[ CAS No. 1197160-78-3 ] {[proInfo.proName]}

Name: 1197160-78-3|1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea|98%
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Quality Control of [ 1197160-78-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 1197160-78-3 ]

CAS No. :	1197160-78-3	MDL No. :	MFCD16875679
Formula :	C₃₂H₄₁N₉O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DWZAEMINVBZMHQ-UHFFFAOYSA-N
M.W :	615.73	Pubchem ID :	44516953
Synonyms :	PKI-587;PF-05212384;PF5212384;PK-1587	Chemical Name :	1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea

Calculated chemistry of [ 1197160-78-3 ]

Physicochemical Properties

Num. heavy atoms :	45
Num. arom. heavy atoms :	18
Fraction Csp3 :	0.47
Num. rotatable bonds :	10
Num. H-bond acceptors :	8.0
Num. H-bond donors :	2.0
Molar Refractivity :	182.07
TPSA :	128.29 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	Yes
Log Kp (skin permeation) :	-8.34 cm/s

Lipophilicity

Log Po/w (iLOGP) :	4.38
Log Po/w (XLOGP3) :	2.42
Log Po/w (WLOGP) :	1.5
Log Po/w (MLOGP) :	1.35
Log Po/w (SILICOS-IT) :	1.2
Consensus Log Po/w :	2.17

Druglikeness

Lipinski :	2.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.17

Water Solubility

Log S (ESOL) :	-4.82
Solubility :	0.00936 mg/ml ; 0.0000152 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.76
Solubility :	0.0108 mg/ml ; 0.0000175 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-6.97
Solubility :	0.0000663 mg/ml ; 0.000000108 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	4.65

Safety of [ 1197160-78-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1197160-78-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1197160-78-3 ]
Downstream synthetic route of [ 1197160-78-3 ]

[ 1197160-78-3 ] Synthesis Path-Upstream 1~5

1
[ 50533-97-6 ]
[ 1197160-66-9 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: With 1,1'-carbonyldiimidazole In tetrahydrofuran at 50℃; for 2 h; Stage #2: at 53℃; for 16 h;	To a slurry of 4-(3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazine-2-yl)phenyl)ureido)benzoic acid (7, 45.5 g, 0.09 mol) in dry THF (1.6 L) heated to 50 ⁰C was added N,N'-carbonyl diimidazole (28 g, 0.17 mol). The reaction mixture was heated for 2 hours and followed by dimethylaminopiperidine (8, 23.5 g, 0.18 mol) and stirred at 53 ⁰C for 16 hours. The reaction mixture was cooled to the room temperature and filtered. The cake was washed with 2-propanol and air-dried to give 97 percent pure white powder in 88percent yield (49.2 g, 0.08 mol). To the solids stirred in dimethyl acetamide (DMAC, 165 ml) at 70° C for 1 hour was added 2-propanol (640 ml) and the mixture was stirred at 65 ⁰C for additional 1 hour. The solids were filtered, washed with 2-propanol and dried in a vacuum oven at 70⁰C for 16 hour to give crystalline white powder (45 g) with >;99percent purity. The above-mentioned work up process and crystallization procedure gave a Pd residue of 20 ppm.

Reference： [1] Patent: WO2010/96619, 2010, A1, . Location in patent: Page/Page column 29
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2636 - 2645

2
[ 50534-08-2 ]
[ 1197159-91-3 ]
[ 1885-14-9 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
17.8%	Stage #1: With pyridine In N,N-dimethyl-formamide at 5 - 20℃; Stage #2: at 90℃; for 12 h;	0.43 g of 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline (1.26 mmol) was dissolved in 5 mL of DMF, then 0.23 g of pyridine (3 mmol) was added and placed In the ice bath, the temperature is below 5 ° C,0.18 g of phenyl chloroformate (1.15 mmol) dissolved in 3 mL of DMF was added dropwise. After the addition is completed,The reaction was carried out at room temperature. After completion of the reaction, 0.27 g of (4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone (1.1 mmol) was added, and the mixture was heated to 90 ° C for 12 h.After the reaction was completed, the reaction solution was poured into 50 mL of water, a large amount of solid was precipitated, stirred for 20 min, and suction filtered to give a solid.0.2g. The purification was carried out by column chromatography, and the mobile phase was obtained by DCM: methanol: methanol ammonia solution = 10:1: 0.2, and finally, 0.11 g of solid was obtained, yield 17.8percent.

Reference： [1] Patent: CN108456183, 2018, A, . Location in patent: Paragraph 0125-0127

3
[ 50534-08-2 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
16.3%	at 90℃; for 12 h;	0.46 g of phenyl(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)carbamate (0.99 mmol)And 0.24 g of (4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone (0.97 mmol) were dissolved in 5 mL of DMF and heated to 90 ° C for 12 h.After the reaction was completed, the reaction solution was poured into 25 mL of water, a large amount of solid was precipitated, stirred for 20 min, and suction filtered to give a solid.0.4g. Purification using column chromatography, mobile phase using DCM: methanol:Methanol ammonia solution = 10:1:0.2,Finally, 0.1 g of solid is obtained.The yield was 16.3percent.

Reference： [1] Organic Process Research and Development, 2018, vol. 22, # 1, p. 62 - 66
[2] Patent: CN108456183, 2018, A, . Location in patent: Paragraph 0014; 0044; 0121-0123

4
[ 619-72-7 ]
[ 1197160-78-3 ]

Reference： [1] Organic Process Research and Development, 2018, vol. 22, # 1, p. 62 - 66
[2] Patent: CN108456183, 2018, A,
[3] Patent: CN108456183, 2018, A,

5
[ 29366-73-2 ]
[ 1197160-78-3 ]

Reference： [1] Organic Process Research and Development, 2018, vol. 22, # 1, p. 62 - 66
[2] Patent: CN108456183, 2018, A,
[3] Patent: CN108456183, 2018, A,

[ 1197160-78-3 ] Synthesis Path-Downstream 1~12

Yield	Reaction Conditions	Operation in experiment
52%
52%	Stage #1: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 20℃; for 1h; Stage #2: In 1-methyl-pyrrolidin-2-one	76 Preparation of N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide General procedure: To a stirred solution of 4-[3-{4-(4,6-dimorpholino-1,3,5-triazin-2yl)phenyl}ureido]benzoic acid (150 mg; 0.297 mmol), Hunig's base (303 μL, 1.782 mmol), HBTU (563 mg, 1.485 mmol) in 2 mL of NMP was stirred for 1 hr. at room temperature and added N′,N′-dimethylethane-1,2-diamine (130 μL, 1.188 mmol) then stirred overnight. Added CH2Cl2 (40 mL) and washed with sat. NaHCO3 and H2O. Concentrated and purified by silica gel chromatography CH2Cl2:MeOH:7N NH3 in MeOH (10:1:0.22) to give the product as a white solid (98 mg, 57% yield); MS (ESI) m/z=576.4.

2
[ 50533-97-6 ]
[ 1197160-66-9 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: 4-(3-(4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid With 1,1′-carbonyldiimidazole In tetrahydrofuran at 50℃; for 2h; Stage #2: dimethyl-piperidin-4-yl-amine In tetrahydrofuran at 53℃; for 16h;	To a slurry of 4-(3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazine-2-yl)phenyl)ureido)benzoic acid (7, 45.5 g, 0.09 mol) in dry THF (1.6 L) heated to 50 0C was added N,N'-carbonyl diimidazole (28 g, 0.17 mol). The reaction mixture was heated for 2 hours and followed by dimethylaminopiperidine (8, 23.5 g, 0.18 mol) and stirred at 53 0C for 16 hours. The reaction mixture was cooled to the room temperature and filtered. The cake was washed with 2-propanol and air-dried to give 97 % pure white powder in 88% yield (49.2 g, 0.08 mol). To the solids stirred in dimethyl acetamide (DMAC, 165 ml) at 70° C for 1 hour was added 2-propanol (640 ml) and the mixture was stirred at 65 0C for additional 1 hour. The solids were filtered, washed with 2-propanol and dried in a vacuum oven at 700C for 16 hour to give crystalline white powder (45 g) with >;99% purity. The above-mentioned work up process and crystallization procedure gave a Pd residue of 20 ppm.
52%	Stage #1: 4-(3-(4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 20℃; Stage #2: dimethyl-piperidin-4-yl-amine In 1-methyl-pyrrolidin-2-one at 20℃;
	Stage #1: 4-(3-(4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: dimethyl-piperidin-4-yl-amine In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	4.1.1.5. Synthesis of compounds 6aa-ao, 6ba-bd, 6ca-cc and 6da-db. General procedure: A mixture of 5 (0.4 mmol) in dry DMF (3 mL) was added DIPEA(0.8 mmol) and HBTU (0.48 mmol). The resulting mixture wasstirred at room temperature for 40 min under nitrogen atmosphere,and then, the corresponding secondary amine or amide(0.42 mmol) was added. The mixture was stirred under nitrogenatmosphere at 80 C for 8.0 h. Poured into ice-water, the mixturewas extract with DCM (50 mL 3). The combined the organicphases was washed with water (50 mL 3) and saturated NaClsolution (50 mL 1), and dried over Na2SO4. The solution wasconcentrated in vacuo and the crude product was purified by columnchromatography on silica gel (DCM: MeOH 10:1) to affordthe corresponding target compound in 40e90% yield.1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea (6aa).White solid;yield 59.9%; purity: 99.9%; Mp: 286e291 C. 1H NMR (600 MHz,DMSO-d6) d 9.06 (s, 1H),8.94 (s, 1H), 8.29 (d, J 8.8 Hz, 2H), 7.57 (d,J 8.8 Hz, 2H), 7.52 (d, J 8.6 Hz, 2H), 7.34 (d, J 8.5 Hz, 2H), 4.38(s, 1H), 3.82 (d, J 52.7 Hz, 9H), 3.66 (s, 8H), 2.90 (s, 2H), 2.33 (dd,J 12.4, 9.1 Hz, 1H), 2.17 (s, 6H), 1.75 (s, 2H), 1.39e1.26 (m, 2H); 13CNMR (150 MHz, DMSO-d6) d 169.4, 169.3, 165.1, 152.6, 143.2, 141.1,130.5, 129.9, 129.5, 128.5, 118.1, 117.8, 66.5, 61.8, 43.8, 41.9, 28.7.HRMS (ESI): m/z [MH] calcd. for [C32H42N9O4]: [C32H42N9O4]:616.3360, found: 616.3360.

Stage #1: 4-(3-(4-(4,6-bismorpholine-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.666667h; Inert atmosphere; Stage #2: dimethyl-piperidin-4-yl-amine In N,N-dimethyl-formamide at 80℃; Inert atmosphere;

4.1.1.5. Synthesis of compounds 6aa-ao, 6ba-bd, 6ca-cc and 6da-db. General procedure: A mixture of 5 (0.4 mmol) in dry DMF (3 mL) was added DIPEA(0.8 mmol) and HBTU (0.48 mmol). The resulting mixture wasstirred at room temperature for 40 min under nitrogen atmosphere,and then, the corresponding secondary amine or amide(0.42 mmol) was added. The mixture was stirred under nitrogenatmosphere at 80 C for 8.0 h. Poured into ice-water, the mixturewas extract with DCM (50 mL 3). The combined the organicphases was washed with water (50 mL 3) and saturated NaClsolution (50 mL 1), and dried over Na2SO4. The solution wasconcentrated in vacuo and the crude product was purified by columnchromatography on silica gel (DCM: MeOH 10:1) to affordthe corresponding target compound in 40e90% yield.1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea (6aa).White solid;yield 59.9%; purity: 99.9%; Mp: 286e291 C. 1H NMR (600 MHz,DMSO-d6) d 9.06 (s, 1H),8.94 (s, 1H), 8.29 (d, J 8.8 Hz, 2H), 7.57 (d,J 8.8 Hz, 2H), 7.52 (d, J 8.6 Hz, 2H), 7.34 (d, J 8.5 Hz, 2H), 4.38(s, 1H), 3.82 (d, J 52.7 Hz, 9H), 3.66 (s, 8H), 2.90 (s, 2H), 2.33 (dd,J 12.4, 9.1 Hz, 1H), 2.17 (s, 6H), 1.75 (s, 2H), 1.39e1.26 (m, 2H); 13CNMR (150 MHz, DMSO-d6) d 169.4, 169.3, 165.1, 152.6, 143.2, 141.1,130.5, 129.9, 129.5, 128.5, 118.1, 117.8, 66.5, 61.8, 43.8, 41.9, 28.7.HRMS (ESI): m/z [MH] calcd. for [C32H42N9O4]: [C32H42N9O4]:616.3360, found: 616.3360.

Reference： [1]Current Patent Assignee: PFIZER INC - WO2010/96619, 2010, A1 Location in patent: Page/Page column 29
[2]Location in patent: experimental part Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Delos Santos, Efren D.; Chen, Zecheng; Dos Santos, Osvald D.; Ayral-Kaloustian, Semiramis; Khafizova, Gulnaz; Brooijmans, Natasja; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Yu, Ker; Gibbons, James; Abraham, Robert T.; Chaudhary, Inder; Mansour, Tarek S. [Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2636 - 2645]
[3]Wu, Chun-Feng; Wang, Qing-Chen; Chen, Rui; Zhou, Hai-Ling; Wu, Ting-Ting; Du, Yao; Zhang, Na-Na; Zhang, Hui-Min; Fan, Zu-Yan; Wang, Li-Li; Hu, Chu-Jiao; Sang, Zhi-Pei; Li, Hong-Liang; Wang, Ling; Tang, Lei; Zhang, Ji-Quan [European Journal of Medicinal Chemistry, 2022, vol. 229]
[4]Wu, Chun-Feng; Wang, Qing-Chen; Chen, Rui; Zhou, Hai-Ling; Wu, Ting-Ting; Du, Yao; Zhang, Na-Na; Zhang, Hui-Min; Fan, Zu-Yan; Wang, Li-Li; Hu, Chu-Jiao; Sang, Zhi-Pei; Li, Hong-Liang; Wang, Ling; Tang, Lei; Zhang, Ji-Quan [European Journal of Medicinal Chemistry, 2022, vol. 229]

3
[ 26811-96-1 ]
[ 1197160-78-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
	In ethyl acetate; N,N-dimethyl-formamide at 23℃; for 24h;	4 Preraration of a crystalline form of I -(4-[4-(dimethylamino)rireridin-1 - yl1carbonyl)henyl)-3-[4-(4,6-dimorholin-4-yl-1 ,3,5-triazin-2-yl)rhenyllurea L-lactate I -(4-[4-(Dimethylamino)piperidin-1 -yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl- I ,3,5-triazin-2-yl)phenyl]urea (52mg) was weighed into a 2m1 vial. A 22 mg/mIsolution of L-lactic acid in 98:2 v/v ethyl acetate:dimethylformamide (0.5m1) was added to the vial. This slurry was stirred at about 23°C for 24 hours. The slurry was then filtered through a 0.2 pm nylon centrifuge filter to isolate the crystalline title compound.

Reference： [1]Current Patent Assignee: PFIZER INC - WO2016/97949, 2016, A1 Location in patent: Page/Page column 15; 16

4
[ 619-72-7 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: potassium hydroxide / ethanol / 3 h / 78 °C / Green chemistry 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 65 °C / Inert atmosphere; Green chemistry 3.1: hydrogen / tetrahydrofuran / 12 h / 20 °C / Green chemistry 4.1: pyridine / dichloromethane / 5 °C / Green chemistry 4.2: 2 h / 5 °C / Green chemistry 5.1: dimethyl sulfoxide / 3 h / 65 °C / Green chemistry
	Multi-step reaction with 4 steps 1.1: potassium hydroxide / 2-methoxy-ethanol / 4 h / 90 °C 2.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / 55 - 60 °C / Inert atmosphere 2.2: 4.5 h / Inert atmosphere 3.1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 4.1: pyridine / N,N-dimethyl-formamide / 5 - 20 °C 4.2: 12 h / 90 °C
	Multi-step reaction with 5 steps 1.1: potassium hydroxide / 2-methoxy-ethanol / 4 h / 90 °C 2.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / 55 - 60 °C / Inert atmosphere 2.2: 4.5 h / Inert atmosphere 3.1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 4.1: pyridine / N,N-dimethyl-formamide / 2 h / 5 - 20 °C 5.1: N,N-dimethyl-formamide / 12 h / 90 °C

Reference： [1]Liu, Xiangyu; Zhu, Guoqing; Li, Lingai; Liu, Yaowei; Wang, Feng; Song, Xiaoping; Mao, Yongjun [Organic Process Research and Development, 2018, vol. 22, # 1, p. 62 - 66]
[2]Current Patent Assignee: SHANGHAI UNIVERSITY OF ENGINEERING SCIENCES - CN108456183, 2018, A
[3]Current Patent Assignee: SHANGHAI UNIVERSITY OF ENGINEERING SCIENCES - CN108456183, 2018, A

5
[ 29366-73-2 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 65 °C / Inert atmosphere; Green chemistry 2.1: hydrogen / tetrahydrofuran / 12 h / 20 °C / Green chemistry 3.1: pyridine / dichloromethane / 5 °C / Green chemistry 3.2: 2 h / 5 °C / Green chemistry 4.1: dimethyl sulfoxide / 3 h / 65 °C / Green chemistry
	Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / 55 - 60 °C / Inert atmosphere 1.2: 4.5 h / Inert atmosphere 2.1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 3.1: pyridine / N,N-dimethyl-formamide / 5 - 20 °C 3.2: 12 h / 90 °C
	Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / 55 - 60 °C / Inert atmosphere 1.2: 4.5 h / Inert atmosphere 2.1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 3.1: pyridine / N,N-dimethyl-formamide / 2 h / 5 - 20 °C 4.1: N,N-dimethyl-formamide / 12 h / 90 °C

6
[ 2161412-22-0 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: hydrogen / tetrahydrofuran / 12 h / 20 °C / Green chemistry 2.1: pyridine / dichloromethane / 5 °C / Green chemistry 2.2: 2 h / 5 °C / Green chemistry 3.1: dimethyl sulfoxide / 3 h / 65 °C / Green chemistry
	Multi-step reaction with 2 steps 1.1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 2.1: pyridine / N,N-dimethyl-formamide / 5 - 20 °C 2.2: 12 h / 90 °C
	Multi-step reaction with 3 steps 1: nickel; hydrogen / tetrahydrofuran / 20 h / 20 °C 2: pyridine / N,N-dimethyl-formamide / 2 h / 5 - 20 °C 3: N,N-dimethyl-formamide / 12 h / 90 °C

7
[ 50534-08-2 ]
[ 1637589-28-6 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
88%	In dimethyl sulfoxide at 65℃; for 3h; Green chemistry;
16.3%	In N,N-dimethyl-formamide at 90℃; for 12h;	12 Example 12 Preparation of 1-(4-(4-(Dimethylamino)piperidin-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazine-2-phenyl)urea 0.46 g of phenyl(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)carbamate (0.99 mmol)And 0.24 g of (4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone (0.97 mmol) were dissolved in 5 mL of DMF and heated to 90 ° C for 12 h.After the reaction was completed, the reaction solution was poured into 25 mL of water, a large amount of solid was precipitated, stirred for 20 min, and suction filtered to give a solid.0.4g. Purification using column chromatography, mobile phase using DCM: methanol:Methanol ammonia solution = 10:1:0.2,Finally, 0.1 g of solid is obtained.The yield was 16.3%.

Reference： [1]Liu, Xiangyu; Zhu, Guoqing; Li, Lingai; Liu, Yaowei; Wang, Feng; Song, Xiaoping; Mao, Yongjun [Organic Process Research and Development, 2018, vol. 22, # 1, p. 62 - 66]
[2]Current Patent Assignee: SHANGHAI UNIVERSITY OF ENGINEERING SCIENCES - CN108456183, 2018, A Location in patent: Paragraph 0014; 0044; 0121-0123

8
[ 50534-08-2 ]
[ 1197159-91-3 ]
[ 1885-14-9 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
17.8%		0.43 g of <strong>[1197159-91-3]4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline</strong> (1.26 mmol) was dissolved in 5 mL of DMF, then 0.23 g of pyridine (3 mmol) was added and placed In the ice bath, the temperature is below 5 C,0.18 g of phenyl chloroformate (1.15 mmol) dissolved in 3 mL of DMF was added dropwise. After the addition is completed,The reaction was carried out at room temperature. After completion of the reaction, 0.27 g of (4-aminophenyl)(4-(dimethylamino)piperidin-1-yl)methanone (1.1 mmol) was added, and the mixture was heated to 90 C for 12 h.After the reaction was completed, the reaction solution was poured into 50 mL of water, a large amount of solid was precipitated, stirred for 20 min, and suction filtered to give a solid.0.2g. The purification was carried out by column chromatography, and the mobile phase was obtained by DCM: methanol: methanol ammonia solution = 10:1: 0.2, and finally, 0.11 g of solid was obtained, yield 17.8%.

Reference： [1]Patent: CN108456183,2018,A .Location in patent: Paragraph 0125-0127

9
[ 1197160-55-6 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; lithium hydroxide monohydrate / 3 h / 85 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere 2.2: 80 °C / Inert atmosphere

Reference： [1]Wu, Chun-Feng; Wang, Qing-Chen; Chen, Rui; Zhou, Hai-Ling; Wu, Ting-Ting; Du, Yao; Zhang, Na-Na; Zhang, Hui-Min; Fan, Zu-Yan; Wang, Li-Li; Hu, Chu-Jiao; Sang, Zhi-Pei; Li, Hong-Liang; Wang, Ling; Tang, Lei; Zhang, Ji-Quan [European Journal of Medicinal Chemistry, 2022, vol. 229]

10
[ 1197159-91-3 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: dichloromethane / 6 h / 20 °C 2.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; lithium hydroxide monohydrate / 3 h / 85 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere 3.2: 80 °C / Inert atmosphere

11
[ 7597-22-0 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: anhydrous sodium carbonate; tetrakis-(triphenylphosphine)-palladium / 1,2-dimethoxyethane / 8 h / 100 °C / Inert atmosphere 2.1: dichloromethane / 6 h / 20 °C 3.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; lithium hydroxide monohydrate / 3 h / 85 °C 4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere 4.2: 80 °C / Inert atmosphere

12
[ 6601-22-5 ]
[ 1197160-78-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C 2.1: anhydrous sodium carbonate; tetrakis-(triphenylphosphine)-palladium / 1,2-dimethoxyethane / 8 h / 100 °C / Inert atmosphere 3.1: dichloromethane / 6 h / 20 °C 4.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran; lithium hydroxide monohydrate / 3 h / 85 °C 5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C / Inert atmosphere 5.2: 80 °C / Inert atmosphere

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1197160-78-3 ] {[proInfo.proName]}

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Application In Synthesis of [ 1197160-78-3 ]

[ 1197160-78-3 ] Synthesis Path-Upstream 1~5

[ 1197160-78-3 ] Synthesis Path-Downstream 1~12

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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