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CAS No. : | 1054543-47-3 | MDL No. : | MFCD19443178 |
Formula : | C33H25F6N3O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZIMMTPFXOMAJTQ-UHFFFAOYSA-N |
M.W : | 625.56 | Pubchem ID : | 24894064 |
Synonyms : |
Apoptosis Activator VII
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30% | at 100℃; for 5 h; | Example 1: Synthesis of 4-2-[3.5-bis(trifluoromethyl')phenyl]-4.5-bis[4-methoχphenyl*)imidazol- 1 -yl-methyl-benzamide f Apoptozole 1); <n="13"/>[64][65] To a stirred solution of ammonium acetate (0.6 g, 8.0 mmol) in acetic acid (5 mL) was added 3,5-bis(trifluoromethyl)benzaldehyde (0.3 μL, 1.7 mmol), 4.4'-dimethoxybenzil (0.5 g, 1.7 mmol) and 4-(aminomethyl)benzamide (0.2 g, 1.3 mmol) at 100 °C. After stirring for 5 h, the reaction mixture was diluted with CH Cl and washed with H 2 O and brine. The organic layer was dried over anhydrous MgSO 4 , filtered and concentrated under the reduced pressure. The crude product was purified by flash column chromatography (3:1 to 1:1 hexane/EtOAc) to give a pure product (0.4 mmol, 30 percent): 1K NMR (250 MHz, CD3OD) δ 8.82 (s,2 H), 8.67 (s, 2 H), 8.40 (d, 2 H, J = 10.0), 8.06 (d, 2 H, J = 8.8), 7.90 (d, 2 H, J = 8.1), 7.62-7.58 (m, 4 H), 7.45 (d, 2 H, J = 8.8), 5.91 (s, 2 H), 4.45 (s, 3 H), 4.40 (s, 3 H) 13C NMR (125 MHz, CD3OD) δ 171.6, 162.0, 160.5, 145.9, 142.4, 140.1, 134.5, 134.3, 133.7, 133.4, 133.2, 132.5, 130.4, 129.6, 129.4, 127.6, 127.2, 123.7, 123.1, 115.8, 114.8, 55.9, 55.8, 40.5 MALDI- TOF-MS calcd for C H F N O (M+Na)+ 648.18, found 648.18. |