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[ CAS No. 1350514-68-9 ] {[proInfo.proName]}

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Chemical Structure| 1350514-68-9
Chemical Structure| 1350514-68-9
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Product Details of [ 1350514-68-9 ]

CAS No. :1350514-68-9 MDL No. :MFCD22741510
Formula : C38H50N6O9S Boiling Point : -
Linear Structure Formula :- InChI Key :OBMNJSNZOWALQB-NCQNOWPTSA-N
M.W : 766.90 Pubchem ID :44603531
Synonyms :
MK-5172

Safety of [ 1350514-68-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1350514-68-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1350514-68-9 ]
  • Downstream synthetic route of [ 1350514-68-9 ]

[ 1350514-68-9 ] Synthesis Path-Upstream   1~25

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YieldReaction ConditionsOperation in experiment
89% With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18 h; A solution (0.1 M) of (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylic acid in CH2Cl2 was treated with (1R,2S)-1-[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropanaminium chloride (1.3 eq), DIEA (3 eq), DMAP (1.5 eq) and TBTU (1.45 eq).
The resulting mixture was stirred at 20° C. for 18 h and then diluted with EtOAc.
The solution was washed with aqueous HCl (0.2 M), saturated aqueous NaHCO3 and brine.
The organic phases were dried and concentrated to give a residue that was purified by flash-chromatography (eluent 2.5percent MeOH/CH2Cl2) to give the title compound (89percent) as a solid. 13C NMR (100 MHz, DMSO-d6) δ 172.32, 170.63, 169.04, 159.86, 156.95, 154.74, 148.10, 140.41, 133.55 (2 signals), 128.94, 118.21, 117.58, 105.89, 74.88, 59.75, 58.71, 55.68, 54.13, 54.01, 40.13, 34.49, 34.04, 33.76, 32.68, 30.71, 30.43, 28.55, 27.69, 27.28, 26.38, 21.98, 18.49, 10.67, 5.69, 5.46; MS (ES+) m/z 767 (M+H)+
Reference: [1] Patent: US2010/29666, 2010, A1, . Location in patent: Page/Page column 10
[2] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] Patent: EP2764866, 2014, A1, . Location in patent: Paragraph 0190
[2] Patent: WO2015/57611, 2015, A1, . Location in patent: Page/Page column 45-46
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
[2] Patent: EP2764866, 2014, A1,
[3] Patent: EP2764866, 2014, A1,
[4] Patent: WO2015/57611, 2015, A1,
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
[2] Patent: EP2764866, 2014, A1,
[3] Patent: WO2015/57611, 2015, A1,
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
[2] Patent: EP2764866, 2014, A1,
[3] Patent: EP2764866, 2014, A1,
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
[2] Patent: EP2764866, 2014, A1,
[3] Patent: EP2764866, 2014, A1,
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 4, p. 332 - 336
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Reference: [1] Patent: EP2764866, 2014, A1,
[2] Patent: EP2764866, 2014, A1,
[3] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: EP2764866, 2014, A1,
[2] Patent: EP2764866, 2014, A1,
[3] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: EP2764866, 2014, A1,
[2] Patent: EP2764866, 2014, A1,
[3] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: EP2764866, 2014, A1,
[2] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: EP2764866, 2014, A1,
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Reference: [1] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: WO2015/57611, 2015, A1,
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Reference: [1] Patent: WO2015/57611, 2015, A1,
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