There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1186486-62-3 | MDL No. : | MFCD23105886 |
Formula : | C31H36F6N6O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IHIUGIVXARLYHP-UXNJHFGPSA-N |
M.W : | 638.65 | Pubchem ID : | 49836058 |
Synonyms : |
LY2484595
|
Chemical Name : | 4-trans-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid |
Num. heavy atoms : | 45 |
Num. arom. heavy atoms : | 17 |
Fraction Csp3 : | 0.55 |
Num. rotatable bonds : | 9 |
Num. H-bond acceptors : | 11.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 160.14 |
TPSA : | 87.38 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | Yes |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -4.73 cm/s |
Log Po/w (iLOGP) : | 4.37 |
Log Po/w (XLOGP3) : | 7.7 |
Log Po/w (WLOGP) : | 8.55 |
Log Po/w (MLOGP) : | 6.18 |
Log Po/w (SILICOS-IT) : | 5.36 |
Consensus Log Po/w : | 6.43 |
Lipinski : | 2.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 1.0 |
Muegge : | 3.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -8.34 |
Solubility : | 0.00000295 mg/ml ; 0.0000000046 mol/l |
Class : | Poorly soluble |
Log S (Ali) : | -9.38 |
Solubility : | 0.000000268 mg/ml ; 0.0000000004 mol/l |
Class : | Poorly soluble |
Log S (SILICOS-IT) : | -8.22 |
Solubility : | 0.00000386 mg/ml ; 0.000000006 mol/l |
Class : | Poorly soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 3.0 |
Synthetic accessibility : | 5.31 |
Signal Word: | Danger | Class: | 4.1 |
Precautionary Statements: | P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313 | UN#: | 1325 |
Hazard Statements: | H228-H315-H319 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.