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Quality Control of [ 123944-75-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 123944-75-2 ]

CAS No. :	123944-75-2	MDL No. :	MFCD11208364
Formula :	C₉H₁₀ClNO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	183.64	Pubchem ID :	-
Synonyms :

Safety of [ 123944-75-2 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501	UN#:	3261
Hazard Statements:	H302-H314	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 123944-75-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 123944-75-2 ]

[ 123944-75-2 ] Synthesis Path-Downstream 1~13

1
[ 68319-44-8 ]
[ 123944-75-2 ]
[ 123944-76-3 ]

Yield	Reaction Conditions	Operation in experiment
65%	With potassium carbonate In N,N-dimethyl-formamide for 60h; Ambient temperature;

Reference： [1]Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al. [Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580]

2
[ 63024-77-1 ]
[ 74-89-5 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
45%	With triethylamine In dichloromethane; water at 0 - 20℃; for 1.16667h;
	With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1h;
	In tetrahydrofuran; dichloromethane at -10℃; for 0.5h;	General procedure: To a mixture of 3-(chloromethyl)benzoic acid (1.7 g, 9.965 mmol, 1.0 eq) in DCM (50 mL) was added (COCl)2 (1.7 mL, 19.931 mmol, 2.0 eq) drop wise at 0° C. The mixture was stirred for 1 h while the solution became clarified. Then the mixture was concentrated under reduced pressure. To a mixture of the residue in DCM was added a solution of NH3 in THF at -10° C. The mixture was stirred for 0.5 h and then concentrated under reduced pressure to give compound PI-28a (1.3 g, 77%)

Reference： [1]Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al. [Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580]
[2]Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M [Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 17, p. 2475 - 2478]
[3]Current Patent Assignee: FORESEE PHARMACEUTICALS USA - US2019/352288, 2019, A1 Location in patent: Paragraph 0532-0533; 0536

3
[ 123944-75-2 ]
[ 220880-22-8 ]

Yield	Reaction Conditions	Operation in experiment
79.5%	With chloro-trimethyl-silane; thionyl chloride In hexane; water; ethyl acetate; toluene; acetonitrile	c Preparation of 3-(1-Methyltetrazol-5-yl)benzyl Chloride c. Preparation of 3-(1-methyltetrazol-5-yl)benzyl chloride. A 250 mL round bottom flask equipped with a magnetic stirrer, reflux condenser and calcium chloride drying tube was charged with 27.2 g (148 mmol) of 3-(chloromethyl)-N-methylbenzamide, 100 mL of toluene (dried over molecular sieves 4A). To this solution was added 16.2 mL (222 mmol) of thionyl chloride and the mixture was heated to 85-90° C. for 15 h (Note 6). While heating, evolution of gas, presumably hydrogen chloride and sulfur dioxide, was observed. After cooling to room temperature, excess thionyl chloride and toluene were removed under vacuum. The resulting residue was azeotroped with 100 mL of toluene, then dried under high vacuum for 1 h to give the crude imidoyl chloride. A 500 mL, three necked, round bottom flask equipped with a magnetic stirrer, thermometer and argon bubbler was charged with 11.6 g (178 mmol) of sodium azide and 140 mL of acetonitrile (freshly opened bottle). To this suspension was added 23.7 mL (187 mmol) of chlorotrimethylsilane and the mixture was stirred for 1.5 h at room temperature. After cooling to 0° C., a solution of the crude imidoyl chloride, prepared above, in 40 mL of acetonitrile was added. This heterogeneous mixture was stirred for 1-2 h at 0° C., then allowed to warm to room temperature and stirred for 15 h. TLC analysis indicated complete reaction. The reaction mixture was quenched by the addition of 150 mL of water, then diluted with 150 mL of ethyl acetate. The two layers were separated and the aqueous phase was extracted with 2*100 mL of ethyl acetate. The combined organic layers were washed successively with 200 mL of water, and 200 mL of saturated sodium chloride solution. After drying over anhydrous magnesium sulfate, the solution was concentrated. The residue was further dried in vacuo to give a light yellow solid (29.7 g). This solid was dissolved in 220 mL of 5.5:4.5 hexane:ethyl acetate at ~60-70° C. The resultant solution was allowed to cool to room temperature and was seeded with crystals of product, then stored in a refrigerator overnight. The resulting precipitate was collected by filtration and washed with 50 mL of hexane. After drying by suction, 24.5 g (79.5% yield) of 3-(1-methyltetrazol-5-yl)benzyl chloride was obtained as a white amorphous solid, mp 63-65° C.
	Stage #1: 3-(chloromethyl)-N-methylbenzamide With thionyl chloride In toluene at 85 - 90℃; for 15h; Stage #2: With chloro-trimethyl-silane; sodium azide In acetonitrile at 0 - 20℃; for 15h;

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - US6455550, 2002, B1
[2]Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M [Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 17, p. 2475 - 2478]

4
[ 899828-10-5 ]
[ 123944-75-2 ]
<i>N</i>-methyl-3-[2-(pyridin-2-ylamino)-thiazol-5-ylsulfanylmethyl]-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
20%	Stage #1: N-(5-thiocyanatothiazol-2-yl)pyridin-2-amine With sodium tetrahydroborate In tetrahydrofuran; ethanol for 0.416667h; Stage #2: 3-(chloromethyl)-N-methylbenzamide In tetrahydrofuran; ethanol for 2h;

Reference： [1]Borzilleri, Robert M.; Bhide, Rajeev S.; Barrish, Joel C.; D'Arienzo, Celia J.; Derbin, George M.; Fargnoli, Joseph; Hunt, John T.; Jeyaseelan Sr., Robert; Kamath, Amrita; Kukral, Daniel W.; Marathe, Punit; Mortillo, Steve; Qian, Ligang; Tokarski, John S.; Wautlet, Barri S.; Zheng, Xiaoping; Lombardo, Louis J. [Journal of Medicinal Chemistry, 2006, vol. 49, # 13, p. 3766 - 3769]

5
[ 31719-77-4 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
80%	With methylamine hydrochloride; N-ethyl-N,N-diisopropylamine In hexane; dichloromethane; water; toluene	b Preparation of 3-(1-Methyltetrazol-5-yl)benzyl Chloride b. Preparation of 3-(chloromethyl)-N-methylbenzamide. A 250 mL, round bottom flask equipped with a magnetic stirrer, reflux condenser and calcium chloride drying tube was charged with 34.1 g (200 mmol) of 3-chloromethylbenzoic acid and 125 mL of toluene (dried over molecular sieves 4A). To this suspension was added 21.9 mL (300 mmol) of thoinyl chloride and the mixture was heated to 85-90° C. for 15 h. While heating, evolution of gas, presumably hydrogen chloride and sulfur dioxide, was observed. The reaction mixture was cooled to room temperature and excess thionyl chloride and toluene were removed under vacuum. The resulting oily residue was azeotroped with 100 mL of toluene, then dried under high vacuum for 1 h to give the crude acid chloride. A 1 L, three necked, round bottom flask equipped with a magnetic stirrer, addition funnel, thermometer and argon bubbler was charged with the crude acid chloride obtained above, and 400 mL of dichloromethane (dried over molecular sieves 4A). After the solution was cooled to -5 to 0° C. (using an ice-sodium chloride bath), 14.9 g (220 mmol) of methylamine hydrochloride was added in one portion. To this mixture was added 69.6 mL (400 mmol) of diisopropylethylamine (DIPEA) dropwise over 15-20 min, while maintaining the temperature of the reaction mixture below 2° C. After completion of the addition, the mixture was stirred for 45 min at 0 to 5° C., then allowed to warm to room temperature. After stirring for 15 min at room temperature, TLC analysis indicated complete reaction. The reaction mixture was diluted with 250 mL of water, and stirred for 5 minutes. The two layers were separated and the aqueous phase was extracted with 2*100 mL of dichloromethane. The combined organic layers were washed successively with 300 mL of water, and 300 mL of saturated sodium chloride solution. After drying over anhydrous magnesium sulfate, the solution was concentrated by rotary evaporation under house vacuum. The residue was further dried in vacuo to give a light yellow solid. This solid was dissolved in 110 mL of toluene at ~60-70° C. The resulting solution was allowed to cool to room temperature and seeded with crystals of product, then stored in a refrigerator overnight. The resulting precipitate was collected by filtration and washed with 30 mL of hexane. After drying under high vacuum 29.4 g (80.0% yield) of 3-(chloromethyl)-N-methylbenzamide was obtained as a light yellow solid; mp 59-61° C.
	Multi-step reaction with 2 steps 1: SOCl₂ / toluene / 15 h / 85 - 90 °C 2: DIPEA / CH₂Cl₂ / 1 h / 0 - 20 °C
	Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 1 h / 0 °C 2: dichloromethane; tetrahydrofuran / 0.5 h / -10 °C

6
[ 99-04-7 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: NCS; benzoylperoxide / chlorobenzene / 8 h / 95 °C 2: SOCl₂ / toluene / 15 h / 85 - 90 °C 3: DIPEA / CH₂Cl₂ / 1 h / 0 - 20 °C

Reference： [1]Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M [Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 17, p. 2475 - 2478]

7
[ 123944-75-2 ]
2-{5-[1-(3-methylaminocarbonylbenzyl)-2,5-dioxoimidazolidin-4-ylmethyl]-1H-indol-3-yl}ethylamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 65 percent / K₂CO₃ / dimethylformamide / 60 h / Ambient temperature 2: H₂, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂ / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 4: ethanol; H₂O / 2 h / Heating

Reference： [1]Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al. [Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580]

8
[ 123944-75-2 ]
3-[4-(4-Aminobenzyl)-2,5-dioxoimidazolidinylmethyl]-N-methylbenzamide hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 65 percent / K₂CO₃ / dimethylformamide / 60 h / Ambient temperature 2: H₂, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate

Reference： [1]Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al. [Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580]

9
[ 123944-75-2 ]
3-[4-(4-Hydrazino-benzyl)-2,5-dioxo-imidazolidin-1-ylmethyl]-N-methyl-benzamide; hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 65 percent / K₂CO₃ / dimethylformamide / 60 h / Ambient temperature 2: H₂, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂ / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h

Reference： [1]Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al. [Journal of Medicinal Chemistry, 1995, vol. 38, # 18, p. 3566 - 3580]

10
[ 63024-77-1 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; methylamine In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran	S.1.b (b) (b) 3-Chloromethyl-N-methylbenzamide A solution of 3-chloromethylbenzoyl chloride (7.4 g, Aldrich) in DCM (35 ml) was added dropwise at 0° C. over 30 minutes to a stirred mixture of 30% aqu. methylamine (4.5 ml) and triethylamine (3.6 g) in DCM (50 ml). When addition was complete, the mixture was allowed to warm to room temperature over 1 hour with stirring. Further methylamine (0.5 ml) was added and the mixture stirred for a further 10 minutes, then washed with water, 1N aqu. HCl, 1N aqu. NaOH and brine, dried over MgSO4 and evaporated in vacuo to give the desired product as a colourless oil which solidified to a white solid on standing.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - US5225431, 1993, A

11
[ 63024-77-1 ]
[ 593-51-1 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	To a solution of 3-(chloromethyl)-benzoic acid (34.1 g, 200 mmol) in toluene (125 ml_) was added thionyl chloride (21.9 ml_, 300 mmol) at room temperature. The resulting solution was heated at reflux for 15 hours. The reaction mixture was cooled to room temperature and concentrated under vacuum. The resulting oily residue was azeotroped with toluene and dried under high vacuum to obtain the crude acid chloride. To a suspension of the above crude acid chloride (200 mmol) in dichloromethane (400 ml_) was added methylamine hydrochloride (14.9 g, 220 mmol) at -5 °C to 0 °C. Diisopropylethylamine (69.6 ml_, 400 mmol) was added drop- wise over 15-20 minutes at 0 °C. After completion of the addition, the mixture was stirred for 45 minutes at 0 °C , then warmed to room temperature. After stirring at room temperature for 15 minutes, the reaction mixture was diluted with water (300 ml_) and the aqueous layer was extracted with dichloromethane (100 ml_). The combined organic layers were washed with brine and dried over anhydrous magnesium sulfate. Filtration and concentration gave the crude solid which was dissolved in toluene at -60-70 °C. The resulting solution was stored in the refrigerator overnight and the precipitated solids were collected by filtration and then washed with hexanes. After drying in air, 3-(chloromethyl)-Λ/-methyl-benzamide (80%) was isolated as a light yellow solid.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2010/55005, 2010, A1 Location in patent: Page/Page column 93-94

12
[ 123944-75-2 ]
C₉H₉Cl₂N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride In toluene at 20℃; Heating; Reflux;	To a suspension of 3-(chloromethyl)-Λ/-methyl-benzamide (27.2 g, 148 mmol) in toluene (100 ml_) was added thionyl chloride (16.2 ml_, 222 mmol) at room temperature. The resulting suspension was heated at reflux for 15 hours. The reaction mixture was cooled to room temperature and then concentrated under vacuum. The residue was azeotroped with toluene and dried under high vacuum. To a suspension of sodium azide (11.6 g, 178 mmol) in acetonitrile (140 ml_) was added chlorotrimethylsilane (23.7 ml_, 187 mmol) at room temperature and the suspension was stirred for 1.5 hours. The reaction mixture was cooled to -10 °C and the above crude imidoyl chloride (148 mmol) in acetonitrile (40 ml_) was added over 5 minutes. The mixture was stirred for 2 hours at 0 °C and then stirred at room temperature for 15 hours. The reaction mixture was diluted with water (200 ml_) and extracted with ethyl acetate (2 X 100 ml_). The combined organic extracts were washed with brine and dried over anhydrous magnesium sulfate. Filtration and concentration gave a light yellow solid which was dissolved in hexanes-ethyl acetate (220 ml_, 11 :9 ratio) at 60-70 °C. The resulting solution was stored in the refrigerator and the precipitated solids were collected by filtration and washed with hexanes. After drying in air, 3-(1 -methyltetrazol-5-yl)benzyl chloride was isolated as 24.5 g (79.5%) of a white amorphous solid, mp 63-65 0C; HRMS (ES+) cald. for C9H9CIN4 [(M+H)+] 209.0589, obsd. 209.0588.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2010/55005, 2010, A1 Location in patent: Page/Page column 94-95

13
[ 593-51-1 ]
[ 31719-77-4 ]
[ 123944-75-2 ]

Yield	Reaction Conditions	Operation in experiment
98%	Stage #1: 3-chloromethylbenzoic acid With thionyl chloride In toluene at 90℃; Stage #2: methylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.25h; Inert atmosphere;	49A Example 49A 3-(Chloromethyl)-N-methylbenzenecarboxamide 5 g (29.31 mmol) of 3-chloromethylbenzoic acid were suspended in 20 ml of abs. toluene, 5.23 g (43.96 mmol) of thionyl chloride were added dropwise and the mixture was stirred at 90° C. overnight. After cooling to RT, excess thionyl chloride and toluene were evaporated and the residue was dried under high vacuum for 1 h. Under argon, the residue was dissolved in 40 ml of abs. dichloromethane and cooled to 0° C., and 2.18 g (32.24 mmol) of methylamine hydrochloride were added. At 0° C., 7.58 g (58.62 mmol) of N,N-diisopropylethylamine were slowly added dropwise, and the reaction mixture was stirred at 0° C. for 15 min. 100 ml of dichloromethane were added, and the reaction mixture was washed three times with water and once with saturated aqueous sodium chloride solution. The organic phase was dried over sodium sulfate, filtered and concentrated using a rotary evaporator. Yield: 5.28 (98% of theory) LC-MS (Method 6): Rt=0.75 min; MS (ESIpos): m/z=184 [M+H]+. 1H NMR (400 MHz, DMSO-d6): δ=8.53-8.45 (m, 1H), 7.91 (s, 1H), 7.79 (d, 1H), 7.58 (d, 1H), 7.47 (t, 1H), 4.81 (s, 2H), 2.78 (d, 3H).

Reference： [1]Current Patent Assignee: BAYER AG - US2013/210795, 2013, A1 Location in patent: Paragraph 0476-0480

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P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 123944-75-2 ] {[proInfo.proName]}

Quality Control of [ 123944-75-2 ]

Related Doc. of [ 123944-75-2 ]

Product Details of [ 123944-75-2 ]

Safety of [ 123944-75-2 ]

Application In Synthesis of [ 123944-75-2 ]

[ 123944-75-2 ] Synthesis Path-Downstream 1~13

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry