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Product Details of [ 10501-17-4 ]

CAS No. :10501-17-4 MDL No. :MFCD07364533
Formula : C10H11NO Boiling Point : -
Linear Structure Formula :- InChI Key :IEKPDICCMASELW-UHFFFAOYSA-N
M.W : 161.20 Pubchem ID :4777667
Synonyms :

Safety of [ 10501-17-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 10501-17-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 10501-17-4 ]
  • Downstream synthetic route of [ 10501-17-4 ]

[ 10501-17-4 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 1953-54-4 ]
  • [ 75-03-6 ]
  • [ 10501-17-4 ]
YieldReaction ConditionsOperation in experiment
90% With potassium carbonate In acetone at 50℃; for 96 h; E1. 5-Ethoxy-indole; A mixture of commercially available 5-hydroxy-indole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 equiv) and iodoethane (40.5 ml, 3.75 equiv) in acetone (180 ml_) is stirred at 50 0C under argon. When TLC (dichloromethane-methanol, 95:5) indicates the disappearance of 5-hydroxy-indole (4 days), the mixture is filtered, the solid is washed with acetone, then the filtrate is concentrated to give 17.67 g (90 percent) of the title compound, which is sufficiently pure to be used in the next step. M. p. 144-146 0C (from ethanol).
90% With potassium carbonate In acetone at 50℃; for 96 h; A mixture of commercially available 5-hydroxy-indole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 equiv) and iodoethane (40.5 ml, 3.75 equiv) in acetone (180 ml_) is stirred at 50 0C under argon. When TLC (dichloromethane-methanol, 95:5) indicates the disappearance of 5-hydroxy- indole (4 days), the mixture is filtered, the solid is washed with acetone, then the filtrate is concentrated to give 17.67 g (90 percent) of the title compound, which is sufficiently pure to be used in the next step. M. p. 144-146 0C (from ethanol).
90% With potassium carbonate In acetone at 50℃; for 96 h; A mixture of commercially available 5-hydroxy-indole (18 g, 13.5 mmol), anhydrous K2CO3 (93.5 g, 5 equiv) and iodoethane (40.5 ml, 3.75 equiv) in acetone (180 mL) is stirred at 50 0C under argon. When TLC (dichloromethane-methanol, 95:5 v.v) indicates the disappearance of 5-hydroxy-indole (4 days), the mixture is filtered, the solid is washed with acetone, then the filtrate is concentrated to give 17.67 g (90 percent) of the title compound, which is sufficiently pure to be used in the next step. M. p. 144-1460C (from ethanol).
Reference: [1] Patent: WO2007/96395, 2007, A1, . Location in patent: Page/Page column 123
[2] Patent: WO2009/24190, 2009, A1, . Location in patent: Page/Page column 81
[3] Patent: WO2009/24613, 2009, A1, . Location in patent: Page/Page column 78
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 12, p. 2865 - 2874
  • 2
  • [ 934975-18-5 ]
  • [ 10501-17-4 ]
Reference: [1] Journal of Molecular Structure, 2007, vol. 831, # 1-3, p. 174 - 179
  • 3
  • [ 5815-08-7 ]
  • [ 52177-06-7 ]
  • [ 10501-17-4 ]
Reference: [1] Journal of medicinal chemistry, 1995, vol. 38, # 13, p. 2331 - 2338
  • 4
  • [ 52177-06-7 ]
  • [ 10501-17-4 ]
Reference: [1] Journal of Molecular Structure, 2007, vol. 831, # 1-3, p. 174 - 179
[2] Justus Liebigs Annalen der Chemie, 1935, vol. 516, p. 76,78
  • 5
  • [ 93476-60-9 ]
  • [ 10501-17-4 ]
Reference: [1] Journal of the Chemical Society, 1951, p. 2462,2466
[2] Justus Liebigs Annalen der Chemie, 1935, vol. 516, p. 76,78
  • 6
  • [ 16382-17-5 ]
  • [ 10501-17-4 ]
Reference: [1] Journal of the Chemical Society, 1951, p. 2462,2466
  • 7
  • [ 856095-51-7 ]
  • [ 10501-17-4 ]
Reference: [1] Justus Liebigs Annalen der Chemie, 1935, vol. 516, p. 76,78
  • 8
  • [ 10501-17-4 ]
  • [ 68-12-2 ]
  • [ 169789-47-3 ]
Reference: [1] Journal of medicinal chemistry, 1995, vol. 38, # 13, p. 2331 - 2338
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