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[ CAS No. 1082949-68-5 ] {[proInfo.proName]}

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Chemical Structure| 1082949-68-5
Chemical Structure| 1082949-68-5
Structure of 1082949-68-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1082949-68-5 ]

CAS No. :1082949-68-5 MDL No. :MFCD29054739
Formula : C28H27F4N7O3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 617.62 Pubchem ID :-
Synonyms :
LY2584702 Tosylate;LY2584702 (tosylate);LYS6K2

Safety of [ 1082949-68-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1082949-68-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1082949-68-5 ]
  • Downstream synthetic route of [ 1082949-68-5 ]

[ 1082949-68-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1082949-67-4 ]
  • [ 104-15-4 ]
  • [ 1082949-68-5 ]
YieldReaction ConditionsOperation in experiment
86% at 20 - 55℃; for 2.33 h; Dissolve 4- {4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-l -methyl- lH-imidazol-2- yl]-piperidin-l-yl}-lH-pyrazolo[3,4-2O:acetone mixture (360 mL). Add a solution of p-toluenesulfonic acid monohydrate (10.25g, 53.9 mmoles, 1.2 eq) in a 20: 1 H2ψ:acetone mixture (40 mL) to the reaction over 20 minutes at 20 0C. Heat the reaction mixture to 55 0C, hold for 1 hour, then cool to 25 0C over 1 hour. Filter the solid and wash the cake with water (40 mL). Drying under vacuum at 50 0C affords 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-l-methyl-lH- imidazol-2-yl]-piperidin-l-yl}-lH-pyrazolo[3,4-(i]pyrimidine p-toluenesulfonate (23.9g, 86percent) as a white solid.
Reference: [1] Patent: WO2008/140947, 2008, A1, . Location in patent: Page/Page column 66
[2] Patent: WO2008/140947, 2008, A1, . Location in patent: Page/Page column 66-68
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Chemical Structure| 1082949-67-4

A125389[ 1082949-67-4 ]

4-(4-(4-(4-Fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Reason: Free-salt