[ CAS No. 14464-30-3 ] {[proInfo.proName]}

Name: 14464-30-3|2,5-Dioxopyrrolidin-1-yl octanoate|97%
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SKU: A386850
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Quality Control of [ 14464-30-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 14464-30-3 ]

Product Details of [ 14464-30-3 ]

CAS No. :	14464-30-3	MDL No. :	MFCD00050404
Formula :	C₁₂H₁₉NO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PEJVSXYBFAVPAQ-UHFFFAOYSA-N
M.W :	241.28	Pubchem ID :	3542774
Synonyms :

Calculated chemistry of [ 14464-30-3 ]

Physicochemical Properties

Num. heavy atoms :	17
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.75
Num. rotatable bonds :	8
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	66.18
TPSA :	63.68 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.2 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.66
Log Po/w (XLOGP3) :	2.22
Log Po/w (WLOGP) :	1.57
Log Po/w (MLOGP) :	1.62
Log Po/w (SILICOS-IT) :	2.06
Consensus Log Po/w :	2.03

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.21
Solubility :	1.5 mg/ml ; 0.00622 mol/l
Class :	Soluble
Log S (Ali) :	-3.19
Solubility :	0.155 mg/ml ; 0.000642 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.62
Solubility :	0.586 mg/ml ; 0.00243 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	2.69

Safety of [ 14464-30-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 14464-30-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 14464-30-3 ]
Downstream synthetic route of [ 14464-30-3 ]

[ 14464-30-3 ] Synthesis Path-Upstream 1~1

1
[ 14464-30-3 ]
[ 491833-28-4 ]
[ 491833-29-5 ]

Yield	Reaction Conditions	Operation in experiment
75%	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18 h;	A compound of formula (VII) (60 mg, 0.22 mmol) in 5 mL of N, N dimethylformamide,Add DIPEA (0.065 mL, 0.38 mmol),Then intermediate A (60 mg, 0.24 mmol),Room temperature 18h,After the TLC is displayed completely,Extracted with 20 mL of ethyl acetate and washed with water.Wash with saturated sodium chloride and dry over anhydrous sodium sulfate.Filtration, evaporation of the solvent, and column chromatography (PE: EA = 10: 1-DCM: MeOH = 10:1) afforded product 65mg, yield 75percent.
74%	at 10 - 20℃; Inert atmosphere	(1 R, 2R)-2-Amino-1 -(2', 3'-dihydro-benzo [1 , 4] dioxin-6'-yl)-3-pyrrolidin-1 -yl-propan- 1 -ol (15g) obtained from above stage 5 was dissolved in dry dichloromethane (150ml) at room temperature under nitrogen atmosphere and cooled to 10-15^° C. Octanoic acid N-hydroxy succinimide ester (13.0 g)was added to the above reaction mass at 10-15^° C and stirred for 15 min. The reaction mixture was stirred at room temperature for 16h-18h. Progress of the reaction was monitored by thin layer chromatography. After completion of reaction, the reaction mixture was cooled to 15°C and diluted with 2M NaOH solution (100 ml_) and stirred for 20 min at 20 °C. The organic layer was separated and washed with 2M sodium hydroxide (3x90ml).The organic layer was dried over anhydrous sodium sulphate (30g) and concentrated under reduced pressure at a water bath temperature of 45^°C to give the crude compound (20g).The crude is again dissolved in methyl tertiary butyl ether (25 ml_) and precipitated with Hexane (60ml). It is stirred for 10 min, filtered and dried under vacuum to afford Eliglustat as a white solid (16g). Yield: 74percent, Mass (m/zj: 404.7 HPLC (percent Area Method): 97.5 percent, ELSD (percent Area Method): 99.78percent, Chiral HPLC (percent Area Method): 99.78 percent.
55%	at 20℃; for 20 h; Inert atmosphere	At 25 ~ 30 °C, the raw material EGS-SMA2.5g (1 eq) was dissolved in 50 ml of anhydrous DCM and the raw material EGS-SMB2.2g (1 eq) was dissolved in 25 ml of anhydrous DCM and replaced with nitrogen twice. Under nitrogen, the EGS-SMA solution was slowly added dropwise to the EGS-SMB solution at room temperature for 30 min. After the addition was completed, the reaction was continued for 20 hours at room temperature. 35 ml of 1 M NaOH was added to the reaction system and stirred for 45 min. After the completion of the reaction, the reaction system was separated, the organic phase was washed twice with 20 ml of 1 M NaOH, washed twice, and dried to dryness to obtain a viscous yellow liquid. And further adding 100 ml of a 5percent EA n-hexane solution to the reaction system, heating and refluxing to dissolve most of the crude product, cooling to 40 ° C, and pouring the liquid into another reaction flask. The remaining yellow viscous yellow liquid was further added to 20 ml of a 5percent EA solution of n-hexane, heated to reflux to dissolve most of the crude product, cooled to 40 ° C, poured out and repeated. The resulting n-hexane solution was stirred at room temperature for 4 h, filtered, and 10 ml of 5percent EA of n-hexane was washed twice to give 2 g of a white product as EGS-API in 55percent yield.

39%	at 20℃; Inert atmosphere	Compound 6 (1R,2R)-Octanoic acid [2-(2',3'-dihydro-benzo[1,4]dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide To Intermediate 5 (22.36 g, 80.33 mmol) dissolved in anhydrous methylene chloride (300 mL) was added a solution of octanoic acid N-hydroxysuccinimide ester (19.4 g, 80.39 mmol) dissolved in anhydrous methylene chloride (150 mL) over 15-30 minutes under nitrogen at room temperature. The solution was stirred at room temperature for 18-20 hours. To the reaction was added 1M aqueous NaOH solution (200 mL). The two phase system was stirred at room temperature for 45 minutes. The layers were separated and the combined organic layers were washed twice with 1M NaOH (2200 mL) and twice with water (2100 mL). The organic layer was dried with sodium sulfate, filtered and rotoevaporated to a yellow oil. Most of the crude material was dissolved in 5percent ethyl acetate in heptane (1 L) at reflux. After cooling to 40° C., the hazy solution was separated from the yellow oil by decanting the solution into a new flask. The first flask was rinsed twice with 5percent ethyl acetate in heptane (2250 mL) by the same process (reflux and cooling to 40° C. and decanting the solution from the oil). The combined solution was heated to reflux and allowed to cool to room temperature over 4 hours. The resulting white solid was filtered and washed with 5percent ethyl acetate in heptane (100 mL) and heptane (100 mL). The white solid (13.9 g) was dried under vacuum for 16-24 hours. This solid was mostly dissolved in 5percent ethyl acetate in heptane (800 mL) at reflux. After cooling to 50° C., the hazy solution was separated from the yellow oil by decanting the solution into a new flask. The first flask was rinsed with 5percent ethyl acetate in heptane (100 mL) by the same process (reflux and cooling to 50° C. and decanting the solution from the oil). The combined solution was heated to reflux and allowed to cool to room temperature over 4 hours. The resulting white solid was filtered and washed with 5percent ethyl acetate/heptane (50 mL) and heptane (50 mL). After drying at room temperature under vacuum for 2-3 days, Compound 6 was obtained in 39percent yield (12.57 g). Analytical chiral HPLC (column: Chirex (S)-VAL and (R)-NE, 4.6250 mm) showed this material to be 99.9percent the desired R,R isomer. Analytical HPLC showed this material to be 99.6percent pure. mp 87-88° C. ¹H NMR (CDCl₃) δ 6.86-6.73 (m, 3H), 5.84 (d, J=7.3 Hz, 1H), 4.91 (d, J=3.4 Hz, 1H), 4.25 (s, 4H), 4.24-4.18 (m, 1H), 2.85-2.75 (m, 2H), 2.69-2.62 (m, 4H), 2.10 (t, J=7.3 Hz, 2H), 1.55-1.45 (m, 2H), 1.70-1.85 (m, 4H), 1.30-1.15 (m, 8H), 0.87 (t, J=6.9 Hz, 3H) ppm.
0.3 g	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 24 h;	1 mmol of compound VIII (wherein R5 is a hydrogen atom) was dissolved in 30 ml of DMF, 1.5 mmol of DIPEA was added1.2 mmol of compound IX (wherein R6 is succinimidoyl). Plus 25, 24 hours under the reaction. After the reaction, add water quenchingAnd extracted twice with ethyl acetate. The combined organic phase was washed and dried and concentrated to give 0.3g of etilogluzide
160 mg	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18 h;	Without furher purification, 7 (150 mg, 0.55 mmol) was dissolved in DMF (5 mL), DIPEA (0.16 mL, 0.95 mmol) was added to the mixture. The reaction was stirred for 5 min, then 2,5-dioxopyrrolidin-1-yl octanoate (150 mg, 0.6 mmol) was added and the mixture was stirred at room temperature for 18 h. Water was added to the reaction (15 mL) and extracted with EtOAc (3×30 mL). The combined organics were washed with brine, dried over Na₂SO₄, filtered, concentrated. The residue was purified by flash chromatography (EtOAc/ petroleum ether, 1:10 to DCM/MeOH, 10:1) to afford 1 (160 mg, 61percent for two steps) as a white solid. mp 85–87°C; [α]eq \o(\s\up 6(20),\s\do 2( D))20 D+13 (c, 0.23, CHCl₃); ¹H NMR (400 MHz, CDCl₃) δ 6.76-6.85 (m, 3H), 5.83 (d, J = 7.2 Hz, 1H), 4.90 (d, J = 3.6 Hz, 1H), 4.24 (s, 4H), 4.16-4.20 (m, 1H), 2.74-2.84 (m, 2H), 2.62-2.67 (m, 4H), 2.08-2.12 (m, 2H), 1.77-1.80 (m, 4H), 1.52-1.55 (m, 2H), 1.20-1.30 (m, 10H), 0.87 (t, J = 6.8 Hz, 3H); ¹³C NMR (150 MHz, CDCl₃) δ 173.4, 143.4, 142.8, 134.4, 118.9, 117.0, 115.0, 75.5, 64.3, 57.8, 55.2, 52.2, 36.8, 31.6, 29.1, 29.0, 25.6, 23.6, 22.6, 14.1. HR-MS (ESI) calcd for C₂₃H₃₇O₄N₂ (M+H)⁺: 405.2748, found 405.2725.^[1]

Reference： [1] Patent: CN108822072, 2018, A, . Location in patent: Paragraph 0074; 0075
[2] Patent: WO2015/59679, 2015, A1, . Location in patent: Page/Page column 17
[3] Patent: CN106349210, 2017, A, . Location in patent: Paragraph 0101; 0102; 0103; 0104; 0105; 0106
[4] Patent: US9546161, 2017, B2, . Location in patent: Page/Page column 25; 26
[5] Patent: WO2017/68496, 2017, A1, . Location in patent: Page/Page column 27; 28; 31; 32
[6] Patent: CN106967042, 2017, A, . Location in patent: Paragraph 0363; 0364; 0365; 0366
[7] Synthetic Communications, 2018, vol. 48, # 5, p. 594 - 600

[ 14464-30-3 ] Synthesis Path-Downstream 1~39

1
[ 6066-82-6 ]
[ 124-07-2 ]
[ 14464-30-3 ]

Yield	Reaction Conditions	Operation in experiment
	With dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile; at 20℃;	Aliphatic acid (0.015 mol) was dissolved/suspended in THF/MeCN (~20 mL), Nhydroxysuccinamide(1.8 g, 0.015 mol) and N,N?-dicyclohexylcarbodiimide (3.3 g, 0.015mol) were added to the solution and stirred at rt overnight. The reaction mixture was cooled tobelow 0 C for 1 h before filtering, the filtrate was concentrated in vacuo to give the Nhydroxysuccinamideester as white solid. The reaction was carried out using hexanoic-,octanoic-, or decanoic acid to give the respective N-hydroxysuccinamide ester, with 80-85%yield. The crude product was used in the next step without purification.

Reference： [1]RSC Advances,2015,vol. 5,p. 66339 - 66354
[2]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 5381 - 5390
[3]Agricultural and Biological Chemistry,1980,vol. 44,p. 1309 - 1313
[4]Tetrahedron,1991,vol. 47,p. 8407 - 8416
[5]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3117 - 3121
[6]Journal of the American Chemical Society,2010,vol. 132,p. 14033 - 14035
[7]Journal of Organic Chemistry,2012,vol. 77,p. 938 - 948
[8]Tetrahedron Letters,2014,vol. 55,p. 5902 - 5904

2
[ 74124-79-1 ]
[ 124-07-2 ]
[ 14464-30-3 ]
[ 10276-85-4 ]

Reference： [1]Tetrahedron Letters,1984,vol. 25,p. 4943 - 4946

3
[ 14464-30-3 ]
N-acetyl-glucosaminyl-β-(1->4)-N-acetyl-muramoyl-L-alanyl-D-isoglutaminyl-L-meso-diaminopimelyl-(D-amide)-(L)-D-alanyl-D-alanine [ No CAS ]
N-caproyl PGM [ No CAS ]

Reference： [1]Tetrahedron,1991,vol. 47,p. 8407 - 8416

4
[ 14464-30-3 ]
[ 82816-64-6 ]
[ 81148-70-1 ]

Reference： [1]Carbohydrate Research,1982,vol. 103,p. 251 - 262

5
[ 14464-30-3 ]
N-acetyl-6-amino-6-deoxymuramoyl-L-alanyl-D-isoglutamine [ No CAS ]
2-Acetamido-2,6-dideoxy-6-octanoylamino-3-O-(D-2-propionyl-L-alanyl-D-isoglutamine)-D-glucopyranose [ No CAS ]

Reference： [1]Agricultural and Biological Chemistry,1980,vol. 44,p. 1309 - 1313

6
[ 14464-30-3 ]
[ 81161-21-9 ]
[ 81148-69-8 ]

Reference： [1]Carbohydrate Research,1982,vol. 103,p. 251 - 262

7
[ 14464-30-3 ]
[ 82816-66-8 ]
[ 82816-57-7 ]

Reference： [1]Carbohydrate Research,1982,vol. 103,p. 251 - 262

8
[ 14464-30-3 ]
H-Ser(Bzl)-Asp(OBzl)-Ala-Arg(NO₂)-OMe*TFA [ No CAS ]
[ 188048-68-2 ]

Reference： [1]Il Farmaco,1996,vol. 51,p. 767 - 773

Yield	Reaction Conditions	Operation in experiment
	With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20℃; for 12h;	General procedure: To a solution of carboxylic acid (1 equivalent) and N-hydroxysuccinimide (1.2 equivalent) in dry dichloromethane was added 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.2 equivalent) at 0 C and stirred for 12 hours at room temperature. The stirring was stopped and the reaction mixture was washed with saturated NaHCO3 aqueous solution and then with brine. The organic solution was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the N-hydroxysuccinimide ester. Yield: 61%. 1H NMR (400MHz, CDCl3) delta: 4.24 (s, 2H), 2.88 (s, 4H). (Ghosh, et al. 2012 Chem. Eur. J 18, 236 1-2365)

10
[ 14464-30-3 ]
(desamino-His)-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Arg-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly [ No CAS ]
K³⁴-(N^ε-octanoyl)-(desamino-His)-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Arg-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 1664 - 1669

11
[ 6066-82-6 ]
[ 111-87-5 ]
[ 14464-30-3 ]

Reference： [1]Advanced Synthesis and Catalysis,2004,vol. 346,p. 252 - 256
[2]Chemistry Letters,2006,vol. 35,p. 566 - 567

12
[ 6066-82-6 ]
[ 124-13-0 ]
[ 14464-30-3 ]

Reference： [1]Advanced Synthesis and Catalysis,2004,vol. 346,p. 252 - 256
[2]Chemistry Letters,2006,vol. 35,p. 566 - 567

13
[ 6066-82-6 ]
[ 124-13-0 ]
[ 14464-30-3 ]
[ 124-07-2 ]

Reference： [1]Advanced Synthesis and Catalysis,2004,vol. 346,p. 252 - 256

14
[ 14464-30-3 ]
[ 94856-68-5 ]
octanoylamino-acetic acid octyl ester [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 5381 - 5390

15
[ 14464-30-3 ]
[ 371123-22-7 ]
Octanoic acid ((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-hydroxymethyl-2-phenylsulfanyl-tetrahydro-pyran-3-yl)-amide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 2300 - 2313

16
3-aminopropyl α-D-xylopyranosyl-(1->3)-β-D-glucopyranoside acetic acid salt [ No CAS ]
[ 14464-30-3 ]
3-(octanoylamino)propyl α-D-xylopyranosyl-(1->3)-β-D-glucopyranoside [ No CAS ]

Reference： [1]Synthesis,2007,p. 3147 - 3154

17
3-aminopropyl α-D-xylopyranosyl-(1->3)-α-D-xylopyranosyl-(1->3)-β-D-glucopyranoside acetic acid salt [ No CAS ]
[ 14464-30-3 ]
3-(octanoylamino)propyl α-D-xylopyranosyl-(1->3)-α-D-xylopyranosyl-(1->3)-β-D-glucopyranoside [ No CAS ]

Reference： [1]Synthesis,2007,p. 3147 - 3154

18
[ 14464-30-3 ]
(S)-2-{(S)-2-[(S)-3-Carboxy-2-((S)-3-hydroxy-2-octanoylamino-propionylamino)-propionylamino]-propionylamino}-5-guanidino-pentanoic acid [ No CAS ]

Reference： [1]Il Farmaco,1996,vol. 51,p. 767 - 773

19
[ 14464-30-3 ]
Capr-Ser(Bzl)-Asp(OBzl)-Ala-Arg(NO₂)-OH [ No CAS ]

Reference： [1]Il Farmaco,1996,vol. 51,p. 767 - 773

20
[ 786666-25-9 ]
[ 14464-30-3 ]
[ 786666-32-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; In ethanol; at 20℃;	11beta-{5-[Methyl(octanoyl)amino]pentyl}-8-vinyl-estra-1,3,5(10)-triene-3,17beta-diol (38a) In the reaction with octanoic acid-N-succinimidyl ester analogously to instructions 24.1, 9 mg of amine 31a yields 10 mg of amine 38a as colorless crystals [LC-MS: m/z theor.: 523, pract.: 524 (M+H)+].

Reference： [1]Patent: US2005/65135,2005,A1 .Location in patent: Page/Page column 23; sheet 7

21
[ 6066-82-6 ]
[ 111-64-8 ]
[ 14464-30-3 ]

Yield	Reaction Conditions	Operation in experiment
84%	With triethylamine; In n-heptane; dichloromethane;	Octanoic Acid N-Hydroxysuccinimide Ester N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over 0.5 hours. The ice bath was removed and the solution with a white solid was stirred for 1 hour at room temperature. The white solid was removed by filtration and the filtrate was washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried with sodium sulfate, filtered and heptane (100 mL) was added. The solution was rotoevaporated to remove most of the methylene chloride and leave a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, Octanoic acid N-hydroxysuccinimide ester was obtained in 84% yield (35.4 g).: 1H NMR (CDCl3) 2.84 (br s, 4H), 2.60 (t, J=7.48 Hz, 2H), 1.78-1.71 (m, 2H), 1.42-1.26 (m, 8H), 0.88 (t, J=6.7 Hz, 3H) ppm.
84%	With triethylamine; In dichloromethane; at 20℃; for 1.5h;Inert atmosphere; Cooling with ice;	Octanoic Acid N-Hydroxysuccinimide Ester N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over 0.5 hours. The ice bath was removed and the solution with a white solid was stirred for 1 hour at room temperature. The white solid was removed by filtration and the filtrate was washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried with sodium sulfate, filtered and heptane (100 mL) was added. The solution was rotoevaporated to remove most of the methylene chloride and leave a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, Octanoic acid N-hydroxysuccinimide ester was obtained in 84% yield (35.4 g).: 1H NMR (CDCl3) 2.84 (br s, 4H), 2.60 (t, J=7.48 Hz, 2H), 1.78-1.71 (m, 2H), 1.42-1.26 (m, 8H), 0.88 (t, J=6.7 Hz, 311) ppm.
84%	With triethylamine; In dichloromethane; at 0 - 30℃; for 1h;Inert atmosphere;	At 25 ~ 30 C, 20 g (1 eq) of raw material EGS-B0 and 21 g (1.2 eq) of triethylamine were dissolved in 200 ml of DCM and the mixture was purged with nitrogen twice, and the ice bath was cooled to 0 to 5 C,EGS-B0'33.3g (1.18eq) was slowly added dropwise to EGS-B0, the dropping time was 30min, the ice bath was removed and the reaction was continued for 1 h at room temperature. After filtration, the organic phase was washed with 100 ml of water, 100 ml of saturated NaHCO3 solution. The organic phase was dried, 100 ml of n-heptane was added, centrifuged at 20 C to DCM, filtered, washed with 10 ml of n-heptane and dried in vacuo for 3 h to give 35 g of white product as EGS-SMB, yield 84%.

With triethylamine; In dichloromethane; acetonitrile; at 20℃; for 3h;Cooling with ice;

NHS (N-hydroxysuccinimide) (380 mg, 3.3 mmol) under ice bathAnd triethylamine (0.42ml, 3mmol)Dissolved in acetonitrile (6ml)And in dichloromethane (6ml),Under the ice bath,Add octanoyl chloride (0.51ml, 3mmol)A solution of dichloromethane.The reaction naturally rises to room temperature,Stir for 3 h.

Reference： [1]Patent: US2003/50299,2003,A1
[2]Patent: US9546161,2017,B2 .Location in patent: Page/Page column 24
[3]Patent: CN106349210,2017,A .Location in patent: Paragraph 0096; 0097; 0098; 0099; 0100
[4]Patent: CN109096243,2018,A .Location in patent: Paragraph 0038; 0072; 0073; 0074

22
[ 14464-30-3 ]
[ 498548-56-4 ]
[ 1080673-14-8 ]
[ 1039560-17-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3117 - 3121

23
[ 14464-30-3 ]
[ 554-62-1 ]
[ 249728-93-6 ]

Reference： [1]Tetrahedron,2009,vol. 65,p. 6390 - 6395

24
[ 14464-30-3 ]
AYSSGAPPMPPF [ No CAS ]
C₆₅H₉₄N₁₂O₁₇S [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 14033 - 14035

25
[ 14464-30-3 ]
[ 950491-35-7 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 938 - 948

26
[ 14464-30-3 ]
[ 1354638-42-8 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 938 - 948

27
[ 14464-30-3 ]
[ 1354638-47-3 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 938 - 948

28
[ 14464-30-3 ]
[ 104566-44-1 ]
[ 1233933-12-4 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 938 - 948

29
[ 14464-30-3 ]
[ 66224-66-6 ]
[ 52854-12-3 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In acetonitrile;Reflux;	Aliphatic acid (0.015 mol) was dissolved/suspended in THF/MeCN (~20 mL), Nhydroxysuccinamide(1.8 g, 0.015 mol) and N,N?-dicyclohexylcarbodiimide (3.3 g, 0.015mol) were added to the solution and stirred at rt overnight. The reaction mixture was cooled tobelow 0 C for 1 h before filtering, the filtrate was concentrated in vacuo to give the Nhydroxysuccinamideester as white solid. The reaction was carried out using hexanoic-,octanoic-, or decanoic acid to give the respective N-hydroxysuccinamide ester, with 80-85%yield. The crude product was used in the next step without purification.Adenine (1.9 g, 0.014 mol), N-hydroxysuccinamide ester (3.0 g, 0.014 mol) andK2CO3 (9.6 g, 0.074 mol) were dissolved/suspended in MeCN (~20 mL) and refluxedovernight. The reaction mixture was cooled to rt, quenched with water (10 mL) and extractedwith CHCl3 (3 × 15 mL), the organic layer was washed with water, brine and dried overanhydrous MgSO4, which was filtered out and the filtrate concentrated in vacuo to obtainwhite amorphous solid. The crude product was purified using a normal phase silica column(100% CHCl3 - 10% MeOH/CHCl3), to give 6N-acyl adenine. The reaction was carried outusing N-hydroxysuccinamide ester hexanoic acid, -octanoic acid, or -decanoic acid to give6N-hexanoyl adenine (1c), 6N-octanoyl adenine (1d) or 6N-decanoyl adenine (1e),respectively.

Reference： [1]Tetrahedron Letters,2014,vol. 55,p. 5902 - 5904

30
[ 14464-30-3 ]
[ 491833-28-4 ]
[ 491833-29-5 ]

Yield	Reaction Conditions	Operation in experiment
82.6%	In dichloromethane; at 10 - 20℃;Inert atmosphere;	A solution of compound 9 (139 g, 0.5 mol) in dichloromethane (1 L) was added to the reaction kettle at room temperature under the protection of nitrogen, and the temperature was lowered to 10-15 C. Add 2,5-dioxopyrrolidin-1-yloctanoate (132.5 g, 0.55 mol) with stirring. The reaction was performed at room temperature for 16-18 h, and the reaction was monitored by TLC. After the reaction was completed, the temperature was lowered to 15 C, and the mixture was quenched with 2N sodium hydroxide solution (1L). The reaction was stirred at 20 C for 20 minutes. The organic phase was separated and washed 3 times with 2N sodium hydroxide solution. Evaporated to dryness under reduced pressure at 45 C to obtain 200 g of crude product. Recrystallized from acetone and isopropanol to obtain eliglustat (167g) as a white solid with a yield of 82.6%.
75%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 18h;	A compound of formula (VII) (60 mg, 0.22 mmol) in 5 mL of N, N dimethylformamide,Add DIPEA (0.065 mL, 0.38 mmol),Then intermediate A (60 mg, 0.24 mmol),Room temperature 18h,After the TLC is displayed completely,Extracted with 20 mL of ethyl acetate and washed with water.Wash with saturated sodium chloride and dry over anhydrous sodium sulfate.Filtration, evaporation of the solvent, and column chromatography (PE: EA = 10: 1-DCM: MeOH = 10:1) afforded product 65mg, yield 75%.
74%	In dichloromethane; at 10 - 20℃;Inert atmosphere;	(1 R, 2R)-2-Amino-1 -(2', 3'-dihydro-benzo [1 , 4] dioxin-6'-yl)-3-pyrrolidin-1 -yl-propan- 1 -ol (15g) obtained from above stage 5 was dissolved in dry dichloromethane (150ml) at room temperature under nitrogen atmosphere and cooled to 10-15 C. Octanoic acid N-hydroxy succinimide ester (13.0 g)was added to the above reaction mass at 10-15 C and stirred for 15 min. The reaction mixture was stirred at room temperature for 16h-18h. Progress of the reaction was monitored by thin layer chromatography. After completion of reaction, the reaction mixture was cooled to 15C and diluted with 2M NaOH solution (100 ml_) and stirred for 20 min at 20 C. The organic layer was separated and washed with 2M sodium hydroxide (3x90ml).The organic layer was dried over anhydrous sodium sulphate (30g) and concentrated under reduced pressure at a water bath temperature of 45C to give the crude compound (20g).The crude is again dissolved in methyl tertiary butyl ether (25 ml_) and precipitated with Hexane (60ml). It is stirred for 10 min, filtered and dried under vacuum to afford Eliglustat as a white solid (16g). Yield: 74%, Mass (m/zj: 404.7 HPLC (% Area Method): 97.5 %, ELSD (% Area Method): 99.78%, Chiral HPLC (% Area Method): 99.78 %.

55%	In dichloromethane; at 20℃; for 20h;Inert atmosphere;	At 25 ~ 30 C, the raw material EGS-SMA2.5g (1 eq) was dissolved in 50 ml of anhydrous DCM and the raw material EGS-SMB2.2g (1 eq) was dissolved in 25 ml of anhydrous DCM and replaced with nitrogen twice. Under nitrogen, the EGS-SMA solution was slowly added dropwise to the EGS-SMB solution at room temperature for 30 min. After the addition was completed, the reaction was continued for 20 hours at room temperature. 35 ml of 1 M NaOH was added to the reaction system and stirred for 45 min. After the completion of the reaction, the reaction system was separated, the organic phase was washed twice with 20 ml of 1 M NaOH, washed twice, and dried to dryness to obtain a viscous yellow liquid. And further adding 100 ml of a 5% EA n-hexane solution to the reaction system, heating and refluxing to dissolve most of the crude product, cooling to 40 C, and pouring the liquid into another reaction flask. The remaining yellow viscous yellow liquid was further added to 20 ml of a 5% EA solution of n-hexane, heated to reflux to dissolve most of the crude product, cooled to 40 C, poured out and repeated. The resulting n-hexane solution was stirred at room temperature for 4 h, filtered, and 10 ml of 5% EA of n-hexane was washed twice to give 2 g of a white product as EGS-API in 55% yield.
39%	In dichloromethane; at 20℃;Inert atmosphere;	Compound 6 (1R,2R)-Octanoic acid [2-(2',3'-dihydro-benzo[1,4]dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide To Intermediate 5 (22.36 g, 80.33 mmol) dissolved in anhydrous methylene chloride (300 mL) was added a solution of octanoic acid N-hydroxysuccinimide ester (19.4 g, 80.39 mmol) dissolved in anhydrous methylene chloride (150 mL) over 15-30 minutes under nitrogen at room temperature. The solution was stirred at room temperature for 18-20 hours. To the reaction was added 1M aqueous NaOH solution (200 mL). The two phase system was stirred at room temperature for 45 minutes. The layers were separated and the combined organic layers were washed twice with 1M NaOH (2200 mL) and twice with water (2100 mL). The organic layer was dried with sodium sulfate, filtered and rotoevaporated to a yellow oil. Most of the crude material was dissolved in 5% ethyl acetate in heptane (1 L) at reflux. After cooling to 40 C., the hazy solution was separated from the yellow oil by decanting the solution into a new flask. The first flask was rinsed twice with 5% ethyl acetate in heptane (2250 mL) by the same process (reflux and cooling to 40 C. and decanting the solution from the oil). The combined solution was heated to reflux and allowed to cool to room temperature over 4 hours. The resulting white solid was filtered and washed with 5% ethyl acetate in heptane (100 mL) and heptane (100 mL). The white solid (13.9 g) was dried under vacuum for 16-24 hours. This solid was mostly dissolved in 5% ethyl acetate in heptane (800 mL) at reflux. After cooling to 50 C., the hazy solution was separated from the yellow oil by decanting the solution into a new flask. The first flask was rinsed with 5% ethyl acetate in heptane (100 mL) by the same process (reflux and cooling to 50 C. and decanting the solution from the oil). The combined solution was heated to reflux and allowed to cool to room temperature over 4 hours. The resulting white solid was filtered and washed with 5% ethyl acetate/heptane (50 mL) and heptane (50 mL). After drying at room temperature under vacuum for 2-3 days, Compound 6 was obtained in 39% yield (12.57 g). Analytical chiral HPLC (column: Chirex (S)-VAL and (R)-NE, 4.6250 mm) showed this material to be 99.9% the desired R,R isomer. Analytical HPLC showed this material to be 99.6% pure. mp 87-88 C. 1H NMR (CDCl3) delta 6.86-6.73 (m, 3H), 5.84 (d, J=7.3 Hz, 1H), 4.91 (d, J=3.4 Hz, 1H), 4.25 (s, 4H), 4.24-4.18 (m, 1H), 2.85-2.75 (m, 2H), 2.69-2.62 (m, 4H), 2.10 (t, J=7.3 Hz, 2H), 1.55-1.45 (m, 2H), 1.70-1.85 (m, 4H), 1.30-1.15 (m, 8H), 0.87 (t, J=6.9 Hz, 3H) ppm.
	In toluene; at 52 - 54℃; for 4.5h;	A flask was charged with (1 R,2R)-2-amino-1 -(2,3-dihydrobenzo[b][1 ,4]dioxin-6-yl)-3- (pyrrolidin-1-yl)propan-1-ol (82 g) in toluene (15 mL) and heated to about 52-54C followed by addition of 2,5-dioxopyrrolidin-1-yl octanoate (71.lg). The mixture was maintained at the same temperature for about 4.5 hours, completion of the reaction is monitored by TLC. Then the mixture was cooled to about 15C at which point 1M sodium hydroxide solution (410 mL) was slowly added over a period of 15 minutes and mixture was stirred at about 28C for another 15-20 minutes. The organic layer was separated and washed with 10% aqueous sodium chloride (2x492 mL), then subjected to vacuum distillation at below 55C to afford the crude compound. Then 20% MTBE in n-hexane (656 mL) was added to the crude material and mixture was stirred at 26-28C for about 3.5 hours followed by filtration of the solid and its washing with n-hexane (246 mL). The obtained solid was dried under vacuum at about 40C for 4.5 hours to afford the title compound.
0.3 g	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25℃; for 24h;	1 mmol of compound VIII (wherein R5 is a hydrogen atom) was dissolved in 30 ml of DMF, 1.5 mmol of DIPEA was added1.2 mmol of compound IX (wherein R6 is succinimidoyl). Plus 25, 24 hours under the reaction. After the reaction, add water quenchingAnd extracted twice with ethyl acetate. The combined organic phase was washed and dried and concentrated to give 0.3g of etilogluzide
160 mg	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 18h;	Without furher purification, 7 (150 mg, 0.55 mmol) was dissolved in DMF (5 mL), DIPEA (0.16 mL, 0.95 mmol) was added to the mixture. The reaction was stirred for 5 min, then 2,5-dioxopyrrolidin-1-yl octanoate (150 mg, 0.6 mmol) was added and the mixture was stirred at room temperature for 18 h. Water was added to the reaction (15 mL) and extracted with EtOAc (3×30 mL). The combined organics were washed with brine, dried over Na2SO4, filtered, concentrated. The residue was purified by flash chromatography (EtOAc/ petroleum ether, 1:10 to DCM/MeOH, 10:1) to afford 1 (160 mg, 61% for two steps) as a white solid. mp 85-87C; [alpha]eq o(sup 6(20),sdo 2( D))20 D +13 (c, 0.23, CHCl3); 1H NMR (400 MHz, CDCl3) delta 6.76-6.85 (m, 3H), 5.83 (d, J = 7.2 Hz, 1H), 4.90 (d, J = 3.6 Hz, 1H), 4.24 (s, 4H), 4.16-4.20 (m, 1H), 2.74-2.84 (m, 2H), 2.62-2.67 (m, 4H), 2.08-2.12 (m, 2H), 1.77-1.80 (m, 4H), 1.52-1.55 (m, 2H), 1.20-1.30 (m, 10H), 0.87 (t, J = 6.8 Hz, 3H); 13C NMR (150 MHz, CDCl3) delta 173.4, 143.4, 142.8, 134.4, 118.9, 117.0, 115.0, 75.5, 64.3, 57.8, 55.2, 52.2, 36.8, 31.6, 29.1, 29.0, 25.6, 23.6, 22.6, 14.1. HR-MS (ESI) calcd for C23H37O4 N2 (M+H)+: 405.2748, found 405.2725. [1]

Reference： [1]Organic Process Research and Development,2019,vol. 23,p. 1204 - 1212
[2]Patent: CN110878079,2020,A .Location in patent: Paragraph 0042-0043
[3]Patent: CN108822072,2018,A .Location in patent: Paragraph 0074; 0075
[4]Patent: WO2015/59679,2015,A1 .Location in patent: Page/Page column 17
[5]Patent: CN106349210,2017,A .Location in patent: Paragraph 0101; 0102; 0103; 0104; 0105; 0106
[6]Patent: US9546161,2017,B2 .Location in patent: Page/Page column 25; 26
[7]Patent: WO2017/68496,2017,A1 .Location in patent: Page/Page column 27; 28; 31; 32
[8]Patent: CN106967042,2017,A .Location in patent: Paragraph 0363; 0364; 0365; 0366
[9]Synthetic Communications,2018,vol. 48,p. 594 - 600

31
[ 14464-30-3 ]
C₃₁H₅₂N₂O₄ [ No CAS ]

Reference： [1]RSC Advances,2015,vol. 5,p. 66339 - 66354

32
[ 14464-30-3 ]
[ 72-18-4 ]
N^α-octanoyl-L-valine [ No CAS ]

Reference： [1]RSC Advances,2015,vol. 5,p. 66339 - 66354

33
[ 14464-30-3 ]
telomycin [ No CAS ]
C₆₇H₉₁N₁₃O₂₀ [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 7692 - 7705

34
[ 14464-30-3 ]
(1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(pyrrolidin-1-yl)-1-((trimethylsilyl)oxy)propan-2-amine [ No CAS ]
N-((1R,2R)-1-((trimethylsilyl)oxy)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(pyrrolidin-1-yl)propan-2-yl)octanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.5 g	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25℃; for 24h;	1 mmol of compound VIII (wherein R5 is trimethylsilyl) was dissolved in 30 ml of DMF and 1.5 mmol of DIPEA was added to 1.2 mmol of compound IX (wherein R6 was succinoxoxy). The reaction was carried out at 25 C for 24 hours. The reaction endsAfter quenching with water and extracting twice with ethyl acetate. The combined organic phases were washed with water and dried to give X 0.5 g.

Reference： [1]Patent: CN106967042,2017,A .Location in patent: Paragraph 0355; 0356; 0357; 0358

35
[ 14464-30-3 ]
(1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(pyrrolidin-1-yl)propan-2-amine [ No CAS ]
N-((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(pyrrolidin-1-yl)propan-2-yl)octanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.9 g	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25℃; for 24h;	1 mmol of compound VIII (wherein R5 is t-butyldimethylsilyl) was dissolved in 30 ml of DMF,1.5 mmol of DIPEA with 1.2 mmol of compound IX (wherein R6 is succinimidyl). Plus complete, 25 C reaction 24 smallTime. After completion of the reaction, the water was quenched and extracted twice with ethyl acetate. After the combined organic phase was washed and dried and concentrated to give X0.9 g.

Reference： [1]Patent: CN106967042,2017,A .Location in patent: Paragraph 0359; 0360; 0361; 0362

36
[ 6066-82-6 ]
C₁₆H₃₃N₃O₂*ClH [ No CAS ]
[ 14464-30-3 ]

Reference： [1]Bioconjugate Chemistry,2017,vol. 28,p. 2772 - 2783

37
[ 124-07-2 ]
[ 14464-30-3 ]

Reference： [1]Bioconjugate Chemistry,2017,vol. 28,p. 2772 - 2783

38
[ 14464-30-3 ]
C₁₅H₁₈⁽²⁾H₄N₂O₃ [ No CAS ]
C₂₃H₃₂⁽²⁾H₄N₂O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
790 mg	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 3.5h;Cooling with ice;	Compound 9 (660 mg, 2.34 mmol) and DIPEA (0.675 ml, 4.09 mmol) were dissolved in dichloromethane (25 ml)After the ice bath is cooled,The existing compound 9a (1.1 eq) was added to the reaction.Naturally rise to room temperature,Reaction 3.5h,TLC monitors the reaction,After the reaction is completed, the solvent is removed by rotary evaporation.Extract with dichloromethane and water,Extracted with dichloromethane to the aqueous phase without product,Combine the organic phase,After drying anhydrous sodium sulfate,Silica gel column chromatography (dichloromethane: MeOH: NH4OH).A white solid was obtained.Merging the columns,The total amount of feed is 950mg,This gave 790 mg of the final product.UV peak position 3.2min (method: acetonitrile / water = 5-100%, 6min)

Reference： [1]Patent: CN109096243,2018,A .Location in patent: Paragraph 0038; 0064; 0065; 0066; 0067; 0068

39
[ 14464-30-3 ]
C₄₄H₆₄N₄O₈Rh₂ [ No CAS ]
C₇₆H₁₂₀N₄O₁₂Rh₂ [ No CAS ]

Reference： [1]Chemical Science,2019,vol. 10,p. 3324 - 3329

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P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 14464-30-3 ] {[proInfo.proName]}

Quality Control of [ 14464-30-3 ]

Related Doc. of [ 14464-30-3 ]

Product Details of [ 14464-30-3 ]

Calculated chemistry of [ 14464-30-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 14464-30-3 ]

Application In Synthesis of [ 14464-30-3 ]

[ 14464-30-3 ] Synthesis Path-Upstream 1~1

[ 14464-30-3 ] Synthesis Path-Downstream 1~39

Pharmaceutical Intermediates of [ 14464-30-3 ]

Eliglustat Intermediates

Related Functional Groups of [ 14464-30-3 ]

Amides

Esters

Related Parent Nucleus of [ 14464-30-3 ]

Aliphatic Heterocycles

Pyrrolidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Pharmaceutical Intermediates of
[ 14464-30-3 ]

Related Functional Groups of
[ 14464-30-3 ]

Related Parent Nucleus of
[ 14464-30-3 ]