1901

2
[ 154-42-7 ]
[ 77-78-1 ]
[ 1198-47-6 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 1898,1901

3
[ 154-42-7 ]
[ 74-88-4 ]
[ 1198-47-6 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 907

4
[ 154-42-7 ]
[ 10310-21-1 ]

Reference： [1]Patent: US2815346,1955,

5
N-(2,4-diamino-6-thioxo-1,6-dihydro-pyrimidin-5-yl)-formamide [ No CAS ]
[ 154-42-7 ]

Reference： [1]Journal of the American Chemical Society,1956,vol. 78,p. 2858,2862

6
[ 10310-21-1 ]
[ 154-42-7 ]

Reference： [1]Patent: US2697709,1952,

7
[ 73-40-5 ]
[ 154-42-7 ]

Reference： [1]Patent: US2697709,1952,
[2]Patent: US2884667,1955,

8
[ 789-61-7 ]
[ 154-42-7 ]
[ 17039-17-7 ]

Yield	Reaction Conditions	Operation in experiment
	With E_. coli purine nucleoside phosphorylase

Reference： [1]Secrist III, John A. [Nucleosides and Nucleotides, 1999, vol. 18, # 4-5, p. 745 - 757]

9
[ 85-31-4 ]
[ 154-42-7 ]
[ 18646-11-2 ]

Reference： [1]Nucleosides and Nucleotides,1999,vol. 18,p. 745 - 757

10
2-chloro-7⁽⁹⁾H-purine-6-thione [ No CAS ]
[ 154-42-7 ]

Reference： [1]Patent: US2697709,1952,

11
[ 154-42-7 ]
[ 4897-25-0 ]
[ 5581-52-2 ]

Reference： [1]Chemistry of Heterocyclic Compounds,2000,vol. 36,p. 182 - 184

12
[ 154-42-7 ]
[ 2302-28-5 ]
2-amino-6-(1-ethyl-2-methyl-4-nitroimidazolyl-5-mercapto)purine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With sodium hydroxide for 1h; Heating;
72%	With sodium hydroxide In water at 70℃;

Reference： [1]Kochergin; Aleksandrova; Korsunskii; Shlikhunova [Chemistry of Heterocyclic Compounds, 2000, vol. 36, # 2, p. 182 - 184]
[2]Kochergin; Aleksandrova; Tolvinskaya; Zhukova; Pukhal'skaya; Telegin; Pevnitskii; Korsunskii [Pharmaceutical Chemistry Journal, 2000, vol. 34, # 11, p. 579 - 581]

13
[ 154-42-7 ]
[ 18874-52-7 ]
6-(2-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-9H-purin-2-ylamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With sodium hydroxide for 1h; Heating;

Reference： [1]Kochergin; Aleksandrova; Korsunskii; Shlikhunova [Chemistry of Heterocyclic Compounds, 2000, vol. 36, # 2, p. 182 - 184]

14
[ 154-42-7 ]
[ 2550-36-9 ]
S⁶-[(cyclohexyl)methyl]-6-thioguanine [ No CAS ]

Reference： [1]Journal of Pharmacology and Experimental Therapeutics,2005,vol. 312,p. 206 - 213

15
[ 154-42-7 ]
[ 585-29-5 ]
[ 97-55-2 ]
6-thioguanosine 5'-O-monophosphate triethylammonium salt [ No CAS ]

Reference： [1]Organic Letters,2007,vol. 9,p. 4179 - 4182

16
[ 154-42-7 ]
[ 452-06-2 ]

Reference： [1]Journal of general chemistry of the USSR,1982,vol. 52,p. 884 - 887
Zhurnal Obshchei Khimii,1982,vol. 52,p. 1015 - 1019

17
[ 3056-33-5 ]
[ 154-42-7 ]

Reference： [1]Pharmaceutical Chemistry Journal,1985,vol. 19,p. 136 - 138
Khimiko-Farmatsevticheskii Zhurnal,1985,vol. 19,p. 206 - 209

18
[ 154-42-7 ]
[ 5446-90-2 ]

Reference： [1]Journal of the American Chemical Society,1957,vol. 79,p. 2185,2188

19
[ 154-42-7 ]
[ 4014-90-8 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 907

20
[ 154-42-7 ]
[ 59856-85-8 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 907

21
[ 154-42-7 ]
[ 91347-76-1 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 907

22
[ 154-42-7 ]
[ 4014-89-5 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 907

Yield	Reaction Conditions	Operation in experiment
		A method according to claim 10wherein the antimetabolite is selected from the group consisting of: mitomicyn C; methotrexate; 6-mercaptopurine; thioguanine; 5-fluorouracil; cytosine arabinoside; 5-azacytidine; hydroxyurea;
		Condensation product of melamine and p-aminophenol ... 14. 2,6-Diaminopurine 15. 2,8-Diaminoacridine Glycarbylamide (1H-imidazole-4,5-dicarboxamide) Thiazolsulfone (Promizole, 5-[(4-aminophenyl)sulfonyl]-2-thiazolamine) 18. Thioguanine 19. 3,5-Diamino-1,2,4-triazole 20. Piperazine 21. Tryptamine ...
		wherein the agent is an antimetabolite selected from the group consisting of: mitomicyn C; methotrexate; 6-mercaptopurine; thioguanine; 5-fluorouracil; cytosine arabinoside; 5-azacytidine; hydroxyurea;

		..., and R3, independently of each other, are selected from -H, -OH, -NH2, and -SH, and the groups R4, R5 and R6 are selected, independently of each other from -H, -CH3, and -CH2CH3, with the following compounds preferred: ... guanine (R1=NH2, R2=R3=R4=R5=R6=H) uric acid (R1=R2=R3=OH, R4=R5=R6=H) hypoxanthine (R1=OH, R2=R3=R4=R5=R6=H) purinethiol (R1=SH, R2=NH2, R3=R4=R5=R6=H) 6-thioguanine (R1=SH, R2=NH2, R3=R4=R5=R6=H) xanthine (R1=R2=OH, R3=R4=R5=R6=H) caffeine (R1=R2=OH, R3H, R4=R5=R6=CH3) theobromine (R1=R2=OH, R3=R4=H, R5=R6=H) ...
		...2, and R3, independently of each other, are selected from -H, -OH, NH2, -SH and the groups R4, R5, and R6, independently of each other, are selected from -H, -CH3 and -CH2CH3, with the following compounds preferred: ... guanine (R1=NH2, R2=R3=R4=R5=R6=H) uric acid (R1=R2=R3=OH, R4=R5=R6=H) hypoxanthine (R1=OH, R2=R3=R4=R5=R6=H) 6-purinethiol (R1=SH, R2=R3=R4=R5=R6=H) 6-thioguanine (R1=SH, R2=NH2, R3=R4=R5=R6=H) xanthine (R1=R2=OH, R3=R4=R5=R6=H) caffeine (R1=R2=OH, R3=H, R4=R5=R6=CH3) theobromine (R1=R2=OH, R3=R4=H, R5=R6=H) ...
		Chemotherapeutic agents that are bound to monoclonal antibodies of the present invention to drive the cytotoxic activity include the following: ... tamoxifen, taxol, testosterone propionate, thalidomide, thioguanine, thiotepa, teniposide, topotecan, ...
		Illustrative examples of chemotherapeutic agents which may be conjugated with the antibody of the invention and have a cytotoxic effect include: ... tamoxifen, taxol, testosterone propionate, thalidomide, thioguanine, thiotepa, teniposide, topotecan, ...
		... independently of one another, are selected from -H, -OH, NH2, -SH and the residues R4, R5 and R6, independently of one another, are selected from -H, -CH3 and -CH2-CH3, wherein the following compounds are preferred: ...guanine (R1=OH, R2=NH2, R3=R4=R5=R6=H)uric acid (R1=R2=R3=OH, R4=R5=R6=H)hypoxanthine (R1=OH, R2=R3=R4=R5=R6=H)6-purinethiol (R1=SH, R2=R3=R4=R5=R6=H)6-thioguanine (R1=SH, R2=NH2, R3=R4=R5=R6=H)xanthine (R1=R2=OH, R3=R4=R5=R6=H)caffeine (R1=R2=OH, R3=H, R4=R5=R6=CH3)theobromine (R1=R2=OH, R3=R4=H, R5=R6=CH3)

24
[ 154-42-7 ]
[ 776-74-9 ]
[ 35611-95-1 ]

Yield	Reaction Conditions	Operation in experiment
24 g (48%)	With potassium carbonate; In N,N-dimethyl-formamide;	(a) 2-Amino-6-[(diphenylmethyl)thio]purine STR25 A mixture of <strong>[154-42-7]thioguanin</strong>e (25 g), bromodiphenylmethane (37.1 g) and potassium carbonate (31.1 g) in N,N-dimethylformamide (250 cm3) was stirred at ambient temperature for 66 hour. The reaction mixture was filtered and the filtrate evaporated to give a cream solid. Recrystallisation from methanol gave 24 g (48%) of the title compound, m.p. 226-227 C. 1 H n.m.r. (D6 DMSO): delta 6.35 (s, 2H, -NH2), 6.70 (s, 1H, SCH<), 7.30 (m, 6H, C6 H5 -), 7.50 (d, 4H, C6 H5 -), 7.90 (s, 1H, H-8), 12.50 (brs, 1H, >N-H).

Reference： [1]Patent: US5017701,1991,A

25
[ 154-42-7 ]
nickel(II) chloride hexahydrate [ No CAS ]
Ni(6-TGH)2*2H₂O [ No CAS ]