Alternatived Products of [ 1384426-12-3 ]
Product Details of [ 1384426-12-3 ]
CAS No. : | 1384426-12-3 |
MDL No. : | MFCD28127272 |
Formula : |
C16H14BrNO5S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
412.26
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1384426-12-3 ]
Application In Synthesis of [ 1384426-12-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1384426-12-3 ]
- 1
-
[ 1384426-09-8 ]
-
[ 1384426-12-3 ]
Yield | Reaction Conditions | Operation in experiment |
60% |
Stage #1: C21H24BrNO5S With boron tribromide In dichloromethane at 20℃; for 2 - 4h;
Stage #2: With hydrogenchloride; water In dichloromethane |
1
Boron tribromide (1.5 equiv excess for each hydroxyl group) was added to a cold solution of the protected product in anhydrous CH2Cl2 (ca. 20 mL/mmol of compounds 5 and (xxiii-xxv)). The reaction mixture was allowed to warm to room temperature and stirred for 2- 4 hours (until HPLC indicated the formation of the desired deprotected product). The solution was cooled and then treated with dilute hydrochloric acid. The solution was extracted three times with ethyl acetate and the combined organic layer was dried over Na2SO4 and evaporated under reduced pressure. The crude product was recrystallized from water/ethanol to give the desired product in 60-70% yield. For compound 9: 1H NMR (400 MHz, in Acetone-d6): δ 9.16 (bs, IH), 7.69 (d, J = 15.4 Hz, IH), 7.31 (d, J= 1.9 Hz, IH), 7.09 (d, J= 1.9 Hz, IH), 7.06 (d, J = 15.4 Hz, IH), 6.44 (s, 2H), 4.76 (d, J = 5.7 Hz, 2H). MS (ESI): found (m/z) 411.93; calculated for C16H15BrNO5S (MH+) 411.97 |