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[ CAS No. 1054543-47-3 ] {[proInfo.proName]}

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Chemical Structure| 1054543-47-3
Chemical Structure| 1054543-47-3
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Product Details of [ 1054543-47-3 ]

CAS No. :1054543-47-3 MDL No. :MFCD19443178
Formula : C33H25F6N3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :ZIMMTPFXOMAJTQ-UHFFFAOYSA-N
M.W : 625.56 Pubchem ID :24894064
Synonyms :
Apoptosis Activator VII

Safety of [ 1054543-47-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1054543-47-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1054543-47-3 ]
  • Downstream synthetic route of [ 1054543-47-3 ]

[ 1054543-47-3 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 401-95-6 ]
  • [ 369-53-9 ]
  • [ 1226-42-2 ]
  • [ 1054543-47-3 ]
YieldReaction ConditionsOperation in experiment
30% at 100℃; for 5 h; Example 1: Synthesis of 4-2-[3.5-bis(trifluoromethyl')phenyl]-4.5-bis[4-methoχphenyl*)imidazol- 1 -yl-methyl-benzamide f Apoptozole 1); <n="13"/>[64][65] To a stirred solution of ammonium acetate (0.6 g, 8.0 mmol) in acetic acid (5 mL) was added 3,5-bis(trifluoromethyl)benzaldehyde (0.3 μL, 1.7 mmol), 4.4'-dimethoxybenzil (0.5 g, 1.7 mmol) and 4-(aminomethyl)benzamide (0.2 g, 1.3 mmol) at 100 °C. After stirring for 5 h, the reaction mixture was diluted with CH Cl and washed with H 2 O and brine. The organic layer was dried over anhydrous MgSO 4 , filtered and concentrated under the reduced pressure. The crude product was purified by flash column chromatography (3:1 to 1:1 hexane/EtOAc) to give a pure product (0.4 mmol, 30 percent): 1K NMR (250 MHz, CD3OD) δ 8.82 (s,2 H), 8.67 (s, 2 H), 8.40 (d, 2 H, J = 10.0), 8.06 (d, 2 H, J = 8.8), 7.90 (d, 2 H, J = 8.1), 7.62-7.58 (m, 4 H), 7.45 (d, 2 H, J = 8.8), 5.91 (s, 2 H), 4.45 (s, 3 H), 4.40 (s, 3 H) 13C NMR (125 MHz, CD3OD) δ 171.6, 162.0, 160.5, 145.9, 142.4, 140.1, 134.5, 134.3, 133.7, 133.4, 133.2, 132.5, 130.4, 129.6, 129.4, 127.6, 127.2, 123.7, 123.1, 115.8, 114.8, 55.9, 55.8, 40.5 MALDI- TOF-MS calcd for C H F N O (M+Na)+ 648.18, found 648.18.
Reference: [1] Angewandte Chemie - International Edition, 2008, vol. 47, # 39, p. 7466 - 7469
[2] Patent: WO2008/105565, 2008, A1, . Location in patent: Page/Page column 11-12
  • 2
  • [ 58914-40-2 ]
  • [ 1054543-47-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 16, p. 3889 - 3905
  • 3
  • [ 6232-88-8 ]
  • [ 1054543-47-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 16, p. 3889 - 3905
  • 4
  • [ 52780-16-2 ]
  • [ 1054543-47-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 16, p. 3889 - 3905
  • 5
  • [ 401-95-6 ]
  • [ 1226-42-2 ]
  • [ 1054543-47-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 16, p. 3889 - 3905
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