Chemistry Heterocyclic Building Blocks Piperidines
Piperidine has the molecular formula (CH2)5NH and is classified as an organic compound. This heterocyclic amine is composed of a six-membered ring that incorporates five methylene bridges (–CH2–) and one amine bridge (–NH–).
Piperidine is a clear, colorless liquid that emits a smell reminiscent of pepper. It has a lower density than water, but it can be mixed with water and will float on its surface. This liquid has a flash point of 37 °F, a melting point of -15.8 °F (-9 °C), and a boiling point of 222.8 °F (106 °C).
Piperidine, like cyclohexane, exhibits a preference for a chair conformation. However, unlike cyclohexane, piperidine displays two distinct chair conformations characterized by the N–H bond occupying either an axial or an equatorial position.
Piperidine serves both as a solvent and a base, and this is also the case for specific derivatives. For instance, N-formylpiperidine acts as a polar aprotic solvent, exhibiting superior hydrocarbon solubility when compared to other amide solvents.
Piperidine, a nitrogen-containing azacycloalkane, serves various functions including that of a reagent, a protic and non-polar solvent, a base, a catalyst, and a metabolite in both humans and plants. It is essentially a cyclohexane in which one carbon atom is substituted with a nitrogen atom.
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Benzyl 4-formylpiperidine-1-carboxylate
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2-Bromo-5-(piperidin-4-yl)pyridine 2,2,2-trifluoroacetate
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2-Oxa-7-azaspiro[3.5]nonane oxalate(2:1)
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tert-Butyl 4-methyl-4-morpholinopiperidine-1-carboxylate
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tert-Butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate
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tert-Butyl 9-formyl-3-azaspiro[5.5]undecane-3-carboxylate
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1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid
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(R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid