Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1027643-30-6 | MDL No. : | MFCD04966888 |
Formula : | C11H13ClN2S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 240.75 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With N-ethyl-N,N-diisopropylamine In acetonitrile at 85℃; Inert atmosphere; | 62 Under argon, a solution of 3-chloro-5-(2,6-dimethoxyphenyl)-1,2,4-triazine (16.4 mg, 0.065 mmol, prepared as in example 41), 2-pyrrolidin-2-yl-1,3-benzothiazole hydrochloride (23.5 mg, 0.098 mmol) and DIPEA (28 µL, 0.16 mmol) in anhydrous acetonitrile (0.25 mL) was stirred at 85°C overnight. The solution was then concentrated and the residue was purified by preparative TLC (silica gel, dichloromethane/methanol 95/5) to afford 2-{1-[5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-yl]pyrrolidin-2-yl}-1,3-benzothiazole (26.8 mg, 98%) as a pale yellow oil. ESI-MS m/z 420 (M+H)+. 1H NMR (CDCl3), δ (ppm): 8.58 (s, 1H), 7.95 (d, J = 8.0 Hz, 1H), 7.80 (d, J = 8.0 Hz, 1H), 7.43 (t, J= 7.9 Hz, 1H), 7.32 (t, J = 8.0 Hz, 2H), 6.53 (d, J = 7.9 Hz, 2H), 5.75 (br s, 1H), 4.15 (br s, 1H), 3.89 (br s, 1H), 3.45 (br s, 6H), 2.54-2.41 (m, 2H), 2.30-2.01 (m, 2H). |